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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 3 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 4 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 5 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 6 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 7 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 8 | Genome sequencing and phylogenetic analysis of Banna virus(genus Seadornavirus,family Reoviridae)isolated from Culicoides显示文摘In an investigation of blood-sucking insects and arboviruses, a virus(YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect(CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA(dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region(1.12 segments) were17,803 bp and 5,925 amino acids in length, respectively. The phylogenetic analysis of VP1 protein(RdRp) revealed that YN12243 belonged to genus Seadornavirus of family Reoviridae, and further analysis indicated that YN12243 belongs to the Banna virus(BAV) genotype A2. Additionally, YN12243 was located in the same evolutionary cluster as BAV strains isolated from different mosquito species, suggesting that the BAV isolated from Culicoides does not have species barriers. These results indicate that Culicoides can also be a vector for BAV. In view of the hematophagous habits of Culicoides on cattle, horses, deer, and other large animals, as well as the possibility of spreading and causing a variety of animal arboviral diseases, it is important to improve infection detection and monitor the BAV in large livestock. | Song Song Yuanyuan Li Shihong Fu Wenwen Lei Xiaofang Guo Yun Feng Xiaoyan Gao Xiaolong Li Zhonghua Yang Ziqian Xu Ying He Huanyu Wang Hongning Zhou Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 8 |
| 9 | Pigsties near dwellings as a potential risk factor for the prevalence of Japanese encephalitis virus in adult in Shanxi,China显示文摘Background:The increasing trend of adult cases of Japanese encephalitis(JE)in China,particularly in northern China,has become an important public health issue.We conducted an epidemiological investigation in the south of Shanxi Province to examine the relationships between mosquitoes,Japanese encephalitis virus(JEV),and adult JE cases.Methods:Mosquito specimens were collected from the courtyards of farmers’households and pig farms in Shanxi Province.Mosquitoes were pooled,homogenized,and centrifuged.Reverse transcription-polymerase chain reaction(RT-PCR)was used to detect mosquito-borne arbovirus genes in homogenates.Specimens positive for these genes were inoculated into the baby hamster kidney cell line(BHK-21)to isolate virus.Minimum infection rate was calculated and phylogenetic analyses were performed.Results:A total of 7943 mosquitoes belonging to six species in four genera were collected;Culex tritaeniorhynchus accounted for 73.08%(5805/7943),C.pipiens pallens for 24.75%(1966/7943),and the remaining 3%(104/7943)consisted of Anopheles sinensis,Aedes vexans,Ae.dorsalis,and Armigeres subalbatus.Sixteen pools were positive for JEV based on RT-PCR using JEV pre-membrane gene nested primers.Phylogenetic analyses showed that all JEVs belonged to genotype I;two pools were positive using Getah Virus(GETV)gene primers.In addition,one JEV strain(SXYC1523)was isolated from C.pipiens pallens specimens.These results indicate that the minimum infection rate of JEV in mosquito specimens collected from the courtyards of farmers’households with pigsties was 7.39/1000;the rate for pig farms was 2.68/1000;and the rate for farmers’courtyards without pigsties was zero.Conclusions:The high-prevalence regions of adult JE investigated in this study are still the natural epidemic focus of JEV.Having pigsties near dwellings is a potential risk factor contributing to the prevalence of adult JE.To prevent the occurrence of local adult JE cases,a recommendation was raised that,besides continuing to implement the Expanded Program on Immunization for children,the government should urge local farmers to cease raising pigs in their own courtyards to reduce the probability of infection with JEV. | Xiaojie Ren Shihong Fu Peifang Dai Huanyu Wang Yuanyuan Li Xiaolong Li Wenwen Lei Xiaoyan Gao Ying He Zhi Lv Jingxia Cheng Guiqin Wang Guodong Liang | 2017 | Infectious Diseases of Poverty2017，6，1： | 6 |
| 10 | Dissipation of polycyclic aromatic hydrocarbons and microbial activity in a field soil planted with perennial ryegrass显示文摘 | Dengqiang FU Ying TENG Yuanyuan SHEN Mingming SUN Chen TU Yongming LUO Zhengao LI Peter CHRISTIE | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 6 |
| 11 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 12 | Regulation Strategy of Transition Metal Oxide-Based Electrocatalysts for Enhanced Oxygen Evolution Reaction显示文摘CONSPECTUS:The deployment of hydrogen as alternative energy carrier is a promising route to reduce the consumption of fossil fuel and achieve the“zero carbon”target.Water electrolysis,powered by renewable energy sources,is regarded as the most environmentally friendly and efficient technology for hydrogen production.Generally,the sluggish oxygen evolution reaction(OER)process at the anode predominantly limits the efficiency of water electrolysis. | Yuanyuan Zhang Qiang Fu Bo Song Ping Xu | 2022 | Accounts of Materials Research2022，3，10： | 3 |
| 13 | Ecological Security Evaluation Algorithm for Resource-Exhausted Cities Based on the PSR Model显示文摘Today,resource depletion threatens a number of resource-based cities in China.The ecological security problem caused by the long-term exploitation of natural resources is a key issue to be solved in the development of resource-exhausted cities.Using 23 indicators,this study evaluated the ecological security status and development trends of 21 resource-exhausted cities in China from 2011 to 2017.The results showed that from 2011 to 2015,the overall ecological security of this type of city was low,with over 60%of the cities at an unsafe level.However,ecological security improved rapidly after 2016,and by 2017,all of the cities had reached the critical safety level.The top 10 indicators of ecological security included industrial sulfur dioxide emissions,water supply,agricultural fertilizer application,and forest coverage.These 10 indicators’cumulative contribution to ecological security was 48.3%;among them,reducing industrial sulfur dioxide emissions contributed the most at 5.7%.These findings can help governments better understand the ecological security status of resource-exhausted cities,and it can provide a reference for the allocation of funds and other resources to improve the ecological safety of these cities. | Xiaozhou Li Zhenggang Xu Yuanyuan Fu Qi Jin Yunlin Zhao Neal NXiong | 2021 | Computers, Materials & Continua2021，，10： | 3 |
| 14 | A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis显示文摘The complex pathogenesis of osteoporosis includes excessive bone resorption,insufficient bone formation and inadequate vascularization,a combination which is difficult to completely address with conventional therapies.Engineered exosomes carrying curative molecules show promise as alternative osteoporosis therapies,but depend on specifically-functionalized vesicles and appropriate engineering strategies.Here,we developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells(MSCs)derived from human induced pluripotent stem cells(iPSCs).The engineered exosomes BT-Exo-siShn3,took advantage of the intrinsic anti-osteoporosis function of these special MSC-derived exosomes and collaborated with the loaded siRNA of the Shn3 gene to enhance the therapeutic effects.Modification of a bone-targeting peptide endowed the BT-Exo-siShn3 an ability to deliver siRNA to osteoblasts specifically.Silencing of the osteoblastic Shn3 gene enhanced osteogenic differentiation,decreased autologous RANKL expression and thereby inhibited osteoclast formation.Furthermore,Shn3 gene silencing increased production of SLIT3 and consequently facilitated vascularization,especially formation of type H vessels.Our study demonstrated that BT-Exo-siShn3 could serve as a promising therapy to kill three birds with one stone and implement comprehensive anti-osteoporosis effects. | Yongzhi Cui Yuanyuan Guo Li Kong Jingyu Shi Ping Liu Rui Li Yongtao Geng Weihang Gao Zhiping Zhang Dehao Fu | 2022 | Bioactive Materials2022，7，4： | 3 |
| 15 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 16 | Seismic anisotropy beneath the Chinese mainland显示文摘We investigated the upper mantle anisotropy beneath China by applying teleseismic shear wave splitting measurements at 119 seismic stations from CDSN and GSN/IRIS networks in China.The splitting observations are characterized by apparent diversity of anisotropy pattern in adjacent tectonic domains,including the Tianshan orogenic belt,Tibetan plateau,the Yangtze craton,the North China craton and northeastern region.In western China(Tianshan orogenic belt and Tibetan plateau),fast polarization directions of split SKS waves coincide strikingly well with the dominating trend of deformational crustal features and delay times range from 0.5 s to 1.6 s.While in eastern China,seismic anisotropy deduced from shear wave splitting reveals a homogeneous NW-SE trending structure,almost perpendicular to the strike of large-scale surface structures.The observed delay times of 1.5 s to more than 2 s favor consistent mantle flow over large mantle thicknesses.Based upon the straightforward relationships between seismic anisotropy and the development of lattice preferred orientation of mineral in upper mantle rocks,we interpret the splitting results in terms of tectonic fabric within the upper mantle.Since the lithosphere is less than 100 km thick beneath eastern China and the observed fast directions are subparallel to the trend of the absolute plate motion(APM) of Eurasian plate,we propose that the asthenosphere may mainly contribute to the anisotropic effects beneath eastern China.However,the upper mantle anisotropy beneath western China may have developed more recently in the subcrustal lithosphere because of rather small delay times and thick lithosphere.We also use the opportunity of the dense geodetic measurements available in China to discuss the coupling between the crust and mantle.In the Eurasia-fixed reference frame,GPS and shear wave splitting both depict a similar trend beneath eastern China,suggesting a lithospheric block 'escaping' toward the east that could orient olivine [001] axis in the upper mantle.There is a strong coupling between the crust and the mantle in eastern China.A different behavior is observed in western China.The GPS vectors trend NS-NE in Tibet and NW in Tianshan,close to the regional compression direction,whereas the fast directions trend EW in Tibet and NE in Tianshan,suggesting a tectonic regime close to a mode of axial shortening,generating the development of EW-trending foliation in Tibet and NE-trending foliation in Tianshan at depth.The crust and mantle deform independently in western China. | Yuanyuan V. Fu Yongshun John Chen Aibing Li | 2010 | Earthquake Science2010，23，6： | 3 |
| 17 | Infl uences of Iodonium Salts on the Properties of a Hybrid Composite Resin Containing Bis S-GMA and Expanding Monomer Modifi ed Epoxy显示文摘In order to reduce shrinkage and improve the mechanical properties of dental composite resins, we designed a hybrid resin formulation containing a novel matrix resin, Bis S-GMA [bisphenol-Sbis(3-methacrylato-2-hydroxypropyl)ether], and epoxy modifi ed by a spiro-orthocarbonate(SOC) expanding monomer. Then, we tested the effects of an iodonium salt, diphenyliodonium hexafl uorphosphate(DPIHFP), on the properties of the hybrid resin with seven different concentrations. The hybrid resin was polymerized by a ternary photo-initiator system. The volumetric shrinkage(VS), degree of conversion(DC) and compressive strength(CS) were assessed using Acu Vol^(TM), FTIR and a universal testing machine, respectively. The VS, DC and CS were improved with increasing DPIHFP concentration, but a high concentration of DPIHFP had a negative infl uence on the mechanical properties of the hybrid resin and offered no added improvement in the VS and DC. The best performance of a composite resin containing Bis S-GMA and SOC-modifi ed epoxy was achieved with 2wt% DPIHFP. The results also indicated that the resin containing Bis S-GMA was superior to that containing Bis-GMA in terms of VS, DC and CS. | 刘文佳 FU Jing WU Xiangnan MA Yuanyuan LIU Xiaoqing LIAO Yunmao 王航 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，6： | 2 |
| 18 | Mantle anisotropy across the southwestern boundary of the Ordos block,North China显示文摘Located at the northeastern margin of the Tibetan plateau,the Ordos block is a stable tectonic unit in North China.With its active boundary fault zones,the Ordos block played an important role in the eastward extrusion mechanism of the Tibetan plateau.Peking University deployed a linear array of 15 portable broadband seismometers across the western Weihe graben during September 2005 to August 2006 and later a 2-D seismic array(Southwest Ordos Array) of 14 portable broadband seismometers during 2007-2008 at its southwestern boundary.Analyses of shear wave splitting of SKS and SKKS phases at these stations show that the fast directions trend ~110° with an average delay time of 0.9 s in the southwestern margin of the Ordos block.The agreement between the lithosphere deformation indicated by GPS data and Quaternary fault slip-rate observations and the mantle flow represented by shear wave splitting implies that accordant deformation patterns from lithosphere to asthenosphere in relation to the eastward extrusion of the Tibetan plateau could extend at least to 200 km depth.Spatial distribution of splitting polarization directions indicates that the mantle flow driven by the Tibetan plateau is blocked by the Ordos block and locally restricted in a narrow channel along the Qinling-Dabie fault zones between the Ordos block and Sichuan basin. | Yongcai Tang Yongshun John Chen Yuanyuan V. Fu Haiyang Wang Shiyong Zhou Eric Sandvol Jieyuan Ning Yongge Feng Mian Liu | 2010 | Earthquake Science2010，23，6： | 2 |
| 19 | Comparative Study of Two Carbon Fiber Cathodes and Theoretical Analysis in Microbial Fuel Cells on Ocean Floor显示文摘Cathode activity plays an important role in the improvement of the microbial fuel cells on ocean floor(BMFCs). A comparison study between Rayon-based(CF-R) and PAN-based carbon fiber(CF-P) cathodes is conducted in the paper. The two carbon fibers were heat treated to improve cell performance(CF-R-H & CF-P-H), and were used to build a new BMFCs structure with a foamy carbon anode. The maximum power density was 112.42 mW m-for CF-R-H, followed by 66.6 mW m-2 for CF-R, 49.7 mW m-2 for CF-P-H and 21.6 mW m-2 for CF-P respectively. The higher specific area and deep groove make CF-R have a better power output than with CF-P. Meanwhile, heat treatment of carbon fiber can improve cell power, nearly two-fold higher than heat treatment of plain fiber. This improvement may be due to the quinones group formation to accelerate the reduction of oxygen and electron transfer on the fiber surface in the three phase boundary after heat treatment. Compared to PAN-based carbon fiber, Rayon-based carbon fiber would be preferentially selected as cathode in novel BMFCs design due to its high surface area, low cost and higher power. The comparison research is significant for cathode material selection and cell design. | FU Yubin LIU Yuanyuan XU Qian LU Zhikai ZHANG Yelong | 2014 | Journal of Ocean University of China2014，13，2： | 2 |
| 20 | Ectopic expression of antifreeze protein gene from Ammopiptanthus nanus confers chilling tolerance in maize显示文摘Improved chilling tolerance is important for maize production. Previous efforts in transgenics and marker-assisted breeding have not achieved practical results. In this study, the antifreeze protein(AnAFP) from the super-xerophyte Ammopiptanthus nanus was aligned to KnS-type dehydrins.Phosphorylation in vitro and subcellular localization showed that AnAFP was phosphorylated by maize casein kinase II and translocated from nucleus to cytoplasm under chilling stress. AnAFP also increased lactate dehydrogenase activity. A parent line of commercial maize hybrids was transformed with the AnAFP gene. Based on thermal asymmetric interlaced PCR, one hemizygous and two homozygous integration sites were identified in one T_(1) line. Ectopic expression of AnAFP in transgenic lines was confirmed by quantitative real-time PCR, RNA-seq, and Western blotting. After chilling treatment, the transgenic lines showed significantly improved phenotype, higher kernel production, survival rate and biomass, and lower relative electrolyte leakage and superoxide dismutation than the untransformed line. Thus, ectopic expression of AnAFP gene improved chilling tolerance in the transgenic lines, which could be used to apply for further safety assessment for commercial breeding. | Yuanyuan Zhang Yang Cao Hongying Zheng Wenqi Feng Jingtao Qu Fengling Fu Wanchen Li Haoqiang Yu | 2021 | The Crop Journal2021，9，4： | 2 |
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