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| 1 | Seasonal and spatial distributions of euphotic zone and longterm variations in water transparency in a clear oligotrophic Lake Fuxian, China显示文摘To assess the seasonal and spatial variations and long-term trends in water optical properties in Lake Fuxian, investigations based on field work in four seasons and a long-term analysis of data from 1980 to 2014 were conducted. The results show that there was no significant variation in the euphotic depth(Z_(eu)) across the four seasons, and no significant correlations between Z_(eu) and potential influencing factors in seasons other than summer, suggesting that the water itself may be a major factor regulating the Z_(eu)in general. Nevertheless, significant differences in Z_(eu) between the north region(NR) and the south region(SR) were observed in all seasonal tests except spring. This finding relates to a higher abundance of chromophoric dissolved organic matter(CDOM) in the NR due to runoff, especially in the rainy seasons(summer and autumn).CDOM and its terrigenous component had an important impact on Z_(eu)in summer, with the highest precipitation, and impacts from suspended solids and non-algal particles were also found in the NR in summer. The Secchi disk depth in the lake decreased clearly over the years,with significantly negative correlations with the increasing permanganate index and air temperature, implying that organic contaminants(CDOM and/or phytoplankton) are important regulators of water transparency. We estimate that the combined effects of climate warming and changes in land use and land cover are also indirect regulating factors. These findings should be considered in the protection of Lake Fuxian, owing to the importance of light penetration in aquatic ecosystems. | Qichao Zhou Yunlin Zhang Kaidi Li Licheng Huang Fengle Yang Yuanyang Zhou Junjun Chang | 2018 | Journal of Environmental Sciences2018，30，10： | 18 |
| 2 | Superplastic Solid-Phase Welding of 40 Cr-T10A Steel显示文摘The microstructure of 40Cr and T10A steel sample and its surface to be welded is ultra-fined through salt-bath cyclic quenching and high frequency hardening, then the surface is cleaned. Under non-vacuum and no shielded gas, the welding parameter of isothermal superplastic solidphase welding and the effect of surface microstructure prior to pressure welding on the quality of joint are studied. At the temperature of 730~750°C and at initial strain rate of (2~4) × 10-4 s-1,the strength of the joint is up to or close to that of 40Cr base metal in 3~5 min pressure welding. | Keke ZHANG Yunlin YANG Changsheng WANG Hongke LI Jin XUE | 2001 | Journal of Materials Science & Technology2001，17，1： | 10 |
| 3 | Angiotensin Ⅱ upregulates fibroblastmyofibroblast transition through Cx43- dependent CaMKⅡ and TGF-β1 signaling in neonatal rat cardiac fibroblasts显示文摘 | Li Cao Yunlin Chen Li Lu Yihao Liu Yaowen Wang Jinqi Fan Yuehui Yin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 6 |
| 4 | Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease显示文摘Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.Methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications. | Zhiqi Song Yajin Qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，3： | 6 |
| 5 | Topographic species-habitat associations of tree species in a heterogeneous tropical karst seasonal rain forest, China显示文摘Aims Tropical and subtropical karst forests of south China are under increas-ing pressure from over-exploitation causing widespread habitat degra-dation and biodiversity loss.Previous research has demonstrated that topography,as a proxy for resource availability,plays an important role in shaping tree species distributions in tropical forests.However,the association between growth stages and habitats types has not been considered in this analysis.Our aim was to examine the differences among different habitat types to determine whether tree species show similar species-habitat associations at young and mature life stages.Methods We used multivariate regression tree analysis to examined species-habitat associations among eight topographically defined habitats.The results were tested with a torus-translation test and canonical correspondence analysis(CCA)for 74 species in a 15 ha karst tropi-cal seasonal rain forest at the Nonggang National Natural Reserve in south China.We considered two life stages(young and mature)of trees species that showed a positive association with topography.Important Findings We found marked differences in community characteristics and number of associations among the eight habitats.Of the 74 species subjected to torus-translation test,63 had significant positive and 70 had significant negative associations with one or more of the eight habitats.Positive associations were more frequent in higher elevation habitats and negative associations were more frequent in lower eleva-tion habitats.This suggests that edaphic and hydrological variation related to topography play important roles in habitat partitioning in heterogeneous karst forests.For the 63 tree species with significant positive associations to at least one habitat,40 of them had the same positive association at young and mature life stages.The CCA revealed that the six topographic variables considered had consistent relation-ships with species distribution among all individuals and their two life stages.This indicates that most of the karst forest tree species show consistent associations with a single habitat throughout their life.We conclude that niche differentiation plays an important role in main-taining the diversity of this heterogeneous species-rich karst forest. | Yili Guo Bin Wang Azim U.Mallik Fuzhao Huang Wusheng Xiang Tao Ding Shujun Wen Shuhua Lu Dongxing Li Yunlin He Xiankun Li | 2017 | Journal of Plant Ecology2017，10，3： | 6 |
| 6 | Clinical characteristics and changes in living quality of patients with radiation encephalopathy induced by radiation therapy for treating nasopharyngeal carcinoma显示文摘BACKGROUND: Radiation encephalopathy (RE) caused by radiation therapy of nasopharyngeal carcinoma severely influences patients' quality of life (QOL). The factors, which influence such patients' QOL, have not been confirmed. OBJECTIVE: To observe the clinical and imageological characteristics of patients with radiation therapy of nasopharyngeal carcinoma-induced RE and the changes in QOL, and analyze QOL influencing factors. DESIGN: Retrospective case analysis. SETTING: Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS: Eighty-nine inpatients or outpatients with RE induced by radiation therapy of nasopharyngeal carcinoma admitted to Sun Yat-sen University Cancer Center and Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University from March 1994 to August 2004 were involved in this experiment. They all met the diagnosis criteria of RE from MERRITT'S neurology (10th edition). Thirty-three involved patients were randomly chosen as RE group. Another 34 concurrent inpatients or outpatients with nasopharyngeal carcinoma who received radiation therapy but without RE were chosen as control group. Informed consents of detected items were obtained from all the involved subjects. METHODS: ① Patients were evaluated when they were followed up. The World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF) was used for on-the-spot evaluation. High points of WHOQOL-BREF indicated better QOL. The Late Effects on Normal Tissues - Subjective, Objective, Management and Analytic (LENT-SOMA) scale for evaluating radiation injury was used to evaluate headache and neurologic disorder of patients with RE induced by radiation therapy of nasopharyngeal carcinoma. The evaluation was graded into 5 degrees. High degrees indicted severer clinical symptoms. ② Disease latency (i.e. time interval from symptoms and body signs appearing or radiation therapy ending to onset), initial symptoms, common symptoms, imageological characteristics, QOL and other related factors of patients were recorded. ③ Statistical management was carried out with SPSS 10.0 software. MAIN OUTCOME MEASURES: QOL and clinical characteristics of patients with RE induced by radiation therapy of nasopharyngeal carcinoma as well as QOL influencing factors. RESULTS: All the involved subjects participated in the final analysis. ① Disease latency of patients with RE ranged from 0 to 24 years, and 95% confidence interval was 0 to 15 years. There were significant differences in amount of invaded cases between 6 months after one radiation therapy and 6 months after two or more radiation therapies (χ2=36.76,P < 0.01). ② The common initial symptom of patients with RE was glossopharyngeal paralysis (33 cases, 37%). ③ The first 3 common symptoms of patients with RE were glossopharyngeal paralysis (52 cases, 58%), limb inertia and sensory disorder (25 cases, 28%) and headache (25 cases, 28%).④Imageology of patients with RE was characterized by long T1 and T2 signal shadow on magnetic resonance. ⑤Total scores of health, of daily life and of social relationship, measured with WHOQOL-BREF, of patients in RE group were significantly lower than those in the control group, respectively [(2.06±0.86)points vs. (2.59±0.66)points; (2.45±0.75)points vs. (2.91±0.75)points; (51.67±15.24) points vs. (59.22±13.03)points, P < 0.05]. Patients undergoing two or more radiation therapies were inferior to those undergoing one radiation therapy in total scores of health, and of daily life, scores of physiology, and of psychology (P < 0.05). ⑥Glossopharyngeal paralysis was negatively correlated with scores of psychology, total scores of daily life and of health in WHOQOL-BREF (P < 0.05); Head was negatively correlated with scores of psychology in WHOQOL-BREF (P < 0.05); Neurologic deficit wasnegatively correlated with scores of psychology, and total scores of health in WHOQOL-BREF (P < 0.05). CONCLUSION: ①The latency of RE of patients undergoing two or more radiation therapies is remarkably shortened, and QOL is decreased, but there is no difference in QOL between two genders. ② Brain edema is common in imageology of RE after radiation therapy. The first 3 ones of initial symptoms and common symptoms both are glossopharyngeal paralysis, neurologic deficit and headache, which greatly negatively influence QOL of patients. | Yamei Tang Yi Li Fusheng Zhang Yunlin Liu Haihong Zhou Jianhong Ye Yigang Xing | 2007 | Neural Regeneration Research2007，2，2： | 5 |
| 7 | Enhanced lakebed sediment erosion in Dongting Lake induced by the operation of the Three Gorges Reservoir显示文摘从 1951 ~ 2011 在东廷·莱克分水岭基于地调查水文学系列, lakebed 沉积 siltation/erosion (证券交易所) 的变化在三座峡水库(TGR ) 的操作以后的东廷·莱克的政体被分析。显著地积极的关联从 Zhicheng 和三个插头在流动率之间被发现(r 2=0.859, p < 0.0001 ) ,并且在流动之间,率和沉积交货在三个插头评价(r 2=0.895, p < 0.0001 ) 。这显示在三个插头的流动率和沉积交货率被流动率大部分从在上游的长江决定。在东廷·莱克盆的沉积免职数量从 +4796.4 落下 ?? | ZHOU Yongqiang LI Jingbao ZHANG Yunlin ZHANG Xinping LI Xichun | 2015 | Journal of Geographical Sciences2015，25，8： | 5 |
| 8 | Simultaneous Prediction of Wheat Yield and Grain Protein Content Using Multitask Deep Learning from Time-Series Proximal Sensing显示文摘Wheat yield and grain protein content(GPC)are two main optimization targets for breeding and cultivation.Remote sensing provides nondestructive and early predictions of yield and GPC,respectively.However,whether it is possible to simultaneously predict yield and GPC in one model and the accuracy and influencing factors are still unclear.In this study,we made a systematic comparison of different deep learning models in terms of data fusion,time-series feature extraction,and multitask learning.The results showed that time-series data fusion significantly improved yield and GPC prediction accuracy with R 2 values of 0.817 and 0.809. | Zhuangzhuang Sun Qing Li Shichao Jin Yunlin Song Shan Xu Xiao Wang Jian Cai Qin Zhou Yan Ge Ruinan Zhang Jingrong Zang Dong Jiang | 2022 | Plant Phenomics2022，4，1： | 4 |
| 9 | Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers显示文摘Alternative splicing is a tightly regulated process that contributes to cancer development.CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several cancers.However,whether deregulated expression of CRNDE is common and which isoforms are mainly involved in cancers remain unclear.In this study,we report that CRNDE is aberrantly expressed in the majority of solid and hematopoietic malignancies.The investigation of CRNDE expression in normal samples revealed that CRNDE was expressed in a tissue- and cell-specific manner.Further comparison of CRNDE expression in 2938 patient samples from 15 solid and hematopoietic tumors showed that CRNDE was significantly overexpressed in 11 malignancies,including 3 reported and 8 unreported,and also implicated that the overexpressed isoforms differed in various cancer types.Furthermore,anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and primary samples,and even had different impacts on the expression of CRNDE isoforms.Finally,experimental profiles of 12 alternatively spliced isoforms demonstrated that the spliced variant CRNDE-g was the most highly expressed isoform in multiple cancer types.Collectively,our results emphasize the cancer-associated feature of CRNDE and its spliced isoforms,and may provide promising targets for cancer diagnosis and therapy. | Xuefei Ma Wei Zhang Rong Zhang Jingming Li Shufen Li Yunlin Ma Wen Jin Kankan Wang | 2019 | Frontiers of Medicine2019，13，3： | 3 |
| 10 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 11 | Molecular cloning of human heat shock protein 27 and study of its protective effects on oxidative damage in rat cardiomyocte H9c2显示文摘Objective: To clone human cardiac heat shock protein 27(HSP27) gene and to determine the effects of HSP27 on the oxidative stress in rat cardiomyocyte cell line H9c2. Methods: Full length of HSP27 cDNA which got by RT-PCR was constructed into pCDNA3.1+. The recombinant was transfected into rat cardiomyocyte cell line H9c2 and the stable transfection cell line was selected by G418. Then we observe the effects of HSP27 over-expression on LDH release and apoptosis induced H2O2 in H9c2. Results:①pCDNA3.1+/HSP27 provided a sound expression of HSP27 in both 293T and H9c2. ②LDH releasing induced by 0, 100,250,500,1000 μmol/L H2O2 in HSP27 over-expression group and wild type group were 0.396±0.017 vs. 0.390±0.009 (p>0.05), 0.437±0.014 vs. 0.416±0.015 (P<0.05), 0.471±0.018 vs. 0.417±0.009 (P<0.001), 0.505±0.030 vs. 0.657±0.022(P<0.001),0.547±0.027 and 0.661±0.011(P<0.001),respectively. ③Apoptosis induced by 150 μmol/L H2O2 in HSP27 over-expression group and wild type group were (10.693±1.122)% vs. (4.027±1.628)%(P<0.01). Conclusion: We cloned and constructed human cardiac HSP27 gene successfully, and over-expression of human HSP27 could inhibit oxidative damage significantly in H9c2. | Li Liu Xiaojin Zhang Surong Jiang Xiang Gao Guoxain Ding Yunlin Cheng | 2005 | Journal of Nanjing Medical University2005，19，4： | 3 |
| 12 | Ecological Security Evaluation Algorithm for Resource-Exhausted Cities Based on the PSR Model显示文摘Today,resource depletion threatens a number of resource-based cities in China.The ecological security problem caused by the long-term exploitation of natural resources is a key issue to be solved in the development of resource-exhausted cities.Using 23 indicators,this study evaluated the ecological security status and development trends of 21 resource-exhausted cities in China from 2011 to 2017.The results showed that from 2011 to 2015,the overall ecological security of this type of city was low,with over 60%of the cities at an unsafe level.However,ecological security improved rapidly after 2016,and by 2017,all of the cities had reached the critical safety level.The top 10 indicators of ecological security included industrial sulfur dioxide emissions,water supply,agricultural fertilizer application,and forest coverage.These 10 indicators’cumulative contribution to ecological security was 48.3%;among them,reducing industrial sulfur dioxide emissions contributed the most at 5.7%.These findings can help governments better understand the ecological security status of resource-exhausted cities,and it can provide a reference for the allocation of funds and other resources to improve the ecological safety of these cities. | Xiaozhou Li Zhenggang Xu Yuanyuan Fu Qi Jin Yunlin Zhao Neal NXiong | 2021 | Computers, Materials & Continua2021，，10： | 3 |
| 13 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 14 | SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration显示文摘SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals.However,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic mice.Moreover,the permeability of the infected vessel was in creased.Furthermore,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans blue.Interestingly,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected animals.Using an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the BMECs.Consistent with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected BMECs.Besides,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 infection.Overall,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs. | Ling Zhang Li Zhou Linlin Bao Jiangning Liu Hua Zhu Qi Lv Ruixue Liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-Hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu Zhang Xiuping Sun Xuan Yu Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 15 | miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway显示文摘 | Weiguo Cao Weiping Yang Rong Fan Hao Li Jinsong Jiang Mei Geng Yening Jin Yunlin Wu | 2014 | Tumor Biology2014，，2： | 2 |
| 16 | An Integrated Method for Tracking and Monitoring Stomata Dynamics from Microscope Videos显示文摘Patchy stomata are a common and characteristic phenomenon in plants.Understanding and studying the regulation mechanism of patchy stomata are of great significance to further supplement and improve the stomatal theory.Currently,the common methods for stomatal behavior observation are based on static images,which makes it difficult to reflect dynamic changes of stomata.With the rapid development of portable microscopes and computer vision algorithms,it brings new chances for stomatal movement observation.In this study,a stomatal behavior observation system(SBOS)was proposed for real-time observation and automatic analysis of each single stoma in wheat leaf using object tracking and semantic segmentation methods.The SBOS includes two modules:the real-time observation module and the automatic analysis module.The real-time observation module can shoot videos of stomatal dynamic changes.In the automatic analysis module,object tracking locates every single stoma accurately to obtain stomatal pictures arranged in time-series;semantic segmentation can precisely quantify the stomatal opening area(SOA),with a mean pixel accuracy(MPA)of 0.8305 and a mean intersection over union(MIoU)of 0.5590 in the testing set.Moreover,we designed a graphical user interface(GUI)so that researchers could use this automatic analysis module smoothly.To verify the performance of the SBOS,the dynamic changes of stomata were observed and analyzed under chilling.Finally,we analyzed the correlation between gas exchange and SOA under drought stress,and the correlation coefficients between mean SOA and net photosynthetic rate(Pn),intercellular CO2 concentration(Ci),stomatal conductance(Gs),and transpiration rate(Tr)are 0.93,0.96,0.96,and 0.97. | Zhuangzhuang Sun Yunlin Song Qing Li Jian Cai Xiao Wang Qin Zhou Mei Huang Dong Jiang | 2021 | Plant Phenomics2021，3，1： | 2 |
| 17 | An improved ileal conduit surgery for bladder cancer with fewer complications显示文摘Background:Radical cystectomy and urinary diversion remains the standard surgical treatment for patients with muscle-invasive or high-risk or recurrent non-muscle-invasive bladder cancer.Although this approach prolongs patient survival remarkably,there are postoperative complications associated with urinary diversion.This study aimed to assess the efficacy of modified ileal conduit surgery for reducing early and late stoma-and ureteroileal anastomo-sis-related complications,as compared with conventional ileal conduit urinary diversion.Methods:We retrospectively evaluated the clinical data of bladder cancer patients treated with radical cystectomy and ileal conduit urinary diversion at Sun Yat-sen University Cancer Center between January 1,2000 and June 30,2016.Ileal conduit was created by the conventional or a modified technique.The clinicopathologic features of the conventional and the modified ileal conduit groups were compared using the t test and the Chi square test.Multivari-able logistic regression analysis and multivariable Cox regression analysis were performed to determine the odds of developing stoma-and ureteroileal anastomosis-related complications in the two groups.Results:145 and 100 patients underwent the modified and conventional ileal conduit surgery,respectively.The two groups were comparable with regard to clinicopathologic features.The rate of stoma-related complications was significantly lower in the modified ileal conduit group than in the conventional ileal conduit group(0.7%vs.17.0%,P<0.001).No late stoma-related complications were seen in the modified ileal conduit group,but were seen in 13(13.0%)patients in the conventional ileal conduit group.The rate of ureteroileal anastomosis-related complications was significantly lower in the modified ileal conduit group than in the conventional ileal conduit group(4.8%vs.15.0%,P=0.001).In multivariable analyses,the modified ileal conduit group was significantly less likely to develop stoma-(odds ratio[OR]=0.024,95%confidence interval[CI]0.003-0.235;P=0.001)or ureteroileal anastomosis-related complications(OR=0.141,95%CI 0.042-0.476;P=0.002)than the conventional ileal conduit group.Conclusions:Our modified surgical technique for ileal conduit urinary diversion may be effective for reducing early and late complications related to the stoma and the ureteroileal anastomosis.Prospective randomized clinical trials are needed to confirm our results. | Zhiyong Li Zhuowei Liu Kai Yao Zike Qin Hui Han Yonghong Li Pei Dong Yunlin Ye Yanjun Wang Zhiming Wu Zhiling Zhang Fangjian Zhou | 2019 | Cancer Communications2019，39，1： | 2 |
| 18 | A Drinking Water Crisis in Lake Taihu, China: Linkage to Climatic Variability and Lake Management显示文摘 | Boqiang Qin Guangwei Zhu Guang Gao Yunlin Zhang Wei Li Hans W. Paerl Wayne W. Carmichael | 2010 | Environmental Management2010，，1： | 2 |
| 19 | Three-dimensional electrochemical process for wastewater treatment: A general review 显示文摘 | Zhang Chao Jiang Yonghai Li Yunlin | 2013 | Chemical Engineering Journal2013，228，： | 1 |
| 20 | Antibacterial Action of Chitosan and Carboxymethylated Chitosan显示文摘 | Xiaofei Yu Yunlin Guan Dongzhi Yang Zhi Li Kangde Yao | 2001 | Journal of Applied Polymer Science2001，79，7： | 1 |
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