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| 1 | Mitochondrial DNA variation analysis suggests extreme low genetic diversity in Guizhou snub-nosed monkeys (Rhinopithecus brelichi)显示文摘Guizhou snub-nosed monkey (Rhinopithecus brelichi) is a unique, endangered primate in China, mainly distributed in Fanjing Mountain National Natural Reserve, Guizhou Province, in an area of 275 km2. Recently, habitat loss and fragmentation have caused population isolation. To assess genetic diversity within this species and its population structure, we sequenced 400 bp of the hypervariable I segment from the mitochondrial DNA control region for 128 individuals. Only one haplotype was identified from these individuals. Compared with other primate species, R. brelichi can be regarded as a species with very low genetic diversity, which further adds to the conservation concern. | PAN HuiJuan SHI FangLei CHANG ZongFei XIANG ZuoFu SUN TingTing LIU ZhiJin LIMing | 2011 | Chinese Science Bulletin2011，56，24： | 15 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Noninvasive genetic assessment of the population trend and sex ratio of the Shennongjia population of Sichuan snub-nosed monkeys(Rhinopithecus roxellana)显示文摘Effective population management relies on assessments of population size and sex ratio.However,these estimates are difficult to obtain for elusive and rare species.Recently,noninvasive genetic census methods have been developed as an alternative to tradi-tional capture-mark-recapture methods.In this study,we estimated the size of the Sichuan snub-nosed monkey(Rhinopithecus roxellana) population in the Shennongjia Nature Reserve(SNR) using a noninvasive sampling method based on 16 microsatellite loci.We also used a PCR-based genetic method to sex the sampled individuals and infer the population sex ratio.The population size of R.roxellana in the SNR was estimated to be 1044 individuals(95% CITIRM:613-1409) .The estimated population sex ratio is more female-biased than expected,which we attribute to the sampling biased towards one male units and limited sampling of bachelor male units.Moreover,there is no suggestion that the heavy traffic road through the reserve might block movement of monkeys.The results of this study indicate genetic assessments based on a noninvasive sampling method can provide useful in-formation regarding populations of elusive primates. | CHANG ZongFei LIU ZhiJin YANG JingYuan LIMing VIGILANT Linda | 2012 | Chinese Science Bulletin2012，57，10： | 7 |
| 4 | Predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome显示文摘AIM To analyze predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome(IBS) and their satisfaction with medical care.METHODS Participating patients met IBS Rome Ⅲ criteria(excluding those with organic diseases) and were enrolled in an IBS database in a tertiary university hospital. Participants completed IBS questionnaires in face-to-face interviews. The questionnaires covered intestinal and extra-intestinal symptoms, medical consultations, colonoscopy,medications, and self-reported response to medications during the whole disease course and in the past year. Univariate associations and multivariate logistic regression were used to identify predictors for frequent healthcareseeking behavior(≥ 3 times/year), frequent colonoscopies(≥ 2 times/year), long-term medications, and poor satisfaction with medical care.RESULTS In total, 516 patients(293 males, 223 females) were included. Participants' average age was 43.2 ± 11.8 years. Before study enrollment, 55.2% had received medical consultations for IBS symptoms. Ordinary abdominal pain/discomfort(non-defecation) was an independent predictor for healthcare-seeking behavior(OR = 2.07, 95%CI: 1.31-3.27). Frequent colonoscopies were reported by 14.7% of patients(3.1 ± 1.4 times per year). Sensation of incomplete evacuation was an independent predictor for frequent colonoscopies(OR = 2.76, 95%CI: 1.35-5.67). During the whole disease course, 89% of patients took medications for IBS symptoms, and 14.7% reported they were satisfied with medical care. Patients with anxiety were more likely to report dissatisfaction with medical care(OR = 2.08, 95%CI: 1.20-3.59). In the past year, patients with severe(OR = 1.74, 95%CI: 1.06-2.82) and persistent(OR = 1.66, 95%CI: 1.01-2.72) IBS symptoms sought medical care more frequently.CONCLUSION Chinese patients with IBS present high rates of frequent healthcare-seeking behavior, colonoscopies, and medications, and low satisfaction with medical care. Intestinal symptoms are major predictors for healthcare-seeking behavior. | Wenjuan Fan Dong Xu Min Chang Liming Zhu Guijun Fei Xiaoqing Li Xiucai Fang | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | In Situ Electrochemical Mn(Ⅲ)/Mn(Ⅳ) Generation of Mn(Ⅱ)O Electrocatalysts for High-Performance Oxygen Reduction显示文摘Among various earth-abundant and noble metal-free catalysts for oxygen reduction reaction(ORR),manganese-based oxides are promising candidates owing to the rich variety of manganese valence.Herein,an extremely facile method for the synthesis of cubic and orthorhombic phase coexisting Mn(Ⅱ)O electrocatalyst as an efficient ORR catalyst was explored.The obtained MnO electrocatalyst with oxygen vacancies shows a significantly elevated ORR catalytic activity with a half-wave potential(E1/2) of as high as 0.895 V,in comparison with that of commercial Pt/C(E1/2=0.877 V).More impressively,the MnO electrocatalyst exhibits a marked activity enhancement after test under a constant applied potential for 1000 s thanks to the in situ generation and stable presence of high-valence manganese species(Mn^3+ and Mn^4+) during the electrochemical process,initiating a synergetic catalytic effect with oxygen vacancies,which is proved to largely accelerate the adsorption and reduction of O_2 molecules favoring the ORR activity elevation.Such an excellent ORR catalytic performance of this MnO electrocatalyst is applied in Zn-air battery,which shows an extra-high peak power density of 63.2 mW cm^-2 in comparison with that(47.4 m W cm^-2) of commercial Pt/C under identical test conditions. | Han Tian Liming Zeng Yifan Huang Zhonghua Ma Ge Meng Lingxin Peng Chang Chen Xiangzhi Cui Jianlin Shi | 2020 | Nano-Micro Letters2020，12，11： | 2 |
| 7 | Disruption of crosstalk between LX-2 and liver cancer stem-like cells from MHCC97H cells by DFOG via inhibiting FOXM1显示文摘Hepatic stellate cell(HSC)line LX-2 is activated by liver cancer stem-like cells(LCSLCs)and produces various cytokines that make up most of the hepatocellular carcinoma(HCC)microenvironment.The new genistein derivative,7-difluoromethoxyl-5,4-dirboctylgenistein(DFOG),shows anticancer effects in multiple malignancies by controlling forkhead box M1(FOXM1).In this study,we aimed to assess whether DFOG disrupts the crosstalk between human HSC LX-2 cells and LCSLCs.Distinct gen erations of MHCC97H-derived spheres were obtained with the sec ond generation considered as LCSLCs which displayed enhanced self-renewal ability and elevated expression levels of CD133,CD44,and EpCAM proteins,as well as tumorigenicity,as revealed by colony formation assay in vitro and tumorigenicity assay in vivo.LX-2 and MHCC97H cells were co-cultured with/without DFOG(1,5,and 10 pM,respectively)using the transwell system.FOXM1 overexpression and/or knockdown were employed for mechanistic investigations.Our results suggested that Co-CM promoted LX-2 cell transformation into liver cancer-associated HSCs.Meanwhile,FOXM1 was up-regulated and the level of hepatocyte growth factor(HGF)was in creased in LX-2 cells and in the super nata nt after Co-CM stimulati on.Sphere and colony formation abilities in MHCC97H cells,and protein levels of CD133r CD44,and EpCAM,were also markedly elevated.DFOG dose-dependently inhibited the above effects,similar to FOXM1 knockdown in LX-2 cells.FOXM1 overexpression reversed the inhibitory effects of DFOG or FOXM1 knockdown or both on LX-2 cell activation and LCSLC feature induction in MHCC97H cells by LCSLC/LX-2 co-culture.This study demonstrated that DFOG disrupts the crosstalk between HSCs and LCSLCs to suppress LCSLC features via dowrrregulating FOXM1 expression and reducing HGF secretion in HSCs. | A Chen Chang Xu Yimin Luo Lihua Liu Kun Song Guangqi Deng Mengjie Yang Jianguo Cao Liming Yuan Xiang Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 2 |
| 8 | A hybrid lattice Boltzmann flux solver for integrated hypersonic fluid-thermal-structural analysis显示文摘In this paper,a hybrid Lattice Boltzmann Flux Solver(LBFS)with an improved switch function is proposed for simulation of integrated hypersonic fluid-thermal-structural problems.In the solver,the macroscopic Navier–Stokes equations and structural heat transfer equation are discretized by the finite volume method,and the numerical fluxes at the cell interface are reconstructed by the local solution of the Boltzmann equation.To compute the numerical fluxes,two equilibrium distribution functions are introduced.One is the D1Q4 discrete velocity model for calculating the inviscid flux across the cell interface of Navier–Stokes equations,and the other is the D2Q4 model for evaluating the flux of structural energy equation.In this work,a new dual thermal resistance model is proposed to calculate the thermal properties at the fluid–solid interface.The accuracy and stability of the present hybrid solver are validated by simulating several numerical examples,including the fluid-thermal-structural problem of cylindrical leading edge.Numerical results show that the present solver can accurately predict the thermal properties of hypersonic fluid-thermalstructural problems and has the great potential for solving fluid-thermal-structural problems of long-endurance high-speed vehicles. | Jiawei LI Jiangfeng WANG Liming YANG Chang SHU | 2020 | Chinese Journal of Aeronautics2020，33，9： | 1 |
| 9 | AerodynamicOptimization of Axial Turbomachinery Blades Using Par-allel Adaptive Range Differential Evolution and Reynolds-Averaged Navier-Stokes Solutions 显示文摘 | Song Liming Luo Chang Li Jun | 2011 | International Jour-nal for Numerical Methods in Biomedical Engineering2011，27，2： | 1 |
| 10 | DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells显示文摘 | ZHU Lin CHANG D W DAI Liming | 2007 | Nano Letters2007，7，12： | 1 |
| 11 | Effects of heat treatments on the microstructures and mechanical properties of Mg–3Nd–0.2Zn–0.4Zr (wt.%) alloy显示文摘 | Fu Penghuai Peng Liming Jiang Haiyan Chang Jianwei Zhai Chunquan | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 12 | Automated Multi-Objective and Multidisciplinary Design Optimiza- tion of a Transonic Turbine Stages 显示文摘 | SONG Liming LUO Chang Li Jun | 2012 | Journal of Power and Energy2012，226，2： | 1 |
| 13 | Emergency resources scheduling based on adaptively mutate genetic algorithm显示文摘 | Liming Zhang Yuhua Lin Guofeng Yang Huiyou Chang | 2011 | Computers in Human Behavior2011，，5： | 1 |
| 14 | Emergency resources scheduling based on adaptively mutate genetic algorithm显示文摘 | Liming Zhang Yuhua Lin Guofeng Yang Huiyou Chang | 2011 | Computers in Human Behavior2011，27，5： | 1 |
| 15 | Determination of L-Cystine by a New Sensitive Cucurbit[7]uril/palmatine Probe显示文摘面对葫芦[7 ] uril (CB [7 ]) , CB [7 ] 能与巴马亭反应,它用作一根敏感荧光探针,到形式主人客人,稳定的建筑群和建筑群的荧光紧张极大地被提高。荧光紧张在包括系统与越来越多的 L 胱氨酸线性地减少了。试验性的结果证明那在那里存在在为 CB 的 L 胱氨酸和巴马亭之间的一场比赛[7 ] 恐水病的洞和 L 胱氨酸占据 CB 的空间[7 ] 洞,要强迫居住在水的环境的领先的巴马亭分子。基于 CB 熄灭的荧光[7 ]/palmatine 建筑群源于在 CB 之间的复杂形成[7 ] 并且 L 胱氨酸,为在水的答案的 L 胱氨酸的决心的一个 spectrofluorimetric 方法面对 CB [7 ] 被开发。在熄灭 F 和 L 胱氨酸集中的荧光的相应价值之间的线性关系在 6.0 ~ 1.5 漠 ? 桴 ? 楦摤敬的范围被获得吗? | Yang, Jiyuan Du, Liming Wu, Hao Chang, Yinxia Li, Changfeng | 2011 | Chinese Journal of Chemistry2011，29，6： | 1 |
| 16 | Supramolecular interaction of cucurbit urils and coptisine by spectrofluofimetry and its an- alyrical application 显示文摘 | Li Chang feng Du Liming Wu Wen ying | 2010 | Talanta2010，80，： | 1 |
| 17 | Topology Optimization with Aperiodic Load Fatigue Constraints Based on Bidirectional Evolutionary Structural Optimization显示文摘Because of descriptive nonlinearity and computational inefficiency,topology optimization with fatigue life under aperiodic loads has developed slowly.A fatigue constraint topology optimization method based on bidirectional evolutionary structural optimization(BESO)under an aperiodic load is proposed in this paper.In viewof the severe nonlinearity of fatigue damagewith respect to design variables,effective stress cycles are extracted through transient dynamic analysis.Based on the Miner cumulative damage theory and life requirements,a fatigue constraint is first quantified and then transformed into a stress problem.Then,a normalized termination criterion is proposed by approximatemaximum stress measured by global stress using a P-normaggregation function.Finally,optimization examples show that the proposed algorithm can not only meet the requirements of fatigue life but also obtain a reasonable configuration. | Yongxin Li Guoyun Zhou Tao Chang Liming Yang Fenghe Wu | 2022 | Computer Modeling in Engineering & Sciences2022，，1： | 1 |
| 18 | Study on the inclusion interaction of cucurbit urils with sanguinarine by spectrofluorimetry and its analytical application显示文摘 | Li Chang feng Du Liming Zhang Hui ming | 2010 | Spectrochimica Acta Part A2010，75，： | 1 |
| 19 | Automated multi-objective and multidisciplinary design optimization of a transonic turbine stage显示文摘 | SONG Liming LUO Chang LI Jun | | 0，，： | 1 |
| 20 | Preparation and electrosorption desalination performance of activated carbon electrode with titanian显示文摘 | Liming Chang Xiaoyue Duan Wei Liu | 2011 | Desalination2011，270，： | 1 |
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