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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus显示文摘Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China.As of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in China.Of these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 years.Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | Zhi-Min Chen Jun-Fen Fu Qiang Shu Ying-Hu Chen Chun-Zhen Hua Fu-Bang Li Ru Lin Lan-Fang Tang Tian-Lin Wang Wei Wang Ying-Shuo Wang Wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-Ming Yuan Chen-Mei Zhang Yuan-Yuan Zhang | 2020 | World Journal of Pediatrics2020，16，3： | 45 |
| 3 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 4 | Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the health | ZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian | 2017 | Biomedical and Environmental Sciences2017，30，8： | 20 |
| 5 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 6 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 7 | Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis显示文摘背景风湿性关节炎(RA ) 被 synovial 膜的发炎描绘,导致进有象后果的关节的软骨和骨头的降级的邻近的软骨矩阵的 synovial 织物的侵略。Dickkopf-1 (DKK-1 ) 和 osteoprotegerin (OPG ) 被表明了是涉及改变的骨头侵蚀和骨头的关键分子。这研究的目的是在蛋白质 DKK-1 铺平的 RA.Methods 的不同舞台探索 DKK-1 和 OPG 的潜在的角色, OPG 被 ELISA 检测。浆液样品与 RA 和 60 健康控制从 300 个病人被收集。哪个, 150 个 RA 病人被定义为早 RA (疾病持续时间 1 年) ,和另外的 150 RA 病人们被定义为 longlasting RA (疾病持续时间 5 年) 。在浆液采样的时候,各种各样临床并且实验室参数被估计。 DKK-1 或 OPG 和 clinical/laboratory 参数的关联是 analyzed.Results 当没有重要差别在 OPG.In 对比的水平在二个组之间被观察时, DKK-1 的浆液水平与健康控制相比与长期的 RA 在病人被提高,在早 RA 病人,传播 OPG 被提高,当在 DKK-1 的表示的二个组之间没有重要差别时。浆液 DKK-1 在长期的 RA 病人与锋利的分数和 DAS28 被相关。在早 RA,年龄是是的唯一的参数显著地与在那里的浆液 OPG.Conclusions 有关是在 DKK-1 和 OPG 之间的串音,它在 RA 在骨头破坏包含了。在 RA 的不同舞台, DKK-1 和 OPG 可以在 RA 的致病起不同作用。 | LIU Yan-ying LONG Li WANG Shi-yao GUO Jian-ping YE Hua CUI Liu-fu YUAN Guo-hua LI Zhan-guo | 2010 | Chinese Medical Journal2010，，11： | 14 |
| 8 | A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population显示文摘Objective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris(UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group(160 patients) and a control group(158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-B-type natriuretic peptide(NT-proBNP), as well as major adverse cardiovascular events(MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angi na attacks(2.92 vs. 4.08, P =0.025), th e biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks(P <0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group(P <0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. | CUI Hua LI Xiao-ying GAO Xue-wen LU Xiang WU Xiu-ping WANG Xiao-fei ZHENG Xiang-qing HUANG Kui LIU Feng LUO Zhi YUAN Hui-shu SUN Gang KONG Jian DU Xiao-hong ZHENG Jin LIU Hong-ying ZHANG Wen-ju | 2019 | Chinese Journal of Integrative Medicine2019，25，10： | 13 |
| 9 | OsBRXL4 Regulates Shoot Gravitropism and Rice Tiller Angle through Affecting LAZY1 Nuclear Localization显示文摘Rice tiller angle is a key agronomic trait that contributes to ideal plant architecture and grain production.LAZY1 (LA1) was previously shown to control tiller angle via affecting shoot gravitropism,but the underlying molecular mechanism remains largely unknown.In this study,we identified an LA1-interacting protein named Brevis Radix Like 4 (OsBRXL4).We showed that the interaction between OsBRXL4 and LA1 occurs at the plasma membrane and that their interaction determines nuclear localization of LA1.We found that nuclear localization of LA1 is essential for its function,which is different from AtLA1,its Arabidopsis ortho.log.Overexpression of OsBRXL4 leads to a prostrate growth phenotype,whereas OsBRXLs RNAi plants,in which the expression levels of OsBRXLI,OsBRXL4,and OsBRXL5 were decreased,display a compact phenotype.Further genetic analysis also supported that OsBRXL4 controls rice tiller angle by affecting nuclear localization of LA1.Consistently,we demonstrated that OsBRXL4 regulates the shoot gravitropism through affecting polar auxin transport as did LA1.Taken together,our study not only identifies OsBRXL4 as a regulatory component of rice tiller angle but also provides new insights into genetic regulation of rice plant architecture. | Zhen Li Yan Liang Yundong Yuan Lei Wang Xiangbing Meng Guosheng Xiong Jie Zhou Yueyue Cai Ningpei Han Lekai Hua Guifu Liu Jiayang Li Yonghong Wang | 2019 | Molecular Plant2019，12，8： | 12 |
| 10 | Hydrogen sulfide suppresses transforming growth factor-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts显示文摘In heart disease, transforming growth factor-β1(TGF-β1) converts fibroblasts into myofibroblasts, which synthesize and secrete fibrillar type I and III collagens. The purpose of the present study was to investigate how hydrogen sulfide(H2S) suppresses TGF-β1-induced differentiation of human cardiac fibroblasts to myofibroblasts. Human cardiac fibroblasts were serum-starved in fibroblast medium for 16 h before exposure to TGF-β1(10 ng m L-1) for 24 h with or without sodium hydrosulfide(Na HS, 100 μmol L-1, 30 min pretreatment) treatment. Na HS, an exogenous H2 S donor, potently inhibited the proliferation and migration of TGF-β1-induced human cardiac fibroblasts and regulated their cell cycle progression. Furthermore, Na HS treatment led to suppression of fibroblast differentiation into myofibroblasts, and reduced the levels of collagen, TGF-β1, and activated Smad3 in TGF-β1-induced human cardiac fibroblasts in vitro. We therefore conclude that H2 S suppresses TGF-β1-stimulated conversion of fibroblasts to myofibroblasts by inhibiting the TGF-β1/Smad3 signaling pathway, as well as by inhibiting the proliferation, migration, and cell cycle progression of human cardiac myofibroblasts. These effects of H2 S may play significant roles in cardiac remodeling associated with heart failure. | ZHANG YouEn WANG JiaNing LI Hua YUAN LiangJun WANG Lei WU Bing GE JunBo | 2015 | Science China(Life Sciences)2015，58，11： | 11 |
| 11 | Anti-fouling ultrafiltration membrane prepared from polysulfone-graft-methyl acrylate copolymers by UV-induced grafting method显示文摘膜犯规是在膜面对的最重要的挑战之一极端过滤操作。压克力吃了的 polysulfone-graft-methyl 的共聚物被影响嫁接的度的同类的开始相片的接枝 copolymerization.The 变量综合,例如时间紫外(紫外可见) 照耀和压克力吃了的甲基和相片开始者的集中,被调查。接枝共聚物膜被阶段倒置方法准备。化学、词法的变化被红外线的光谱学(ATR/FT-TR ) ,扫描电子显微镜学,和水联系的稀释全部的 reflection-Fourier 变换描绘角度大小。结果表明甲基压克力吃了组在膜和压克力吃了的甲基的接枝度上是在场的膜的表演上的有的显著效果。有甲基压克力的增加的膜表面减少上的纯水接触角度吃了接枝度,它显示接枝共聚物膜的 hydrophilicity 被改进。纯水和牛的浆液白朊答案的浸透流动被测量评估对接枝共聚物膜,其结果显示出为接枝共聚物膜对性质犯规的反的改进的性质犯规的反。 | HUA Helin LI Na WU Linlin ZHONG Hui WU Guangxia YUAN Zonghuan LIN Xiangwei TANG Lianyi | 2008 | Journal of Environmental Sciences2008，20，5： | 11 |
| 12 | 2019 Chinese guideline for the management of hypertension in the elderly显示文摘Table of contents Preamble 1 Introduction 1.1 Class of recommendations and level of evidences 1.2 Definition and categories of hypertension in the elderly 1.3 Current status of epidemiology of hypertension in the elderly 1.4 The characteristics of hypertension in the elderly. | 无 Qi HUA Li FAN Jun CAI Lu-Yuan CHEN Wei-Wei CHEN Ping-Jin GAO Yi-Fang GUO Qing HE Jing LI Nan-Fang LI Wei-Min LI Yue LI Mei-Lin LIU Ning-Ling SUN Wen WANG Liang-Di XIE Jin-Gang YANG Hong YUAN | 2019 | Journal of Geriatric Cardiology2019，16，2： | 11 |
| 13 | Analysis of threshed rice mixture separation through vibration screen using discrete element method显示文摘The discrete element method was utilized to construct three-dimensional discrete element models for the rice mixture,and their motions were analyzed numerically on a planar vibration screening device.The results showed that,after falling onto the vibrating screen surface,the mixture undergoes a reciprocating motion within the same cycle.During the screening process,the mixture undergoes segregation,slides along the screen surface,passes through the screen and then falls.In comparing the movement of grains and shriveled grains,it can be seen that the velocity of shriveled grains experiences cyclical changes,which is consistent with the grains’motion cycle.The impact on grains is shown to be greater than that on shriveled grains,and the average speeds of shriveled grains and grains converge.The curve shows that the screening of repetitive movements has a significant effect on the average velocity of shriveled grains,but also the velocity of shriveled grains and the vibration parameters can be well represented by a fitting equation.It is beneficial for the separation of grains from shriveled grains to choose a greater vibration frequency and screen surface inclination in the range of commonly used. | Li Hua Wang Jinshuang Yuan Jianbo Yin Wenqing Wang Zhiming Qian Youzhang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 10 |
| 14 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 15 | Downregulation of Aquaporin 4 Expression through Extracellular Signal-regulated Kinases1/2 Activation in Cultured Astrocytes Following Scratch-injury显示文摘Objective To investigate the role of extracellular signal-regulated kinase1/2(ERK1/2) pathway in the regulation of aquaporin 4(AQP4) expression in cultured astrocytes after scratch-injury. Methods The scratch-injury model was produced in cultured astrocytes of rat by a 10-μL plastic pipette tip. The morphological changes of astrocytes and lactate dehydrogenase(LDH) leakages were observed to assess the degree of scratch-injury. AQP4 expression was detected by immunofluorescence staining and Western blot, and phosphorylated-ERK1/2(p-ERK1/2) expression was determined by Western blot. To explore the effect of ERK1/2 pathway on AQP4 expression in scratch-injured astrocytes, 10 μmol/L U0126(ERK1/2 inhibitor) was incubated in the medium at 30 min before the scratch-injury in some groups. Results Increases in LDH leakage were observed at 1, 12, and 24 h after scratch-injury, and AQP4 expression was reduced simultaneously. Decrease in AQP4 expression was associated with a significant increase in ERK1/2 activation. Furthermore, pretreatment with U0126 blocked both ERK1/2 activation and decrease in AQP4 expression induced by scratch-injury. Conclusion These results indicate that ERK1/2 pathway down-regulates AQP4 expression in scratch-injured astrocytes, and ERK1/2 pathway might be a novel therapeutic target in reversing the effects of astrocytes that contribute to traumatic brain edema. | SHI Zhong Fang ZHAO Wei Jiang XU Li Xin DONG Li Ping YANG Shao Hua YUAN Fang | 2015 | Biomedical and Environmental Sciences2015，28，3： | 10 |
| 16 | Profound thrombocytopenia induced by clopidogrel with a prior history of long-term safe administration显示文摘Clopidogrel has shown an excellent safety,tolerability and efficacy ever since its marketing.However,here we report a rare case with profound thrombocytopenia following clopidogrel administration previously safely exposed to this same drug.This reminds us that thrombocytopenia might be induced by clopidogrel even with a prior,safe history of long-term administration. | Yuan-Lin Guo Jian-Jun Li Jin-Qing Yuan Xue-Wen Qin Xin Zheng Chao-Wei Mu Yi-Hong Hua | 2010 | World Journal of Cardiology2010，2，6： | 9 |
| 17 | Quality of life in patients with liver cancer after operation:a 2-year follow-up study显示文摘BACKGROUND:Quality of life (QL) is a concept which reflects the physical, social, and emotional attitudes and behaviours of an individual. QL assessment is becoming in- creasingly recognised as an outcome and predictor for can- cer patients. Although hepatectomy has been widely ac- cepted as treatment of choice to offer a chance of cure for patients with liver cancer, little is known about the subjec- tive clinical results after this operation. This prospective study was designed to evaluate the Pre- and postoperative quality of life in patients with liver cancer. METHODS: The quality of life of 36 consecutive patients was measured using gastrointestinal quality of life index (GQLI) regularly 2 years after the operation, starting with a preoperative measurement. RESULTS: The score of mean preoperative GQLI was 106 ± 13 points, and it was reduced significantly 2-10 weeks after the operation (86-98) (P <0. 05-0.001). The quality of life recovered gradually. The GQLI score was 101 ± 21 points 4 months after operation and increased to the preo- perative level ( P > 0. 05 ). In the patients who survived more than 9 months, the GQLI score was higher than that before the operation. Major hepatectomy (lobectomy and combined segmentectomy) reduced the GQLI score more evidently than did minor hepatectomy (simple segmentec- tomy ) in 2-5 weeks after the operation (P <0.05). The age and preoperative liver function of the patients played an im- portant role in the recovery of the quality of life in the early postoperative stage (P <0.05). The patients with tumor re- currence showed a continuous decrease of the quality of life (P<0.05-0.001). CONCLUSIONS: The assessment of the quality of life is meaningful for patients with liver cancer. Tumor recur- rence, poor liver function and major operation are the most important factors for reducing the quality of life. He- patic resection is justified by its effects on the survival and the quality of life of the patients. | Li Chen, Yong Liu, Guo-Gang Li, Si-Feng Tao, Yuan Xu and Hua Tian Hangzhou, China : Department of Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 9 |
| 18 | Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction显示文摘Objective To investigate whether recuperating lung decoction(RLD) can modulate the composition of gut microbiota in rats during asthma treatment.Methods Fifteen Sprague-Dawley rats were divided randomly and equally into control group,model group,dexamethasone(DEX) group,RLD medium-dose group,and RLD high-dose group.The asthma model was established in all groups,except for the control group.The rats in the DEX and RLD groups were treated orally with DEX and RLD,respectively.The rats in the control and model groups were treated orally with 0.9% saline.The intestinal bacterial communities were compared among groups using 16 S r RNA gene amplification and 454 pyrosequencing.Results The microbial flora differed between the control and model groups,but the flora in the RLD groups was similar to that in the control group.No significant differences were observed between the RLD high-dose and medium-dose groups.RLD treatment resulted in an increase in the level beneficial bacteria in the gut,such as Lactobacillus and Bifidobacterium spp.Conclusion Oral administration of RLD increased the number of intestinal lactic acid-producing bacteria,such as Lactobacillus and Bifidobacterium,in asthma model rats. | KONG Yan Hua SHI Qi HAN Na ZHANG Ling ZHANG Yuan Yuan GAO Tong Xin CHEN Chen LI You Lin | 2016 | Biomedical and Environmental Sciences2016，29，8： | 9 |
| 19 | OsSPL18 controls grain weight and grain number in rice显示文摘Grain weight and grain number are two important traits directly determining grain yield in rice. To date,a lot of genes related to grain weight and grain number have been identified; however, the regulatory mechanism underlying these genes remains largely unknown. In this study, we studied the biological function of OsSPL18 during grain and panicle development in rice. Knockout (KO) mutants of OsSPL18exhibited reduced grain width and thickness, panicle length and grain number, but increased tiller number. Cytological analysis showed that OsSPL18 regulates the development of spikelet hulls by affecting cell proliferation. qRT-PCR and GUS staining analyses showed that OsSPL18 was highly expressed in developing young panicles and young spikelet hulls, in agreement with its function in regulating grain and panicle development. Transcriptional activation experiments indicated that OsSPL18is a functional transcription factor with activation domains in both the N-terminus and C-terminus, and both activation domains are indispensable for its biological functions. Quantitative expression analysis showed that DEP1, a major grain number regulator, was significantly down-regulated in OsSPL18 KO lines.Both yeast one-hybrid and dual-luciferase (LUC) assays showed that OsSPL18 could bind to the DEP1promoter, suggesting that OsSPL18 regulates panicle development by positively regulating the expression of DEP1. Sequence analysis showed that OsSPL18 contains the OsmiR156k complementary sequence in the third exon; 5?RLM-RACE experiments indicated that OsSPL18 could be cleaved by OsmiR156k. Taken together, our results uncovered a new OsmiR156k-OsSPL18-DEP1 pathway regulating grain number in rice. | Hua Yuan Peng Qin Li Hu Shijie Zhan Shifu Wang Peng Gao Jing Li Mengya Jin Zhengyan Xu Qiang Gao Anping Du Bin Tu Weilan Chen Bingtian Ma Yuping Wang Shigui Li | 2019 | Journal of Genetics and Genomics2019，46，1： | 8 |
| 20 | Effects of surfactants on enzyme-containing reversed micellar system显示文摘With the development of colloid interface and enzyme technologies,enzyme-containing reversed micellar system has been receiving much attention in bioseparation and bioconversion. Because of its high efficiency,it has brought new opportunities for the development of molecular biotechnology. Reversed micelles represent nano-sized aqueous droplets stabilized by surfactant amphiphiles inside the bulk organic solvents. The entrapped enzymes have enhanced activities under those conditions as suited in the lipid bilayers of biological membranes. The fundamentals of enzyme-containing reversed micellar system are described in this paper,with special emphasis on the effects of surfactants varying in concentrations and structures. The latest study progress on the surfactants application in enzyme-containing reversed micelles is reviewed. The introduction of novel functional surfactants in micellar enzymology and their future development are also discussed. | LIANG YunShan,YUAN XingZhong,ZENG GuangMing,ZHONG Hua,LI Hui & WANG WeiWei Key Laboratory of Environmental Biology and Pollution Control (Hunan University),Ministry of Education College of Environmental Science and Engineering,Hunan University,Changsha 410082,China | 2011 | Science China Chemistry2011，54，5： | 8 |
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