|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Scutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25-35)显示文摘Scutellaria baicalensis stem-leaf total flavonoid might attenuate learning/memory impairment and neuronal loss in rats induced by amyloid beta-peptide. This study aimed to explore the effects of Scutellaria baicalensis stem-leaf total flavonoid on amyloid beta-peptide-induced neuronal apoptosis and the expression of apoptosis-related proteins in the rat hippocampus. Male Wistar rats were given intragastric administration of Scutellaria baicalensis stem-leaf total flavonoid, 50 or 100 mg/kg, once per day. On day 8 after administration, 10 μg amyloid beta-peptide (25-35) was injected into the bilateral hippocampus of rats to induce neuronal apoptosis. On day 20, hippocampal tissue was harvested and probed with the terminal deoxyribonucleotidyl transferase-mediated biotin-16-dUTP nick-end labeling assay. Scutellaria baicalensis stem-leaf total flavonoid at 50 and 100 mg/kg reduced neuronal apoptosis induced by amyloid beta-peptide (25-35 in the rat hippocampus. Immunohistochemistry and western blot assay revealed that expression of the pro-apoptotic protein Bax, cytochrome c and caspase-3 was significantly diminished by 50 and 100 mg/kg Scutellaria baicalensis stem-leaf total flavonoid, while expression of the anti-apoptotic protein Bcl-2 was increased. Moreover, 100 mg/kg Scutellaria baicalensis stem-leaf total flavonoid had a more dramatic effect than the lower dosage. These experimental findings indicate that Scutellaria baicalensis stem-leaf total flavonoid dose-dependently attenuates neuronal apoptosis induced by amyloid beta-peptide in the hippocampus, and it might mediate this by regulating the expression of Bax, cytochrome c, caspase-3 and Bcl-2. | Ruiting Wang Xingbin Shen Enhong Xing Lihua Guan Lisheng Xin | 2013 | Neural Regeneration Research2013，8，12： | 8 |
| 2 | An Experimental Study on Optimization of Large-volume Airgun Source Excitation Conditions in a Reservoir显示文摘Through manual pickup of seismic phases,the number of recording stations,the farthest observation distance of station and received energy are determined,then optimal operating condition processing software is developed to evaluate the excitation effect of operating conditions. The optimal operating conditions in the Mianhuatan Reservoir are determined using this software. They are: optimal water depth 25 m,airgun array sink depth 9m and airgun array size 7m × 7m. At the same time,accumulative stacking results for every 10 times are analyzed for 300 fixed-point excitations. It is concluded that the excitation effect shows a rapidly rising trend at 10 to 90 times stacking,a slowly rising trend at 100 to 150 times stacking,a rapidly rising trend at 160 to 240 times stacking,and a slowly rising trend at 250 to 300 times stacking. As the number of stacking increases,the propagation distance and the number of recording stations also increase gradually. | Chen Huifang Lin Binhua Jin Xing Wu Lihua Cai Huiteng | 2016 | Earthquake Research in China2016，30，3： | 4 |
| 3 | Medicinals with properties of warming Yang and tonifying Qi in terms of Traditional Chinese Medicine: their effects on left ventricular ejection fraction and aldosterone in rats with induced failure heart显示文摘OBJECTIVE: To investigate on Left ventricular ejection fraction value and aldosterone of two medicinals of Traditional Chinese Medicine(TCM) with the properties of warming Yang and tonifying Qi in terms of TCM theory.METHODS: An animal model of coronary ligation of heart failure after myocardial infarction was employed to study the influence of these two kinds of drugs on three batches of rats. On the basis of the average score of left ventricle ejection fraction during the investigation, there were some different groups, including Wen Yang(the warming Yang)group, Yi Qi(tonifying Qi) group, Wen Yang and Yi Qi group, captopril group, digoxin group. In additional, an artificial operation group was set for compari-son. The systemic intervention using these medicinal and drugs was taken effects on the 2nd day after the operation of myocardial infraction(MI) with once a day. At week one, two, and four after the MI treatment, evaluated were EF values, and ferritin,angiotensin-II and aldosterone in the rats' plasma.RESULTS: At week one and week two, the medicinal of Wen Yang, Yi Qi, Wen Yang pluse Yi Qi, and digoxin could improve left ventricular ejection fraction in rats with heart failure; Compared to the model group, captopril Left ventricular EF value increased, but there was not significant. At week four,heart failure and left ventricular EF values was improved in the intervention group and the other four captopril drug intervention. At week one in the rats with drug intervention, the medicinals of Yi Qi, Wen Yang plus Yi Qi, and captopril could inhibit activation in vivo hormone aldosterone in heart failure rats; aldosterone in Wen Yang group and digoxin group were not different from that in the model group at week two and four.CONCLUSION: Chinese medicinals with properties of Wen Yang, Yi Qi have significant effect on improving left ventricular EF in rats with heart failure; compared to Yi Qi medicinals, Wen Yang medicinals that inhibit the effectiveness of the time required for the activation of the role of aldosterone. The medicinals of Wen Yang and Yi Qi seems better by inhibiting the activation of the hormone aldosterone after failing to inhibit ventricular remodeling to improve heart failure. | Han Lihua Wang Zhentao Chai Songbo Xing Guohui Wang Hongxing Yuan Bin Li Zhiwei Su Shihao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 4 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 5 | IgG4-related Autoimmune Pancreatitis Mimicking Acute Pancreatitis:A Case Report显示文摘IGG4-RELATED autoimmune pancreatitis (AIP) is themost common type of IgG4-related diseases. Theobservation of a diffused and localized enlargementof the pancreas and strictures in the main pancreaticduct on radiological imaging is essential fordiagnosing AIP. The clinical features of AIP which presentas a localized pancreatic mass greatly mimic pancreaticcancer. Cases with AIP mimicking pancreatic cancer arereported numerously. However, cases of IgG4-related AIPmanifesting acute pancreatitis symptoms and extensiveperipancreatic effusion are rarely observed. Meanwhile,acute pancreatitis is a common disease. If misdiagnosed asacute pancreatitis, IgG4-related AIP may progressseriously. Here, we report a rare case of IgG4-related AIPsuspected of acute pancreatitis because of epigastric painand extensive peripancreatic effusion on computed tomography(CT) images. | Xing Chen Lihua Wang Lixian Zhang Caihong Zhao | 2017 | Chinese Medical Sciences Journal2017，32，1： | 2 |
| 6 | Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells显示文摘Background:Mesencephalic astrocyte-derived neurotrophic factor(MANF)is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress(ER stress).HSP70 family,a chaperon like heat shock protein family,was proved to be involved in the MANF induced survival pathway in 6-OHDA treated SHSY-5Y cells.However,the ER stress relative transcriptome,in MANF signaling cascades is still investigated.The involvement of HSP70,a 70kd member of HSP70 family,need further to be verified.Methods:The cell apoptosis was assayed by MTT,TUNEL staining and western blot of cleaved Caspase-3.The differentially expressed genes in SHSY-5Y cells under different conditions(control,6-OHDA,6-OHDA+MANF)were investigated by RNA-seq.Expression of HSP70 was further confirmed by real-time PCR.RNAi knockdown for HSP70 was performed to investigate the role of HSP70 in the MANF signaling pathway.Results:MANF inhibits 6-OHDA-induced apoptosis in SHSY-5Y cells.Six ER stress relative genes(HSP70,GRP78,xbp-1,ATF-4,ATF-6,MAPK)were found enriched in 6-OHDA+MANF treatment group.HSP70 was the most significantly up-regulated gene under 6-OHDA+MANF treatment in SHSY-5Y cells.RNAi knockdown for HSP70 inhibits the protective effects of MANF against 6-OHDA toxicity in SHSY-5Y cells.Conclusion:MANF exerts a protective role against 6-OHDA induced apoptosis in SHSY-5Y cells via up-regulating some ER stress genes,including HSP70 family members.The HSP70 expression level plays a key role in MANFmediated survival pathway. | Hui Sun Ming Jiang Xing Fu Qiong Cai Jingxing Zhang Yanxin Yin Jia Guo Lihua Yu Yun Jiang Yigang Liu Liang Feng Zhiyu Nie Jianmin Fang Lingjing Jin | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 7 | Integrated Reform of Electronic Technology Courses in Higher Vocational Colleges Based on the OBE Concept显示文摘The education model based on outcomes-based education(OBE)emphasizes on taking educational achievements as the guide as well as focusing on student-centered and ability-based concepts.OBE is consistent with the talent output goals of higher vocational and technical education.Using the construction of electronic technology courses in higher vocational and technical colleges as an example,this article takes the course reform as an important carrier to promote ability training and explores the course reform scheme to meet the ability needs of higher vocational talents in the new era based on the concept of OBE in order to provide a useful reference for improving the level of talent training in higher vocational colleges. | Jian Pan Li Wen Lihua Qi Dongqiu Xing Yuting Zhao | 2021 | Journal of Contemporary Educational Research2021，5，9： | 2 |
| 8 | Soaking seed with paclobutrazol increased tolerance of juvenile oilseed rape to waterlogging显示文摘Global increase in demand for edible plant oil along with changing climates has led to a greater need to grow oilseed rape even in wet and humid environments.To find effective measures to increase tolerance of juvenile oilseed rape to waterlogging is vitally important.A pot experiment was conducted to investigate effects of soaking seed in paclobutrazol(PBZ)solution(0(W),0.1(P1),0.3(P2)or 0.5(P3)g/L)on the growth of juvenile oilseed rape(Brassica napus L.cv.‘Zhongshuang 11’).Seed soaking with water without waterlogging was used as a control.Results showed that waterlogging decreased oilseed rape growth significantly;however,soaking seed with lower doses of PBZ(P1 and P2)significantly ameliorated the decrease in plant dry weight caused by waterlogging.Compared with W,both root dry weights and shoot dry weights of P1 and P2 treatments were significantly increased at 5 d and 10 d after waterlogging,and photosynthetic pigment contents and antioxidative enzyme activities were increased by P2 treatment at both 2 samples.Since it is labor saving and economical,soaking seed with an optimal dose(0.3 g/L)of PBZ might be an efficient way to improve waterlogging tolerance of oilseed rape. | Chiming Gu Yinshui Li Changbing Yu Lihua Xie Xiaojia Hu Xinjie Shen Margot Brooks Xing Liao Lu Qin | 2019 | Oil Crop Science2019，4，3： | 1 |
| 9 | Grey forecasting model for active Vibration control systems显示文摘 | Zou Lihua Dai Suliang John Butterworth Xing Ma Bo Dong Aiping Liu | 2009 | Journal of Sound and Vibration2009，322，45： | 1 |
| 10 | Microbial community structure of ethanol type fermentation in bio-hydrogen production 显示文摘 | Ren Nanqi Xing Defeng Rittmann B E Zhao Lihua Xie Tianhui Zhao Xin | 2007 | Environmental Microbiology2007，9，5： | 1 |
| 11 | Oligomerization and Polymerization of Ethylene Initiated by a Novel Ni(Ⅱ)-Based Acetyliminopyridine Complexes as Single-Site Catalysts显示文摘新奇的镍( II )基于 acetyliminopyridine 建筑群 1b , 2b , 3b ( 1 ¨C 3b )从 ligands 1a 被综合, 2a , 3a ( 1-3a )并且[ NiCl2 ( DME )],是为为乙烯 oligomerization 和聚合反应是必要的催化剂的合适的先锋,由 methylaluminoxane (毛)激活。对待 MAO 1 ¨ C 3b 介绍一个活跃催化中心,它可以分别地生产线性 | á - 石蜡和聚乙烯的 oligomerize 和聚合乙烯。被获得的 oligomers 的分子量分布在对 oligomers 的 Schulz-Flory 规则的好同意 > C4。3b-MAO 建筑群的活动是 6.3 ? á 10 (7 ) 在 50 点的 g/(molNi-h )??6 号元素碳的化学符号。oligomers 的活动和分子量分布在催化剂先锋的结构上显示出重要信赖。给词调音:oligomerization;聚合;乙烯;镍(II ) 基于催化剂;| á - | Baojun Zhang Yanji Wang Gang Wang Jun Cao Shukun Sun Lihua Xing Yongcheng Sun Yunguang Han | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 1 |
| 12 | The substi-tution of sand filtration by immersed-UF for surface watertreatment:pilot-scale studies显示文摘 | SUN Lihua LI Xing ZHANG Guoyu | 2009 | Water Science&Technology2009，69，9： | 1 |
| 13 | SPAD chorophyll meter was suitable in nitrogen quick diagnosis,yield forecast and fertilization recommendation in rapeseed(Brassica napus L. )显示文摘 | Changbing YU Yinshui LI Lihua XIE Xiaojia HU Zhi CHE Xiangsheng LIAO Xing LIAO | 2016 | Oil Crop Science2016，1，2： | 1 |
| 14 | Effect of high pressure torsion process on the microhardness,microstructure and tribological property of Ti6Al4V alloy显示文摘In the present study,a fully lamellar Ti6Al4V alloy was severely deformed by high pressure torsion(HPT)process under a pressure of 7.5 GPa up to 10 revolutions.Experimental results revealed that the microhardness of Ti6Al4V was increased remarkably by about~41%and saturated at about 432 Hv after the HPT process.A relatively uniform bulk nanostructured Ti6Al4V alloy with an average grain size of about52.7 nm was obtained eventually,and no obvious formation of metastableωphase was detected by XRD analysis.For the first time,the tribological properties of the HPT processed Ti6Al4V alloy were investigated by a ball-on-disc test at room temperature under a dry condition.It was found that HPT process had a great influence on the friction and wear behaviors of Ti6Al4V alloy.With increasing the number of HPT revolutions,both friction coefficient and specific wear rate were obviously decreased due to the reduction of abrasion and adhesion wears.After being deformed by 10 HPT revolutions,the friction coefficient was reduced from about 0.49 to 0.37,and the specific wear rate was reduced by about 48%.The observations in this study indicated that HPT processed Ti6Al4V alloys had good potential in structural applications owing to their greatly improved mechanical and tribological properties. | Guanyu Deng Xing Zhao Lihong Su Peitang Wei Liang Zhang Lihua Zhan Yan Chong Hongtao Zhu Nobuhiro Tsuji | 2021 | Journal of Materials Science & Technology2021，，35： | 1 |
| 15 | Design and analysis of discrete-time robust kalman filters 显示文摘 | Xing Zhu Yeng Chai Soh Lihua Xie | 2002 | Automatica2002，38，6： | 1 |
| 16 | Grey forecasting model for active vibration control systems显示文摘 | Zou Lihua Dai Suliang John Butterworth Xing Ma Bo Dong Aiping Liu | 2009 | Journal of Sound and Vibration2009，322，45： | 1 |
| 17 | Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics显示文摘 | Shishan Deng Hongying Zhou Ruohong Xiong Youguang Lu Dazhong Yan Tianyong Xing Lihua Dong Enjie Tang Huijun Yang | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 18 | Design and Analysis of Discrete-Time Robust Kalman Filters显示文摘 | Zhu Xing Soh Yeng Chai Xie Lihua | 2002 | Automatica2002，38，6： | 1 |
| 19 | Occurrence and distribution of micro-and mesoplastics in the high-latitude nature reserve,northern China显示文摘Microplastics pollution has received growing attention worldwide in recent years.However,data on microplastics in the freshwater environment are still limited,especially in high-latitude nature reserves in Northern China.The first study on microplastic pollution in the Liaohe River Reserve in Northern China is reported here,and mesoplastics were also incorporated.Surface water and sediment samples were collected from 32 sites along the nature reserve.The abundance,type,shape,color,and size of micro-and mesoplastics were measured using density extraction,optical microscopy,and FTIR spectroscopy.The data showed that diverse micro-and mesoplastics were found widespread in the 32 sites,and the average abundance of these plastics was 0.11±0.0410^(–2) items/L in surface water and 62.29±54.30 items/kg in sediment.Moreover,70%and 66%were smaller than 2000μm in surface water and sediment,respectively.Fiber accounted for 91.86%in surface water and 43.48%in sediment,indicating that the major source of micro-and mesoplastics in the Liaohe River Reserve may be domestic sewage and aquaculture.A total of 16 and 27 polymers were identified in surface water and sediment,respectively,and mostly consisted of rayon,polyester,polystyrene,and poly(ethylene terephthalate).Moreover,both the risk index and the pollution load index demonstrated a low risk of micro-and mesoplastics in surface water and sediment in the Liaohe River Reserve. | Wenwen Gong Yu Xing Lihua Han Anxiang Lu Han Qu Li Xu | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 0 |
| 20 | Modulation of the electronic states of perovskite SrCrO3 thin films through protonation via low-energy hydrogen plasma implantation approaches显示文摘Hydrogenation of transition metal oxides offers a powerful platform to tailor physical functionalities as well as for potential applications in modern electronic technologies.An ideal nondestructive and efficient hydrogen incorporation approach is important for the realistic technological applications.We demonstrate the proton injection on SrCro3 thin films via an efficient low-energy hydrogen plasma implantation experiments,without destroying the original lattice framework.Hydrogen ions accumu-late largely at the interfacial regions with amorphous character which extend about one-third of the total thickness.The Hx.SrCro3(HSCO)thin films appear like exfoliated layers which however retain the fully strained state with distorted perovskite structure.Proton doping induces the change of Cr oxidation state from Cr^4+to Cr^3+in HSCO thin films and a transition from metallic to insulat-ing phase.Our investigations suggest an attractive platform in manipulating the electronic phases in proton-based approaches and may offer a potential peeling off strategy for nanoscale devices through low-energy hydrogen plasma implantation approaches. | Meng Wu Shanquan Chen Chuanwei Huang Xing Ye Haiping Zhou Xiaochun Huang Kelvin H.L.Zhang Wensheng Yan Lihua Zhang Kisslinger Kim Yingge Du Scott Chambers Jin-Cheng Zheng Hui-Qiong Wang | 2020 | Frontiers of physics2020，15，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员