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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 4 | Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair显示文摘The critical factor determining the in vivo effect of bone repair materials is the microenvironment,which greatly depends on their abilities to promote vascularization and bone formation.However,implant materials are far from ideal candidates for guiding bone regeneration due to their deficient angiogenic and osteogenic microenvironments.Herein,a double-network composite hydrogel combining vascular endothelial growth factor(VEGF)-mimetic peptide with hydroxyapatite(HA)precursor was developed to build an osteogenic microenvironment for bone repair.The hydrogel was prepared by mixing acrylatedβ-cyclodextrins and octacalcium phosphate(OCP),an HA precursor,with gelatin solution,followed by ultraviolet photo-crosslinking.To improve the angiogenic potential of the hydrogel,QK,a VEGF-mimicking peptide,was loaded in acrylatedβ-cyclodextrins.The QK-loaded hydrogel promoted tube formation of human umbilical vein endothelial cells and upregulated the expression of angiogenesis-related genes,such as Flt1,Kdr,and VEGF,in bone marrow mesenchymal stem cells.Moreover,QK could recruit bone marrow mesenchymal stem cells.Furthermore,OCP in the composite hydrogel could be transformed into HA and release calcium ions facilitating bone regeneration.The double-network composite hydrogel integrated QK and OCP showed obvious osteoinductive activity.The results of animal experiments showed that the composite hydrogel enhanced bone regeneration in skull defects of rats,due to perfect synergistic effects of QK and OCP on vascularized bone regeneration.In summary,improving the angiogenic and osteogenic microenvironments by our double-network composite hydrogel shows promising prospects for bone repair. | Jiaying Li Jinjin Ma Qian Feng En Xie Qingchen Meng Wenmiao Shu Junxi Wu Liming Bian Fengxuan Han Bin Li | 2023 | Research2023，，3： | 3 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | A hybrid lattice Boltzmann flux solver for integrated hypersonic fluid-thermal-structural analysis显示文摘In this paper,a hybrid Lattice Boltzmann Flux Solver(LBFS)with an improved switch function is proposed for simulation of integrated hypersonic fluid-thermal-structural problems.In the solver,the macroscopic Navier–Stokes equations and structural heat transfer equation are discretized by the finite volume method,and the numerical fluxes at the cell interface are reconstructed by the local solution of the Boltzmann equation.To compute the numerical fluxes,two equilibrium distribution functions are introduced.One is the D1Q4 discrete velocity model for calculating the inviscid flux across the cell interface of Navier–Stokes equations,and the other is the D2Q4 model for evaluating the flux of structural energy equation.In this work,a new dual thermal resistance model is proposed to calculate the thermal properties at the fluid–solid interface.The accuracy and stability of the present hybrid solver are validated by simulating several numerical examples,including the fluid-thermal-structural problem of cylindrical leading edge.Numerical results show that the present solver can accurately predict the thermal properties of hypersonic fluid-thermalstructural problems and has the great potential for solving fluid-thermal-structural problems of long-endurance high-speed vehicles. | Jiawei LI Jiangfeng WANG Liming YANG Chang SHU | 2020 | Chinese Journal of Aeronautics2020，33，9： | 1 |
| 7 | Outcome of Kidney Retransplantation and Associated Factors显示文摘 | Shu Han Youhua Zhu Liming Wang Li Zeng Meisheng Zhou Lei Zhang Shangx Fu | 2009 | 器官移植内科学杂志2009，4，1： | 1 |
| 8 | 查看详情显示文摘 | Liming Guan Shu Chen Yupeng Wang Zhong-Qi Ma | | 0，，16： | 1 |
| 9 | Is it safe to withdraw steroids within seven days of renal transplantation?显示文摘 | Xin Zhang Hejing Huang Shu Han Shangxi Fu Liming Wang | 2012 | Clin Transplant2012，，1： | 1 |
| 10 | Exact so-lution for infinitely strongly interacting Fermi gases in tightwaveguide 显示文摘 | Guan Liming Chen Shu Wang Yupeng | 2009 | Physical Review Letters2009，102，16： | 1 |
| 11 | Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development显示文摘Dear Editor,Necroptosis,a form of caspase-independent cell death,is tightly regulated to maintain tissue homeostasis.The execution of necroptosis depends on receptor interacting protein kinase 3(RIP3)-activated mixed lineage kinase domain-like protein(MLKL).MLKL is phosphorylated by RIP3,which releases MLKL autoinhibi-tion and drives its self-oligomerization.1-3 Oligomerized MLKL translocates to cellular membranes,where it disrupts membrane integrity causing necroptotic cell death. | Xinxin Zhu Na Yang Yu Yang Feiyang Yuan Dandan Yu Yu Zhang Zhaoqian Shu Ning Nan Hong Hu Xiaoyan Liu She Chen Liming Sun Huayi Wang | 2022 | Cell Research2022，32，4： | 1 |
| 12 | SAHA, an HDAC inhibitor, synergizes with tacrolimus to Prevent murine cardiac allograft rejection显示文摘Suberoylanilide hydroxamic 酸(SAHA ) 一个 histone deacetylase (HDAC ) 禁止者(HDACi ) ,最近被发现展出抑制免疫力的效果。然而,是否有拒绝和它的内在的机制尚待禁止 allograft 的 calcineurin 禁止者(CNI ) 的 SAHA 罐头 synergize 逃犯。在这研究,我们在延长 allograft 幸存在表明了 SAHA 的 synergistic 效果和 tacrolimus (FK506 ) 的非治疗学的剂量一鼠科心脏移植模型。伴随物 intragraft 检查表明从对待 SAHA 的接受者的 allografts 显著地证明 IL-17 表示的底层,和为 IL-17 表情的没有可辨别的差别被检测在之间对待 SAHA 并且 SAHA/FK506-treated allograft 作为与从对待 FK506 的动物的 allografts 相比。相反, FK506 的管理显著地压制了干扰素(IFN )-γ但是作为与对待 SAHA 的动物,和这效果的相比增加了 IL-10 表示独立于 SAHA。有趣地,有 FK506 到的 SAHA synergizes 支持 Foxp3 和 CTLA4 表示。在 vitro, SAHA 在孤立的 CD4 +T 房间减少了 Th17 房间的比例人口和 IL-17A, IL-17F, STAT3 和 RORγ 的减少的表情;在这些房间的 t。而且, SAHA 由 upregulating 提高规章的 T (Treg ) 房间的镇压功能没有影响 T 受动器房间增长的 CTLA-4 的表达式,并且由有选择地支持 T 受动器房间的 apoptosis 增加了 Treg 的比例。因此, SAHA, HDACi,可以是有与 CNI 药一起的潜在的利益的一个有希望的抑制免疫力的代理人。 | Xin Zhang Shu Hann Yindong Kang Meng Guo Shanjuan Hong Fang Liu Shangxi Fu Liming Wang Quan-Xing Wang | 2012 | Cellular & Molecular Immunology2012，9，5： | 1 |
| 13 | Therapeutic effectiveness of pediatric renal transplantation in 63 cases显示文摘ObjectiveTo 在小儿科的肾的移植探索操作,intra操作治疗和抑制免疫力的药的申请的特征以便改进治疗学的 effectiveness.MethodsFrom 1986年3月到2006年10月,在我们的医院里经历了肾的移植的 63 个孩子的临床的数据是回顾地 analyzed.ResultsThe 1-,3-,5-,10年的接枝幸存率分别地是98.4%,90.5%,88.9%和68.3%。并且相应耐心的幸存率是 100% , 95.2% , 92.1% , 71.4% 。体重增加了 4 ~ 12 kg,身高长大了 2 ~ 6 厘米在第一年期间移植以后。第一年里的主要复杂并发症移植以后是高血压( 26/63 ,41.3%),多毛( 14/63 ,22.2%),导致药的肝的损害( 11/63 ,17.5%),齿龈的增生( 10/63 ,15.8%),肺的感染( 9/63 ,14.3%),骨髓抑制( 5/63 ,7.9%),疱疹( 4/63 ,6.3%)并且糖尿病( 3/63 ,4.8%) .ConclusionRenal 移植是为在结束阶段的孩子的治疗的一个比较喜欢的方法肾的疾病( ESRD )。匹配的好织物,合适的起作用的时间和模式, peri-operactive 照顾对成功,以及适当抑制免疫力的药策略和好依从必要。 | Han Shu Wang Mu Zhu Youhua Zeng Li Zhou Meisheng zhang Lei Fu Shangxi Wang Liming | 2008 | Journal of Medical Colleges of PLA(China)2008，23，1： | 1 |
| 14 | Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment显示文摘Hepatocellular carcinoma(HCC)is a life-threatening disease for which there is no effective treatment currently.Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy.Herein,we develop the sialic acid(SA)modified polymeric micelles at an upper critical solution temperature(UCST)of 43℃(sialic acid-poly(ethylene glycol)-poly(acrylamide-co-acrylonitrile),SA-PEG-p(AAm-co-AN)),which further encapsulated with doxorubicin(DOX)and Gd-CuS nanoparticles(Gd-CuS NPs)for chemo-photothermal treatment of HCC guided by magnetic resonance(MR)/photoacoustic(PA)dual-mode imaging.The resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS(SPDG)had an excellent photothermal conversion efficiency,enabling SPDG with an instantaneous release behavior of DOX under near-infrared(NIR)irradiation.This study also revealed that SPDG could actively target to HCC,which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site.Moreover,benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX,SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment.Overall,our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics. | Yan Du Di Liu Mingchen Sun Gaofeng Shu Jing Qi Yuchan You Yiting Xu Kai Fan Xiaoling Xu Feiyang Jin Jun Wang Qiying Shen Luwen Zhu Xiaoying Ying Jiansong Ji Liming Wu Daren Liu Yongzhong Du | 2022 | Nano Research2022，15，3： | 0 |
| 15 | Cytotoxicity and genotoxicity of multi-walled carbon nanotubes with human ocular cells显示文摘Cytotoxicity and genotoxicity of plasma-modified multi-walled carbon nanotubes (MWCNTs), including hydroxyl-MWCNTs (MWCNT-OH), carboxyl-MWCNTs (MWCNT-COOH) and pristine MWCNTs, with human ocular cells (e.g. retinal pigment epithelium (RPE) cells) have been studied in this work. The addition of MWCNT-based materials caused few change in cell morphology while the presence of MWCNTs was observed inside the cells using transmission electron microscopy (TEM), suggesting possibility of MWCNTs passing through the cell membranes without damaging cells. Cell viability measurements suggested that MWCNT-COOH exhibited better biocompatibility than other MWCNT materials studied in this work. Lactate Dehydrogenase (LDH) release level was found to be less than 30% with all types of MWCNT-based materials. Reactive Oxygen Species (ROS) generation was visible but not severe with addition of nanotubes. A smaller oxidative stress level was obtained from MWCNT-COOH. Cell apoptosis was found to be less than 1.5% with addition of MWCNT-based materials. Particularly MWCNTs were found to be swallowed by cells and released by cells after 72 h without damaging cells, which may be considered as a potential vector for ocular genetic diseases. Plasma modification of MWCNTs particularly with-COOH was found to be an efficient way to improve ocular biocompatibility of MWCNTs, suggesting a fast and useful way to modify MWCNTs for applications in areas such as biology and biomedicine. | YAN Lu LI GuoXing ZHANG Shu SUN Fei HUANG XiaoJie ZHANG Qian DAI LiMing LU Fan LIU Yong | 2013 | Chinese Science Bulletin2013，58，19： | 0 |
| 16 | Systematic review of computational modelling for biomechanics analysis of total knee replacement显示文摘In vitro and in vivo testing can provide insight into knee joint mechanics and implant performance.However,these methods are costly and time-consuming,which always limits their widespread use during the design stage of the implant.This review presents a critical analysis of computational modelling(in-silicon)techniques including(i)development of a generic model of total knee replacement(TKR)and application of material properties,loading,and boundary conditions;(ii)design and execution of computational experiments;and(iii)practical applications and significant findings.The results show that the generic model and techniques provide significant insight into the general performance of TKR but have limited explicit validation.The introduction of design-of-experiments,probabilistic,and neural network methodologies in computational modelling has enabled simulation at the population level.Further advances in subjective modelling appear to be limited,mainly because of the lack of subjective materials and boundary conditions.Computational modelling will increasingly be used in the preclinical testing and design of TKR.This modelling should include subjective,multi-scale,and closely corroborated analyses to account for the variability of TKR. | Liming Shu Shihao Li Naohiko Sugita | 2020 | Biosurface and Biotribology2020，6，1： | 0 |
| 17 | Towards a shape-performance integrated digital twin for lumbar spine analysis[version 1;peer review:1 approved,1 not approved]显示文摘Background:With significant advancement and demand for digital transformation,the digital twin has been gaining increasing attention as it is capable of establishing real-time mapping between physical space and virtual space.In this work,a shape-performance integrated digital twin solution is presented to predict the real-time biomechanics of the lumbar spine during human movement.Methods:A finite element model(FEM)of the lumbar spine was firstly developed using computed tomography(CT)and constrained by the body movement which was calculated by the inverse kinematics algorithm.The Gaussian process regression was utilized to train the predicted results and create the digital twin of the lumbar spine in real-time.Finally,a three-dimensional virtual reality system was developed using Unity3D to display and record the real-time biomechanics performance of the lumbar spine during body movement.Results:The evaluation results presented an agreement(R-squared>0.8)between the real-time prediction from digital twin and offline FEM prediction.Conclusions:This approach provides an effective method of real-time planning and warning in spine rehabilitation. | Xiwang He Yiming Qiu Xiaonan Lai Zhonghai Li Liming Shu Wei Sun Xueguan Song | 2021 | Digital Twin2021，1，1： | 0 |
| 18 | X-Ray Fine Structure of a Limb Solar Flare Revealed by Insight-HXMT,RHESSI and Fermi显示文摘We conduct a detailed analysis of an M1.3 limb flare occurring on 2017 July 3,which have the X-ray observations recorded by multiple hard X-ray telescopes,including Hard X-ray Modulation Telescope(Insight-HXMT),Ramaty High Energy Solar Spectroscopic Imager(RHESSI),and the Fermi Gamma-ray Space Telescope(Fermi).Joint analysis has also used the extreme ultraviolet(EUV)imaging data from the Atmospheric Imaging Assembly(AIA)aboard the Solar Dynamic Observatory.The hard X-ray spectral and imaging evolution suggest a lower corona source,and the non-thermal broken power law distribution has a rather low break energy~15 keV.The EUV imaging shows a rather stable plasma configuration before the hard X-ray peak phase,and accompanied by a filament eruption during the hard X-ray flare peak phase.Hard X-ray image reconstruction from RHESSI data only shows one foot point source.We also determined the DEM for the peak phase by SDO/AIA data.The integrated EM beyond 10 MK at foot point onset after the peak phase,while the>10 MK source around reconnection site began to fade.The evolution of EM and hard X-ray source supports lower corona plasma heating after non-thermal energy dissipation.The combination of hard X-ray spectra and images during the limb flare provides the understanding on the interchange of non-thermal and thermal energies,and relation between lower corona heating and the upper corona instability. | Ping Zhang Wei Wang Yang Su Shuangnan Zhang Liming Song Fangjun Lu Shu Zhang | 2022 | Research in Astronomy and Astrophysics2022，22，5： | 0 |
| 19 | Influence of Delayed Renal Allograft Function (DGF) to Transplant Kidney Livability显示文摘 | Li Zeng Youhua Zhu Liming Wang Meisheng Zhou Lei Zhang Shu Han Hong Meng. | 2008 | 器官移植内科学杂志2008，3，4： | 0 |
| 20 | Intravenous prograf in maintenance treatment of intestinal obstruction complicated with hepatic function injury after renal transplantation: a case report显示文摘For renal transplant recipients, intestinal obstruction caused by incisional hernia is a rarely encountered event. Until now, there is no specific literature concerning the adjustment of immunosuppressants under such clinical condition. We present such a case who received a successful long-term single intravenous prograf administration to transitionally maintain the immunosuppression. | Zhang Xin Han Shu Fu Shangxi Zhou Meisheng Wang Liming | 2011 | Journal of Medical Colleges of PLA(China)2011，26，5： | 0 |
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