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| 1 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 2 | Conservative and functional surgery in the treatment of salivary gland tumours显示文摘The principle of modern oncological surgery is to conserve the functional organs or tissues as much as possible based on eradication of the tumour.For salivary gland tumours,conservative and functional salivary surgery,including partial sialoadenectomy as well as anatomical and functional preservation of the facial nerve,great auricular nerve,superficial musculoaponeurotic system (SMAS),and Stensen’s duct,has become increasingly popular.In the present review,we discuss the following aspects of conservative and functional surgery in the treatment of salivary gland tumours:(i) partial superficial parotidectomy (PP) to treat benign parotid gland tumours,(ii) modification of surgical incisions to improve cosmetic results,(iii) modification of the surgical approach to decrease complications,(iv) extracardial dissection to treat benign superficial parotid tumours,(v) partial sialoadenectomy to treat benign submandibular gland tumours,and (vi) 125I brachytherapy to preserve facial nerves.The majority of the operated parotid or submandibular glands are preserved,and surgical complications are also decreased.Conservative and functional surgery plays a significant role in maintaining normal salivary gland function and in improving patients’ quality of life during the treatment of salivary gland tumours and thus should be further promoted. | Guangyan Yu Xin Peng | 2019 | International Journal of Oral Science2019，11，3： | 10 |
| 3 | Aquaporin 5 is degraded by autophagy in diabetic submandibular gland显示文摘Autophagy is a catabolic process which is involved in the development of many diseases including diabetes mellitus and its complications. Hyposalivation is a common complication of diabetes mellitus, whereas its mechanism remains unclear. Here, we observed that the stimulated salivary flow rate of SMG was significantly decreased in db/db mice, a diabetic mice model. The expressions of aquaporin 5(AQP5), a water channel protein, were decreased, whereas the m RNA level of AQP5 was increased in SMGs of both diabetic patients and mice. Under transmission electron microcope, more autophagosomes were detected in diabetic SMGs. Expressions of autophagy related proteins LC3 II, Beclin-1 and ATG5 were increased, meanwhile autophagy substrate p62 was decreased in SMGs of diabetic patients and mice, indicating that autophagy was activated in diabetic SMG.Double immunofluorescence staining showed that the colocalization of AQP5 and LC3 was increased in SMGs of diabetic mice.In cultured SMG-C6 cells, high glucose(HG), but not high osmotic pressure, reduced AQP5 protein expression and induced autophagy. Moreover, inhibition of autophagy by 3-methyladenin, an autophagy inhibitor, or by autophagy-related gene 5 siRNA, decreased HG-induced AQP5 reduction in SMG-C6 cells. Additionally, the expression of p-p85, p-Akt and p-mTOR were decreased in HG-treated SMG-C6 cells. Pretreatment with 740 Y-P, a PI3 K agonist, significantly suppressed HG-induced autophagy and AQP5 degradation. Taken together, these results indicate that autophagy plays a crucial role in AQP5 degradation in diabetic SMG via PI3 K/Akt/mTOR signaling pathway, which contributes to the dysfunction of diabetic SMG. Our study provides a novel mechanism of diabetic hyposalivation. | Yan Huang Xijin Shi Qianying Mao Yan Zhang Xin Cong Xueming Zhang Zhejing Zhang Liling Wu Ruolan Xiang Guangyan Yu | 2018 | Science China(Life Sciences)2018，61，9： | 5 |
| 4 | Effect of Yb^(3+) concentration on the structures and upconversion luminescence properties of Y_2O_3:Er^(3+) ultrafine phosphors显示文摘Y2O3:Er3+ ultrafine phosphors with a varying Yb3+ ion concentration were prepared by a urea homogeneous precipitation method. The results of XRD show that all the samples are of a pure cubic structure and the average crystallite sizes can be calculated as 45, 34, and 28 nm for Y2O3:Er3+ ultrafine phosphors with Yb3+ ion concentrations of 0, 10%, and 20%, respec- tively. The lattice constant and cell volume of the ultrafine phosphors decrease with enhancing Yb3+ ion concentration. The upconversion luminescence spectra of all the samples were studied under 980 nm laser excitation. The strong green and red upconversion emission were observed, and attributed to the 2H11/2 → 4I15/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions of Er3+, respectively. The intensity of red emission increases with increasing Yb3+ ion concentration. The effect of Yb3+ ion concentra- tion on the structures and upconversion luminescence mechanism were discussed. | ZHANG Yongming LI Yanhong ZHANG Yang HONG Guangyan YU Yingning | 2008 | Rare Metals2008，27，6： | 4 |
| 5 | Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine显示文摘Dear Editor,Urine passes through the entire kidney and urinary tract system starting from the glomerulus and ending to the urethra.Cells in the kidney and urinary tract could be exfoliated from the epithelium into the urine,while leukocyte could infiltrate from the local tissue into the urine,which makes the urine a useful subject for clinical evaluation of relevant diseases. | Yujia Wang Yu Zhao Zixian Zhao Dandan Li Hao Nie Yufen Sun Xiaobei Feng Ting Zhang Yu Ma Jing Nie Guangyan Cai Xiangmei Chen Wei Zuo | 2021 | Protein & Cell2021，12，4： | 2 |
| 6 | Amphiphilic Pd@micro-organohydrogels with controlled wettability for enhancing gas-liquid-solid triphasic catalytic performance显示文摘The wettability of catalyst plays an important role in regulating catalytic performance in heterogenous catalysis because the microenvironment around the catalytic sites directly determines the mass transfer process of reactants.Inspired by gas trapped on the surface of subaquatic spiders,amphiphilic micro-organohydrogels with tunable surface wettabilities were developed by anchoring various alkane chains onto a poly(2-(dimethylamino)ethyl methacrylate)(p(DMAEMA))hydrophilic microgel network.Palladium nanoparticles(Pd NPs)were encapsulated in amphiphilic microgels(amphiphilic Pd@M)to catalyze hydrogenation reaction,achieving higher activities than pristine monohydrophilic Pd@M composite.The underwater oleophilicity and aerophilicity of Pd@M composites were quantified by oil/gas adhesion measurements and computational simulations.The higher amphiphilic catalytic activities are attributed to the formation of a gas-oil-solid reaction interface on the catalyst surfaces,allowing rapid transport of H2 and organic substrates through water to the Pd catalytic sites.Additionally,amphiphilic Pd@M composites also exhibit more superior catalytic performance in multi-substrates reaction. | Minghui Zhang Tianyi Zhao Cunming Yu Qian Liu Guangyan Wang Hui Yang Ming Yang Lei Jiang Mingjie Liu | 2022 | Nano Research2022，15，1： | 2 |
| 7 | Optimization of ultrasound-assiste dextraction (UAE) of flavonoids compounds (PC) from hawthorn seed(HS)显示文摘 | PAN Guangyan YU Guoyang ZHU Chuanhe | 2012 | Ultrason Sonochemistry2012，19，3： | 1 |
| 8 | Optimization of ultrasound-assisted extraction (UAE) of flavonoids compounds ( FC ) from hawthorn seed ( HS ) 显示文摘 | Guangyan Pan Guoyong Yu Julin Qiao etc | 2012 | Ulrrasonics Sonochemistry2012，，19： | 1 |
| 9 | Optimization of ultrasound-assisted extraction(UAE)of flavonoids compounds(FC) from hawthorn seed(HS)显示文摘 | PAN Guangyan YU Guoyong ZHU Chuanhe | 2012 | Ultrasonics Sonochemistry2012，19，3： | 1 |
| 10 | Green light emission by Ce 3+ and Tb 3+ co-doped Sr 3 MgSi 2 O 8 phosphors for potential application in ultraviolet whitelight-emitting diodes显示文摘 | Hong Yu Wenwen Zi Shi Lan Shucai Gan Haifeng Zou Xuechun Xu Guangyan Hong | 2012 | Optics and Laser Technology2012，，7： | 1 |
| 11 | Optimization of ultrasound-assisted extraction (UAE) of flavonoids compounds (FC) from hawthorn seed (HS)显示文摘 | Guangyan Pan Guoyong Yu Chuanhe Zhu Julin Qiao | 2011 | Ultrasonics - Sonochemistry2011，，3： | 1 |
| 12 | Evaluating biotoxicity with fibroblasts derived from human embryonic stem cells显示文摘 | Xiaoying Wang Shenglin Li Tong Cao Xin Fu Guangyan Yu | 2012 | Toxicology in Vitro2012，，6： | 1 |
| 13 | Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats显示文摘 | Te Liu Na Li Jian Zhu Guangyan Yu Kun Guo Liting Zhou Dongchun Zheng Xiaofeng Qu Jian Huang Xin Chen Shuyue Wang Lin Ye | 2014 | Reproductive Toxicology2014，，： | 1 |
| 14 | Vacuum ultraviolet optical properties of (La,Gd)PO 4 :RE 3+ (RE=Eu, Tb)显示文摘 | Xueyan Wu Hongpeng You Hongtao Cui Xiaoqing Zeng Guangyan Hong Chang-Hong Kim Chong-Hong Pyun Byung-Yong Yu Cheol-Hee Park | 2002 | Materials Research Bulletin2002，，9： | 1 |
| 15 | Optimization of ultrasound-assisted extraction (UAE) offlavonoids compounds (FC) from hawthorn seed (HS)显示文摘 | PAN GUANGYAN YU GUOYONG ZHU CHUANHE | 2012 | Ultrasonics Sonochemistry2012，19，3： | 1 |
| 16 | Preparation and properties of dental zirconia ceramics显示文摘Y2O3-stabilized tetragonal zirconia polycrystalline (Y-TZP) ceramics with high-performance were prepared for dental ap-plication by use of the micro-emulsion and two-step sintering method. The crystal phase, morphology, and microstructure of the re-action products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron mi-croscopy (TEM). XRD results show that the ceramics mainly consist of tetragonal zirconia. Physical and mechanical properties test results show that the bending strength, fracture toughness, and the density of full sintered Y-TZP ceramics are 1150 MPa, 5.53 MPa·m1/2, and 6.08 g/cm3, respectively, which suggest that the material is relatively suitable for dental restoration. The dental base crown machined with this material by CAD/CAM system exhibits a verisimilitude configuration and the material’s expansion coeffi-cient well matches that of the glaze. These results further indicate that the product can be used as a promising new ceramic material to fabricate dental base crowns and bridges. | Xinjie Liang Yuexiu Qiu Shaoxiong Zhou Xiaoyang Hu Guangyan Yu Xuliang Deng | 2008 | Journal of University of Science and Technology Beijing2008，15，6： | 1 |
| 17 | Advances in emission control of diesel vehicles in China显示文摘Diesel vehicles have caused serious environmental problems in China.Hence,the Chinese government has launched serious actions against air pollution and imposed more stringent regulations on diesel vehicle emissions in the latest China VI standard.To fulfill this stringent legislation,two major technical routes,including the exhaust gas recirculation(EGR)and high-efficiency selective catalytic reduction(SCR)routes,have been developed for diesel engines.Moreover,complicated aftertreatment technologies have also been developed,including use of a diesel oxidation catalyst(DOC)for controlling carbon monoxide(CO)and hydrocarbon(HC)emissions,diesel particulate filter(DPF)for particle mass(PM)emission control,SCR for the control of NOx emission,and an ammonia slip catalyst(ASC)for the control of unreacted NH3.Due to the stringent requirements of the China VI standard,the aftertreatment system needs to be more deeply integrated with the engine system.In the future,aftertreatment technologies will need further upgrades to fulfill the requirements of the near-zero emission target for diesel vehicles. | Guangyan Xu Wenpo Shan Yunbo Yu Yulong Shan Xiaodong Wu Ye Wu Shaojun Zhang Liqiang He Shijin Shuai Hailong Pang Xuefeng Jiang Heng Zhang Lei Guo Shufen Wang Feng-Shou Xiao Xiangju Meng Feng Wu Dongwei Yao Yan Ding Hang Yin Hong He | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 18 | Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis显示文摘Immunoglobulin G4-related sialadenitis(IgG4-RS)is an immune-mediated fibro-inflammatory disease and the pathogenesis is still not fully understood.The aim of this study was to explore the role and mechanism of interleukin-13(IL-13)in the cellular senescence during the progress of IgG4-RS.We found that the expression of IL-13 and IL-13 receptorα1(IL-13Rα1)as well as the number of senescent cells were significantly higher in the submandibular glands(SMGs)of IgG4-RS patients.IL-13 directly induced senescence as shown by the elevated activity of senescence-associatedβ-galactosidase(SA-β-gal),the decreased cell proliferation,and the upregulation of senescence markers(p53 and p16)and senescence-associated secretory phenotype(SASP)factors(IL-1βand IL-6)in SMG-C6 cells.Mechanistically,IL-13 increased the level of phosphorylated signal transducer and activator of transcription 6(p-STAT6)and mitochondrial-reactive oxygen species(mt ROS),while decreased the mitochondrial membrane potential,ATP level,and the expression and activity of superoxide dismutase 2(SOD2).Notably,the IL-13-induced cellular senescence and mitochondrial dysfunction could be inhibited by pretreatment with either STAT6 inhibitor AS1517499 or mitochondria-targeted ROS scavenger Mito TEMPO.Moreover,IL-13 increased the interaction between p-STAT6 and c AMP-response element binding protein(CREB)-binding protein(CBP)and decreased the transcriptional activity of CREB on SOD2.Taken together,our findings revealed a critical role of IL-13 in the induction of salivary gland epithelial cell senescence through the elevated mitochondrial oxidative stress in a STAT6–CREB–SOD2-dependent pathway in IgG4-RS. | Mengqi Zhu Sainan Min Xiangdi Mao Yuan Zhou Yan Zhang Wei Li Li Li Liling Wu Xin Cong Guangyan Yu | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 19 | Microvascular autologous submandibular glandtransfer in severe cases of keratoconjunctivititis sicca显示文摘 | Yu Guangyan Zhu Zhenghong Mao Chi | 2004 | Int J Oral Maxillofac Surg2004，33，： | 1 |
| 20 | Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca显示文摘Autologous submandibular gland(SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously.This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time. The results showed that autonomic nerves distributed in the transplanted SMGs and parasympathetic ganglionic cells were observed in the stroma of the glands. Low-dense and unevenly distributed cholinergic axons, severe acinar atrophy and fibrosis were visible in the patients' glands 4–6 months post-transplantation, whereas the cholinergic axon density and acinar area were increased with time. The acinar area or the secretory flow rate of the transplanted glands was statistically correlated with the cholinergic axon density in the rabbit model, respectively. Meanwhile, large cholinergic nerve trunks were found to locate in the temporal fascia lower to the gland, and sympathetic plexus concomitant with the arteries was observed both in the adjacent fascia and in the stroma of the glands. In summary, the transplanted SMGs are reinnervated by autonomic nerves and the cholinergic nerves play a role in the morphological and functional restoration of the glands. Moreover, these autonomic nerves might originate from the auriculotemporal nerve and the sympathetic plexus around the supplying arteries. | Xueming Zhang Ningyan Yang Xiaojing Liu Jiazeng Su Xin Cong Liling Wu Yan Zhang Guangyan Yu | 2018 | International Journal of Oral Science2018，10，2： | 1 |
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