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| 1 | 勾勒关键能力,打造优质生活——OECD关键能力框架概述显示文摘关键能力是个人实现自我、终身发展、融入主流社会和充分就业所必需的知识、技能及态度之集合,是一种通用能力或横向能力,从而使得每个人具有追求完美人生的热忱,以积极公民的身份参与社会进步的本领和在劳动力市场获得充分就业的表现。关键能力框架的核心是'个体的自我认识能力',表明其心智成熟、道德完善,勇于为自我学习和行动负责。 | Dominique Simone Rychen Laura Hersh Salganik 滕梅芳 盛群力 | 2007 | 远程教育杂志2007，25，5： | 19 |
| 2 | Non-invasive diagnostic imaging of colorectal liver metastases显示文摘Colorectal cancer is one of the few malignant tumors in which synchronous or metachronous liver metastases [colorectal liver metastases(CRLMs)] may be treated with surgery. It has been demonstrated that resection of CRLMs improves the long-term prognosis. On the other hand, patients with un-resectable CRLMs may benefit from chemotherapy alone or in addition to liverdirected therapies. The choice of the most appropriate therapeutic management of CRLMs depends mostly on the diagnostic imaging. Nowadays, multiple non-invasive imaging modalities are available and those have a pivotal role in the workup of patients with CRLMs. Although extensive research has been performed with regards to the diagnostic performance of ultrasonography, computed tomography, positron emission tomography and magnetic resonance for the detection of CRLMs, the optimal imaging strategies for staging and follow up are still to be established. This largely due to the progressive technological and pharmacological advances which are constantly improving the accuracy of each imaging modality. This review describes the non-invasive imaging approaches of CRLMs reporting the technical features, the clinical indications, the advantages and the potential limitations of each modality, as well as including some information on the development of new imaging modalities, the role of new contrast media and the feasibility of using parametric image analysis as diagnostic marker of presence of CRLMs. | Pier Paolo Mainenti Federica Romano Laura Pizzuti Sabrina Segreto Giovanni Storto Lorenzo Mannelli Massimo Imbriaco Luigi Camera Simone Maurea | 2015 | World Journal of Radiology2015，7，7： | 13 |
| 3 | Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior显示文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation (CA) and virtual reality (VR) haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby"reducing" and "replacing" the animals used, and "refining" the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss (I) the creation, (11) the presentation, and (111) the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior. | Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE Spencer J. INGLEY John R. STOWERS Joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE | 2017 | Current Zoology2017，63，1： | 10 |
| 4 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 5 | Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature显示文摘Lymphoepithelioma-like hepatocellular carcinoma(LELHCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here,a case of LEL-HCC is described. An 81-year-old woman with a chronic hepatitis C infection was referred to the general surgery department of our hospital in August 2013 with a diagnosis of HCC. A past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. After a needle biopsy,the lesion was diagnosed as HCC. The patient underwent surgery with a liver segmentectomy. Two additional nodes on the gastric wall were detected during the surgical operation. The histology of the removed specimen showed a poorly differentiated HCC with significant lymphoid stroma. Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2,CK8,CK18,CEA(polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3,CD4 and CD8. The tumor cells were negative for Epstein-Barr virus. The gastric nodes were ultimately determined to be two small gastrointestinal stromal tumors(GISTs).The synchronous occurrence of HCC and GIST is another very uncommon finding rarely described in the literature. Here,we report the clinicopathological features of our case,along with a review of the few cases present in the literature. | Andrea Cacciato Insilla Pinuccia Faviana Luca Emanuele Pollina Paolo De Simone Laura Coletti Franco Filipponi Daniela Campani | 2015 | World Journal of Gastroenterology2015，21，36： | 5 |
| 6 | Heterotopic bone formation in the musculus latissimus dorsi of sheep usingβ-tricalcium phosphate scaffolds:evaluation of different seeding techniques显示文摘Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial surgery.In addition to autogenous bone grafts,which despite potential donor-site mobility still represent the gold standard in reconstructive surgery,many studies have investigated less invasive alternatives such as in vitro cultivation techniques.This study compared different types of seeding techniques on pureβ-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in vivo.Cylindrical scaffolds loaded with autologous cancellous bone,venous blood,bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month period.Histological and histomorphometric analyses revealed that scaffolds loaded with cancellous bone were superior at promoting heterotopic bone formation and ceramic degradation,with autogenous bone and bone marrow aspirate concentrate inducing in vivo formation of vital bone tissue.These results confirm that autologous bone constitutes the preferred source of osteoinductive and osteogenic material that can reliably induce heterotopic bone formation in vivo. | Simon Spalthoff Rudiger Zimmerer Jan Dittmann Horst Kokemuller Marco Tiede Laura Flohr Philippe Korn Nils-Claudius Gellrich Philipp Jehn | 2018 | Regenerative Biomaterials2018，5，2： | 3 |
| 7 | Enhanced characterization of solid solitary pulmonary nodules with Bayesian analysis-based computer-aided diagnosis显示文摘The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomography(CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator(BIMC) model predictions. Raters' predictions were evaluated by means of receiver operating characteristic(ROC) curve analysis and decision analysis. Overall ROC area under the curve was 0.758 before and 0.803 after the disclosure of CAD predictions(P = 0.003). A net gain in diagnostic accuracy was found in 6 out of 7 readers. Mean risk class of benign nodules dropped from 2.48 to 2.29, while mean risk class of malignancies rose from 3.66 to 3.92. Awareness of CAD predictions also determined a significant drop on mean indeterminate SPNs(15 vs 23.86 SPNs) and raised the mean number of correct and confident diagnoses(mean 39.57 vs 25.71 SPNs). This study provides evidence supporting the integration of the Bayesian analysis-based BIMC model in SPN characterization. | Simone Perandini Gian Alberto Soardi Massimiliano Motton Raffaele Augelli Chiara Dallaserra Gino Puntel Arianna Rossi Giuseppe Sala Manuel Signorini Laura Spezia Federico Zamboni Stefania Montemezzi | 2016 | World Journal of Radiology2016，8，8： | 3 |
| 8 | 猪混群攻击行为研究进展显示文摘自20世纪70年代以来,猪的混群攻击一直是动物福利研究的一个重要课题。文章综述了减少攻击行为的研究现状,包括最近在育种、猪早期社交、激素和营养等方面有效地对付攻击行为的最新研究进展。 | 张振玲(编译) Rachel S.E.Peden Simon P.Turner Laura A.Boyle | 2018 | 猪业科学2018，35，12： | 2 |
| 9 | Multicenter results of stereotactic body radiotherapy (SBRT) for non-resectable primary liver tumors显示文摘 | Rafael A. Ibarra Daniel Rojas Laura Snyder Min Yao Jeffrey Fabien Michael Milano Alan Katz Karyn Goodman Kevin Stephans Galal El-Gazzaz Federico Aucejo Charles Miller John Fung Simon Lo Mitchell Machtay Juan R. Sanabria | 2012 | Acta Oncologica2012，，5： | 2 |
| 10 | <ce:link locator='fx1'/> Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells显示文摘 | Stuart A.C. McDonald Laura C. Greaves Lydia Gutierrez–Gonzalez Manuel Rodriguez–Justo Maesha Deheragoda Simon J. Leedham Robert W. Taylor Chung Yin Lee Sean L. Preston Matthew Lovell Toby Hunt George Elia Dahmane Oukrif Rebecca Harrison Marco R. Novelli I | 2008 | Gastroenterology2008，，2： | 1 |
| 11 | Update on best available options in obstetrics anaesthesia: perinatal outcomes, side effects and maternal satisfaction. Fifteen years systematic literature review显示文摘 | Salvatore Gizzo Marco Noventa Simone Fagherazzi Laura Lamparelli Emanuele Ancona Stefania Gangi Carlo Saccardi Donato D’Antona Giovanni Battista Nardelli | 2014 | Archives of Gynecology and Obstetrics2014，，： | 1 |
| 12 | Predicting hydrate plug formation in oil-dominated flowlines显示文摘 | Davies Simon R Boxall John A Dieker Laura E | 2010 | Journal of Petroleum Science and Engineering2010，72，： | 1 |
| 13 | THE ROLE OF ROOT EXUDATES IN RHIZOSPHERE INTERACTIONS WITH PLANTS AND OTHER ORGANISMS显示文摘 | Harsh P. Bais Tiffany L. Weir Laura G. Perry Simon Gilroy Jorge M. Vivanco | 2006 | Annual Review of Plant Biology2006，，： | 1 |
| 14 | Effect of the cluster heterogeneity on mechanical properties, chromatic indices and chemical composition of Italia table grape berries ( V itis vinifera L.) sorted by flotation显示文摘 | Susana Río Segade Simone Giacosa Laura Palma Vittorino Novello Fabrizio Torchio Vincenzo Gerbi Luca Rolle | 2012 | Int J Food Sci Technol2012，，1： | 1 |
| 15 | Predominant growth of Alcanivorax during experiments on “oil spill bioremediation” in mesocosms显示文摘 | Simone Cappello Renata Denaro Maria Genovese Laura Giuliano Michail M. Yakimov | 2006 | Microbiological Research2006，，2： | 1 |
| 16 | Penetration and haptenation of p ‐phenylenediamine显示文摘 | Laura M. Pot Simone M. Scheitza Pieter‐Jan Coenraads Brunhilde Bl?meke | 2013 | Contact Dermatitis2013，，4： | 1 |
| 17 | Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer显示文摘 | Simon N. Waddington John H. McVey David Bhella Alan L. Parker Kristeen Barker Hideko Atoda Rebecca Pink Suzanne M.K. Buckley Jenny A. Greig Laura Denby Jerome Custers Takashi Morita Ivo M.B. Francischetti Robson Q. Monteiro Dan H. Barouch Nico van Rooijen | 2008 | Cell2008，，3： | 1 |
| 18 | Pain Prevalence and Trajectories Following Pediatric Spinal Fusion Surgery显示文摘 | Christine B. Sieberg Laura E. Simons Mark R. Edelstein Maria R. DeAngelis Melissa Pielech Navil Sethna M. Timothy Hresko | 2013 | Journal of Pain2013，，12： | 1 |
| 19 | The Influence of Different Nitrogen Treatments on the Growth and Yield of Basil (Ocimum Basificum L.)显示文摘 | Laura Frabboni Giuseppina de Simone Vittoria Russo | 2011 | Journal of Chemistry and Chemical Engineering2011，5，9： | 1 |
| 20 | Obesity prevalence in Mexico: impact on health and economic burden显示文摘 | Ketevan Rtveladze Tim Marsh Simon Barquera Luz Maria Sanchez Romero David Levy Guillermo Melendez Laura Webber Fanny Kilpi Klim McPherson Martin Brown | 2013 | Public Health Nutrition2013，，1： | 1 |
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