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| 1 | Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats显示文摘 | Wang Jian Jiang Qian Wan Limei Yang Kai Zhang Yi Chen Yuqin Wang Elizabeth Lai Ning Zhao Lei Jiang Hua Sun Yueqian Zhong Nanshan Ran Pixin Lu Wenju | 2013 | American Journal of Respiratory Cell and Molecular Biology2013，，1： | 1 |
| 2 | Prevalence of Chronic Obstructive Pulmonary Disease in China-A Large Population-based spirometry based Cross-sectional Survey显示文摘 | Nanshan Zhong Chen Wang Pixin Ban | 2007 | Am J Respir Cxit Care Med2007，176，8： | 1 |
| 3 | Effect of acetylation on the properties of corn starch显示文摘 | Hui Chi Kun Xu Xiuli Wu Qiang Chen Donghua Xue Chunlei Song Wende Zhang Pixin Wang | 2007 | Food Chemistry2007，，3： | 1 |
| 4 | Fabrication and charac- terization of microstructured and pH sensitive interpenetration networks hydrogel films and application in drug delivery field 显示文摘 | Yumei Yue Xiang Sheng Pixin Wang | 2009 | Eur Polym J2009，45，： | 1 |
| 5 | Functional polymorphisms in NFκB1 / IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese显示文摘 | Dongsheng Huang Lei Yang Yehua Liu Yumin Zhou Yuan Guo Mingan Pan Yunnan Wang Yigang Tan Haibo Zhong Min Hu Wenju Lu Weidong Ji Jian Wang Pixin Ran Nanshan Zhong Yifeng Zhou Jiachun Lu | 2013 | Human Genetics2013，，4： | 1 |
| 6 | Prevalence of Chronic Obstructive Pulmonary Disease in China, A Large, Population -based Survey显示文摘 | Zhong Nanshan Wang C Ran Pixin | 2007 | Am J Respir Crit Care Med2007，176，8： | 1 |
| 7 | Effect of acetylation on the properties of corn starch显示文摘 | Hui Chi Kun Xu Xiuli Wu Qiang Chen Donghua Xue Chunlei Song Wende Zhang Pixin Wang | 2007 | Food Chemistry2007，，3： | 1 |
| 8 | Interventional effect of laser acupoint radiation on the expression of Nissl body and brain-derived neurotrophic factor in newborn rat models with ischemic/hypoxic cerebral injury显示文摘BACKGROUND: Some researches report that He-Ne laser can activate function of erythrocytes and increase content of blood and oxygen via bio-stimulating effect; therefore, it suspects that laser radiation at Baihui and Dazhui can partially increase blood circulation for oxygen-supplying content of brain and improve functional status of neurons. OBJECTIVE: To verify the effects of laser radiation at Baihui and Dazhui on the expression of Nissl body of brain tissue neurons and brain-derived neurotrophic factor (BDNF) in newborn rats with ischemic/hypoxic cerebral injury. DESIGN: Randomized controlled animal study. SETTING: Department of Neurological Histochemistry, Xianning University. MATERIALS: Forty Wistar rats of 7-8 days old, weighing 15-20 g and of both genders, were selected from Wuhan Experimental Animal Center. All the rats were randomly divided into sham operation group (n =8), model group (n =16) and radiation group (n =16). The experimental animals were disposed according to ethical criteria. BDNF kit was provided by Wuhan Boster Bioengineering Co., Ltd. METHODS: The experiment was carried out in the Department of Neurological Histochemistry, Xianning University from April 2005 to October 2006. Rats in the radiation group and model group were performed with ligation of left common carotid artery, recovered at room temperature for 1-6 days, maintained in self-made hypoxic cabin under normal pressure and injected mixture gas (0.05 volume fraction of O2 and 0.92 volume fraction of N2) for 2 hours. In addition, rats in the sham operation group were treated with separation of left common carotid artery but not ligation and hypoxia. Rats in the model group were not given any treatment; while, rats in the radiation group were exposed with He-Ne laser of 63.28 nm in the wave length at Baihui and Dazhui acupoints on the second day after ischemia-hypoxia. The radiation was given for 10 minutes per day and once a day. Ten days were regarded as a course and the rats were exposed for 2 courses in total. At 20 days after routine breeding, left hemisphere tissues of rats in the three groups were collected for staining of Nissl body and immunohistochemistry of BDNF. MAIN OUTCOME MEASURES: Nissl body staining in left hemisphere tissue and expression of immune positive cells of BDNF. RESULTS: All 40 rats were involved in the final analysis. ① Nissl body staining: Neuronal cytoplasm of brain tissue was full of blue granule Nissl bodies in the sham operation group; while, Nissl body in neuronal cytoplasm in the model group was stained slightly and had a certain degree of degeneration; meanwhile, there were a lot of blank area in ischemic region. Nissl body in neuron cytoplasm was gradually recovered in the radiation group and relieved as compared with that in the model group. ② Positive cells of BDNF: Number of immune positive cells of BDNF which were ligated in lateral cerebral hemisphere of rats in the model group was higher than that in the sham operation group (P < 0.05); while, BDNF expression in the radiation group was increased as compared with that in the model group (P < 0.05). CONCLUSION: After laser acupoint radiation, Nissl body is increased and BDNF expression is also increased. This suggests that laser acupoint radiation has neuroprotective effect on brain tissue after ischemia-hypoxia injury. | Shengwang Hu Pixin Nong Yong Hu Zhijie Tang | 2007 | Neural Regeneration Research2007，2，12： | 0 |
| 9 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 10 | The Preparation and Properties of Starch Based Shape Memory Hydrogel显示文摘In this work,the–catechol and–thiol modified starch was prepared by the esterification and amino condensation reaction,then a fully starch based hydrogel was prepared via the thiol-catechol Michael addition reaction.The starch hydrogel gained shape memory behaviors by coordinate with Fe^(3+)ions at alkaline condition.1H-NMR had been used to character the structure of the starch derivatives and its character peaks.The hydrogel’s modulus had also been measured before and after coordinating with Fe^(3+)ions in linear area and the result showed that both the hydrogel’s storage modulus and loss modulus kept constant in linear area from 0.1 rad/s to 100 rad/s,which demonstrated a good network was formed inside the hydrogel.Furthermore,the shape memory behaviors had been tested by changing the pH value in solution.The result showed that the hydrogel can keep its temporary shape in high pH condition and recover to its original state after the shaped hydrogel immersed into acidic solution.This hydrogel might have great application prospects in the field of biomedical and engineering. | Yangling Li Zhengrong Li Hui Yu Gang Huang Xiaopeng Pei Kun Xu Pixin Wang Ying Tan | 2021 | Journal of Renewable Materials2021，9，8： | 0 |
| 11 | SARS-CoV-2-specific CD4^(+)T cells are associated with long-term persistence of neutralizing antibodies显示文摘Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing antibodies in infected or vaccinated people and how vaccines protect against other SARS-CoV-2 variants is critical for assessing public vaccination plans.Here,we measured different plasm antibody levels 2 and 12 months after disease onset,including anti-RBD,anti-N,total neutralizing antibodies,and two neutralizing-antibody clusters.We found that total neutralizing antibodies declined more slowly than total anti-RBD and anti-N IgG. | Zhongfang Wang Xiaoyun Yang Xinyue Mei Yumin Zhou Zhiqiang Tang Guichang Li Jiaying Zhong Mengqiu Yu Mingzhu Huang Xiaoling Su Bijia Lin Pengxing Cao Ji Yang Pixin Ran | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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