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| 1 | A nomogramfor predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis显示文摘Background:Low-grade endometrial stromal sarcoma(LG-ESS)is a rare tumor that lacks a prognostic prediction model.Our study aimed to develop a nomogram to predict overall survival of LG-ESS patients.Methods:A total of 1172 patients confirmed to have LG-ESS between 1988 and 2015 were selected from the Surveillance,Epidemiology and End Results(SEER)database.They were further divided into a training cohort and a validation cohort.The Akaike information criterion was used to select variables for the nomogram.The discrimination and calibration of the nomogram were evaluated using concordance index(C-index),area under time-dependent receiver operating characteristic curve(time-dependent AUC),and calibration plots.The net benefits of the nomogram at different threshold probabilities were quantified and compared with those of the International Federation of Gynecology and Obstetrics(FIGO)criteria-based tumor staging using decision curve analysis(DCA).Net reclassification index(NRI)and integrated discrimination improvement(IDI)were also used to compare the nomogram’s clinical utilitywith that of the FIGO criteria-based tumor staging.The risk stratifications of the nomogram and the FIGO criteria-based tumor staging were compared.Results:Seven variables were selected to establish the nomogram for LG-ESS.The C-index(0.814 for the training cohort and 0.837 for the validation cohort)and the time-dependent AUC(>0.7)indicated satisfactory discriminative ability of the nomogram.The calibration plots showed favorable consistency between the prediction of the nomogram and actual observations in both the training and validation cohorts.The NRI values(training cohort:0.271 for 5-year and 0.433 for 10-year OS prediction;validation cohort:0.310 for 5-year and 0.383 for 10-year OS prediction)and IDI(training cohort:0.146 for 5-year and 0.185 for 10-year OS prediction;validation cohort:0.177 for 5-year and 0.191 for 10-year OS prediction)indicated that the established nomogram performed significantly better than the FIGO criteria-based tumor staging alone(P<0.05).Furthermore,DCA showed that the nomogram was clinically useful and had better discriminative ability to recognize patients at high risk than the FIGO criteria-based tumor staging.Conclusions:A prognostic nomogram was developed and validated to assist clinicians in evaluating prognosis of LG-ESS patients. | Jie Wu Huibo Zhang Lan Li Mengxue Hu Liang Chen Bin Xu Qibin Song | 2020 | Cancer Communications2020，40，7： | 35 |
| 2 | Roles of a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism in ABA signal production in Arabidopsis显示文摘ABA, acting as a stress signal, plays crucial roles in plant resistance to water stress. Because ABA signal production is based on ABA biosynthesis, the regulation of NCED, a key enzyme in the ABA biosynthesis pathway, is normally thought of as the sole factor controlling ABA signal production. Here we demonstrate that ABA catabolism in combination with a synergistic regulation of ABA biosynthesis plays a crucial role in governing ABA signal production. Water stress induced a significant accumulation of ABA, which exhibited different patterns in detached and attached leaves. ABA catabolism followed a temporal trend of exponential decay for both basic and stress ABA, and there was little difference in the catabolic half-lives of basic ABA and stress ABA. Thus, the absolute rate of ABA catabolism, i.e. the amount of ABA catabolized per unit time, increases with increased ABA accumulation. From the dynamic processes of ABA biosynthesis and catabolism, it can be inferred that stress ABA accumulation may be governed by a synergistic regulation of all the steps in the ABA biosynthesis pathway. Moreover, to maintain an elevated level of stress ABA sustained activation of NCED3 should be required. This inference was supported by further findings that the genes encoding major enzymes in the ABA biosynthesis pathway, e.g. NCED3, AAO3 and ABA3 were all activated by water stress, and with ABA accumulation progressing, the expressions of NCED3, AAO3 and ABA3 remained activated. Data on ABA catabolism and gene expression jointly indicate that ABA signal production is controlled by a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism. | REN HuiBo FAN YiJian GAO ZhiHui WEI KaiFa LI GuiFen LIU Jing CHEN Lin LI BingBing HU JianFang JIA WenSuo | 2007 | Chinese Science Bulletin2007，52，4： | 12 |
| 3 | Advances in luminescent lanthanide complexes and applications显示文摘Luminescent lanthanide complexes have been widely investigated as light emitting materials in bio-imaging and sensing, solid state lighting and display, anti-fake tags and light conversion films, due to their characterized photophysical properties including large Stokes shift, long lifetime, and sharp emission spectrum, arising from the sensitized f-f transitions. In this review, we summarize the most recent advances in luminescent lanthanide complexes and their applications from 2015 to August 2017 concerning of general concepts to potential applications. We first introduce the basic concept of sensitized luminescence of lanthanide complexes and the strategies used for highly luminescent complexes. Then recent varieties of luminescent lanthanide complexes and their hybrid materials are presented. Finally, applications are discussed in detail. | WEI Chen MA Li WEI HuiBo LIU ZhiWei BIAN ZuQiang HUANG ChunHui | 2018 | Science China(Technological Sciences)2018，61，9： | 8 |
| 4 | Postconditioning of stellate ganglion block improves intestinal barrier function by inhibiting autophagy in conscious rats following hemorrhagic shock and resuscitation显示文摘To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfunction is a critical link of distant organ injury caused by hemorrhagic shock.Prophylactic treatment with stellate ganglion block(SGB)significantly reduces hemorrhagic shock-induced intestinal barrier damage. | Zhonghua Li Wendi Wang Qi Sun Tingjiao Suo Jiayi Zhai Huibo Du Zhen’ao Zhao Fulong Li Chunyu Niu Zigang Zhao | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 5 | Realizing the highly reversible Zn^(2+)and Na^(+) dual ions storage in high-crystallinity nickel hexacyanoferrate microcubes for aqueous zinc-ion batteries显示文摘Prussian blue analogues(PBAs)with the 3D open framework are regarded as promising cathode candidates for aqueous Zinc ion batteries(ZIBs).Among various PBAs,nickel hexacyanoferrate(NiHCF)has attracted considerable attention because of its high operating voltage and economic merit.However,the cyclability of NiHCF is unsatisfactory due to poor structural stability during Zn^(2+) ions insertion/deinsertion.Moreover,the ion storage mechanism of NiHCF in aqueous electrolytes has not been fully revealed yet.Herein,high-crystallinity NiHCF(HC-NiHCF)microcubes with improved structural stability and larger crystal plane spacing are synthesized.For the first time,highly reversible Zn2+ions and Na+ions co-insertion/extraction are achieved for the HC-NiHCF microcubes in mixed aqueous electrolyte,as evidenced by various observations including two separated discharge plateaus and sequential changes of Na 1s and Zn 2p signals in ex-situ X-ray photoelectron spectroscopy(XPS).As a result,a high specific capacity of 73.9 mAh g^(−1) is obtained for the HC-NiHCF microcubes at 0.1 A g−1,combined with enhanced cycle stability(75%vs.16.4%)over 1000 cycles at 2 A g^(−1).The reversible Zn^(2+) ions and Na+ions co-insertion in HC-NiHCF microcubes reveals a new ion storage mechanism of Ni-based PBAs in aqueous electrolytes. | Kexuan Wang Zhu Xu Heng Li Huibo Wang Mingzheng Ge Jilei Liu Shengwen Li Zekun Hu Mengyu Zhu Yanyan Zhang Yuxin Tang Shi Chen | 2023 | Journal of Materials Science & Technology2023，，33： | 1 |
| 6 | Geochemistry of the late Permian No. 30 coal seam, Zhijin Coalfield of Southwest China: influence of a siliceous low-temperature hydrothermal fluid显示文摘 | Shifeng Dai Dahua Li Deyi Ren Yuegang Tang Longyi Shao Huibo Song | 2004 | Applied Geochemistry2004，，8： | 1 |
| 7 | Defective super-long carbon nanotubes and polypyrrole composite for high-performance supercapacitor electrodes显示文摘 | Yue Hu Yang Zhao Yan Li Hui Li Huibo Shao Liangti Qu | 2012 | Electrochimica Acta2012，，： | 1 |
| 8 | Multi-innovation least squares identification methods based on the auxiliary model for MISO systems显示文摘 | Feng Ding Huibo Chen Ming Li | 2006 | Applied Mathematics and Computation2006，，2： | 1 |
| 9 | Influence of Dust Weather on Air Quality in Lanzhou City显示文摘[Objective]The study aimed to discuss the effects of dust weather on air quality in Lanzhou City.[Method]Under the influence of a strong sandstorm during March 8-15,2013 on air quality in Gansu Province,the changes of wind speed,atmospheric visibility and PM_(10)concentration as well as air pollution in Lanzhou were analyzed.[Result]The dust weather during March 8-15,2013 affected Lanzhou City for the longest time in recent 10 years,and the city suffered medium pollution on March 8 and heavy pollution during March 9-15 under the influence of the dust weather,while PM_(10)was the primary pollutant.[Conclusion]The research could provide the corresponding technical support for the prevention and control of environmental pollution in Lanzhou City. | Xiaohong Li Huibo Cheng | 2013 | Meteorological and Environmental Research2013，4，11： | 1 |
| 10 | A Novel Uniplanar Multi-Electrode Capacitive Sensor for In-Situ Weathering Damage Detection of Nonmetallic Materials显示文摘A uniplanar capacitive sensor with 5-electrodes on one plane substrate and a large reflector electrode,was designed to get the corresponding capacitance information for weathering damage detection of non-metallic materials exposed to a service environment.A 2-D finite-element method was employed to simulate the electric potential distribution and capacitance measurements for the sensor.2 marble slabs,one was healthy and the other was notched,were experimentally detected.Both the simulation and the preliminary experimental results show that the measured capacitances decrease after weathering damage occurs in nonmetallic material.The reflector can enlarge the sensitive depth.The weathering assessment of nonmetallic materials can be done by processing the measured capacitances.The proposed approach can effectively detect the weathering damage of nonmetallic material and can be practically used for in-situ weathering damage evaluation. | Ensheng Dong Yonggui Dong Wener Lv Huibo Jia Jun Li | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 11 | Thermal Contact Resistance between Aero Engine Compressor Blade and Flexible Fixture显示文摘In the process of two-pass micro plasma arc welding of titanium alloy sheet,based on the thermal contact resistance theory,a three-dimensional transient heat transfer finite element model of contact heat transfer between titanium alloy sheet and flexible fixture was established.The effects of contact upper surface temperature,micro-contact thermal resistance,micro-gap thermal resistance,DC and pulse welding on thermal contact resistance were investigated,and the simulation and experimental results were compared.The results show that the thermal contact resistance increases as the temperature increases when the temperature of the contact upper surface (titanium alloy sheet) is in the range of 290-350 K.The effect of micro-contact thermal resistance on the thermal contact resistance is 26.1%-46.3% larger than the micro-gap thermal resistance.The thermal contact resistance of pulse welding is 3.1%-3.5% larger than DC welding.The error of simulation and experimental results of weld pool depth is 8.6%,which verifies the reliability of the model. | DAI Shijie WANG Dong ZHANG Huibo LI Shibo WANG Zhiping | 2021 | Journal of Thermal Science2021，30，2： | 1 |
| 12 | Functions and mechanisms of protein lysine butyrylation(Kbu):Therapeutic implications in human diseases显示文摘Post-translational modifications(PTM)are covalent modifications of proteins or peptides caused by proteolytic cleavage or the attachment of moieties to one or more amino acids.PTMs play essential roles in biological function and regulation and have been linked with several diseases.Modifications of protein acylation(Kac),a type of PTM,are known to induce epigenetic regulatory processes that promote various diseases.Thus,an increasing number of studies focusing on acylation modifications are being undertaken.Butyrylation(Kbu)is a new acylation process found in animals and plants.Kbu has been recently linked to the onset and progression of several diseases,such as cancer,cardiovascular diseases,diabetes,and vascular dementia.Moreover,the mode of action of certain drugs used in the treatment of lymphoma and colon cancer is based on the regulation of butyrylation levels,suggesting that butyrylation may play a therapeutic role in these diseases.In addition,butyrylation is also commonly involved in rice gene expression and thus plays an important role in the growth,development,and metabolism of rice.The tools and analytical methods that could be utilized for the prediction and detection of lysine butyrylation have also been investigated.This study reviews the potential role of histone Kbu,as well as the mechanisms underlying this process.It also summarizes various enzymes and analytical methods associated with Kbu,with the goal of providing new insights into the role of Kbu in gene regulation and diseases. | Qianqian Xue Yanyan Yang Hong Li Xiaoxin Li Lu Zou Tianxiang Li Huibo Ma Hongzhao Qi Jianxun Wang Tao Yu | 2023 | Genes & Diseases2023，10，6： | 0 |
| 13 | MtRGF3 peptide activates defense responses and represses the expressions of nodulation signaling genes in Medicago truncatula显示文摘Root meristem growth factors(RGFs)were first discovered in Arabidopsis thaliana and regulate root development,including primary root growth,lateral root formation and root gravitropism,etc.[1‒3].RGF belongs to a 13-amino-acid peptide family,which usually contains conserved aspartate(D1),tyrosine(Y2),proline(P9 and P10),histidine(H12)and asparagine(N13)residues.Among these residues,the second tyrosine residue(Y2)is modified by a sulfate group,and the tenth proline residue(P10)is hydroxylated[1‒3].The active peptide is processed from a precursor that consists of a signal peptide,a variant region and a conserved C-terminal domain.The peptide is recognized by the leucine rich repeat(LRR)receptor kinases(RGFR)and then regulates the activities of the AP transcription factors TLPs in A.[4‒6].Nine genes of AtRGF or AtGLV were identified in A.thaliana,and 15 corresponding genes were reported in the model legume Medicago truncatula[7]. | Qiong Li Dandan Shan Wenjia Zheng Yawen Wang Zhiyin Lin Huibo Jin Anqi Ding Junhui Yan Liangliang Yu Li Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 14 | Effects of physical properties of supercritical water on coarse graining of particle cluster显示文摘The coarse graining of particle cluster is of great significance to the study of a fluidized bed. The effects of variations in the physical properties of supercritical water on the coarse graining of particle cluster are investigated in this work. The drag coefficient distributions of the particle cluster are not influenced by the physical properties. However, the physical properties have effects on the values of drag coefficient. The effects of physical properties are weaker in the case of large particle concentrations. Furthermore, the physical properties lead to that the effect of particle cluster wake on the drag of downstream particles being significantly different from that of constant property flow. The variation trend of drag of coarse graining particle is consistent with that of isolated particle. The physical properties lead to significant differences in the values of drag. In this paper, the dominance of the effects of physical properties in a variety of cases is confirmed. Finally, a physical properties effect model is developed accordingly. | Xiaoyu Li Huibo Wang Yi Li Hui Jin | 2023 | Particuology2023，，11： | 0 |
| 15 | Quantum microwave photonics in radio-over-fiber systems显示文摘As the main branch of microwave photonics,radio-over-fiber technology provides high bandwidth,low-loss,and long-distance propagation capability,facilitating wide applications ranging from telecommunication to wireless networks.With ultrashort pulses as the optical carrier,a large capacity is further endowed.However,the wide bandwidth of ultrashort pulses results in the severe vulnerability of high-frequency radio frequency(RF)signals to fiber dispersion.With a time-energy entangled biphoton source as the optical carrier combined with the singlephoton detection technique,a quantum microwave photonics method in radio-over-fiber systems is proposed and demonstrated experimentally.The results show that it not only realizes unprecedented nonlocal RF signal modulation with strong resistance to the dispersion but also provides an alternative mechanism to distill the RF signal out from the dispersion effectively.Furthermore,the spurious-free dynamic ranges of the nonlocally modulated and distilled RF signals have been significantly improved.With the ultra-weak detection and the high-speed processing advantages endowed by the low-timing-jitter single-photon detection,the quantum microwave photonics method opens new possibilities in modern communication and networks. | YAQING JIN YE YANG HUIBO HONG XIAO XIANG RUNAI QUAN TAO LIU SHOUGANG ZHANG NINGHUA ZHU MING LI RUIFANG DONG | 2022 | Photonics Research2022，10，7： | 0 |
| 16 | The Distribution of Benefits for Players in Agricultural Industrial Chain显示文摘Players of the agricultural industrial chain pursue their own profit maximization,which can lead to conflicts of interest and affect the stability of the industrial chain. Therefore,fair and reasonable profit allocation mechanism is the key to guaranteeing the development and strengthening the strategic alliance relationship between participate members. Shapley model is an effective method to solve the profit distribution in cooperative relations. But it does not consider the three factors: risks faced by players during the operation of the agricultural industrial chain,technology innovation ability,and the degree of participating in the cooperation. So,correction factors are introduced to modify the Shapley value model,in order to make the distribution of benefits more equitable and reasonable,and effectively guide practice. | Wanming LI Huibo SUN | 2015 | Asian Agricultural Research2015，7，1： | 0 |
| 17 | PP2A interacts with KATANIN to promote microtubule organization and conical cell morphogenesis显示文摘The organization of the microtubule cytoskeleton is critical for cell and organ morphogenesis.The evolutionarily conserved microtubule-severing enzyme KATANIN plays critical roles in microtubule organization in the plant and animal kingdoms.We previously used conical cell of Arabidopsis thaliana petals as a model system to investigate cortical microtubule organization and cell morphogenesis and determined that KATANIN promotes the formation of circumferential cortical microtubule arrays in conical cells.Here,we demonstrate that the conserved protein phosphatase PP2A interacts with and dephosphorylates KATANIN to promote the formation of circumferential cortical microtubule arrays in conical cells.KATANIN undergoes cycles of phosphorylation and dephosphorylation.Using co-immunoprecipitation coupled with mass spectrometry,we identified PP2A subunits as KATANIN-interacting proteins.Further biochemical studies showed that PP2 A interacts with and dephosphorylates KATANIN to stabilize its cellular abundance.Similar to the katanin mutant,mutants for genes encoding PP2A subunits showed disordered cortical microtubule arrays and defective conical cell shape.Taken together,these findings identify PP2A as a regulator of conical cell shape and suggest that PP2A mediates KATANIN phospho-regulation during plant cell morphogenesis. | Huibo Ren Jinqiu Rao Min Tang Yaxing Li Xie Dang Deshu Lin | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 18 | Biocompatible carbon dots with low-saturation-intensity and highphotobleaching-resistance for STED nanoscopy imaging of the nucleolus and tunneling nanotubes in living cells显示文摘Many kinds of nano particles and organic dyes as fluorescent probes have been used in the stimulated emission depletion(STED)nanoscopy.Due to high toxicity,photobleaching and non-water solubility,these fluorescent probes are hard to apply in living cell imaging.Here,we reporta new fluorescence carbon dots(FNCDs)with high photoluminescence quantum yield(56%),low toxicity,anti-photobleaching and goodwater-solubility that suitable for live-cell imaging can be obtained by doping fluorine element.Moreover,the FNCDs can stain the nucleolusand tunneling nanotubes(TNTs)in the living cell.More importantly,for STED nanoscopy imaging,the FNCDs effectively depleted backgroundsignals and improved imaging resolution.Furthermore,the lateral resolution of single FNCDs size under the STED nanoscopy is up to 22.1 nm for FNCDs deposited on a glass slide was obtained.And because of their good water dispersibility,the higher resolution of single FNCDs sizein the nucleolus of a living cell can be up to 19.7 nm.After the image optimizati on steps,the fine fluoresce nee images of TNTs diameter with ca.75 nm resolution is obtained living cell,yielding a threefold enhancement compared with that in confocal imaging.Additionally,the FNCDs show excellent photobleaching resistance after 1,000 scan cycles in the STED model.All results show that FNCDs have significant potentialfor application in STED nanoscopy. | Hao Li Shuai Ye Jiaqing Guo Huibo Wang Wei Yan Jun Song Junie Qu | 2019 | Nano Research2019，12，12： | 0 |
| 19 | Leaf Morphology Genes SRL1 and RENL1 Co-Regulate Cellulose Synthesis and Affect Rice Drought Tolerance显示文摘The morphological development of rice(Oryza sativa L.)leaves is closely related to plant architecture,physiological activities,and resistance.However,it is unclear whether there is a co-regulatory relationship between the morphological development of leaves and adaptation to drought environment.In this study,a drought-sensitive,roll-enhanced,and narrow-leaf mutant(renl1)was induced from a semi-rolled leaf mutant(srl1)by ethyl methane sulfonate(EMS),which was obtained from Nipponbare(NPB)through EMS.Map-based cloning and functional validation showed that RENL1 encodes a cellulose synthase,allelic to NRL1/OsCLSD4.The RENL1 mutation resulted in reduced vascular bundles,vesicular cells,cellulose,and hemicellulose contents in cell walls,diminishing the water-holding capacity of leaves.In addition,the root system of the renl1 mutant was poorly developed and its ability to scavenge reactive oxygen species(ROS)was decreased,leading to an increase in ROS after drought stress.Meanwhile,genetic results showed that RENL1 and SRL1 synergistically regulated cell wall components.Our results revealed a theoretical basis for further elucidating the molecular regulation mechanism of cellulose on rice drought tolerance,and provided a new genetic resource for enhancing the synergistic regulation network of plant type and stress resistance,thereby realizing simultaneous improvement of multiple traits in rice. | LIU Dan ZHAO Huibo WANG Zi’an XU Jing LIU Yiting WANG Jiajia CHEN Minmin LIU Xiong ZHANG Zhihai CEN Jiangsu ZHU Li HU Jiang REN Deyong GAO Zhenyu DONG Guojun ZHANG Qiang SHEN Lan LI Qing QIAN Qian HU Songping ZHANG Guangheng | 2024 | Rice science2024，31，1： | 0 |
| 20 | Electrochemical performance of Pt/CN nanocatalyst显示文摘This paper describes a novel process which is used to prepare well-dispersed Pt nanoparticles on zeolitic imidazolate framework-90(ZIF-90).The electrocatalytic activity of Pt/CN is evaluated by cyclic voltammetry(CV).Compared with the commercial Pt/C catalyst,the so-prepared Pt/CN composite materials show higher electrotrocatalytic cativity.These properties recommend Pt nanoparticles-functionalized ZIF-90 as a promising catalyst for direct methanol fuel cells. | He Zhongyi 刘佳妮 Xiao Ting Sun Xinxiao Rao Sainan Li Huibo | 2017 | 石化技术2017，24，4： | 0 |
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