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| 1 | Patients'perspectives on smoking and inflammatory bowel disease:An online survey in collaboration with European Federation of Crohn's and Ulcerative Colitis Associations显示文摘BACKGROUNDSmoking has detrimental effects on Crohn’s disease (CD) activity while data onulcerative colitis (UC) are conflicting. Little is known about the use and impact ofalternative smoking products in inflammatory bowel diseases (IBD).AIMTo understand the patients’ perceptions of the impact of smoking on their IBDand to assess differences between CD and UC patients.METHODSThe questionnaire was developed by Philip Morris Products SA in cooperationwith European Federation of Crohn's and Ulcerative Colitis Associations. Thefinal survey questionnaire consisted of 41 questions divided in 8 categories: (1)Subject screener;(2) Smoking history;(3) Background information;(4) IBD diseasebackground;(5) Current disease status;(6) Current therapeutics and medications;and (7) Current nicotine/cigarettes use and awareness of the impacts of smokingon IBD. The questionnaire was submitted online from 4th November 2019 to 11th March 2020 through the European Federation of Crohn's and Ulcerative ColitisAssociations website to IBD patients who were current smokers or had a historyof smoking.RESULTSIn total 1050 IBD patients speaking nine languages participated to the survey.Among them, 807 (76.9%) patients declared to have ever smoked or consumed analternative smoking product, with a higher proportion of current cigarettesmokers among CD patients (CD: 63.1% vs UC: 54.1%, P = 0.012). About twothirdsof the participants declared to have ever stopped cigarette smoking andrestarted (67.0%), with a significantly higher proportion among UC patientscompared to CD patients (73.1% vs 62.0%, P = 0.001). We also found significantdifferences between CD and UC patients in the awareness of the healthconsequences of smoking in their disease and in the perceived impact of smokingon disease activity, for both cigarettes and alternative smoking products.CONCLUSIONThis survey found significant differences between CD and UC patients in bothawareness and perception of the impact of smoking on their disease. Furtherefforts should be done to encourage smoking cessation for all IBD patients,including UC patients. | Catherine Le Berre Laura Loy Sanna Lönnfors Luisa Avedano Daniele Piovani | 2020 | World Journal of Gastroenterology2020，26，29： | 4 |
| 2 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 3 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 4 | JUPITER-02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps显示文摘Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。 | Laura Ling Ying Tan Quynh-Thu Le Nancy Ying Ying Lee Melvin Lee Kiang Chua | 2022 | Cancer Communications2022，42，1： | 2 |
| 5 | Telecentres in Mountain Regions-A Peruvian Case Study of the Impact of Information and Communication Technologies on Remoteness and Exclusion显示文摘Communities in developing country mountain areas,in part due to their remoteness,find themselves excluded from social,political and economic systems; and excluded from access to resources. This paper aims to study the impact of information and communication technologies (ICTs) on remoteness and exclusion. It utilises two models - the resource movement framework,and the 'information chain' - to analyse a telecentre in one district of mountainous Huancavelica,Peru's poorest region,set in the high Andes. It finds ICTs enabling new and positive resource flows for the two key user groups:teenaged school students and young farmers. These help to maintain social networks. They also support information searches that have improved agricultural practice where other information chain resources have been available. But non-use and ineffective use of the telecentre are found where information chain resources are lacking. ICTs have some impacts on intangible elements of remoteness. In this particular example,they also offer access to some previously-excluded resources. But they have not really addressed the systematic exclusions faced by mountain communities. And they so far appear to be a technology of inequality; favouring those residents who begin with better resource endowments.The paper concludes by offering some recommendations for mountain ICT project practice. | Richard Heeks Laura León Kanashiro | 2009 | Journal of Mountain Science2009，6，4： | 2 |
| 6 | Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal显示文摘 | Laurae LE Golijamin D hin A | 1999 | J Chin Invest1999，103，2： | 1 |
| 7 | College students and HIV/AIDS: A comparison of nontraditional and traditional student perspectives显示文摘 | SUSAN OP DONALD LE LAURA KM | 2007 | J Am Coil Health2007，56，2： | 1 |
| 8 | Effects of cadmium and mycorrhizal fungi on growth,fitness,and cadmium accumulation in flax(Linum usitatissimum;Linaceae)显示文摘 | LAURA MSH CHARLOTTE LE REBECCA C | 2012 | American Journal of Botany2012，99，9： | 1 |
| 9 | Features of vulnerable plaques and clinical outcome of UA/NSTEMI: Relationship with matrix metalloproteinase functional polymorphisms显示文摘 | Nicola Fiotti Michèle Emilia Moretti Rossana Bussani Nicola Altamura Francesca Zamolo Riccardo Gerloni Laura Ukovich Elisa Ober Furio Silvestri Gabriele Grassi Roberto Adovasio Carlo Giansante | 2011 | Atherosclerosis2011，，1： | 1 |
| 10 | Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells显示文摘 | María Laura Sbaraglini María Silvina Molinuevo Claudia Sedlinsky León Schurman Antonio Desmond McCarthy | 2014 | European Journal of Pharmacology2014，，： | 1 |
| 11 | AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function显示文摘 | Dugan Laura L You Young-Hyun Ali Sameh S Diamond-Stanic Maggie Miyamoto Satoshi DeCleves Anne-Emilie Andreyev Aleksander Quach Tammy Ly San Shekhtman Grigory Nguyen William Chepetan Andre Le Thuy P Wang Lin Xu Ming Paik Kacie P Fogo Agnes | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 12 | Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice显示文摘 | Hanh K. Le Laura Graham Esther Cha Johanna K. Morales Masoud H. Manjili Harry D. Bear | 2009 | International Immunopharmacology2009，，7： | 1 |
| 13 | Determination of Cholesterol in Italian Chicken Eggs 显示文摘 | Daniele Naviglio Monica Gallo Laura Le Grottaglie | 2012 | Food Chemistry2012，132，： | 1 |
| 14 | Analysis of the 5′ untranslated region (5′UTR) of the alcohol oxidase 1 ( AOX1 ) gene in recombinant protein expression in Pichia pastoris显示文摘 | Chris A. Staley Amy Huang Maria Nattestad Kristin T. Oshiro Laura E. Ray Tejas Mulye Zhiguo Harry Li Thu Le Justin J. Stephens Seth R. Gomez Allison D. Moy Jackson C. Nguyen Andreas H. Franz Joan Lin-Cereghino Geoff P. Lin-Cereghino | 2012 | Gene2012，，2： | 1 |
| 15 | Evolution of microbiological and chemical parameters during red wine making with extended post-fermentation maceration显示文摘 | Romano Nicola Francesca Raffaele Sannino Ciro Le Grottaglie Laura | 2014 | International Journal of Food Microbiology2014，171，： | 1 |
| 16 | Phase 2 Study of Erlotinib Combined With Adjuvant Chemoradiation and Chemotherapy in Patients With Resectable Pancreatic Cancer显示文摘 | Joseph M. Herman Katherine Y. Fan Aaron T. Wild Amy Hacker-Prietz Laura D. Wood Amanda L. Blackford Susannah Ellsworth Lei Zheng Dung T. Le Ana De Jesus-Acosta Manuel Hidalgo Ross C. Donehower Richard D. Schulick Barish H. Edil Michael A. Choti Ralph H. H | 2013 | International Journal of Radiation Oncology Biology Physics2013，，4： | 1 |
| 17 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 1 |
| 18 | Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4^(+) head and neck squamous cell carcinoma tumors显示文摘Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma(HNSCC) mortality. The overexpression of chemokine receptor 4(CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4^(+)tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4^(+)HNSCC cells, achieving a high accumulation in CXCR4^(+)tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4^(+)cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted proteinonly nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients. | Elisa Rioja-Blanco Irene Arroyo-Solera Patriciaálamo Isolda Casanova Alberto Gallardo Ugutz Unzueta Naroa Serna Laura Sánchez-García Miquel Quer Antonio Villaverde Esther Vázquez Ramon Mangues Lorena Alba-Castellón Xavier León | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 19 | Meeting tomorrow's de- mands today : VAE - based emulsions for tile indian paints and coat- ings market 显示文摘 | LAURA BITI'LE SURENDRA K SINGH | 2012 | Paintindia2012，62，2： | 1 |
| 20 | Rheological and hydration characterization of calcium sulfoaluminate cement pastes显示文摘 | Marta García-Maté Isabel Santacruz ángeles G. De la Torre Laura León-Reina Miguel A.G. Aranda | 2012 | Cement and Concrete Composites2012，，5： | 1 |
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