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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Metallogenic Epoch of Nonferrous Metallic and Silver Deposits in the Jiaodong Peninsula, China and its Geological Significance显示文摘As China's most important gold-producing district,the Jiaodong Peninsula also contains copper,lead-zinc,molybdenum(tungsten),and other nonferrous metal ore deposits,but the space-time and genetic relationships with gold deposits remain uncertain.To investigate the temporal relationship between these nonferrous metal and gold ore deposits,We collected the samples from a number of nonferrous metallic and silver deposits and metallogenetic rock bodies in the eastern Jiaodong Peninsula for isotopic dating.The results show that the Re-Os isotopic model ages of the Lengjia molybdenum deposit in Rongcheng range from 114.5± 1.8 Ma to 112.6± 1.5 Ma,with an average age of 113.6± 1.6Ma;the LA-ICP-MS ^(206)Pb/^(238)U ages of 33 zircons in the sericitization porphyritic monzogranite that hosts the Tongjiazhuang silver deposit in Rongcheng range between 122 Ma and 109 Ma,with a weighted mean age of 116.04± 0.95 Ma;the LA-ICP-MS ^(206)Pb/^(238)U ages of 31 zircons in the copper metallogenic pyroxene monzodiorite that hosts the Kuangbei copper deposit in Rongcheng range from126 Ma to 106 Ma,with a weighted mean age of 116.6± 1.7 Ma;and the LA-ICP-MS ^(206)Pb/^(238)U ages of19 zircons in the pyroxene monzodiorite surrounding the Dadengge gold and multimetal deposit in Weihai range from 113 Ma to 110 Ma,with a weighted mean age of 111.7± 0.6 Ma.All these results indicate that the metallogenic ages of the silver and nonferrous metallic deposits in the Jiaodong Peninsula are in a limited range from 118 Ma to 111 Ma.Previous studies have demonstrated that the isotopic ages of gold deposits in the Jiaodong Peninsula range from 123 Ma to 110 Ma,while Weideshanian magmatism occurred between 126 Ma to 108 Ma.Both these ranges are grossly consistent with the metallogenic ages of silver and nonferrous metallic deposits in this study,suggesting that the large-scale mineralization occurred in the Early Cretaceous when magmatic activities were strong.This epoch may be linked to the lithosphere thinning and the thermo-upwelling extension in eastern China at that time.In addition,field investigation also shows that gold and nonferrous metallic deposits are distributed nearby the Weideshanian granite,with the nonferrous metallic deposits lying within or surrounding the granite pluton and the gold deposits outside the granite pluton.We propose the following mineralization scenario:In the Early Cretaceous,an intensive lithospheric extension induced partial melting and degassing of the metasomatized lithospheric mantle,which resulted in the formation of mantle-derived fluids enriched in metal elements.During the rapid process of magma ascent and intrusion,crust-derived fluids were activated by the magmatic thermal dome and served to further extract ore-forming materials from the crust.These fluids may have mixed with the mantle-derived fluid to form a crust-mantle mixing-type ore-forming fluid.The high-temperature conditions in the center or in contact with the granitic magmatic thermal dome would have been favorable for the formation of porphyry-type,skarn-type,and hydrothermal-vein-type ores,thus forming a series of Mo(W),Cu,and Pb-Zn deposits in the mid-eastern Jiaodong Peninsula.In contrast,the medium-to low-temperature conditions in the periphery of the magmatic thermal dome would have favored the deposition of gold(silver) ores under the appropriate physiochemical and structural conditions.The metallogenic epoch of the molybdenum,copper,and silver deposits,and their spatio-temporal and genetic relations to the gold deposits,as demonstrated in this study,not only provide important insights to the study of regional metallogeny,our understanding of the metallogenesis of the Jiaodong type gold deposit,and the geodynamic background of the large-scale mineralization in the Jiaodong Peninsula,but also have practical value in guiding the mineral exploration. | SONG Mingchun WANG Shanshan YANG Lixin LI Jie LI Shiyong DING Zhengjiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 12 |
| 3 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 4 | A load simulation method of piezoelectric actuator in FEM for smart structures显示文摘More and more piezoelectric materials and structures have been used for structure control in aviation and aerospace industry. More efficient and convenient computation method for large complex structure with piezoelectric actuation devices is required. A load simulation method of piezoelectric actuation is presented in this paper. By this method, the freedom degree of finite element simulation is significantly reduced, the difficulty in defining in-plane voltage for multi-layers piezoelectric composite is overcome and the transfer computation between material main direction and the element main direction is simplified. The concept of simulation load is comprehensible and suitable for engineers of structure strength in shape and vibration control, thereby is valuable for promoting the application of piezoelectric material and structures in practical aviation and aerospace fields. | LI Min CHEN WeiMin WANG MingChun JIA LiJie | 2009 | Science China(Technological Sciences)2009，52，9： | 7 |
| 5 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 6 | Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8^+ T Cells Ex Vivo显示文摘Artificial antigen-presenting cells are expected to stimulate the expansion and acquisition of optimal therapeutic features of T cells before infusion. Here CD32 that binds to a crystallizable fragment of IgG monoclonal antibody was genetically expressed on human K562 leukemia cells to provide a ligand for T-cell receptor. CD86 and 4-1BBL,which are ligands of co-stimulating receptors of CD28 and 4-1BB,respectively,were also expressed on K562 cells. Then we accomplished the artificial antigen-presenting cells by coupling K32/CD86/4-1BBL cell with OKT3 monoclonal antibody against CD3,named K32/CD86/4-1BBL/OKT3 cells. These artificial modified cells had the abilities of inducing CD8+ T cell activation,promoting CD8+ T cell proliferation,division,and long-term growth,inhibiting CD8+ T cell apoptosis,and enhancing CD8+ T cell secretion of IFN-γ and perforin. Furthermore,antigen-specific cytotoxic T lymphocytes could be retained in the culture stimulated with K32/CD86/4-1BBL/OKT3 cells at least within 28 days. This approach was robust,simple,reproducible and economical for expansion and activation of CD8+ T cells and may have important therapeutic implications for adoptive immunotherapy. | Weijuan Gong Mingchun Ji Zhengfeng Cao Liheng Wang Yayun Qian Maozhi Hu Li Qian Xingyuan Pan | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 7 | Two Types of Granites in the Western Yangtze Block and Their Implications for Regional Tectonic Evolution: Constraints from Geochemistry and Isotopic Data显示文摘In the western Yangtze Block, widespread Mesoproterozoic to Neoproterozoic rocks are the key to understanding the Precambrian tectonic-magmatic evolution of the region. However, their petrogenesis and tectonic setting are still controversial. In this paper, zircon U-Pb ages, Sm-Nd isotopic and whole-rock geochemical data are reported from selected fresh samples in the southern Dechang county, southwestern China, in order to constrain their emplacement age and magma source, as well as their petrogenesis and tectonic setting. They are mainly composed of biotite monzogranite, monzonitic granite, biotite granodiorites, and quartz diorite. Two ages of 1055 ± 43 Ma and 837.6 ± 3.8 Ma were obtained through zircon U-Pb dating by LA-ICP-MS and LA-MC-ICP-MS, respectively. According to their major element compositions, the Grenville-age granites are peraluminous calc-alkaline series calcic S-type granite. In contrast, the mid-Neoproterozoic granites are metaluminous calc-alkaline series alkalic I-type granite. Furthermore, the S-type granites are enriched in LREEs relative to HREEs with(La/Yb)_N ratios of 3.85–18.56 and underwent major fractionation with strongly negative Eu anomalies(Eu/Eu~* = 0.38–0.66). In the MORB-normalized trace element variation diagram, all the samples are enriched in Ce and large ion lithophile elements such as Rb, Th, and K, and depleted in high field strength elements such as Nb, and Ti, with negative Sr and Ti anomalies. The I-type granites are enriched in LREEs with slight negative Eu anomalies(Eu/Eu~* = 0.83–0.93). They are characterized by the enrichment of highly incompatible elements(such as K, Rb, Ba, Th) and LREEs, relative to MORB. Neodymium isotopic data show that the S-type granites display ^(143)Nd/(^(144) Nd) values of 0.51241–0.51256, and have ε_(Nd)(t = 1055 Ma) values of(-3.29) to(-3.81). Calculated t_(DM) ages yield values from 1.87 to 1.91 Ga with the t_(DM).2 stg ages of 1.86 to 1.9 Ga. The I-type granites have ^(143)Nd/(^(144) Nd) ratios between 0.51192 and 0.51195, corresponding to initial ε_(Nd)(t = 837 Ma) values of 1.22 to 5.63. Calculated t_(DM) ages yield values from 1.0 to 1.38 Ga and the t_(DM).2 stg ages yield values from 0.99 to 1.06 Ga. The S-type granites are distinguished as syn-collision granite, whereas the I-type granites were formed as arc magmas according to the Rb-(Yb+Ta) and R_1-R_2 tectonic discrimination diagrams. To conclude, there are two types of spatially associated granite, the Mesoproterozoic S-type granite which were derived from remelting of upper crustal mudstone and/or clastics and resulted from the convergence of two continental plates, and the mid-Neoproterozoic I-type granite which formed in continental arc and resulted from mantle-derived magma mixed crust material, in the western Yangtze Block. Furthermore, we suggest that collision between the Yangtze and Cathaysia blocks occurred at about 1055 Ma, and caused the Stype granite. The I-type granite related to the subduction of oceanic lithosphere eastward underneath the Yangtze Block in the mid-Neoproterozoic. | MABI Awei YANG Zhengxi ZHANG Mingchun WEN Dengkui LI Yanlong LIU Xuyang | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 8 | Immobilized MHC class I chain-related protein A synergizes with IL-15 and soluble 4-1BB ligand to expand NK cells with high cytotoxicity ex vivo显示文摘Major histocompatibility complex(MHC)class I chain-related protein A(MICA),which is a ligand for human NKG2D,is expressed by a variety of epithelial tumor cells and promotes the activation of natural killer(NK),CD81 and cd-T cells.Although ectopic expression of MICA on tumor cells elicits anti-tumor responses,soluble MICA downregulates the activities of lymphocytes.In this study,we showed that recombinant,immobilized MICA(iMICA)molecules coated on plastic wells weakly promote peripheral NK cell activation,secretion of interferon(IFN)-c and degranulation without inducing apoptosis.In addition,iMICA synergized with IL-15 and soluble 4-1BB ligand(s4-1BBL)to expand NK cells 25-to 42-fold in a 13-day culture,whereas NK cells stimulated only with IL-15 and s4-1BBL expanded 10-to 16-fold.In contrast toNKcells expanded by IL-15 and s4-1BBL stimulation,NKcells expanded long term in the presence of iMICA exhibited increased cytotoxicity against leukemia cells.These results suggest that large numbers ofNKcells with high cytotoxicity can be generated by stimulation with IL-15 and s4-1BBL in the presence of iMICA and that these cells can be used for adoptive cancer immunotherapy. | Weijuan Gong Weiming Xiao Li Qian Chunxiang Gong Maozhi Hu Xianyuan Pan Mingchun Ji | 2010 | Cellular & Molecular Immunology2010，7，6： | 2 |
| 9 | Newly Discovered Fluvial-Lacustrine Sediments in the Western Yangtze Block and their Geological Significance for the Emeishan Large Igneous Province显示文摘Objective The Emeishan large igneous province(ELIP)in SW China is the only one large igneous province in China recognized by international geologists.Previous studies of ELIP over past two decades indicate that the ELIP age,duration,scale and generation mechanism are still controversial.Among those scientific topics。 | MABI Awei ZHANG Mingchun YANG Zhengxi LI Yanlong WEN Dengkui LIU Xuyang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 10 | Vegetation distribution pattern in the dam areas along middle-low reach of Lancang-Mekong River in Yunnan Province, China显示文摘Lancang 湄公河河盆在世界上是有富有的生物多样性和高生态的价值的 ecoregions 之一。盆被人的活动强烈影响了,特别地由水坝建设。这研究被进行在中国的云南省沿着 Lancang 湄公河河的中间低的活动范围在水坝区域调查植被分发模式,在八个串联水坝被计划了或被构造的地方。识别植被作文和结构,我们沿着从 2004 ~ 2010 的一年垂直地穿到河隧道的双方的横断取样了 126 空铅。我们发现森林,灌木和草社区广泛地沿着河边被散布。在 Lancang 湄公河河的低活动范围分水岭,统治植被是被人的活动严重地扰乱的草和灌木。在 Lancang 湄公河河的中间的活动范围,干燥热的山谷植被在低山谷被发现。在高高度,松森林和半常绿树的季节的森林被发现。由于水坝建设和操作,河边的植被的结构和作文强烈被改变。一些工厂由于他们的产地的改变衰退了或消失。保护或恢复干预着急地被需要减轻沿着 Lancang 湄公河河的中间、低的活动范围与水坝工程联系的植被损坏的风险[出版摘要] | Jinpeng LI Shikui DONG Mingchun PENG Xiaoyan LI Shiliang LIU | 2012 | Frontiers of Earth Science2012，6，3： | 2 |
| 11 | Influence of anisotropic piezoelectric actuators on wing aerodynamic forces显示文摘Changing the shape of an airfoil to enhance overall aircraft performance has always been a goal of aircraft designers. Using smart material to reshape the wing can improve aerodynamic performance. The influence of anisotropic effects of piezoelectric actuators on the aerodynamic characteristics of a simplified HALE wing model was investigated. Test verification was conducted. | GUAN De LI Min LI Wei WANG MingChun | 2008 | Science China(Technological Sciences)2008，51，5： | 1 |
| 12 | Effects of Injection Angles and Aperture Ratios on Film Cooling Performance of Sister Holes显示文摘In this paper,to analyze the influences of the injection angles and aperture ratios (AR) of the primary hole and the side hole on the film cooling performance of a flat plate model,pressure sensitive paint (PSP) technology was used to study the forward and backward jet of a single hole and four sister holes,and a numerical simulation was supplemented to explore the flow structure of the sister holes.The sister holes had a better film cooling performance than the cylindrical hole at all blowing ratios (BR).The backward jet of the primary hole or the side hole could increase the spanwise film coverage of the sister hole.In this study,with the primary hole featuring a backward jet and the side hole featuring a forward jet,the film cooling performance was the best,11.9 times higher than the areal mean film cooling efficiency of the cylindrical hole when AR=1 and BR=1.5.At a low blowing ratio,the counter-rotating vortex pair (CRVP) of the side hole could suppress the strength of the CRVP of the primary hole.At a high blowing ratio,when the primary hole featured a backward jet and the side hole featured a forward jet,the CRVP of the side hole had the optimal performance for suppressing the CRVP of the primary hole. | LI Mingchun HE Yeguang LI Rundong YANG Tianhua | 2021 | Journal of Thermal Science2021，30，2： | 1 |
| 13 | Synthesis, characteristic and antibacterial activity of N,N,N-trimethyl chitosan and its carboxymethyl derivatives显示文摘 | Xu Tao Xin Meihua Li Mingchun | 2010 | Carbohydrate Polymers2010，81，： | 1 |
| 14 | Role of ethylene response factors(ERFs)in fruit ripening显示文摘The ethylene response factors(ERFs)belong to the APETALA2/ethylene response factor(AP2/ERF)superfamily and act downstream of the ethylene signalling pathway to regulate the expression of ethylene responsive genes.In different species,ERFs have been reported to be involved in plant development,flower abscission,fruit ripening,and defense responses.In this review,based on the new progress made by recent studies,we summarize the specific role and mode of action of ERFs in regulating different aspects of ripening in both climacteric and non-climacteric fruits,and provide new insights into the role of ethylene in non-climacteric fruit ripening. | Jin Gao Yaoxin Zhang Zhengguo Li Mingchun Liu | 2020 | Food Quality and Safety2020，4，1： | 1 |
| 15 | Synthesis, characterization, and antibacterial activity of N, O-quaternary ammonium chitosan显示文摘 | Xu Tao Xin Meihua Li Mingchun | 2011 | Carbohydrate Research2011，346，： | 1 |
| 16 | Relationship between N,N-dialkyl chitosan monolayer and corresponding vesicle显示文摘 | Li Mingchun Su Sheng Xin Meihua | 2007 | Journal of Colloid and Interface Science2007，311，： | 1 |
| 17 | Synthesis,characterization,and antibacterial activity of N,O-quaternary ammonium chitosan显示文摘 | Xu Tao Xin Meihua Li Mingchun | 2011 | Carbohydrate Research2011，346，： | 1 |
| 18 | Experimental study of an actively managed thermal loading method in turbine disk显示文摘 | DING Shuiting LI Guo DENG Mingchun | 2014 | Journal of Thermophysics and Heat Transfer2014，28，1： | 1 |
| 19 | Synthesis, characterization, and antibacterial activity of N,O-quaternary ammonium chitosan显示文摘 | Xu Tao Xin Meihua Li Mingchun | 2011 | Carbohydrate Research2011，346，： | 1 |
| 20 | Synthesis, characteristic and antibacterial activity of N,N,N-trimethyl chitosan and its carboxymethyl derivatives显示文摘 | Xu Tao Xin Meihua Li Mingchun | 2010 | Carbohydrate Polymers2010，81，： | 1 |
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