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| 1 | Particle sizing in dense two-phase droplet systems by ultrasonic attenuation and velocity spectra显示文摘Size and size distribution of particles in particulate two-phase flow play an important role in a wide variety of industrial areas,while their measurement still remains a hard task till now.Ultrasonic wave as a mechanical vibration contains plenty of information about medium when it passes through.Thus the size distribution could be extracted from the measured ultrasonic attenuation and velocity spectra by means of well established models and data processing techniques.This paper contributes to the extraction of information of droplet size of a two-phase fat emulsion simultaneously from signals of broad-band ultrasonic attenuation and velocity spectra.According to the formulated single particle scattering model,the relationship between particle size distribution and ultrasonic spectrum is estab-lished.The sensitivities of ultrasonic spectra to the variation of particle size are illustrated.Distin-guishing features for attenuation and velocity spectra are summarized.Demonstration calculations of inversion by optimum regularization factor method are carried out to yield the typical numerical results for discussion.Based on the proposed inversion algorithm and theoretical model,a fat emulsion sam-ple with a volume fraction up to 20% is measured and analyzed.To validate the proposed ultrasonic spectrum particle sizing method,the results are compared to those obtained from optical measure-ment. | SU MingXu CAI XiaoShu XUE MingHua DONG LiLi XU Feng | 2009 | Science China(Technological Sciences)2009，52，6： | 11 |
| 2 | Storage reliability assessment model based on competition failure of multi-components in missile显示文摘The degradation data of multi-components in missile is derived by periodical testing. How to use these data to assess the storage reliability(SR) of the whole missile is a difficult problem in current research. An SR assessment model based on competition failure of multi-components in missile is proposed. By analyzing the missile life profile and its storage failure feature, the key components in missile are obtained and the characteristics voltage is assumed to be its key performance parameter. When the voltage testing data of key components in missile are available, a state space model(SSM) is applied to obtain the whole missile degradation state, which is defined as the missile degradation degree(DD). A Wiener process with the time-scale model(TSM) is applied to build the degradation failure model with individual variability and nonlinearity. The Weibull distribution and proportional risk model are applied to build an outburst failure model with performance degradation effect. Furthermore, a competition failure model with the correlation between degradation failure and outburst failure is proposed. A numerical example with a set of missiles in storage is analyzed to demonstrate the accuracy and superiority of the proposed model. | Yunxiang Chen Qiang Zhang Zhongyi Cai Lili Wang | 2017 | Journal of Systems Engineering and Electronics2017，28，3： | 9 |
| 3 | Spatial distribution of heavy metals(Cu, Pb, Zn, and Cd)in sediments of a coastal wetlands in eastern Fujian, China显示文摘We investigated the spatial distribution(horizontal and vertical concentrations) of copper(Cu),lead(Pb), zinc(Zn), and cadmium(Cd) in five wetland types(mudflat, aquaculture wetland, water area, farmland wetland and mangrove) from three areas(Ningde, Fuding,and Xiapu), China. Cu concentrations in five wetland types descended in the order: farm wetland, mudflat, aquaculture,water area and mangrove. Pb concentrations decreased in the order: aquaculture, mangrove, farm wetland, mudflat,and water area. Zn content decreased in the order: farm wetland, water area, aquaculture, mudflat and mangrove,and Cd content decreased as follows: mangrove, aquaculture, water area, mudflat, and farm wetland. Comparison of the concentrations of the same heavy metals in different areas showed that the highest Cu(63.75 mg kg^-1) and Zn(152.32 mg kg^-1) concentrations occurred in Ningde coastal wetlands; Pb(110.58 mg kg^-1) and Cd(2.81 mg kg^-1) contents were highest in Fuding wetlands,and the average contents of all heavy metals were very low in Xiapu wetlands. Examination of the vertical distribution showed that the Cu content was high in all mudflat layers;Pb and Cd concentrations were highest in aquaculture and mangrove wetlands, respectively, and Zn content was highest in farm wetlands. The spatial distribution of Cu and Zn contents for different areas decreased as follows:Ningde [ Fuding [ Xiapu, for Pb and Cd were most concentrated in Fuding coastal wetlands. Concentrations of Zn and Cu were highly correlated, while Zn and Cu were not significantly correlated with Pb. | Lili Zhao Weibin You Haiqing Hu Wei Hong Xiaojuan LIAO Shihong Xiao Ren Wang Jinbiao Cai Xuncheng Fan Yong Tan Dongjin He | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 4 | A 2.833-kb Insertion in BnFLC.A2 and Its Homeologous Exchange with BnFLC.C2 during Breeding Selection Generated Early-Flowering Rapeseed显示文摘 | Lei Chen Faming Dong Jing Cai Qiang Xin Caochuang Fang Liang Liu Lili Wan Guangsheng Yang Dengfeng Hong | 2018 | Molecular Plant2018，11，1： | 6 |
| 5 | Studies of key technologies for CdTe solar modules显示文摘In this paper, CdS thin films, which act as the window layer and n-type partner to the p-type CdTe layer, were prepared by chemical bath deposition (CBD). CdTe thin films were deposited by the close-spaced sublimation (CSS) method. To obtain high-quality back contacts, a Te-rich layer was created with chemical etching and back contact materials were applied after CdTe annealing. The results indicate that the ZnTe/ZnTe:Cu complex layers show superior performance over other back contacts. Finally, by using laser scribing and mechanical scribing, the CdTe mini-modules were fabricated, in which a glass/SnO2:F/CdS/CdTe/ZnTe/ZnTe:Cu/Ni solar module with a PWQC-confirmed total-area efficiency of 7.03% (54 cm2) was achieved. | LI Wei FENG LiangHuan ZHANG JingQuan WU LiLi CAI YaPing ZHENG JiaGui CAI Wei LI Bing LEI Zhi | 2008 | Science China(Technological Sciences)2008，51，1： | 5 |
| 6 | Variable Selection in Logistic Regression Model显示文摘Variable selection is one of the most important problems in pattern recognition. In linear regression model, there are many methods can solve this problem,such as Least absolute shrinkage and selection operator(LASSO) and many improved LASSO methods, but there are few variable selection methods in generalized linear models. We study the variable selection problem in logistic regression model. We propose a new variable selection method – the logistic elastic net, prove that it has grouping effect which means that the strongly correlated predictors tend to be in or out of the model together. The logistic elastic net is particularly useful when the number of predictors(p) is much bigger than the number of observations(n). By contrast, the LASSO is not a very satisfactory variable selection method in the case when p is more larger than n. The advantage and effectiveness of this method are demonstrated by real leukemia data and a simulation study. | ZHANG Shangli ZHANG Lili QIU Kuanmin LU Ying CAI Baigen | 2015 | Chinese Journal of Electronics2015，24，4： | 5 |
| 7 | Methods for predicting the remaining useful life of equipment in consideration of the random failure threshold显示文摘The value range of the failure threshold will generate an uncertain influence on the prediction results for the remaining useful life(RUL) of equipment. Most of the existing studies on the RUL prediction assume that the failure threshold is a fixed value,as they have difficulty in reflecting the random variation of the failure threshold. In connection with the inadequacies of the existing research, an in-depth analysis is carried out to study the effect of the random failure threshold(RFT) on the prediction results for the RUL. First, a nonlinear degradation model with unit-to-unit variability and measurement error is established based on the nonlinear Wiener process. Second, the expectation-maximization(EM) algorithm is used to solve the estimated values of the parameters of the prior degradation model, and the Bayesian method is used to iteratively update the posterior distribution of the random coefficients. Then, the effects of three types of RFT constraint conditions on the prediction results for the RUL are analyzed, and the probability density function(PDF) of the RUL is derived. Finally,the degradation data of aero-turbofan engines are used to verify the correctness and advantages of the method. | WANG Zezhou CHEN Yunxiang CAI Zhongyi GAO Yangjun WANG Lili | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 5 |
| 8 | Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China显示文摘Food consumption is one of the key exposure routes of humans to contaminants.This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls(PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province,Southeast China.The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatographytandem mass spectrometry(GC-MS/MS).The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes(DDTs),hexachlorocyclohexanes(HCHs),hexachlorobenzene(HCB) and mirex and other pesticides including chlorpyrifos,pyrethroid pesticides,metolachlor,pyridaben and trifluralin were frequently detected in the samples,which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong.Meanwhile,correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed.Combined with dietary survey results at the same sampling locations,human health risk assessment of ingestion through the dietary route was performed.The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area,however,the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels. | Na Wang Li Yi Lili Shi Deyang Kong Daoji Cai Donghua Wang Zhengjun Shan | 2012 | Journal of Environmental Sciences2012，24，10： | 5 |
| 9 | Large area perovskite solar cell module显示文摘The recent dramatic rise in power conversion efficiencies(PCE)of perovskite solar cells has triggered intense research worldwide.However,their practical development is hampered by poor stability and low PCE values with large areas devices.Here,we developed a gas-pumping method to avoid pinholes and eliminate local structural defects over large areas of perovskite film,even for 5 x 5 cm2 modules,the PCE reached 10.6%and no significant degradation was found after 140 days of outdoor testing.Our approach enables the realization of high performance large-area PSCs for practical application. | Longhua Cai Lusheng Liang Jifeng Wu Bin Ding Lili Gao Bin Fan | 2017 | Journal of Semiconductors2017，38，1： | 4 |
| 10 | Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease显示文摘A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD. | Chang Kong Hao Xie Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li | 2019 | Virologica Sinica2019，34，5： | 4 |
| 11 | Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. | Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 12 | Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome显示文摘OBJECTIVE: To observe the clinical effects of the Lixujieyu recipe combined with Five Elements music therapy on chronic fatigue syndrome(CFS) identified as the symptom patterns of liver stagnation and spleen deficiency in terms of Traditional Chinese Medicine.METHODS: Patients with CFS were randomly divided into treatment group 1(Lixujieyu recipe combined with Gong-Tune, n = 15); treatment group 2(Lixujieyu recipe combined with Jiao-Tune, n = 15);treatment group 3(Lixujieyu recipe combined with Yu-Tune, n = 15); treatment group 4(Lixujieyu recipe combined with Shang-Tune, n = 15); treatment group 5(Lixujieyu recipe combined with Zhi-Tune,n = 15); and the control group(Lixujieyu recipe alone, n = 15). Chinese medicine was given twice daily, and music was listened to for 45 minutes daily, 5 days a week. All patients were treated for4 weeks. Patients were assessed via the Fatigue Scale, the Hamilton Depression Rating Scale, and the Hamilton Anxiety Rating Scale before and after treatment.RESULTS: Treatment groups 1 and 2 had better effects on relieving the symptoms of physical fatigue related to anxiety and depression than the control group(P < 0.05).CONCLUSION: Lixujieyu recipe combined with Gong-Tune or Jiao-Tune significantly relieved the symptoms of CFS. | Zhang Zhenxian Cai Zhixing Yu Yonghui Wu Lili Zhang Ye | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 3 |
| 13 | Distribution of soil aggregates and organic carbon in deep soil under long-term conservation tillage with residual retention in dryland显示文摘To ascertain the effects of long-term conservation tillage and residue retention on soil organic carbon(SOC) content and aggregate distribution in a deep soil(>20-cm depth) in a dryland environment,this paper analyzed the SOC and aggregate distribution in soil, and the aggregate-associated organic carbon(OC) and SOC physical fractions. Conservation tillage(reduced tillage with residue incorporated(RT) and no-tillage with residue mulch(NT)) significantly increased SOC sequestration and soil aggregation in deep soil compared with conventional tillage with residue removal(CT). Compared with CT, RT significantly increased the proportion of small macroaggregates by 23%–81% in the 10–80 cm layer, and the OC content in small macroaggregates by 1%–58% in the 0–80 cm layer. RT significantly increased(by 24%–90%) the OC content in mineral-SOC within small macroaggregates in the 0–60 cm layer, while there was a 23%–80% increase in the 0–40 cm layer with NT. These results indicated that:(1) conservation tillage treatments are beneficial for soil aggregation and SOC sequestration in a deep soil in a dryland environment; and(2)the SOC in mineral-associated OC plays important roles in soil aggregation and SOC sequestration. In conclusion, RT with NT is recommended as an agricultural management tool in dryland soils because of its role in improving soil aggregation and SOC sequestration. | WANG Bisheng GAO Lili YU Weishui WEI Xueqin LI Jing LI Shengping SONG Xiaojun LIANG Guopeng CAI Dianxiong WU Xueping | 2019 | Journal of Arid Land2019，11，2： | 3 |
| 14 | Fast nanoparticle sizing by image dynamic light scattering显示文摘In this paper,an image dynamic light scattering method for nanoparticle sizing is introduced.The spatial distribution of the scattered lights from nanoparticles undergoing Brownian motion was captured at a high frame rate by a digital camera within one second,which is considerably faster than the conventional photon correlation spectroscopy method.The captured series of photographs were meshed into thousands of small units for calculating the intensity autocorrelation functions in parallel.Experimental results from the measurements of three reference nanoparticle samples(27,80,and 352 nm in diameters)demonstrated the feasibility of this method. | Chengze Xu Xiaoshu Cai Jie Zhang Lili Liu | 2015 | Particuology2015，13，2： | 3 |
| 15 | Quantitative assessment of the influence of prostate stem cell antigen polymorphisms on gastric cancer risk显示文摘 | Xixi Gu Wen Zhang Lili Xu Dingfang Cai | 2014 | Tumor Biology2014，，3： | 2 |
| 16 | An Effective Long String Searching Algorithm towards Component Security Testing显示文摘In the execution of method invocation sequences to test component security,abnormal or normal information is generated and recorded in a monitor log. By searching abnormal information from monitor log,the exceptions that the component has can be determined. To facilitate the searching process,string searching methods could be employed. However,current approaches are not effective enough to search long pattern string. In order to mine the specific information with less number of matches,we proposed an improved Sunday string searching algorithm in this paper. Unlike Sunday algorithm which does not make use of the already matched characters,the proposed approach presents two ideas — utilizing and recycling these characters. We take advantage of all matched characters in main string,if they are still in the matchable interval compared with pattern string,to increase the distance that pattern string moves backwards. Experimental analysis shows that,compared to Sunday algorithm,our method could greatly reduce the matching times,if the scale of character set constituting both main string and pattern string is small,or if the length of pattern string is long. Also,the proposed approach can improve the search effectiveness for abnormal information in component security testing. | Jinfu Chen Lili Zhu Zhibin Xie Michael Omari Hilary Ackah-Arthur Saihua Cai Rubing Huang | 2016 | China Communications2016，13，11： | 2 |
| 17 | Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis显示文摘Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment. | Zhenxing Gao Min Peng Liang Chen Xiaowen Yang Huan Li Run Shi Guiru Wu Lili Cai Qibin Song Chaoyang Li | 2019 | Virologica Sinica2019，34，2： | 2 |
| 18 | Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake显示文摘LRP6,a co-receptor for the morphogen Wnt,aids endocytosis of anthrax complexes.Here we report that Dickkopf1(DKK1)protein,a secreted LRP6 ligand and antagonist,is also a modulator of anthrax toxin sensitivity.shRNA-mediated gene silencing or TALEN-mediated gene knockout of DKK1 reduced sensitivity of cells to PA-dependent hybrid toxins.However,unlike the solely inhibitory effect on Wnt signaling,the effects of DKK1 overexpression on anthrax toxicity were bidirectional,depending on its endogenous expression and cell context.Fluorescence microscopy and biochemical analyses showed that DKK1 facilitates internalization of anthrax toxins and their receptors,an event mediated by DKK1-LRP6-Kremen2 complex.Monoclonal antibodies against DKK1 provided dose-dependent protection to macrophages from killing by anthrax lethal toxin(LT).Our discovery that DKK1 forms ternary structure with LRP6 and Kremen2 in promoting PA-mediated toxin internalization provides a paradigm for bacterial exploitation of mechanisms that host cells use to internalize signaling proteins. | QIAN LiLi CAI ChangZu YUAN PengFei JEONG Sun-Young YANG XiaoZhou DEALMEIDA Venita ERNST James COSTA Michael COHEN Stanley N. WEI WenSheng | 2014 | Science China(Life Sciences)2014，57，5： | 2 |
| 19 | The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration显示文摘Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell migration.However,the regulatory mechanism of TNFAIP1 degradation remains largely elusive.In the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)complex.More importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and degradation.Mechanistically,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in cells.As such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this effect.Finally,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of patients.Taken together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration. | Lihui Li Wenjuan Zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang Yunjing Zhang Wenlian Chen Changsheng Dong Yanmei Zhang Mingsong Wang Wenyi Wei Lijun Jia | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 20 | Livistona chinensis seed suppresses hepatocellular carcinoma growththrough promotion of mitochondrial-dependent apoptosis显示文摘 | Wei Lin Jinyan Zhao Zhiyun Cao Qunchuan Zhuang Liangpu Zheng Qiaoyan Cai Daxin Chen Lili Wang Zhenfeng Hong Jun Peng | 2013 | Oncology Reports2013，，5： | 1 |
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