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| 1 | Numerical Simulation of a Planing Vessel at High Speed显示文摘计划容器处于民用、军事的状况广泛地被使用。由于他们的高速度,计划容器的运动是复杂的。以便预言计划容器的运动,分析以高速度计划容器的水动力学表演是重要的。计算液体动态方法(CFD ) 被建议了计算计划容器的水动力学性能。在很传统的 CFD 途径,然而,模型测试或实验公式被需要在计算前获得计划容器的跑的态度。这份报纸论述一个新 CFD 方法计算计划容器的水动力学力量。数字方法基于平均 Reynolds 的海军司烧(RANS ) 方程。液体(VOF ) 的体积方法和 six-degrees-of-freedom 方程被使用。一个有效过程被介绍在数字模拟解决数字分叉问题。与试验性的结果相比,数字模拟结果显示跑的态度和水动力学性能能以高速度被预言很好。 | Yumin Su Qingtong Chen Hailong Shen Wei Lu | 2012 | Journal of Marine Science and Application2012，11，2： | 15 |
| 2 | Productivity matching and quantitative prediction of coalbed methane wells based on BP neural network显示文摘It is a great challenge to match and predict the production performance of coalbed methane (CBM) wells in the initial production stage due to heterogeneity of coalbed, uniqueness of CBM production process, complexity of porosity-permeability variation and difficulty in obtaining some key parameters which are critical for the conventional prediction methods (type curve, material balance and numerical simulation). BP neural network, a new intelligent technique, is an effective method to deal with nonlinear, instable and complex system problems and predict the short-term change quantitatively. In this paper a BP neural model for the CBM productivity of high-rank CBM wells in Qinshui Basin was established and used to match the past gas production and predict the futural production performance. The results from two case studies showed that this model has high accuracy and good reliability in matching and predicting gas production with different types and different temporal resolutions, and the accuracy increases as the number of outliers in gas production data decreases. Therefore, the BP network can provide a reliable tool to predict the production performance of CBM wells without clear knowledge of coalbed reservoir and sufficient production data in the early development stage. | LU YuMin TANG DaZhen XU Hao TAO Shu | 2011 | Science China(Technological Sciences)2011，54，5： | 9 |
| 3 | K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis显示文摘增加的氧气的 glycolysis 和氧化应力是癌症房间新陈代谢的重要特征,但是内在的生物化学、分子的机制留下逃犯。用四圜素可诱导的模型,我们显示出 K 地岬 G12V 原因 mitochondrial 机能障碍,导致反应的氧的减少的呼吸,提高的 glycolysis,和增加的产生种类。K 地岬蛋白质与线粒体被联系,并且导致呼吸的链建筑群的快速的抑制 -- 我和在由影响 cyclosporin 敏感的渗透的 mitochondrial transmembrane 潜力的减少转移毛孔。而且, K 地岬 在 vitro 的 G12V 表示提高转变房间的能力允许新陈代谢的改编到高 glycolytic 新陈代谢在 vivo 形成肿瘤。我们的学习建议 mitochondrial 机能障碍的那正式就职是由 K 地岬 G12V 在癌症房间引起新陈代谢的变化和 ROS 应力,并且支持肿瘤开发。 | Yumin Hu Weiqin Lu Gang Chen Peng Wang Zhao Chen Yan Zhou Marcia Ogasawara Dunyaporn Trachootham Li Feng Helene Pelicano Paul J Chiao Michael J Keating Guillermo Garcia-Manero Peng Huang | 2012 | Cell Research2012，22，2： | 6 |
| 4 | An experiment-library least-squares method on on-line coal element contents analysis显示文摘A new experiment-library least-squares(experiment-LLs) method used in the neutron inelastic-scattering and thermal-capture analysis(NITA) technique for on-line coal analysis was developed,which has significantly decreased the non-linear radiation effects.In this method,sixty samples with preset elemental contents were made,from whose experimental spectra twenty single-element spectrum libraries corresponding to twenty kinds of coal were built using the least-squares method.The spectrum of the unknown sample was analyzed based on these twenty libraries to estimate its element contents.With the initial estimated result,the procedure of developing library and analysis was iterated to build a new library with the closest element contents to the unknown sample.Hence the experiment-LLs method can reduce non-linear radiation effects.The experiment-LLs method was performed on an improved coal analysis system which was equipped with a long-life 14 MeV pulsed-neutron generator,a bulk BGO detector with a temperature controller,a moisture meter and coal-smoothing device.The precisions of this system for ash content,water content,volatile content and calorific value have reached 1.0wt%,0.5wt%,1.0wt%,350 kJ/kg,respectively. | WANG HuiDong LU JingBin LU YuPing YANG Dong MA KeYan YANG Kang LIU YuMin CHENG DaoWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 6 |
| 5 | Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase显示文摘Introduction:Oncogenic aaivation of the K-ras gene occurs in >90%of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this malignancy.Increase of reactive oxygen species(ROS) has also been observed in a wide spectrum of cancers.This study aimed to investigate the mechanistic association between K-ras-induced transformation and increased ROS stress and its therapeutic implications in pancreatic cancer.Methods:ROS level,NADPH oxidase(NOX) aaivity and expression,and cell invasion were examined in human pancreatic dua epithelial E6E7 cells transfeaed with K-ras^(G12V) compared with parental E6E7 cells.The cytotoxic effea and antitumor effect of capsaicin,a NOX inhibitor,were also tested in vitro and in vivo.Results:K-ras transfeaion caused activation of the membrane-associated redox enzyme NOX and elevated ROS generation through the phosphatidylinositol 3'-kinase(PI3K) pathway.Importantly,capsaicin preferentially inhibited the enzyme aaivity of NOX and induced severe ROS accumulation in K-ras-transformed cells compared with parental E6E7 cells.Furthermore,capsaicin effeaively inhibited cell proliferation,prevented invasiveness of /(-ras-transformed pancreatic cancer cells,and caused minimum toxicity to parental E6E7 cells.In vivo,capsaicin exhibited antitumor aaivity against pancreatic cancer and showed oxidative damage to the xenograft tumor cells.Conclusions:K-ras oncogenic signaling causes increased ROS stress through NOX,and abnormal ROS stress can selectively kill tumor cells by using NOX inhibitors.Our study provides a basis for developing a novel therapeutic strategy to effectively kill K-ras-transformed cells through a redox-mediated mechanism. | Peng Wang Yi-Chen Sun Wen-Hua Lu Peng Huang Yumin Hu | 2015 | Chinese Journal of Cancer2015，34，4： | 5 |
| 6 | Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells:detected by untargeted metabolomics and stable isotope tracing analysis显示文摘Background:Internal tandem duplications(ITD)within the juxtamembrane domain of FMS-like tyrosine kinase 3(FLT3)represent a poor prognostic indicator in acute myeloid leukemia(AML).Therapeutic benefits of tyrosine kinase inhibitors,such as sorafenib,are limited due to the emergence of drug resistance.While investigations have been con-ducted to improve the understanding of the molecular mechanisms underlying the resistance to this FLT3 inhibitor,a profile of cell functioning at the metabolite level and crosstalk between metabolic pathways has yet to be created.This study aimed to elucidate the alteration of metabolomic profile of leukemia cells resistant to the FLT3 inhibitor.Methods:We established two sorafenib-resistant cell lines carrying FLT3/ITD mutations,namely the murine BaF3/ITD-R and the human MV4-11-R cell lines.We performed a global untargeted metabolomics and stable isotope-labe-ling mass spectrometry analysis to identify the metabolic alterations relevant to the therapeutic resistance.Results:The resistant cells displayed fundamentally rewired metabolic profiles,characterized by a higher demand for glucose,accompanied by a reduction in glucose flux into the pentose phosphate pathway(PPP);and by an increase in oxidative stress,accompanied by an enhanced glutathione synthesis.We demonstrated that the highest scoring network of altered metabolites in resistant cells was related to nucleotide degradation.A stable isotope tracing experiment was performed and the results indicated a decrease in the quantity of glucose entering the PPP in resistant cells.Further experiment suggested that the inhibition of major enzymes in the PPP consist of glucose-6-phosphate dehydrogenase deficiency(G6PD)in the oxidative arm and transketolase(TKT)in the non-oxidative arm.In addition,we observed that chronic treatment with sorafenib resulted in an increased oxidative stress in FLT3/ITD-positive leu-kemia cells,which was accompanied by decreased cell proliferation and an enhanced antioxidant response.Conclusions:Our data regarding comparative metabolomics characterized a distinct metabolic and redox adaptation that may contribute to sorafenib resistance in FLT3/ITD-mutated leukemia cells. | Xin You Weiye Jiang Wenhua Lu Hui Zhang Tiantian Yu Jingyu Tian Shijun Wen Guillermo Garcia-Manero Peng Huang Yumin Hu | 2019 | Cancer Communications2019，39，1： | 1 |
| 7 | Design and Fabrication of CD-Like Microfluidic Platforms for Diagnostics: Polymer-Based Microfabrication显示文摘 | L. James Lee Marc J. Madou Kurt W. Koelling Sylvia Daunert Siyi Lai Chee Guan Koh Yi-Je Juang Yumin Lu Liyong Yu | 2001 | Biomedical Microdevices2001，，4： | 1 |
| 8 | SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation显示文摘Oral squamous cell carcinoma(OSCC)become a heavy burden of public health,with approximately 300000 newly diagnosed cases and 145000 deaths worldwide per year.Nucleotide metabolism fuel DNA replication and RNA synthesis,which is indispensable for cell proliferation.But how tumor cells orchestrate nucleotide metabolic enzymes to support their rapid growth is largely unknown.Here we show that expression of pyrimidine metabolic enzyme dihydroorotate dehydrogenase(DHODH)is upregulated in OSCC tissues,compared to non-cancerous adjacent tissues.Enhanced expression of DHODH is correlated with a shortened patient survival time.Inhibition of DHODH by either shRNA or selective inhibitors impairs proliferation of OSCC cells and growth of tumor xenograft.Further,loss of functional DHODH imped de novo pyrimidine synthesis,and disrupt mitochondrial respiration probably through destabilizing the MICOS complex.Mechanistic study shows that transcriptional factor SOX2 plays an important role in the upregulation of DHODH in OSCC.Our findings add to the knowledge of how cancer cells co-opt nucleotide metabolism to support their rapid growth,and thereby highlight DHODH as a potential prognostic and therapeutic target for OSCC treatment. | Xuemei Qiu Sheng Jiang Yanxuan Xiao Yumin He Tao Ren Lu Jiang Rui Liu Qianming Chen | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 9 | Clinical manifestations and outcomes in severe ulcerative colitis显示文摘In order to evaluate the clinical manifestations and outcomes of severe ulcerative colitis(UC),we retrospectively reviewed 41 patients with severe UC from 144 consecutively hospitalized UC cases from 1988 to 2004.Data recorded included onset,symptoms,signs,laboratory results,endoscopic,radiologic and pathologic findings,the clinical treatment process and follow-up.Of these severe cases,92.7%(38/41)had pancolitis.Clinically,36.9%(15/41)were categorized as first onset type,36.9%(15/41)were chronic persistent and 26.8%(11/41)were chronic recurrent.Steroids played a main role in the remission of severe UC(61.0%).Thirty-one cases(75.6%)were relieved by drug therapy.Seven cases(17.1%)progressed to the need for operation.An early age of onset,pancolitis,low hemoglobin and serum albumin levels,and the need for intravenous steroids tended to be associated with the need for surgery.In conclusion,most of the severe UC patients respond well to drug therapy,but for individuals who are unresponsive to drug therapy,or for those depending on steroids,after a reasonable duration of treatment,the necessity for surgery should be considered. | YANG Xuesong YAO Wei LIU Wenbin LI Jun LU Yumin | 2007 | Frontiers of Medicine2007，1，2： | 1 |
| 10 | A New ID-based Multi-Recipient Public-key Encryption Scheme显示文摘 | PANG Liaojun GAO Lu PEI Qingqi GUI Jingjing WANG Yumin | 2013 | Chinese Journal of Electronics2013，22，1： | 1 |
| 11 | Functional polymorphisms in NFκB1 / IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese显示文摘 | Dongsheng Huang Lei Yang Yehua Liu Yumin Zhou Yuan Guo Mingan Pan Yunnan Wang Yigang Tan Haibo Zhong Min Hu Wenju Lu Weidong Ji Jian Wang Pixin Ran Nanshan Zhong Yifeng Zhou Jiachun Lu | 2013 | Human Genetics2013，，4： | 1 |
| 12 | Isolation and identification of a novel cDNA that encodes human yrdC protein显示文摘 | Jinzhong Chen Chaoneng Ji Shaohua Gu Enpeng Zhao Jianliang Dai Lu Huang Ji Qian Kang Ying Yi Xie Yumin Mao | 2003 | Journal of Human Genetics2003，，4： | 1 |
| 13 | Influence of support on catalytic activity of Ni catalysts in p-nitro- phenol hydrogenation to p-aminophenol显示文摘 | Lu Huihong Yin Hengbo Liu Yumin | 2008 | Catal Com- mu2008，10，3： | 1 |
| 14 | A near-complete genome assembly of the allotetrapolyploid Cenchrus fungigraminus(JUJUNCAO)provides insights into its evolution and C4 photosynthesis显示文摘JUJUNCAO(Cenchrus fungigraminus;2n=4x=28)is a Cenchrus grass with the highest biomass production among cultivated plants,and it can be used for mushroom cultivation,animal feed,and biofuel production.Here,we report a nearly complete genome assembly of JUJUNCAO and reveal that JUJUNCAO is an allopolyploid that originated2.7 million years ago(mya).Its genome consists of two subgenomes,and subgenome A shares high collinear synteny with pearl millet.We also investigated the genome evolution of JUJUNCAO and suggest that the ancestral karyotype of Cenchrus split into the A and B ancestral karyotypes of JUJUNCAO.Comparative transcriptome and DNA methylome analyses revealed functional divergence of homeologous gene pairs between the two subgenomes,which was a further indication of asymmetric DNA methylation.The three types of centromeric repeat in the JUJUNCAO genome(CEN137,CEN148,and CEN156)may have evolved independently within each subgenome,with some introgressions of CEN156 from the B to the A subgenome.We investigated the photosynthetic characteristics of JUJUNCAO,revealing its typical C4 Kranz anatomy and high photosynthetic efficiency.NADP-ME and PEPCK appear to cooperate in the major C4 decarboxylation reaction of JUJUNCAO,which is different from other C4 photosynthetic subtypes and may contribute to its high photosynthetic efficiency and biomass yield.Taken together,our results provide insights into the highly efficient photosynthetic mechanism of JUJUNCAO and provide a valuable reference genome for future genetic and evolutionary studies,as well as genetic improvement of Cenchrus grasses. | Huakun Zheng Baiyu Wang Xiuting Hua Ruiting Gao Yuhao Wang Zixin Zhang Yixing Zhang Jing Mei Yongji Huang Yumin Huang Hui Lin Xingtan Zhang Dongmei Lin Siren Lan Zhongjian Liu Guodong Lu Zonghua Wang Ray Ming Jisen Zhang Zhanxi Lin | 2023 | Plant Communications2023，4，5： | 1 |
| 15 | Autoantibodies to tumor-associated antigens as biomarkers in cancer immunodiagnosis显示文摘 | Weihong Liu Bo Peng Yumin Lu Weijia Xu Wei Qian Jian-Ying Zhang | 2010 | Autoimmunity Reviews2010，，6： | 1 |
| 16 | Thermochemical Studies of Selenium Ⅰ.Microcalorimetric Study of Efect of Na_2SeO_3 on Bacilus subtilis Growth显示文摘ThermochemicalStudiesofSeleniumⅠ.MicrocalorimetricStudyofEfectofNa2SeO3onBacilussubtilisGrowthYanChengnong,LiuYi,WangCunxin,S... | Du Yumin Xia Zuyong Lu Rong | 1997 | Wuhan University Journal of Natural Sciences1997，2，2： | 0 |
| 17 | Detection of the synoptic southeastward-extending Siberian cold high during 1978-2017显示文摘为了更好地研究西伯利亚地区反气旋与冷空气活动,东亚地区气温变化之间的关联,本文提出一种基于Mask R-CNN的反气旋识别方法,能够较为准确地刻画反气旋形态特征变化.使用该方法能够识别对中国冬季气温具有较大影响的东南延伸型西伯利亚冷高压(SEESCH),这种冷高压是冬季出现在西伯利亚地区的主要天气系统之一(45.7%).SEESCH携带的冷空气与下游地区温度变化呈显著负相关,52%的SEESCH伴随着华北华东地区冷空气聚集,对区域降温有显著影响.这些结果为研究SEESCH与极端寒冷事件之间的联系提供线索. | Yumin Zhang Chuhan Lu | 2022 | Atmospheric and Oceanic Science Letters2022，15，3： | 0 |
| 18 | Influence of moderate hypothermia on cerebral oxygenation in pigs with intracranial hypertension显示文摘BACKGROUND: Moderate hypothermia is one of the effective therapeutic methods for head injury in recent years, there are many mechanisms of moderate hypothermia for brain protection, and its influence on cerebral oxygenation is also one of them. OBJECTIVE: To observe the influence of moderate hypothermia on cerebral oxygenation of animals with acute intracranial hypertension, and further investigate the protective mechanism of moderate hypothermia. DESIGN: A randomized controlled trial. SETTING: Department of Neurosurgery, Renji Hospital affiliated to the Medical College of Shanghai Jiao Tong University. MATERIALS: Twenty healthy little pigs, either male or female, weighing 4.5–5.5 kg, were used. Neurotrend-typed multiparameter monitoring system (Diametrics Company, British); CMA/100 micro-injection pump (Carnegie Company, Sweden). METHODS: The experiment was conducted in the Changzheng Hospital affiliated to the Second Military Medical University of Chinese PLA in November, 2001. The pigs were randomized into two groups: the normothermia group (control group, n =10) and moderate hypothermia group (n =10). ① Bilateral femoral arteries were separated, one was connected to pressometer for monitoring mean arterial pressure (MEP), and the other for analysis of blood gases [including peripheral blood pH value, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of carbon dioxide (PaCO2), HCO3–]. ② Rectal temperature was monitored with mercurial thermometer. ③ Intracranial pressure was monitored using Camino optic ICP probe placed in the subdural space. ④ Neurotrend multiparameter monitoring sensor was inserted into the white matter for about 4 cm to determine cerebral perfusion pressure (CPP, CPP=MAP(ICP), brain tissue partial oxygen pressure (PO2), partial pressure of carbon dioxide (PCO2), HCO3– and brain temperature. The rectal temperature of animals in the moderate hypothermia group was lowered to 34 ℃ using ice bags, and the body temperature was maintained at 33–35 ℃ for 2 hours. The changes of the parameters were observed continuously, and the pigs in the normothermia group were not treated with cooling. MAIN OUTCOME MEASURES: ① MAP, ICP, rectal temperature, CCP; Indexes of cerebral oxygenation detected with Neurotrend-typed multiparameter monitoring system; ② Results of blood gases analysis in the moderate hypothermia group. RESULTS: All the 20 pigs were involved in the analysis of results. ① MAP, ICP, rectal temperature, CCP and indexes of cerebral oxygenation: In the moderate hypothermia group, the ICP after cooling was obviously lower than that before cooling [(3.31±1.19), (5.33±0.95) kPa, P < 0.05], CCP was higher, brain tissue PCO2 [(12.03±1.73), (10.59±2.01) kPa, P < 0.05], and brain tissue pH value was higher [(7.03± 1.63), (9.40±1.30) kPa, P < 0.05], whereas the brain temperature was decreased as compared with that before cooling [(34.9±0.3), (37.2±0.2) ℃, P < 0.05]. ② Results of blood gases analysis in the moderate hypothermia group: There were no significant differences in the parameters of peripheral arterial blood gases analysis before and after cooling in the moderate hypothermia group (P > 0.05) CONCLUSION: Moderate hypothermia will not impair the cerebral oxygenation, and it can reduce brain tissue CO2 and decrease brain tissue acidosis. | Yinghui Bao Yumin Liang Jiyao Jiang Qizhong Luo Yicheng Lu | 2007 | Neural Regeneration Research2007，2，5： | 0 |
| 19 | RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair显示文摘Exposure to radiation causes DNA damage;hence, continuous surveillance and timely DNA repair are important for genome stability. Epigenetic modifications alter the chromatin architecture, thereby affecting the efficiency of DNA repair. However, how epigenetic modifiers coordinate with the DNA repair machinery to modulate cellular radiosensitivity is relatively unknown. Here, we report that loss of the demethylase ribosomal oxygenase 1(RIOX1) restores cell proliferation and reduces cell death after exposure to ionizing radiation. Furthermore, RIOX1 depletion enhances homologous recombination(HR) repair but not nonhomologous endjoining(NHEJ) repair in irradiated bone marrow cells and oral mucosal epithelial cells. Mechanistic study demonstrates that RIOX1 removes monomethylation at K491 of cyclic GMP-AMP synthase(c GAS) to release c GAS from its interaction with the methyl-lysine reader protein SAGA complex-associated factor 29(SGF29), which subsequently enables c GAS to interact with poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase 1(PARP1) at DNA break sites, thereby blocking PARP1-mediated recruitment of Timeless. High expression of RIOX1 maintains c GAS K491 me at a low level, which impedes HR repair and reduces cellular tolerance to ionizing radiation. This study highlights a novel RIOX1-dependent mechanism involved in the non-immune function of c GAS that is essential for the regulation of ionizing radiation-elicited HR repair. | Yanxuan Xiao Jingyi Li Xiaoyu Liao Yumin He Tao He Cuiping Yang Lu Jiang So Mi Jeon Jong-Ho Lee Yongbin Chen Rui Liu Qianming Chen | 2022 | Bone Research2022，10，2： | 0 |
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