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| 1 | Target delineation and dose prescription of adaptive replanning intensity-modulated radiotherapy for nasopharyngeal carcinoma显示文摘Dear Editor,Intensity-modulated radiotherapy(IMRT)has a distinct advantage of high conformity and is an appropriate tech-nique for treating nasopharyngeal carcinoma(NPC).Pre-vious studies have demonstrated that anatomical changes in the external contour,shape,and location of the target and critical structures are significant and result in dosi-metric changes[1,2].Patients’quality of life and clini-cal outcomes might be improved by IMRT replanning[3].Therefore,replanning strategies should be consid-ered instead of single-planning strategies throughout the entire course of radiotherapy.However,there are sub-stantial controversies on(1)the appropriate time for tar-get redelineation,(2)how to modify the target volumes,and(3)how to evaluate the modified plans.The present study provides a new perspective in replanning with regard to these three aspects. | Dehuan Xie Wanqin Cheng Shaowen Lv Rui Zhong Lei Wang Jiang Hu Mingli Wang Shaomin Huang Yong Su Yunfei Xia | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2显示文摘In contrast to the extensive research about viral protein–host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection,few studies have examined interactions between host factors and viral RNAs(vRNAs).Here,we profiled vRNA–host protein interactomes for three RNA virus pathogens(SARS-CoV-2,Zika,and Ebola viruses)using ChIRP-MS.Comparative interactome analyses discovered both common and virus-specific host responses and vRNA-associated proteins that variously promote or restrict viral infection.In particular,SARS-CoV-2 binds and hijacks the host factor IGF2BP1 to stabilize vRNA and augment viral translation.Our interactome-informed drug repurposing efforts identified several FDA-approved drugs(e.g.,Cepharanthine)as broad-spectrum antivirals in cells and hACE2 transgenic mice.A co-treatment comprising Cepharanthine and Trifluoperazine was highly potent against the newly emerged SARS-CoV-2 B.1.351 variant.Thus,our study illustrates the scientific and medical discovery utility of adopting a comparative vRNA-host protein interactome perspective. | Shaojun Zhang Wenze Huang Lili Ren Xiaohui Ju Mingli Gong Jian Rao Lei Sun Pan Li Qiang Ding Jianwei Wang Qiangfeng Cliff Zhang | 2022 | Cell Research2022，32，1： | 5 |
| 3 | Research progress of semiconductive shielding layer of HVDC cable显示文摘As an indispensable part of high-voltage direct current(HVDC)cable,the semiconductive shielding layer plays the role of uniforming electric field in the cable.However,cable shielding materials>35 kV mainly rely on foreign imports in China,which belongs to the technical weak issues in the field of electrical materials.At present,there are few systematic reports on semiconductive shielding material of HVDC cable.In the work,the mechanisms of charge conduction and thermal conduction of semiconductive material have been introduced.Effect of raw material,carbon black content and the second conductive filler on the resistance characteristics of the semiconductive layer,the charge accumulation characteristics of the insulating layer and the interface characteristics have been studied.A kind of semiconductive layer as a high voltage terminal charge emission method has been proposed to study charge emission from the semiconducting layer to the insulation layer.This work can provide theoretical guidance for the research of semiconductive shielding materials. | Yanhui Wei Wang Han Guochang Li Qingquan Lei Mingli Fu Chuncheng Hao Guanjun Zhang | 2020 | High Voltage2020，5，1： | 2 |
| 4 | Application of a wax-based binder in PIM of WC–TiC–Co cemented carbides显示文摘 | Xuanhui Qu Jianxiang Gao Mingli Qin Changming Lei | 2005 | International Journal of Refractory Metals and Hard Materials2005，，4： | 1 |
| 5 | Intensified inactivation of model and environmental bacteria by an atmospheric-pressure air-liquid discharge plasma compared with chlorination显示文摘Water-borne pathogenic bacteria are always the top priority to be removed through disinfection process in water treatment due to their threat to human health. It was necessary to develop novel disinfection methods since the conventional chlorine disinfection was inefficient in inactivating chlorine-resistant bacteria, inducing the viable but non-culturable(VBNC) bacteria and forming disinfection by-products(DBPs). In this study, the inactivation of four model strains including Gram-negative(G), Gram-positive(G) and environmental samples by atmospheric-pressure air-liquid discharge plasma(ALDP) was assessed systematically. The results showed that ALDP was superior in inactivating all of the samples compared with chlorination. During 10 min ALDP treatment, the Gbacteria were completely inactivated, and the Gone was inactivated by more than 4.61 logs. The inactivation of bacteria from a campus lake and a wastewater treatment plant effluent exceeded 99.82% and 97.78%, respectively. For G-bacteria, ALDP resulted in a much lower(10~2~10~3 times) levels of VBNC cells than chlorination. ALDP could effectively remove the chlorine-resistant bacteria. More than 96.41% of the intracellular DNA and 99.99% of the extracellular DNA were removed, whereas it was only 56.35% and 12.82% for chlorination. ALDP had a stronger ability to destroy cell structure than chlorination, presumably due to the existence of ROS( ·OH, ~1Oand O). GC-MS analysis showed that ALDP produced less DBPs than chlorination. These findings provided new insights for the application of discharge plasma in water disinfection, which could be complemental or alternative to the conventional disinfection methods. | Mingli Shao Chengsong Ye Ting Li Jiaming Gan Xin Yu Lei Wang | 2022 | Journal of Environmental Sciences2022，34，7： | 1 |
| 6 | Removal of gaseous acetic acid using ionic liquid [EMIM][BF_4]显示文摘This work proposed to use the ionic liquid [EMIM][BF_4] as absorbent for the absorption of gaseous acetic acid. The feasibility of this technology was investigated from molecular level to industrial scale. The acetic acid absorption experiment was carried out using [EMIM][BF_4],and the removal ratio of acetic acid in the gas product can achieve 88.6% at 20C under atmospheric pressure at the laboratory scale. Based on the experimental results, a reliable strict equilibrium phase model embedding the parameters of the UNIFAC model was established. On this basis, the conceptual process design and optimization of acetic acid removal by [EMIM][BF_4] at an industrial scale was done, and the most suitable design and operation parameters were obtained. For a further step, the binding energy between [EMIM][BF_4] and acetic acid was calculated to give some insights into the separation mechanism, and the results indicate that the interaction between acetic acid and IL is much stronger than that between nitrogen and IL. Moreover, hydrogen bond can be formed between the cation-acetic acid as well as the anion-acetic acid. | Mingli Mu Jun Cheng Chengna Dai Ning Liu Zhigang Lei Yanzhou Ding Jianjiang Lu | 2019 | Green Energy & Environment2019，4，2： | 1 |
| 7 | A proposed grey model for short-term electricity price forecasting in competi- tive power markets 显示文摘 | LEI Mingli FENG Zuren | 2012 | Electrical Power and Energy Systems2012，43，： | 1 |
| 8 | Evolutionary grey model algorithm for short- term electricity price predictions 显示文摘 | Song Qingsong Lei Mingli | 2012 | ICIC Express Let- ters2012，6，10： | 1 |
| 9 | Mechanism and Clinical Observation of Effect of Growgx Yeast Fermentation Product Extract on Photo-aged HFF-1 Cells显示文摘[Objectives]To explore the effect of the extract of Growgx yeast fermentation product on ultraviolet A(UVA)-induced photo-aging of human skin fibroblasts(HFF-1)and its specific mechanisms from the level of cell biology,and discussed the application of the Growgx yeast fermentation product extract for skin aging.[Methods]A photo-aging model of HFF-1 cells was induced by UVA radiation meter,and it was given different concentrations of Growgx for intervention.The proliferation activity of the HFF-1 cells was detected with MTT method,and their migration and invasion ability was measured by scratch test.The SOD,HYP and MDA levels were detected with corresponding kits.After oxygen infusion apparatus assisted facial skin administration,the repair of the skin was observed through the VISIA skin tester.[Results]The survival rate of HFF-1 cells was reduced significantly by UVA with an irradiation dose of 10.8 J/cm2(P<0.05),while Growgx significantly increased their survival rate(P<0.001)and sped up the repair of damaged cells.Growgx promoted the production of SOD(P<0.05),reduced the level of MDA(P<0.05),and increased the level of HYP(P<0.05).Growgx effectively inhibited UVA-induced photo-aging of HFF-1 cells.The mechanism may be related to accelerating cell damage repair,up-regulating SOD and HYP expression levels,and reducing MDA expression level.The clinical observation showed that Growgx effectively improved skin spots and pores,making the skin smoother and more delicate.[Conclusions]Growgx can effectively fight against photo-aging caused by ultraviolet rays,and can significantly improve skin wrinkles. | Hong ZHANG Jianfei WAN Yuetong ZHAO Yang WU Mingli LEI Xiaoqun DUAN | 2022 | Medicinal Plant2022，13，1： | 0 |
| 10 | Thermal–moisture dynamics and thermal stability of active layer in response to wet/dry conditions in the central region of the Qinghai–Tibet Plateau,China显示文摘The amount of rainfall varies unevenly in different regions of the Qinghai-Tibet Plateau, with some regions becoming wetter and others drier. Precipitation has an important impact on the process of surface energy balance and the energy-water transfer within soils. To clarify the thermal-moisture dynamics and thermal stability of the active layer in permafrost regions under wet/dry conditions, the verified water-vapour-heat coupling model was used. Changes in the surface energy balance, energy-water transfer within the soil, and thickness of the active layer were quantitatively analyzed. The results demonstrate that rainfall changes significantly affect the Bowen ratio, which in turn affects surface energy exchange. Under wet/dry conditions, there is a positive correlation between rainfall and liquid water flux under the hydraulic gradient;water vapour migration is the main form under the temperature gradient, which indicates that the influence of water vapour migration on thermalmoisture dynamics of the active layer cannot be neglected. Concurrently, regardless of wet or dry conditions,disturbance of the heat transport by conduction caused by rainfall is stronger than that of convection by liquid water. In addition, when rainfall decreases by 1.5 times(212 mm) and increases by 1.5 times(477 mm), the thickness of the active layer increases by 0.12 m and decreases by 0.21 m, respectively. The results show that dry conditions are not conducive to the preservation of frozen soil;however, wet conditions are conducive to the preservation of frozen soil, although there is a threshold value. When this threshold value is exceeded, rainfall is unfavourable for the development of frozen soil. | MingLi Zhang ZhiXiong Zhou Zhi Wen FengXi Zhou Zhao Ma BingBing Lei | 2023 | Research in Cold and Arid Regions2023，15，1： | 0 |
| 11 | Synergistic catalytic ozonation of toluene with manganese and cerium varies at low temperature显示文摘The temperature of waste gas in refuse transfer station,airport smoking area,and RTO terminal is low,which needs deep oxidation.Catalytic ozonation is one of the most effective treatment techniques in these scenarios.In this study,we reported that catalysts were modified under the condition of mag-netic field to simulate the low temperature dynamic conditions of low concentration toluene for catalytic ozonation.This paper aims to explore the relationship between oxygen vacancy and active oxygen species,and the specific pathways of toluene oxidation.The study found that citric acid can enhance the syner-gistic effect between Mn and Ce,and promote the generation of oxygen vacancies.The surface molecule adsorption oxygen is more conducive to catalytic oxidation than subsurface atom adsorption oxygen.Fi-nally,we proposed the main pathways of toluene in this reaction system,which runs through the whole process of the reaction. | Qi Gan Mingli Fu Peng Liu Yuchen Zhang Juxia Xiong Jinping Zhong Lei Liu Junliang Wu Xiaojun Niu Yun Hu Daiqi Ye | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 12 | Investigation on Thermal Insulation and Mechanical Strength of Lightweight Aggregate Concrete and Porous Mortar in Cold Regions显示文摘Thermal insulation is an important indicator to evaluate the construction material in cold region engineering.As we know,adding the industrial waste as lightweight aggregate or creating the pore inside the cement-based composite could make the texture loose,and the thermal insulating capacity of the material would be improved with this texture.Using these methods,the industrial by-product and engineering waste could be cycled in an efficient way.Moreover,after service the fragmented cement composites paste could be used as aggregate in the thermal insulating concrete again.While the porous texture is not favorable for the mechanical strength and long-term durability in a cold environment.To balance the above three requirements from two opposite directions,different processing methods were applied to create the thermal insulation concrete/mortar.Firstly,the organic/inorganic lightweight aggregate,including the Expanded Polystyrene(EPS),Expanded Perlite(EP),and Ceramsite(CRMST)particles,were applied to create the Lightweight Aggregate Concrete(LWAC).As the comparative tests,the expanded Superabsorbent Polymer(SAP)hydrogel and Air-Entraining Agent(AEA)were also introduced to create the porous mortar.The above concrete/mortar was tested in the normal state and under the Freeze-Thaw cycle to explore the engineering performance in cold regions.During the experimenting process,the thermal insulation,mechanical strength,and frost resistance of these cement-based composites were investigated,and an optimal thermal insulation concrete/mortar was determined. | Jianan Wu Ke Xue Zhaowei Ding Lei Lang Kang Gu Xiaolin Li Mingli Zhang Desheng Li | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
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