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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis显示文摘补充 5a (C5a ) 被导致 neutrophils 的功能的缺陷在败血的致病含有;然而, C5a 受体的用途(C5aRs;C5aR 和 C5L2 ) 因为为败血的管理的 biomarkers 是不明确的。这研究在嗜中性的功能上在 neutrophils 和他们的效果上调查了 C5aR 和 C5L2 的动态表示。我们发现败血病人与健康、全身的煽动性的反应相比在 neutrophils 上显示了 C5aR 和 C5L2 的低表示层次症候群(先生) 题目,和这个表示模式与疾病严厉被相关。另外, C5aR 和 C5L2 的表示层次与败血病人的幸存被联系。在 vitro, C5a 的增加显著地从败血病人在 neutrophils 减少了 C5aR 和 C5L2 表示层次和 IL-8 生产。那些调查结果建议 C5aRs 的减少的表示为败血病人与 neutrophils 和差的预后的功能的缺陷被联系。总的来说,这些调查结果可以帮助作为早标记建立 C5aRs 表示层次预言败血的严厉。 | Ruonan Xu Fang Lin Chunmei Bao Huihuang Huang Chengcheng Ji Siyu Wang Lei Jin Lijian Sun Ke Li Zheng Zhang Fu-Sheng Wang | 2016 | Cellular & Molecular Immunology2016，13，1： | 10 |
| 3 | Curcumin protects against ischemic spinal cord injury The pathway effect显示文摘Inducible nitric oxide synthase and N-methyl-D-aspartate receptors have been shown to participate in nerve cell injury during spinal cord ischemia.This study observed a protective effect of curcumin on ischemic spinal cord injury.Models of spinal cord ischemia were established by ligating the lumbar artery from the left renal artery to the bifurcation of the abdominal aorta.At 24 hours after model establishment,the rats were intraperitoneally injected with curcumin.Reverse transcription-polymerase chain reaction and immunohistochemical results demonstrated that after spinal cord ischemia,inducible nitric oxide synthase and N-methyl-D-aspartate receptor mRNA and protein expression significantly increased.However,curcumin significantly decreased inducible nitric oxide synthase and N-methyl-D-aspartate receptor mRNA and protein expression in the ischemic spinal cord.Tarlov scale results showed that curcumin significantly improved motor function of the rat hind limb after spinal cord ischemia.The results demonstrate that curcumin exerts a neuroprotective effect against ischemic spinal cord injury by decreasing inducible nitric oxide synthase and N-methyl-D-aspartate receptor expression. | Jinhua Zhang Hao Wei Meimei Lin Chunmei Chen Chunhua Wang Maobai Liu | 2013 | Neural Regeneration Research2013，8，36： | 9 |
| 4 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 5 | Effects of antisense CENP-B on the proliferation of HeLa (Tet-off) cells显示文摘In order to study the change of the expression of centromere protein B (CENP-B) caused by antisense transfection, proto-eukaryotically expressed fused protein GST-CENP-B (65 ku) was injected into mouse, and a peculiar anti-CENP-B serum MaCenpB was collected. A strain of transfected HeLa Tet-off cell HaCb, which contains antisense CENP-B expressing vector pBI-EGFP-as-CenpB, was prepared. Northern blot and Western blot were used to analyze the repression of internal CENP-B in transfected cells. According to the growth curve, the proliferation of HeLa (Tet-off) is repressed by antisense CENP-B, and the multiplication time is prolonged for 32.81 h. The analysis of flow cytometry revealed that, compared with HeLa (Tet-off), the G1 cell population of HaCb is increased (AG1=9%) while S fraction is decreased (AS=11%), but the G2/M phase is nearly unchanged (AG2/M=3%). In the meanwhile, the mi-totic index of HaCb declines greatly compared with that of HeLa (Tet-off). Immunofluorescence showed that the | Qianjin Liang Qian Wang Haiyan Lin Song Luo Chunmei Wang Dacheng He Yongchao Wang | 2002 | Chinese Science Bulletin2002，47，5： | 5 |
| 6 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 7 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 8 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 9 | Residual oil evolution based on displacement characteristic curve显示文摘The purpose of this study was to determine the displacement and dynamic distribution characteristics of the remaining oil in the two development stages of water flooding and subsequent alkaline surfactant polymer(ASP) flooding. The well pattern types in the water and ASP flooding stages are a longdistance determinant well pattern and short-distance five-point well pattern, respectively. The type A displacement characteristic curve can be obtained using the production data, and the slope of the straight-line section of the curve can reflect the displacement strength of the oil displacement agent. A numerical simulation was carried out based on the geological model. The results revealed that the injected water advances steadily with a large-distance determinant water-flooding well pattern. The single-well water production rate increases monotonically during water flooding. There is a significant positive correlation between the cumulative water-oil ratio and the formation parameter. Differential seepage between the oil and water phases is the main factor causing residual oil formation after water flooding, while the residual oil is still relatively concentrated. The effect of the chemical oildisplacement agent on improving the oil-water two-phase seepage flow has distinct stages during ASP flooding. The remaining oil production is extremely sporadic after ASP flooding. | Duanchuan Lyu Chengyan Lin Lihua Ren Chunmei Dong Jinpeng Song | 2020 | International Journal of Mining Science and Technology2020，30，3： | 2 |
| 10 | Effects of friction stir processing on the microstructure and superplasticity of in situ nano-ZrB_2/2024Al composite显示文摘In this study, in situ nano-ZrB_2/2024 Al composites fabricated from 2024Al–K_2ZrF_6–KBF_4 system were processed by friction stir processing(FSP) to achieve superplasticity of the composites. And the effects of particle contents(1 wt%, 3 wt%, 5 wt%), matrix grain size(micron or submicron), strain rates(5×10^(-3)s^(-1), 1×10^(-2)s^(-1), 2×10^(-2)s^(-1) and deformation temperatures(400 K, 480 K, 600 K, 700 K, 750 K) on the superplasticity of the composites were investigated. After the friction stir processing, the coarse grains of the cast composites with matrix grain size of about 80–100 μm and nano-Zr B2 reinforcement size of 30–100 nm were crushed into small grains about 1 μm in size, and the uniformity of the nano-Zr B_2 reinforcements was also improved. And under the same superplastic tensile testing condition at the temperature of 750 K and strain rate of 5×10^(-3)s^(-1), the FSP nano 3 wt%Zr B_2/2024 Al composite exhibited an superplastic elongation of 292.5%, while the elongation of the corresponding cast composite was only less than 100%. Meanwhile, the m values of the FSP composites were always higher than the cast composites, especially the FSP composites with 3 wt% particles has the m value of 0.5321 i.e., the FSP composites should had better superplastic properties than cast ones. Furthermore, the FSP composites had higher apparent deformation activation energy(Q) than that of the lattice diffusion of pure aluminium, indicating that the deformation mechanisms of the FSP composites should be grain boundary sliding mechanisms. | Yutao Zhao Xizhou Kai Gang Chen Weili Lin Chunmei Wang | 2016 | Progress in Natural Science:Materials International2016，26，1： | 2 |
| 11 | The distribution law of re-malning oil in the fluvial sandstone reservoir with high water-cut: an example from the Zhong - 1 district in Gudao oil field 显示文摘 | Lin Chengyan Dang Chunmei Chen Li | 1998 | Scientia Geologica Sinica1998，7，3： | 1 |
| 12 | Apolipoprotein A-I mimetic peptide D-4F promotes human endothelial progenitor cell proliferation, migration, adhesion though eNOS/NO pathway显示文摘 | Zhengang Zhang Jianhua Qun Chunmei Cao Jun Wang Wei Li Yong Wu Lin Du Pei Zhao Kaizheng Gong | 2012 | Molecular Biology Reports2012，，4： | 1 |
| 13 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 14 | The distribution law of remaining oil in the fluvial sandstone reservoir with high water-ut an example from the zhong-1 district in Gudao oil field显示文摘 | Lin Chengyan Dong Chunmei Chen Li | 1998 | Scientia Geologica Sinica1998，7，3： | 1 |
| 15 | Learning fuzzy cognitive map based on im- mune algorithm显示文摘 | LIN Chunmei | 2007 | Wseas Transactions on Systems2007，6，3： | 1 |
| 16 | Naphthalene hydrogenation over Pt/TiO2-ZrO2 and the behavior of strong metalsupport interaction(SMSI)显示文摘 | Lu Chunmei Lin Yuming Wang Ikai | | 0，，： | 1 |
| 17 | The distribution law of remaining oil in the fluvial sandstone reservoir with high water-cut an example from the zhong-1 district in Gudao oil field显示文摘 | Lin Chengyan Dong Chunmei Chen Li | 1998 | Scientia Geologica Sinica1998，7，3： | 1 |
| 18 | Mechanical behaviours of sandstone containing intersecting fissures under uniaxial compression显示文摘Predicting rock cracking is important for assessing the stability of underground engineering.The effects of the intersecting angle a and the distribution orientation angleβof intersecting fissures on the uniaxial compressive strength and the failure characteristics of sandstone containing intersecting fissures are investigated through laboratory experiments and two-dimensional particle flow code(PFC2D).The relationship between the mechanical properties of sandstone and the intersecting angle a and the distribution orientation angleβis analysed.Crack initiation forms and the final failure modes are then categorised and determined via empirical methods.In addition,the cracking processes of intersecting fissures with different a andβvalues are discussed.The results show that variations in the peak stress,peak strain,average modulus,and crack initiation stress of sandstone containing intersecting fissures show a“moth”shape in the space of the a-β-mechanical parameters.Two crack initiation forms are identified:inner tip cracking(usually accompanied by one outer tip cracking)and only outer tips cracking.Two failure modes are observed:(1)the main fracture planes are created at the inner tip and one outer tip,and(2)the main fracture planes are formed at the two outer tips.Two main crack evolution processes of sandstone containing intersecting fissures under uniaxial compression are found.Approaches for quickly determining the crack initiation form and the failure mode are proposed.The combination of the determination equations for the crack initiation form and the failure mode can be used to predict the crack evolution.The approach for determining the crack evolution processes is hence proposed with acceptable precision. | Fei Xiong Xinrong Liu Xiaohan Zhou Guangyi Lin Dongshuang Liu Yafeng Han Bin Xu Chunmei He Zijuan Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 19 | Mechanism of C5a-induced immunologic derangement in sepsis显示文摘Sepsis is a life-threatening medical condition that triggers an uncontrolled inflammatory reaction and is caused by the entry of various microorganisms into the human bloodstream.Sepsis is mainly encountered in intensive care units(ICUs)due to the reduced immunological defenses of ICU patients.Approximately 1.5 million patients develop sepsis annually in industrialized countries. | Ruonan Xu Fang Lin Chunmei Bao Fu-Sheng Wang | 2017 | Cellular & Molecular Immunology2017，14，9： | 1 |
| 20 | Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases:a systematic review and meta-analysis显示文摘Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the rapy.We comprehensively evaluated the efficacy of mesenchymal stem cell-de rived extracellular vesicles in traumatic central nervous system diseases in this meta-analysis based on preclinical studies.Our meta-analysis was registered at PROSPERO(CRD42022327904,May 24,2022).To fully retrieve the most relevant articles,the following databases were thoro ughly searched:PubMed,Web of Science,The Cochrane Library,and Ovid-Embase(up to April 1,2022).The included studies were preclinical studies of mesenchymal stem cell-derived extracellular vesicles for traumatic central nervous system diseases.The Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE)’s risk of bias tool was used to examine the risk of publication bias in animal studies.After screening 2347studies,60 studies were included in this study.A meta-analysis was conducted for spinal co rd injury(n=52) and traumatic brain injury(n=8).The results indicated that mesenchymal stem cell-derived extracellular vesicles treatment prominently promoted motor function recovery in spinal co rd injury animals,including rat Basso,Beattie and Bresnahan locomotor rating scale scores(standardized mean difference [SMD]:2.36,95% confidence interval [CI]:1.96-2.76,P <0.01,I2=71%) and mouse Basso Mouse Scale scores(SMD=2.31,95% CI:1.57-3.04,P=0.01,I2=60%) compared with controls.Further,mesenchymal stem cell-de rived extracellular vesicles treatment significantly promoted neurological recovery in traumatic brain injury animals,including the modified N eurological Severity Score(SMD=-4.48,95% CI:-6.12 to-2.84,P <0.01,I2=79%) and Foot Fault Test(SMD=-3.26,95% CI:-4.09 to-2.42,P=0.28,I2=21%) compared with controls.Subgroup analyses showed that characteristics may be related to the therapeutic effect of mesenchymal stem cell-de rived extra cellular vesicles.For Basso,Beattie and Bresnahan locomotor rating scale scores,the efficacy of allogeneic mesenchymal stem cell-derived extracellular vesicles was higher than that of xenogeneic mesenchymal stem cell-derived extracellular vesicles(allogeneic:SMD=2.54,95% CI:2.05-3.02,P=0.0116,I2=65.5%;xenogeneic:SMD:1.78,95%CI:1.1-2.45,P=0.0116,I2=74.6%).Mesenchymal stem cellde rived extracellular vesicles separated by ultrafiltration centrifugation combined with density gradient ultra centrifugation(SMD=3.58,95% CI:2.62-4.53,P <0.0001,I2=31%) may be more effective than other EV isolation methods.For mouse Basso Mouse Scale scores,placenta-derived mesenchymal stem cell-de rived extracellular vesicles worked better than bone mesenchymal stem cell-derived extracellular vesicles(placenta:SMD=5.25,95% CI:2.45-8.06,P=0.0421,I2=0%;bone marrow:SMD=1.82,95% CI:1.23-2.41,P=0.0421,I2=0%).For modified Neurological Severity Score,bone marrow-derived MSC-EVs worked better than adipose-derived MSC-EVs(bone marrow:SMD=-4.86,95% CI:-6.66 to-3.06,P=0.0306,I2=81%;adipose:SMD=-2.37,95% CI:-3.73 to-1.01,P=0.0306,I2=0%).Intravenous administration(SMD=-5.47,95% CI:-6.98 to-3.97,P=0.0002,I2=53.3%) and dose of administration equal to 100 μg(SMD=-5.47,95% CI:-6.98 to-3.97,P <0.0001,I2=53.3%)showed better res ults than other administration routes and doses.The heterogeneity of studies was small,and sensitivity analysis also indicated stable results.Last,the methodological quality of all trials was mostly satisfactory.In conclusion,in the treatment of traumatic central nervous system diseases,mesenchymal stem cell-derived extracellular vesicles may play a crucial role in promoting motor function recovery. | Zhelun Yang Zeyan Liang Jian Rao Fabin Lin Yike Lin Xiongjie Xu Chunhua Wang Chunmei Chen | 2023 | Neural Regeneration Research2023，18，11： | 1 |
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