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| 1 | Insights on the solubilization products after combined alkaline and ultrasonic pre-treatment of sewage sludge显示文摘This work provides insights on the solubilization products after a simultaneous combination of alkaline and ultrasonic(ALK + ULS) pre-treatment of sewage sludge.Soluble chemical oxygen demand(SCOD) increased from 1200 to 11,000 mg/L after such treatment. Organics with molecular weight around 5.6 k Da were solubilized because of the synergistic effect of ultrasound and alkali. Organics with molecular weight larger than300 k Da increased from 7.8% to 60%, 16% and 42.3% after ULS, ALK and ALK + ULS treatment, respectively. Excitation emission matrix fluorescence spectroscopy analysis identified soluble microbial product-like and humic acid-like matters as the main solubilization products. Sludge anaerobic biodegradability was significantly enhanced with the simultaneous application of ALK + ULS pre-treatment. ALK + ULS pre-treatment resulted in 37.8% biodegradability increase compared to the untreated sludge. This value was higher compared to the biodegradability increase induced by individual ALK pre-treatment(5.7%) or individual ULS pre-treatment(20.7%) under the same conditions applied. | Xinbo Tian Chong Wang Antoine Prandota Trzcinski Leonard Lin Wun Jern Ng | 2015 | Journal of Environmental Sciences2015，27，3： | 19 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Smoking Behavior Among Secondary School Students--China, 2021显示文摘Summary What is already known about this topic?In 2019,China CDC conducted the National Youth Tobacco Survey among secondary school students,and the prevalence rates of ever,current,and frequent smoking were 17.9%,5.9%,and 1.8%,respectively.What is added by this report?The prevalence rate of cigarette use in males decreased largely from 2019 to 2021 in China,while it increased in 18 provincial-level administrative divisions(PLADs)for females.The tobacco control situation remains challenging among vocational senior high school(VSHS)students.Significant geographical disparities existed in cigarette use.What are the implications for public health practice?Targeted tobacco control policies aimed at VSHS students are needed,specifically those PLADs with higher smoking rates.Additionally,close attention should be paid to female smokers. | Xinying Zeng Xinbo Di Shiwei Liu Huiyu Xie Zida Meng Lin Xiao | 2022 | China CDC weekly2022，4，21： | 5 |
| 4 | Impact of ozone assisted ultrasonication pre-treatment on anaerobic digestibility of sewage sludge显示文摘Impact of ultrasonication(ULS) and ultrasonication–ozonation(ULS-Ozone) pre-treatment on the anaerobic digestibility of sewage sludge was investigated with semi-continuous anaerobic reactors at solid retention time(SRT) of 10 and 20 days. The control, ULS and ULS-Ozone reactors produced 256, 309 and 348 m L biogas/g CODfedand the volatile solid(VS) removals were 35.6%, 38.3% and 42.1%, respectively at SRT of 10 days. At SRT of20 days, the biogas yields reached 313, 337 and 393 m L biogas/g CODfedand the VS removal rates were 37.3%, 40.9% and 45.3% in the control, ULS and ULS-Ozone reactors, respectively.ULS-Ozone pre-treatment increased the residual organic amount in the digested sludge.These soluble residual organics were found to contain macromolecules with molecular weights(MW) larger than 500 k Da and smaller polymeric products with MW around 19.4and 7.7 k Da. These compounds were further characterized to be humic acid-like substances with fluorescent spectroscopy analysis. | Xinbo Tian Antoine Prandota Trzcinski Li Leonard Lin Wun Jern Ng | 2015 | Journal of Environmental Sciences2015，27，7： | 5 |
| 5 | Tobacco Use and Exposure Among Secondary School Students — China, 2019显示文摘Summary What is already known about this topic?Using the framework of the global youth tobacco survey(GYTS),China CDC conducted the first round of a national tobacco survey among junior high school(JHS)students in 2014,indicating that 17.9%and 5.9%of respondents were experimental and current cigarette smokers,respectively. | Shiwei Liu Lin Xiao Xinying Zeng Xinbo Di Xinhua Li | 2020 | China CDC weekly2020，2，22： | 4 |
| 6 | Flow stress of carbon steel 08F in temperature range of warm-forging 显示文摘 | Lin Xinbo Xiao Hongsheng Zhang Zhiliang | 2003 | Journal of Materials Processing Technology2003，139，： | 1 |
| 7 | Utilization of Smoking Cessation Support Among Adults-18 PLADs,China,2020显示文摘Summary What is already known about this topic?In 2018,unassisted smoking cessation(USC)was the predominant method for quitting smoking among Chinese adult smokers,accounting for 90.1%of cases.The utilization of professional smoking cessation support was comparatively low in this population.What was added by this report?In 2020,the prevalence of USC methods increased to 93.1%.Concurrently,there was a slight increase in the utilization of pharmaceuticals(from 4.6%in 2018 to 5.5%in 2020)and counseling and quit line services(from 3.2%in 2018 to 7.5%in 2020).On the other hand,the use of e-cigarettes as a cessation aid decreased from 14.9%in 2018 to 9.8%in 2020.Smokers aged 15–24 years old were more likely to rely on pharmaceutical interventions(7.9%),and less likely to choose USC methods(79.0%).What are the implications for public health practice?The promotion of professional cessation support is essential for enhancing smoking cessation rates. | Yongfu Yan Bingliang Lin Qingqing Xu Huiyu Xie Xinying Zeng Xinbo Di Zida Meng Lin Xiao Shiwei Liu | 2023 | China CDC weekly2023，5，21： | 1 |
| 8 | Tobacco Use and Cessation Among College Students--China, 2021显示文摘Summary What is already known about this topic?Previous studies about tobacco use among college students in China were conducted at the school level or city level,with fewer than 5,000 students participating.What is added by this report?In 2021,China CDC conducted a national tobacco survey targeting students enrolled in the public higher education system.Overall,124,119 students from 220 colleges and universities in 31 provincial-level administrative divisions participated in this survey.Current cigarette smoking,current daily smoking,willingness to quit,and smoking cessation among college students were explored.What are the implications for public health practice?The current daily cigarette smoking rate of college students was significantly higher than that of senior high school students,especially higher vocational college students.Tobacco control interventions,such as a smoke-free school policy and smoking cessation services,need to be reinforced on college campuses. | Huiyu Xie Xinbo Di Shiwei Liu Xinying Zeng Zida Meng Lin Xiao | 2022 | China CDC weekly2022，4，21： | 1 |
| 9 | Hot deformation behavior of Co-base ODS alloys显示文摘 | Lin Zhang Xuanhui Qu Xinbo He Din Rafi-ud Mingli Qin Hongmin Zhu | 2011 | Journal of Alloys and Compounds2011，，1： | 1 |
| 10 | Flow stress of carbon steel 08F in the temperature range of warm forging 显示文摘 | Lin Xinbo Zhang Zhiliang | 2003 | Journal of Materials Processing Technology2003，0103，： | 1 |
| 11 | Preparation of copper-diamond compos- ites with chromium carbide coatings on diamond particles for heat sink applieations显示文摘 | Qiping Kang Xinbo He Shubin Ren Lin Zhang MaoWu Caiyu Guo Wei Cui Xuanhui Qu | 2013 | 110( 1 - 2)2013，，： | 1 |
| 12 | Infiltra- tion mechanism of diamond/SiC composites fabricated by Si-va- por vacuum reactive infiltration process显示文摘 | Zhenliang Yang Xinbo He Mao Wu Lin Zhang An Ma Rongjun Liu Haifeng Hu Yudi Zhang Xuanhui Qu | 2013 | Journal of the Euro- pean Ceramic Society2013，33，： | 1 |
| 13 | LDL receptor-related protein 1 (LRP1),a novel target for opening the blood-labyrinth barrier(BLB)显示文摘Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide.However,the presence of the blood-labyrinth barrier(BLB)on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability,which restricts the entry of most drug compounds from the bloodstream into the inner ear tissue.Here,we report the finding of a novel receptor,low-density lipoprotein receptor-related protein 1(LRP1),that is expressed on the BLB,as a potential target for shuttling therapeutics across this barrier.As a proof-ofconcept,we developed an LRP1-binding peptide,IETP2,and covalently conjugated a series of model small-molecule compounds to it,including potential drugs and imaging agents.All compounds were successfully delivered into the inner ear and inner ear lymph,indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the BLB.The discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders. | Xi Shi Zihao Wang Wei Ren Long Chen Cong Xu Menghua Li Shiyong Fan Yuru Xu Mengbing Chen Fanjun Zheng Wenyuan Zhang Xinbo Zhou Yue Zhang Shiwei Qiu Liyuan Wu Peng Zhou Xinze Lv Tianyu Cui Yuehua Qiao Hui Zhao Weiwei Guo Wei Chen Song Li Wu Zhong Jian Lin Shiming Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 14 | Cigarette Package Warnings for Adult Smoking Cessation—China,2018显示文摘Summary What is already known about this topic?After the framework convention on tobacco control(FCTC)came into force,the health warnings on cigarette packaging in the mainland of China had been changed in three rounds.But the warning label is still only pure text and without descriptions of specific health consequences caused by tobacco use.What is added by this report?Although there were two rounds of changes from 2010 to 2018,current health warning labels did not work in increasing Chinese smokers’smoking cessation intention compared with the previous one.Large pictorial warning labels were more effective than the current health warning label in stimulating Chinese smoker’s willingness to quit. | Lin Xiao Xinbo Di Yi Nan Tianchu Lyu Yuan Jiang | 2020 | China CDC weekly2020，2，22： | 0 |
| 15 | PD-L1 regulates genomic stability via interaction with cohesin-SAl in the nucleus显示文摘Dear Editor,Programmed death ligand-1(PD-L1)is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells,inhibits T cell activity and proliferation,facilitates cancer cells to escape T cell-mediated immune surveillance.Immunotherapies by PD-L1/PD-1 blockade have shown effectiveness against different cancer types and revolutionizes cancer treatment in the clinic.However,the response rate to anti-PD-L1/PD-1 antibody remains at about 15-30%as a single agent.1 Thus,there is more to understand regarding the function of PD-L1 in cancer. | Wen Zhang Jiali Jin Yanjin Wang Lan Fanq Liu Min Xinbo Wang Lin Ding Linjun Weng Tan Xiao Tianhua Zhou Ping Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 0 |
| 16 | Prevalence and Determinants of Secondhand Smoke Exposure Among Adolescent Girls-China,2019显示文摘Summary What is already known about this topic?The rate of secondhand smoke(SHS)exposure among female junior high students in 2013-2014 in China was 69.9%.What is added by this report?The rate of SHS among adolescent girls in 2019 in China was 62.8%,with 60.8%in junior high and 65.3%in senior high school,meanwhile,higher SHS exposure was correlated to higher grade levels,senior high school over junior high school,urban areas,those with more pocket money,those who’ve attempted smoking,exposure to tobacco advertisements,those with parents who smoke,those with close friends who smoke,use of e-cigarettes,and belief that SHS exposure is detrimental to health.What are the implications for public health practice?The rate of SHS exposure among adolescent girls in China still remains extraordinarily high.Targeted public health initiatives to curb SHS exposure among adolescent girls are urgently needed in China. | Fulin Huang Xinying Zeng Xinbo Di Lin Xiao Shiwei Liu | 2022 | China CDC weekly2022，4，44： | 0 |
| 17 | Roadmap for rechargeable batteries:present and beyond显示文摘Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate change.Due to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable batteries.Tremendous efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow batteries.Despite the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a battery.This roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable batteries.New computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research. | Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan | 2024 | Science China Chemistry2024，67，1： | 0 |
| 18 | Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery显示文摘We exploited a unique porous structure of the nano-covalent triazinepolymer(NCTP)containing aggregation-induced emission(AlE)group to achievecontrolled release and drug tracking in tumor acidic microenvironment.NCTP wassynthesized by the Friedel-Crafts alkylation and the McMurry coupling reaction.It notonly had strong doxorubicin(DOX)-loading capacity due to its high specific surface areaand large pore volume,but also showed the significant cumulative drug release as aresult of the pH response of triazine polymers.NCTP was induced luminescence aftermass accumulation near tumor cells.Besides,it had excellent biocompatibility andobvious antineoplastic toxicity.The results demonstrate that NCTP as a utility-type drugcarrier provides a new route for designing the multi-functional drug delivery platform. | Yifan ZHANG Xueying PENG Xinbo JING Lin CUI Shengchao YANG Jianning WU Guihua MENG Zhiyong LIU Xuhong GUO | 2021 | Frontiers of Materials Science2021，15，1： | 0 |
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