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| 1 | Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination:Successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface显示文摘Coronavirus disease 2019(COVID-19)pandemic has spread in 220 countries/regions towreak havoc to human beings around theworld.At present,the second wave of COVID-19 has begun in many European countries.The complete control of COVID-19 is very urgent.Although China quickly brought the virus under control,there have been eight sporadic outbreaks in China since then.Both in Xinfadi of Beijing and Dalian outbreak of COVID-19,environmental swab samples related to imported cold chain food were tested nucleic acid positive for SARS-CoV-2.In this outbreak in Qingdao,we directly isolated SARS-CoV-2 from the cod outer package's surface swab samples.This is the first time worldwide,SARS-CoV-2 were isolated from the imported frozen cod outer package's surface,which showed that imported frozen food industry could import SARS-CoV-2 virus. | Peipei Liu Mengjie Yang Xiang Zhao Yuanyuan Guo Liang Wang Jing Zhang Wenwen Lei Weifang Han Fachun Jiang William J.Liu George F.Gao Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 41 |
| 2 | Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses显示文摘适应免疫在肝炎 B 的控制起一个关键作用,这很好被接受病毒(HBV ) 感染。相反,天生的免疫的贡献仅仅在最近的年里收到了注意。像使用费的受体(TLR ) 察觉到联系病原体的分子模式并且激活抗病毒的机制,包括细胞内部的抗病毒的小径和抗病毒的受动器干扰素(IFN ) 和支持 inflammatory cytokines 的生产。从在 vitro 并且在 vivo 模型的试验性的结果证明了 TLR 调停细胞的发信号的小径和抗病毒的 cytokines 的生产的激活,导致 HBV 复制的抑制。然而, HBV 感染在主人房间和下游地表明小径的激活的封锁上与 TLR 表示的 downregulation 被联系。在主要 HBV 感染, TLR 可以减慢 HBV 感染,但是仅仅间接地作出贡献到病毒的清理。重要地, TLR 可以在 vivo 调制 HBV 特定的 T 房间和 B 房间回答,它为 HBV 感染的结束是必要的。因此, TLR 收缩筋正在答应候选人为长期的 HBV 感染的处理充当 immunomodulators。抗病毒的处理可以在长期的 HBV 感染恢复 TLR 表示和功能并且可以基于 TLR 激活增加治疗学的途径的功效。有抗病毒的治疗和 TLR 激活的联合治疗学的策略能便于 HBV 特定的有免疫力的回答的恢复并且从而,在长期地感染的 HBV 病人完成病毒的清理。 | Zhiyong Ma Ejuan Zhang Dongliang Yang Mengji Lu | 2015 | Cellular & Molecular Immunology2015，12，3： | 22 |
| 3 | Epidemiological Characteristics of Newly-Reported HIV Cases Among Youth Aged 15−24 Years-China, 2010−2019显示文摘Summary What is already known about this topic?An estimated 1,400 new cases of human immunodeficiency virus(HIV)occur every day among youths globally.However,HIV distribution among youth aged 15–24 years in China has not been researched extensively. | Hao Zhao Hui Liu Lu Wang Xuan Yang Shaorong Wang Mengjie Han Jian Li | 2020 | China CDC weekly2020，2，48： | 23 |
| 4 | Recent advances in energy storage mechanism of aqueous zinc-ion batteries显示文摘Aqueous rechargeable zinc-ion batteries(ZIBs)have recently attracted increasing research interest due to their unparalleled safety,fantastic cost competitiveness and promising capacity advantages compared with the commercial lithium ion batteries.However,the disputed energy storage mechanism has been a confusing issue restraining the development of ZIBs.Although a lot of efforts have been dedicated to the exploration in battery chemistry,a comprehensive review that focuses on summarizing the energy storage mechanisms of ZIBs is needed.Herein,the energy storage mechanisms of aqueous rechargeable ZIBs are systematically reviewed in detail and summarized as four types,which are traditional Zn^(2+)insertion chemistry,dual ions co-insertion,chemical conversion reaction and coordination reaction of Zn^(2+)with organic cathodes.Furthermore,the promising exploration directions and rational prospects are also proposed in this review. | Duo Chen Mengjie Lu Dong Cai Hang Yang Wei Han | 2021 | Journal of Energy Chemistry2021，30，3： | 12 |
| 5 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 6 | Stepwise-Nanocavity-Assisted Transmissive Color Filter Array Microprints显示文摘Visible-light color flters using patterned nanostructures have attracted much interest due to their various advantages such as compactness,enhanced stability,and environmental friendliness compared with traditional pigment or dye-based optical flters.While most existing studies are based on planar nanostructures with lateral variation in size,shape,and arrangement,the vertical dimension of structures is a long-ignored degree of freedom for the structural colors.Herein,we demonstrate a synthetic platform for transmissive color flter array by coordinated manipulations between height-varying nanocavities and their lateral flling fractions.Te thickness variation of those nanocavities has been fully deployed as an alternative degree of freedom,yielding vivid colors with wide gamut and excellent saturation.Experimental results show that the color-rendering capability of the pixelated nanocavities can be still retained as pixels are miniaturized to 500 nm.Crosstalk between closely spaced pixels of a Bayer color flter arrangement was calculated,showing minimal crosstalk for 1μm2 square subpixels.Our work provides an approach to designing and fabricating ultracompact color flter arrays for various potential applications including stained-glass microprints,microspectrometers,and high-resolution image sensing systems. | Yasi Wang Mengjie Zheng Qifeng Ruan Yanming Zhou Yiqin Chen Peng Dai Zhengmei Yang Zihao Lin Yuxiang Long Ying Li Na Liu Cheng-Wei Qiu Joel K.W.Yang Huigao Duan | 2018 | Research2018，，1： | 8 |
| 7 | A Case of Hepatitis B Reactivation due to the Hepatitis B Virus Escape Mutant in a Patient undergoing Chemotherapy显示文摘A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis.At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg),antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc),while antibody to hepatitis B surface antigen (anti-HBs) and HBV DNA were negative.Later the patient received chemotherapy for malignancy.However,this was interrupted due to elevated liver enzymes.At the same time HBV DNA became positive.Lamivudine (LMV) therapy was administered immediately.However,the levels of serum aminotransferase and total bilirubin (TB) were still rising.Finally the patient died of fulminant hepatic failure.A sequence revealed HBV genotype C (HBsAg subtype adw) with immune escape mutations,F8L,S34L,F41S,G44V,F93C,V96G,L110I,C149Y and F161Y.The high morbidity and mortality of this complication is one of the major obstacles to completing the standard treatment for malignancy in HBV carriers.Therefore,the relative risk of antiviral prophylactic failure should be further assessed and the optimal strategy for antiviral prophylaxis in HBsAg-positive patients with oncologic and hematologic malignancies undergoing chemotherapy should be revised. | Chunchen Wu Hui Shi Yun Wang Mengji LU Yang Xu Xinwen Chen | 2012 | Virologica Sinica2012，27，6： | 7 |
| 8 | 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1显示文摘 | Huirong Yang Jia Wang Mengjie Liu Xizi Chen Min Huang Dan Tan Meng-Qiu Dong Catherine C. L, Wong Jiawei Wang Yanhui Xu Hong-Wei Wang | 2016 | Protein & Cell2016，7，12： | 7 |
| 9 | Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle显示文摘mRNA is a novel class of therapeutic modality that holds great promise in vaccination,protein replacement therapy,cancer immunotherapy,immune cell engineering etc.However,optimization of mRNA molecules and efficient in vivo delivery are quite important but challenging for its broad application.Here we present an ionizable lipid nanoparticle(iLNP)based on iBL0713 lipid for in vitro and in vivo expression of desired proteins using codon-optimized mRNAs.mRNAs encoding luciferase or erythropoietin(EPO)were prepared by in vitro transcription and formulated with proposed iLNP,to form iLP171/mRNA formulations.It was revealed that both luciferase and EPO proteins were successfully expressed by human hepatocellular carcinoma cells and hepatocytes.The maximum amount of protein expression was found at 6 h post-administration.The expression efficiency of EPO with codon-optimized mRNA was significantly higher than that of unoptimized mRNA.Moreover,no toxicity or immunogenicity was observed for these mRNA formulations.Therefore,our study provides a useful and promising platform for mRNA therapeutic development. | Tongren Yang Chunhui Li Xiaoxia Wang Deyao Zhao Mengjie Zhang Huiqing Cao Zicai Liang Haihua Xiao Xing-Jie Liang Yuhua Weng Yuanyu Huang | 2020 | Bioactive Materials2020，5，4： | 7 |
| 10 | MOF-derived ZnCo_2O_4/C wrapped on carbon fiber as anode materials for structural lithium-ion batteries显示文摘To meet the requirements for the mechanical and electrochemical performance for carbon fiber-based (CF-based) composites in the structural lithium ion batteries (SLIBs) application, better CF-Based composites are urgently needed. Herein, we report a novel composite metal organic framework (MOF)-derived ZnCo_2 O_4/C@carbon fiber via a facile method and subsequent annealing treatment. In this anode,the nano ZnCo_2 O_4/C coatings wrapped on the surface of CF provide more active sites for electrode reactions and the thin carbon layers give the additional protection. For this material, after 100 cycles, it exhibits excellent cycling stability including high reversible capacity of 463 mAh/g at 50 mA/g, which increases 201% than that of the CF. Thus, this structural anode material exhibits enhanced capacity, high initial columbic efficiency. | Huagen Li Shubin Wang Mengjie Feng Jiping Yang Boming Zhang | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 11 | Methylation of RAR-β2, RASSF1A, and CDKN2A Genes Induced by Nickel Subsulfide and Nickel-carcinogenesis in Rats显示文摘Objective To investigate the expression variation of RAR‐β2, RASSF1A, and CDKN2A gene in the process of nickel‐induced carcinogenesis. Methods Nickel subsulfide (Ni 3 S 2 ) at dose of 10 mg was given to Wistar rats by intramuscular injection. The mRNA expression of the three genes in induced tumors and their lung metastasis were examined by Real‐time PCR. The methylation status of the 5' region of these genes were detected by Quantitative Real‐time methylation specific PCR. Results The mRNA expressions of the three genes both in muscle and lung tumor were decreased distinctly in comparison with normal tissue. But hypermethylation was found only in muscle tumor. Conclusion These findings suggest that loss of function or decrease of RAR‐β2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure. | ZHANG Jun ZHANG Jing LI MengJie Wu YouJun FAN YingYing ZHOU Yang TAN LiLi SHAO ZhiHua SHI HongJun | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 12 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 13 | Solvent engineering towards scalable fabrication of high-quality perovskite films for efficient solar modules显示文摘Over the last decade,remarkable progress has been made in metal halide perovskite solar cells(PSCs),which have been a focus of emerging photovoltaic techniques and show great potential for commercialization.However,the upscaling of small-area PSCs to large-area solar modules to meet the demands of practical applications remains a significant challenge.The scalable production of high-quality perovskite films by a simple,reproducible process is crucial for resolving this issue.Furthermore,the crystallization behavior in the solution-processed fabrication of perovskite films can be strongly influenced by the physicochemical properties of the precursor inks,which are significantly affected by the employed solvents and their interactions with the solutes.Thus,a comprehensive understanding of solvent engineering for fabricating perovskite films over large areas is urgently required.In this paper,we first analyze the role of solvents in the solution-processed fabrication of large-area perovskite films based on the classical crystal nucleation and growth mechanism.Recent efforts in solvent engineering to improve the quality of perovskite films for solar modules are discussed.Finally,the basic principles and future challenges of solvent system design for scalable fabrication of high-quality perovskite films for efficient solar modules are proposed. | Zhaoyi Jiang Binkai Wang Wenjun Zhang Zhichun Yang Mengjie Li Fumeng Ren Tahir Imran Zhenxing Sun Shasha Zhang Yiqiang Zhang Zhiguo Zhao Zonghao Liu Wei Chen | 2023 | Journal of Energy Chemistry2023，，5： | 4 |
| 14 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 15 | 联吡啶嗡盐共价有机框架材料合成与选择性捕获放射性高鍀酸根显示文摘具有高比表面积及规则孔道结构的离子型共价有机框架(COF)材料表现出广泛的应用前景.本文设计合成了一种基于联吡啶嗡盐的阳离子型COF材料(PS-COF-1).PS-COF-1比表面积为2703 m^(2) g^(-1),高于目前报道的其他离子型COF材料.PS-COF-1具有固定的一维通道(~4.5 nm)、良好的化学稳定性和耐辐照稳定性,表现出优异的吸附ReO_(4)^(-)(最大吸附量为1262 mg g^(-1))和^(99)TcO_(4)^(-)性能.进一步研究表明,PS-COF-1在高离子强度下表现出快速吸附动力学、高吸附容量和对^(99)TcO_(4)^(-)和ReO_(4)^(-)的高选择性,在模拟美国汉福德低活性废物流条件下成功选择性去除了^(99)TcO_(4)^(-).此外,PS-COF-1能够在10 min内将ReO_(4)^(-)和^(99)TcO_(4)^(-)污染水净化至饮用水级别.密度泛函理论计算表明,PS-COF-1对低电荷密度阴离子ReO_(4)^(-)和^(99)TcO_(4)^(-)具有强的亲和力(优于其他常见阴离子,如Cl^(-),NO_(3)^(-),SO_(4)^(2-),CO_(3)^(2-)),阐明了PS-COF-选择性吸附^(99)TcO_(4)^(-)的机理.本文展示了一种用于选择性捕获放射性核素新型阳离子COF吸附剂,为放射性污染治理提供了重要的理论依据和指导. | Mengjie Hao Zhongshan Chen Hui Yang Geoffrey I.N.Waterhouse Shengqian Ma Xiangke Wang | 2022 | Science Bulletin2022，67，9： | 3 |
| 16 | CRISPR/Cas9-based tools for targeted genome editing and replication control of HBV显示文摘Hepatitis B virus(HBV) infection remains a major global health problem because current therapies rarely eliminate HBV infections to achieve a complete cure. A different treatment paradigm to effectively clear HBV infection and eradicate latent viral reservoirs is urgently required. In recent years, the development of a new RNA-guided gene-editing tool, the CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9) system, has greatly facilitated site-specific mutagenesis and represents a very promising potential therapeutic tool for diseases, including for eradication of invasive pathogens such as HBV. Here, we review recent advances in the use of CRISPR/Cas9, which is designed to target HBV specific DNA sequences to inhibit HBV replication and to induce viral genome mutation, in cell lines or animal models. Advantages, limitations and possible solutions, and proposed directions for future research are discussed to highlight the opportunities and challenges of CRISPR/Cas9 as a new, potentially curative therapy for chronic hepatitis B infection. | Cheng Peng Mengji Lu Dongliang Yang | 2015 | Virologica Sinica2015，30，5： | 2 |
| 17 | Role of Toll-like receptor 2 in the immune response against hepadnaviral infection显示文摘 | Xiaoyong Zhang Zhiyong Ma Hongyan Liu Jia Liu Zhongji Meng Ruth Broering Dongliang Yang Joerg F. Schlaak Michael Roggendorf Mengji Lu | 2012 | Journal of Hepatology2012，，3： | 2 |
| 18 | Estimating leaf mercury content in Phragmites australis based on leaf hyperspectral reflectance显示文摘Introduction:Highmercury(Hg)concentrations affect the chlorophyll in leaves,therebymodifying leaf spectra.Hyperspectra is a promising technique for the rapid,nondestructive evaluation of leaf Hg content.In this study,we investigated Hg contents and reflective hyperspectra of reed leaves(Phragmites communis)in a gold mining(Jilin province,China).Spectral parameters sensitive to Hg content were identified through basic spectral transformations,continuous wavelet transformation(CWT),and spectral indices techniques.Leaf Hg inversion models were developed using stepwise multiple linear regression,partial least squares regression,and random forest algorithms.Outcomes:The results indicated that:1)leaf Hg content decreased with increasing distance from the mine:Jiapigou(JPG)>Erdaocha(EDC)>Laojingchang(LJC)>Erdaogou(EDG)>Lingqian(LQ)>Weishahe(WSH).2)Hg–sensitive wavelengths were primarily in the visible region;CWT increased the correlation between hyperspectral data and leaf Hg content,and improved the regression and accuracy of inversion;3)the continuumremoval–CWT–stepwise multiple linear regression was better for estimating low leaf Hg content;while the differential spectral index–partial least squares regression was better for estimating high leaf Hg content.Conclusion:These hyperspectral inversion methods could be used for rapid,nondestructive monitoring of wetland plants. | Weiwei Liu Mengjie Li Manyin Zhang DaanWang Ziliang Guo Songyuan Long Si Yang Henian Wang Wei Li Yukun Hu Yuanyun Wei Hongye Xiao | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
| 19 | A Case of Hepatitis B Reactivation in an Anti-HBs Positive,Anti-HBc Positive non-Hodgkin’s Lymphoma Patient显示文摘Dear Editor,We report a case of HBV reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin’s lymphoma patient. Hepatitis B virus (HBV) reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas. The presence of antibodies to the | Chunchen Wu Hui Shi Mengji Lu Yang Xu Xinwen Chen | 2013 | Virologica Sinica2013，28，1： | 2 |
| 20 | Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy显示文摘CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool,that relies on Cas9 protein and single guided RNA(sgRNA)to edit target DNA.However,the lack of safe and efficient delivery carrier is one of the crucial factors restricting its clinical transformation.Here,we report an ionizable lipid nanoparticle(iLP181,pKa=6.43)based on iLY1809 lipid enabling robust gene editing in vitro and in vivo.The iLP181 effectively encapsulate psgPLK1,the best-performing plasmid expressing for both Cas9 protein and sgRNA targeting Polo-like kinase 1(PLK1).The iLP181/psgPLK1 nanoformulation showed uniformity in size,regular nanostructure and nearly neutral zeta potential at pH 7.4.The nanoformulation effectively triggered editing of PLK1 gene with more than 30%efficiency in HepG2-Luc cells.iLP181/psgPLK1 significantly accumulated in the tumor for more than 5 days after a single intravenous injection.In addition,it also achieved excellent tumor growth suppression compared to other nucleic acid modalities such as siRNA,without inducing adverse effects to the main organs including the liver and kidneys.This study not only provides a clinically-applicable lipid nanocarrier for delivering CRISPR/Cas system(even other bioactive molecules),but also constitutes a potential cancer treatment regimen base on DNA editing of oncogenes. | Chunhui Li Tongren Yang Yuhua Weng Mengjie Zhang Deyao Zhao Shuai Guo Bo Hu Wanxuan Shao Xiaoxia Wang Abid Hussain Xing-Jie Liang Yuanyu Huang | 2022 | Bioactive Materials2022，7，3： | 2 |
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