|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 2 | Thin-bed thickness calculation formula and its approximation using peak frequency显示文摘在调节厚度下面的量的厚度评价是在地震探索的大挑战。的大多数研究焦点薄床系数相等的大小和相反的极性是其顶和底部思考。另外的薄床的类型上没有系统的研究。在这篇文章,所有薄床被分类进四种类型:与不相等的大小和相同极性与相等的大小和相反的极性薄床、与不相等的大小和相反的极性薄床、与相等的大小和相同极性薄床、薄床。由分析学习,描述在地震山峰频率和薄床的厚度之间的一般关系的一个方程被导出它在那里的表演并且哪个是在他们之间的一种复杂含蓄的非线性的关系是困难的在实践使用。以便解决这个问题,我们由泰勒扩大简化关系并且为四种类型与不同订单讨论近似公式的精确薄床。与为薄床的厚度计算的传统的振幅方法相比,方法我们在场有更高的精确并且没被顶或底部思考系数的绝对值影响,它因此对在实践的使用方便。 | Sun Luping Zheng Xiaodong Li Jingsong Shou Hao | 2009 | Applied Geophysics2009，6，3： | 13 |
| 3 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 4 | Ultra-broadband on-chip twisted light emitter for optical communications显示文摘On-chip twisted light emitters are essential components of orbital angular momentum(OAM)communication devices1,2.These devices address the growing demand for high-capacity communication systems by providing an additional degree of freedom for wavelength/frequency division multiplexing(WDM/FDM).Although whispering-gallery-mode-enabled OAM emitters have been shown to possess some advantages3–5,such as compactness and phase accuracy,their inherent narrow bandwidths prevent them from being compatible with WDM/FDM techniques.Here,we demonstrate an ultra-broadband multiplexed OAM emitter that utilizes a novel joint path-resonance phase control concept.The emitter has a micron-sized radius and nanometer-sized features.Coaxial OAM beams are emitted across the entire telecommunication band from 1,450 to 1,650 nm.We applied the emitter to an OAM communication with a data rate of 1.2 Tbit/s assisted by 30-channel optical frequency combs(OFCs).The emitter provides a new solution to further increase capacity in the OFC communication scenario. | Zhenwei Xie Ting Lei Fan Li Haodong Qiu Zecen Zhang Hong Wang Changjun Min Luping Du Zhaohui Li Xiaocong Yuan | 2018 | Light(Science & Applications)2018，7，1： | 7 |
| 5 | DCT domain filtering method for multi-antenna code acquisition显示文摘For global navigation satellite system(GNSS) signals in Gaussian and Rayleigh fading channel, a novel signal detection algorithm is proposed. Under the low frequency uncertainty case, after performing discrete cosine transform(DCT) to the outputs of the partial matched filter(PMF) for every antenna, the high order components in the transforming domain will be filtered, then the equalgain(EG) combination for the inverse discrete cosine transform(IDCT) reconstructed signal would be done subsequently. Thus,due to the different frequency distribution characteristics between the noise and signals, after EG combination, the energy of signals has almost no loss and the noise energy is greatly reduced. The theoretical analysis and simulation results show that the detection algorithm can effectively improve the signal-to-noise ratio of the captured signal and increase the probability of detection under the same false alarm probability. In addition, it should be pointed out that this method can also be applied to Rayleigh fading channels with moving antenna. | Xiaojie Li Luping Xu Shibin Song Hua Zhang | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 6 |
| 6 | Emergy-based sustainability assessment of Inner Mongolia显示文摘内部蒙古自治区域(IMAR ) 的综合环境财务从 1987 ~ 2007 与数据基于 emergy 分析在这份报纸被介绍。通过精明的环境、经济的输入和一系列 emergy 指示物,这份报纸讨论 IMAR 资源使用结构,经济状况,和贸易地位。结果证明在 IMAR 使用的超过 85% emergy 从家来源被导出,显示为自足的一个强壮的能力。集中使用的本地非可更新的 emergy,向 IMAR 经济提供大多数驱动力,在 2004 以后在全部的 emergy 使用拿了最大的份额并且在 2007 到达了 58% 。2000 的西方的中国发展计划从 IMAR 迎来了煤和电生产和出口的快速的生长到中国的另外的区域。IMAR 的出口 / 进口 emergy 比率在 2007 到达了 3.46,与出口的煤(3.44 ? 楤敶獲瑩 ? 湡 ? 灳瑡慩? 慰瑴牥 ? 景攠潣祳瑳浥猠牴 ' 壮肭勉硴秤硿爆崫?眠楨档椠 ? 桴 ? 慭湩 ' 獪珷箾 K 映捡潴 ? 湯瘠来瑥瑡潩 ? 慬摮 ' 諡?楤敶獲瑩 ? 湡 ? 灳瑡慩? 楤瑳楲畢楴湯漠 ?题传 | ZHU Luping LI Haitao CHEN Jiquan JOHN Ranjeet LIANG Tao YAN Maochao | 2012 | Journal of Geographical Sciences2012，22，5： | 5 |
| 7 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 8 | A new acyclic peroxide from Aspergillus nidulans SD-531,a fungus obtained from deep-sea sediment of cold spring in the South China Sea显示文摘A new acyclic peroxide derivative asperoxide A(1),along with 13 known compounds,namely,microperfuranone(2),9-hydroxymicroperfuranone(3),gibellulin A(4),lecanoric acid(5),terrequinone A(6),sterigmatocystin(7),isosecosterigmatocystin(8),arugosin C(9),curvularin(10),3,3'-diindolylmethane(11),austinol(12),austin(13),and dehydroaustin(14),were isolated and identified from the culture extract of Aspergillus nidulans SD-531,a fungus obtained from the deep-sea sediment of cold spring in the South China Sea.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic and mass spectrometry data analysis.All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi.Compounds 1–8,10,and 11 exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration(MIC)values ranging from^2 to 64μg/mL.Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents. | LÜFengyi LI Xiaoming CHI Luping MENG Linghong WANG Bingui | 2020 | Journal of Oceanology and Limnology2020，38，4： | 4 |
| 9 | Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production显示文摘Japanese encephalitis virus(JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a52-amino acid C-terminal extension of NS1, is generated with a-1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1' plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1' defected(rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus(pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type Ⅰ interferon(IFN) response than that by pSA14, and JEV NS1' significantly inhibited the production of IFN-b and IFN-stimulated genes. Taken together, our results reveal that NS1' plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication. | Dengyuan Zhou Fan Jia Qiuyan Li Luping Zhang Zheng Chen Zikai Zhao Min Cui Yunfeng Song Huanchun Chen Shengbo Cao Jing Ye | 2018 | Virologica Sinica2018，33，6： | 3 |
| 10 | Genome editing and animal models显示文摘Transgenic technology allows a gene of interest to be introduced into the genome of a laboratory animal,and provides an extremely powerful tool to dissect the molecular mechanisms of disease.Transgenic mouse models made by microinjection of DNA into zygotic pronuclei in particular have been widely used by the genetics community for 30 years.However,it remains a rather crude approach:injected sequences randomly insert in multiple copies as concatamers,they can be mutagenic,and they have variable or silenced expression depending on the site of integration,a phenomenon called position effects.As a result,multiple lines are required in order to confirm appropriate transgene expression.This can be partially overcome by flanking transgenes with insulator sequences to protect the transgene from the influence of the surrounding regulatory elements.Large(\300 kb)BACbased transgenic vectors have also been shown to be more resistant to position effects.However,animals carrying extra copies of fairly large regions of the genome could have unpredictable phenotypes.The most effective method used to control for position effects is to target transgene insertion to specific genomic loci,the so-called targeted transgenesis;for instance,the fast,site-specific transgenic technology Targatt TM.The purpose of this review is to provide an overview on the current existing methods for making targeted transgenic mouse models. | Ruby Yanru Chen-Tsai Ruhong Jiang Luping Zhuang Junfeng Wu Lingsong Li Jiarui Wu | 2014 | Chinese Science Bulletin2014，59，1： | 2 |
| 11 | On the Spectral Moments of Wind Waves显示文摘In order to obtain high order spectral moments, the residual moment M( ωn )i =∫ωn0ωiS(ω)dω, as proposed by Dehis, is presented for approximate estimation of spectral moment mi =∫m0ωiS(ω)dω. Glazman's partial averaging idea isdiscussed. It is pointed out that Glazman's method and definition of non-dimensional spectral moment can not be used to es-timate spectral moments for engineering purposes and that method is not supported by theory and computation. The non-di-mensional spectral moment of PM spectnun, which should be expressed as Mi = M(ωn ) i/ag2ω0i-p+1 , is related to wind speed. The0~ 8th moments of PM spectrum are estimated for wind speeds of 10, 20 and 30 m/s and some discussions are given. | LI Luping(李陆平) HUANG Peiji(黄培基) | 2002 | China Ocean Engineering2002，17，1： | 2 |
| 12 | Diagnosis Technology for the Icing Status of Wind Turbine Blades Based on Vibration Detection显示文摘对不同覆冰状态下的风力机叶片动力特性进行了模拟实验研究,定义叶片覆冰状态参数,包括覆冰区域起点参数、覆冰区域长度参数和覆冰厚度参数。利用人工环境实验室和模态分析系统建立风力机叶片覆冰振动测试实验台,对风力机模拟叶片在不同覆冰状态下进行模态分析,从叶片的曲率模态参数中提取判断风力机叶片覆冰参数的特征值指标,从实验结果获得的特征值较准确地诊断出风力机模拟叶片覆冰状态。通过仿真计算得到叶片结构的质量变化率和抗弯刚度变化率重合点。上述仿真及实验结果表明风力机叶片覆冰诊断理论方法以及技术具备正确性与可行性。 | LIU Shengxian LI Luping Yu Tao LEI Libin LI Mangmang | 2013 | 中国电机工程学报2013，33，32： | 2 |
| 13 | Neuroprotective effect of heat shock protein 70 Inhibition of Tau protein expression显示文摘BACKGROUND: Previous studies have shown that heat shock protein 70 (HSP70) hasneuroprotective effects by decreasing phosphorylation of Tau protein, thereby reducing theexpression of Tau protein and proper aggregation.OBJECTIVE: To observe and verify expressional changes of HSP70 and Tau in retinal ganglioncells following stretch injury to the right optic nerve in rats, and to determine the effect of heat stresspretreatment on HSP70 and Tau protein expressions.DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at theLaboratory of Neurology Research Institute of the First Affiliated Hospital of Chongqing MedicalUniversity from March to June 2006.MATERIALS: Instant SABC immunohistochemistry kit, as well as mouse anti-HSP70 and rabbitanti-Tau polyclonal antibodies, were purchased from Wuhan Boster Bioengineering Limited, China.METHODS: A total of 57 male, Wistar rats were randomly assigned to 4 groups: control (n = 3);150-180 g stretch force was induced in the right optic nerves in stretch-only group (n = 18) toestablish optic nerve stretch injury model; heat stress was applied to 18 animals in heat-stresstreatment group; 18 rats in the heat-stress pretreatment plus stretch group were subjected toidentical stretch injury as stretch-only group after 24-hour heat-stress pretreatment. According tosacrifice time, the groups were assigned to 6 subgroups at different time points of 4, 8, and 16 hours,and 1,3, and 5 days, with 3 rats in each subgroup. No treatment was performed in the control groupexcept anesthesia.MAIN OUTCOME MEASURES: Morphological changes of optic nerves and retinal ganglion cellsfollowing stretch injury were observed by light microscopy following hematoxylin-eosin staining.HSP70 and Tau protein expression levels were observed in retinal ganglial cells from each groupusing im munohistochemistry.RESULTS: (1) Compared with the control group, morphological axonal and retinal ganglial cellchanges, as well as a decreased number of retinal ganglial cells, were identified in the stretch-onlygroup (P< 0.01). Pathological damage in optical nerve and retinal ganglial cells were not remarkablein the heat-stress pretreatment plus stretch group, with no statistical difference in the number ofretinal ganglial cells compared with the control group (P > 0.05). (2) Compared with the control groupsignificantly increased HSP70 expression in retinal ganglial cells occurred in the stretch-only,heat-stress treatment, and heat-stress pretreatment plus stretch groups (P < 0.05 or P < 0.01). Thepeak of HSP70 expression was earlier in the heat-stress pretreatment plus stretch group comparedwith the stretch-only and heat-stress treatment groups, and was expressed over a longer period oftime compared with the heat-stress treatment group. Compared with the control group, Tauexpression in the retinal ganglial cells rapidly increased 4-16 hours following stretch injury in thestretch-only group (P < 0.05 or P < 0.01), and obviously decreased in the heat-stress pretreatmentplus stretch group (P < 0.05 or P < 0.01).CONCLUSION: Tau expression increased following stretch injury, with an earlier expression peakthan HSP70, which indicated that stretch injury-induced HSP70 expression was not strong or quickenough to sufficiently protect the nerve. A much more enhanced HSP70 expression, with an earlierpeak and longer expression period, was observed in rats subjected to stretch injury following heatstress, which demonstrated that HSP70 exhibited neuroprotective functions by reducing abnormalaggregation of Tau. | Zhaohui He Xiaochuan Sun Feng Li Yong Jiang Haitao Wu Luping Zheng | 2009 | Neural Regeneration Research2009，4，12： | 1 |
| 14 | The Stepwise Pricing Mechanism Research of Residents' Living Power 显示文摘 | Li Renfang Sun Luping GuoSidaia | 2011 | Energy Procedia2011，5，： | 1 |
| 15 | Development of up-converting phosphor technology-based lateral-flow assay for rapidly quantitative detection of hepatitis B surface antibody显示文摘 | LI Luping ZHOU Lei YU Yang | 2009 | Diag Microbiol Infec Dis2009，63，2： | 1 |
| 16 | High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization显示文摘 | Changling Li Hailin Yang Xiaole Xia Yuji Li Luping Chen Meng Zhang Ling Zhang Wu Wang | 2013 | Bioresource Technology2013，，： | 1 |
| 17 | Annual Variation of Water Quality in Aquaculture Ponds for Apostichopus japonicus显示文摘By measuring water temperature,salinity,pH,dissolved oxygen,nitrite and ammonia nitrogen,the annual variation regularity of water quality in the aquaculture ponds for sea cucumbers Apostichopus japonicus in Dalian were studied.Results showed that the physicochemical indicators kept changing in the year,and the various ranges of water temperature,salinity,pH,dissolved oxygen,nitrite,and ammonia nitrogen were 6.38-27.27℃,29.20‰-33.78‰,7.86-8.38,5.19-13.36 mg/L,0.0037-0.0090 mg/L and 0.0171-0.0908 mg/L,respectively.Analysis indicated that there was an extremely significant negative correlation between water temperature and dissolved oxygen(P<0.01),an extremely significant positive correlation between water temperature and ammonia nitrogen(P<0.01),a significant negative correlation between salinity and nitrite(P<0.05),a significant negative correlation between dissolved oxygen and nitrite(P<0.05),and an extremely significant negative correlation between dissolved oxygen and ammonia nitrogen(P<0.01)in the aquaculture ponds for sea cucumber in Dalian.Research showed that the water quality of aquaculture ponds kept fluctuating all the time during the tested period,there were complicated and close relationships among physicochemical indicators,and a slight variation of external factors would bring consecutive reactions to different indicators in the water quality of aquaculture ponds.A reference for the production and management of sea cucumbers could be provided from the results. | Yaoming LUO Yuan CHENG Duohui LI Zhiying GAO Luping WANG Jiangyi WU Dawei JIANG | 2019 | Asian Agricultural Research2019，11，11： | 1 |
| 18 | Phase transformation and morphological evolution of electrospun zirconia nanofibers during thermal annealing显示文摘 | Li Luping Zhang Peigen Liang Jiandong | 2010 | Ceram Int2010，36，2： | 1 |
| 19 | Fruit stem blight on kiwifruit (Actinidia chinensis) in China显示文摘 | Cheng Li Junxi Jiang Luping Liu Chaoyu Cui Ting Huang Dengquan Liu | 2013 | Canadian Journal of Plant Pathology2013，，3： | 1 |
| 20 | Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence显示文摘 | Santosh Tumkur Anthony Vu Luping Li Pottumarthi V. Prasad | 2006 | Investigative Radiology2006，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员