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| 1 | Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization显示文摘 | Wanglin Lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu Zheng Liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang | 2014 | Nano Research2014，7，6： | 36 |
| 2 | Defects as a factor limiting carrier mobility in WSe2: A spectroscopic investigation显示文摘二维的转变金属 dichalcogenides (TMD ) 的电的表演被结构的缺点的数字强烈影响。在这个工作,我们提供一条光分光镜的描述途径相关结构的缺点的数字和 WSe 2 设备的电的表演。electron-beam-lithographyprocessed WSe 2 的低温度的光致发光(PL ) 系列由于缺点一定的激子展出清楚的导致缺点的 PL 排出物,它将强烈降级电的表演。由采用一种 electron-beam-free 转移电极技术,我们成功地准备了包含缺点的有限数量的一台 backgated WSe 2 设备。约 200 厘米 2 | Zhangting Wu Zhongzhong Luo Yuting Shen Weiwei Zhao Wenhui Wang Haiyan Nan Xitao Guo Litao Sun Xinran Wang Yumeng You Zhenhua Ni | 2016 | Nano Research2016，9，12： | 8 |
| 3 | Synergistic graphene/aluminum surface plasmon coupling for zinc oxide lasing improvement显示文摘免费电子的集体摆动在材料的表面上产生电浆子。耳语画廊 microcavity 有效地从它的内部墙基于全部的思考在它的表面上限制轻地。当这些二种电磁波遇见对方时,多于在耳语画廊 microcavity 与 graphene 和艾尔 nanoparticles 的单层是涂的以后, 50 褶层和阀值被减少,从单个 ZnO microrod 的刺激排出物被提高。放射激光的表演的改进被归因于与 ZnO 激子 graphene/Al 表面电浆子联合的 synergistic 精力。放射激光的特征和联合机制系统地被调查。 | Qiuxiang Zhu Feifei Qin Junfeng Lu Zhu Zhu Haiyan Nan Zengliang Shi Zhenhua Ni Chunxiang Xu | 2017 | Nano Research2017，10，6： | 6 |
| 4 | KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer显示文摘Background:Although immune checkpoint inhibitors(ICIs)against programmed cell death protein 1(PD-1)and its ligand PD-L1 have demonstrated potency towards treating patients with non-small cell lung carcinoma(NSCLC),the potential association between Kirsten rat sarcoma viral oncogene homolog(KRAS)oncogene substitutions and the efficacy of ICIs remains unclear.In this study,we aimed to find point mutations in the KRAS gene resistant to ICIs and elucidate resistance mechanism.Methods:The association between KRAS variant status and the efficacy of ICIs was explored with a clinical cohort(n=74),and confirmed with a mouse model.In addition,the tumor immune microenvironment(TIME)of KRASmutant NSCLC,such as CD8+tumor-infiltrating lymphocytes(TILs)and PD-L1 level,was investigated.Cell lines expressing classic KRAS substitutions were used to explore signaling pathway activation involved in the formation of TIME.Furthermore,interventions that improved TIME were developed to increase responsiveness to ICIs.Results:We observed the inferior efficacy of ICIs in KRAS-G12D-mutant NSCLC.Based upon transcriptome data and immunostaining results from KRAS-mutant NSCLC,KRAS-G12D point mutation negatively correlated with PD-L1 level and secretion of chemokines CXCL10/CXCL11 that led to a decrease in CD8+TILs,which in turn yielded an immunosuppressive TIME.The analysis of cell lines overexpressing classic KRAS substitutions further revealed that KRAS-G12D mutation suppressed PD-L1 level via the P70S6K/PI3K/AKT axis and reduced CXCL10/CXCL11 levels by down-regulating high mobility group protein A2(HMGA2)level.Notably,paclitaxel,a chemotherapeutic agent,upregulated HMGA2 level,and in turn,stimulated the secretion of CXCL10/CXCL11.Moreover,PD-L1 blockade combined with paclitaxel significantly suppressed tumor growth compared with PD-L1 inhibitor monotherapy in a mouse model with KRAS-G12D-mutant lung adenocarcinoma.Further analyses revealed that the combined treatment significantly enhanced the recruitment of CD8+TILs via the up-regulation of CXCL10/CXCL11 levels.Results of clinical study also revealed the superior efficacy of chemo-immunotherapy in patients with KRAS-G12D-mutant NSCLC compared with ICI monotherapy.Conclusions:Our study elucidated the molecular mechanism by which KRASG12D mutation drives immunosuppression and enhances resistance of ICIs in NSCLC.Importantly,our findings demonstrate that ICIs in combination with chemotherapy may be more effective in patients with KRAS-G12D-mutant NSCLC. | Chengming Liu Sufei Zheng Zhanyu Wang Sihui Wang Xinfeng Wang Lu Yang Haiyan Xu Zheng Cao Xiaoli Feng Qi Xue Yan Wang Nan Sun Jie He | 2022 | Cancer Communications2022，42，9： | 4 |
| 5 | Realization of vertical and lateral van der Waals heterojunctions using two-dimensional layered organic semiconductors显示文摘凡 der Waals (vdW ) 异质接面基于二维(2D ) 原子晶体广泛地在最近的年里被学习了。此处,我们证明垂直、侧面的 vdW 异质接面能用一个二拍子的圆舞与分层的分子的晶体被认识到物理蒸汽运输(PVT ) 过程。没有阶段在原子力量显微镜学(AFM ) 下面混合,异质接面的两种类型显示出干净、锋利的接口。他们也展出类似于他们的无机的对应物的一个强壮的界面的内建的电场。这些异质接面比单个材料为设备应用有更大的潜力。当垂直异质接面(VHJ ) 设备象 metal-insulator-semiconductor 隧道连接一样表现时,侧面的异质接面(LHJ ) 设备出现在接口为洞由于不对称的精力障碍修正特征,与显著否定微分传导力(NDC ) 。我们的工作扩大 vdW 异质接面的概念到分子的材料,它能被概括到另外的分层的器官的半导体(振荡) 获得新设备功能。 | Yuhan Zhang Zhongzhong Luo Fengrui Hu Haiyan Nan Xiaoyong Wang Zhenhua Ni Jianbin Xu Yi Shi Xinran Wang | 2017 | Nano Research2017，10，4： | 3 |
| 6 | Tectonic Evolution of the North Depression of the South Yellow Sea Basin Since Late Cretaceous显示文摘On the basis of subsidence history analysis and balanced cross-section analysis, the vertical uplift/subsidence history and horizontal extension/compression history of the north depression of the south Yellow Sea basin are quantitatively studied. The results show that the tectonic evolution of the north depression of the south Yellow Sea basin since late Cretaceous can be divided into a rifting phase(late Cretaceous to Paleogene) and a post-rifting phase(Neogene to Quaternary). The rifting phase can be further subdivided into an initial rifting stage(late Cretaceous), an intensive rifting stage(Paleocene), a rifting termination stage(Eocene), and an inversion-uplifting stage(Oligocene). Together, this division shows the characteristics of an episodic-evolved intracontinental rift-depression basin. The deformation of the north depression of the south Yellow Sea basin since late Cretaceous was mainly fault-related. The horizontal extension and tectonic subsidence were controlled by the activity of faults. The differential evolution of faults also caused variations in local uplift/subsidence movements and the regional heterogeneity in extension. The late Cretaceous initial rifting of the north depression of the south Yellow Sea basin is related to the Pacific-Eurasia convergence. From the Paleocene intensive rifting stage to present, the Pacific-Eurasia convergence and India-Eurasia convergence have played important roles in the evolution of this region. | LI Nan LI Weiran LONG Haiyan | 2016 | Journal of Ocean University of China2016，15，6： | 3 |
| 7 | Possibility of women treated with fertility-sparing surgery fornon-epithelial ovarian tumors to safely and successfully becomepregnant--a Chinese retrospective cohort study among 148cases显示文摘This study was performed to evaluate the oncological and reproductive outcomes of childbearing-agewomen treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred andforty eight non-epithelial ovarian tumor women treated with FSS between January I, 2000 and August 31, 2015from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overallsurvival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023),whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associatedwith PFS and OS (P 〈 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), nonedeveloped amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestationsincluding 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis afterFSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followedby ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase thePFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility. | Bin Yang Yan Yu Jing Chen Yan Zhang Ye Yin Nan Yu Ge Chen Shifei Zhu Haiyan Huang Yongqun Yuan Jihui Ai Xinyu Wang Kezhen Li | 2018 | Frontiers of Medicine2018，12，5： | 3 |
| 8 | Retrospective Studies on Clinical Features of Melanosis of the Colon and Its Correlation with the Polypus and Carcinoma of Large Intestine显示文摘OBJECTIVE To investigate the clinical characteristics ofmelanosis of the colon (MC) and its correlation with polypus andcarcinoma of the large intestine.METHODS Clinical feature and colonoscopic findings of 156MC patients were retrospectively analyzed. Final diagnosis of MCcase was made after colonoscopic and pathological examination,and data of the case history was recorded.RESULTS The overall detection rate of MC was 1.12%, with0.46% in males, 0.66% in females. An 82.69% of the patientssuffered various constipations and had a history of takingcathartics. The clinical manifestation of total-colon melanosisoccurred in 83.97% of the patients. There was no significantdifference between the rate of concomitant polypus (27.56%) inthe MC patients and the detection rate of polypus in the patientswho underwent a synchronous colonoscopy (x^2 = 1.205, P = 0.298).Also there was no significant difference between the detectionrate of carcinoma of the large intestine (8.97%) in MC patientsand the detection rate of the same disease in the patients whounderwent synchronous colonoscopy (x^2 = 0.268, P = 0.604). Alogistic regression analysis has shown that the older the age of MCpatients is, the more opportunities of MC and the concomitantpolypus would occur.CONCLUSION MC may be related to constipations and along-term administration of cathartics, among which total-colonmelanosis ranks first in the cases. There is an earlier age of onsetin the females, with a higher detection rate. The older the age ofthe patients is, the higher the detection rate of MC is, and the morepossibility the onset of the concomitant polypus. | Qiong Nan Lei Zhang Jian Shen Xiaoyan Li Yumei Yang Haiyan Jiang | 2009 | Chinese Journal of Clinical Oncology2009，6，2： | 2 |
| 9 | Investigation of multilayer domains in large-scale CVD monolayer graphene by optical imaging显示文摘CVD graphene is a promising candidate for optoelectronic applications due to its high quality and high yield.However,multi-layer domains could inevitably form at the nucleation centers during the growth.Here,we propose an optical imaging technique to precisely identify the multilayer domains and also the ratio of their coverage in large-scale CVD monolayer graphene.We have also shown that the stacking disorder in twisted bilayer graphene as well as the impurities on the graphene surface could be distinguished by optical imaging.Finally,we investigated the effects of bilayer domains on the optical and electrical properties of CVD graphene,and found that the carrier mobility of CVD graphene is seriously limited by scattering from bilayer domains.Our results could be useful for guiding future optoelectronic applications of large-scale CVD graphene. | Yuanfang Yu Zhenzhen Li Wenhui Wang Xitao Guo Jie Jiang Haiyan Nan Zhenhua Ni | 2017 | Journal of Semiconductors2017，38，3： | 2 |
| 10 | Spatial diff erence in net growth rate of Yesso scallop Patinopecten yessoensis revealed by an aquaculture ecosystem model显示文摘Identifying the main factors on spatial diff erences in net growth rate of Yesso scallop(Patinopecten yessoensis)in culture system is the key to eff ective aquaculture management and development.Coupling a 3D ecosystem model(ROMS-CoSiNE)with a dynamic energy budget model for scallops,a Yesso scallop culture ecosystem(YeSCE)model was established with which scallop growth was simulated with real seeding density and juvenile size from local aquaculture experiments from December 1,2012 to November 30,2013.Results show that the YeSCE model has reasonably simulated the environmental variation and scallop net growth rate in the Changhai sea area.The growth of scallops was slow in winter and midsummer and was limited mainly by temperature.Food availability was a key factor that contributed to the fast growth of the scallops during spring to early summer and in autumn.Generally,the scallops cultured in the north part of the Changhai sea area grew faster than those in the south;and the net growth rate for scallops cultured near the island was signifi cantly higher compare to the others,which is probably correlated to the spatial distribution of food availability.Based on the correlation analysis,the spatial diff erences of the net growth rate were largely aff ected by the length of the match timing of temperatures and food availability.The results of this study provide a scientifi c support for optimizing bottom culture planning and adjusting bottom culture methods. | Xueliang NAN Hao WEI Haiyan ZHANG Hongtao NIE | 2022 | Journal of Oceanology and Limnology2022，40，1： | 1 |
| 11 | Remifentanil protects liver against ischemia/reperfusion injury through activation of anti-apoptotic pathways显示文摘 | Ge Zhao Xin Shen Haiyan Nan Linfeng Yan Haikang Zhao Jun Yu Yi Lv | 2013 | Journal of Surgical Research2013，，2： | 1 |
| 12 | Probing the intrinsic optical quality of CVD grown MoS2显示文摘二维的分层的转变金属 dichalcogenides (TMD ) 的光排放效率是影响他们的 optoelectronic 性能的最重要的参数之一。由化学蒸汽免职(CVD ) 的生长参数的优化因此,完成 optoelectronic 等级质量 TMD 是高度合乎需要的。这里,我们在场系统的光致发光(PL ) 估计 CVD 成年瞬间 2 的内在的光、水晶的质量的分光镜的途径(CVD 瞬间 2) 。我们建议在作为监视 CVD 瞬间 2 的内在的光质量的一个有效方法在空和真空中测量的 PL 之间的紧张比率的使用。低温度的 PL 大小也被用来经由联系缺点的界限激子排放在瞬间 2, 评估结构的缺点,它很好与在不同温度种的瞬间 2 的地效果搬运人活动性相关。这个工作因此提供一敏感,描绘 TMD 的光性质的 noninvasive 方法,允许为 optoelectronic 设备的发展调节生长参数。 | Amina Zafar Haiyan Nan Zainab Zafar Zhangting Wu Jie Jiang Yumeng You Zhenhua Ni | 2017 | Nano Research2017，10，5： | 1 |
| 13 | De novo sequencing and comparative analysis of the blueberry transcriptome to discover putative genes related to antioxidants显示文摘 | Xiaoyan Li Haiyue Sun Jiabo Pei Yuanyuan Dong Fawei Wang Huan Chen Yepeng Sun Nan Wang Haiyan Li Yadong Li | 2012 | Gene2012，，1： | 1 |
| 14 | A phase I clinical trial assessing the safety and tolerability of combretastatin A4 phosphate injections显示文摘 | Peng Liu Yan Qin Lingying Wu Sheng Yang Nan Li Haijun Wang Haiyan Xu Kelin Sun Shuxiang Zhang Xiaohong Han Yan Sun Yuankai Shi | 2014 | Anti-Cancer Drugs2014，，4： | 1 |
| 15 | Toxic Effect of Inorganic Arsenite [As(III)] on Metabolic Activity of Bacillus subtilis by Combined Methods显示文摘 | Yanjiao Chen Jun Yao Fei Wang Yong Zhou Huilun Chen Nan Gai Haiyan Chen Ke Chen Thomas Maskow Brunello Ceccanti Polonca Trebse Gyula Zaray | 2008 | Current Microbiology2008，，3： | 1 |
| 16 | Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19显示文摘Dear Editor,Since December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been rapidly spreading worldwide.Hydroxychloroquine and chloroquine are candidates for the treatment of coronavirus disease 2019(COVID-19)owing to its antiviral effect and immunomodulation properties. | Qiuyu Li Cheng Cui Fei Xu Jianping Zhao Nan Li Haichao Li Tianbing Wang Hua Zhang Na Liu Yudong Wei Xiaoye Niu Yan Xu Jianping Dong Xueting Yao Xiaohong Wang Yahong Chen Haiyan Li Chunli Song Jie Qiao Dongyang Liu Ning Shen | 2021 | Science China(Life Sciences)2021，64，4： | 1 |
| 17 | A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea显示文摘To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were detected.Six types of toxins were detected in 24 samples from 9 stations.Lipophilic marine toxins(LMTs)were more common and diverse in these areas.Pectenotoxin 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to south.According to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab research.Meanwhile,contamination risks of cyclic imine toxins in the north and domoic acid(DA)in the south of ECS should also be paid with attention to.Only 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of ECS.As the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two areas.In Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn seasons.To ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas. | Xiaoqing TIAN Chengqi FAN Yunyu TANG Haiyan ZHANG Wei KANG Sha CHEN Chongbin LI Ya’nan LU | 2022 | Journal of Oceanology and Limnology2022，40，6： | 1 |
| 18 | Evaluating Tislelizumab, Lenvatinib, and FOLFOX4-HAIC as a Conversion Therapy for Unresectable Hepatocellular Carcinoma显示文摘Background and aims:Conversion therapy downstages tumors and renders patients with unresectable hepatocel-lular carcinoma(HCC)eligible for radical resection.This study aimed to evaluate the efficacy and safety of tislelizumab plus lenvatinib and hepatic artery infusion chemotherapy with oxaliplatin,fluorouracil,and leuco-vorin(FOLFOX4-HAIC)as a first-line conversion therapy.Methods:Clinical data from HCC patients who were treated with the triple therapy between April 2021 and April 2022 were retrospectively analyzed.The primary outcome included objective response rate(ORR),disease control rate(DCR),conversion resection rate(CRR),and treatment-related adverse events(TRAEs).Results:A total of 18 patients completed conversion therapy assessment,which ended on March 27,2023.The patients had a median age of 55.5(37–72)years,and 94.4%were male.According to mRECIST,tumor shrinkage was observed in all patients,with an ORR of 94.4%(17/18),a DCR of 94.4%(17/18),and a median time to response of 1.4(0.7–3.0)months.Successful conversion was observed in 61.1%(11/18)of patients(mRECIST).The CRR and pathological complete response were 38.9%(7/18)and 57.1%(4/7),respectively.The median progression-free survival(PFS)was 17.8 months,while median overall survival was not reached.The 6-and 9-month PFS rates were 83.3%and 66.7%,respectively.The most common TRAE(16/18 patients,88.9%)was an increase in aspartate aminotransferase levels.Conclusion:Tislelizumab combined with lenvatinib and FOLFOX4-HAIC achieved a high conversion rate and acceptable toxicity in patients with unresectable HCC,suggesting that this combination may represent a new conversion strategy for this population. | Kai Tan Xiaojun He Haoran Yuan Shoujie Zhao Chenyu Gong Yaoyao Zhao Haiyan Nan Li Zang Zhonghua Luo Xilin Du | 2023 | iLIVER2023，2，3： | 0 |
| 19 | Corrigendum to'Discovery and identification of quality markers of Sparganii Rhizoma based on zebrafish thrombosis model'[Chin.Herb.Med.13(2021)389-395]显示文摘When this paper was first published,the authors'affiliation“(“Department of Clinical Pharmacy,The First Affliated Hospital of Shandong First Medical University,Jinan 250014,China)was incom-plete.The corrected affiliation has shown above. | Nan Xu Rong Sun Yinping Shi Liwen Han Haiyan Shi | 2022 | Chinese Herbal Medicines2022，14，1： | 0 |
| 20 | Evaluation of the Application Effect of Short Video Combined with BOPPPS Teaching Mode in Clinical Anesthesia Teaching显示文摘Objective:To study the application effect of short video combined with BOPPPS teaching mode in clinical anesthesia practice.Method:48 students assigned to clinical anesthesia in digestive endoscopy of Shanxi Bethune Hospital from July 1,2022 to April 1,2023 were selected as research objects.They were randomly divided into the control group(PowerPoint presentation teaching group)and the observation group(short video combined with BOPPPS teaching group),with 24 students in each group.After the internship,the students’theoretical and technical scores were tested,the effects of the two teaching modes were compared,and the students’satisfaction was investigated.Results:The test scores of students in the observation group were significantly better than those in the control group(P<0.05).The short video combined with BOPPPS teaching mode can significantly improve students’learning interest,operation skills,and memory(P<0.05).The students’satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion:In clinical practice,the application of short video combined with BOPPPS teaching mode has achieved great effect,which is worth further promotion and research. | Hong Xi Hua Bai Xianhong Jiang Haiyan Huo Huihui Liu Nan Liu | 2023 | Journal of Contemporary Educational Research2023，7，12： | 0 |
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