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| 1 | Studies on the evolution process of rockbursts in deep tunnels显示文摘This paper focuses on the evolution processes of different types of rockbursts occurring in deep tunnels. A series of laboratory tests and in-situ monitoring in deep tunnels excavated by tunnel boring machine (TBM) and drill-and-blast (D&B) method have been conducted to understand the mechanisms and processes of the evolution of different types of rockbursts, including strain rockburst, strain-structure slip rockburst, immediate rockburst and time-delayed rockburst. Three different risk assessment methods are proposed to evaluate the intensity and potential failure depth of rockbursts. These methods can be applied before excavation and the results can be updated according to the real-time information during excavation. Two micro-seismicity based real-time warning systems have been established for predicting various intensities of rockbursts, such as slight, moderate, intensive and extremely intensive rockbursts. Meanwhile, the probability and intensity of the rockburst are also given. The strategy for excavation and support design has been suggested for various intensities of rockbursts before excavation. The strategy for dynamic control of the rockburst evolution process is also proposed according to the monitoring results. The methodology has been successfully applied to rockburst risk reduction for deep tunnels at Jinping II hydropower project. The results have illustrated the applicability of the proposed methodology and techniques concerning rockbursts. | Xiating Feng Bingrui Chen Shaojun Li Chuanqing Zhang Yaxun Xiao Guangliang Feng Hui Zhou Shili Qiu Zhouneng Zhao Yang Yu Dongfang Chen Huajun Ming | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 11 |
| 2 | Preparation and hydrogen gas sensitive characteristics of highly ordered titania nanotube arrays显示文摘In this paper, we report the growth and characteristics of titania nanotube arrays prepared by anodic oxidation and then annealed in an oxygen atmosphere at 500℃. The titania nanotube arrays presented high sensitivity to hydrogen gas. The crystalline phase of the samples was checked by X-ray diffraction (XRD). The differences in the nanotubes morphology attributed to the etched samples due to anodiza- tion potential, reaction time and the electrolyte concentration were analyzed by scanning electron mi- croscopy (SEM). The gas sensitive parameters of the samples were obtained from resistance, the re- sponse time and the recovery time at different temperatures. | JI HuiMing LU HuiXiang MA DongFang YU JianJun MA ShiCai | 2008 | Chinese Science Bulletin2008，53，9： | 7 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Fabrication of bilayer Pd-Pt nanocages with sub-nanometer thin shells for enhanced hydrogen evolution reaction显示文摘The hydrogen evolution reaction (HER),which generates molecular hydrogen through the electrochemical reduction of water,is an important clean-energy technology.Platinum (Pt) is an ideal material for HER electrocatalysts in terms of low overpotential and fast kinetics.An effective method to improve the atom utilization efficiency of Pt is to fabricate Pt-based core-shell or nanocage structures with ultra-thin walls.This paper describes the construction of bilayer palladium (Pd)-Pt alloy nanocages catalyst with enhanced HER catalytic activity.The nanocages were fabricated by etching away the Pd templates of multishelled nanocubes composed of alternate shells of Pd and Pt with well-defined (100) facets.The bilayer Pd-Pt nanocages with sub-nanometer shells have a high dispersion of the active atoms on the outside and inside surfaces of outer layer and inner layer,respectively.Moreover,the Pd-Pt alloy lowers the overpotential for HER and speeds up the reaction rate of HER due to the synergies between Pd and Pt.The rational design of bilayer nanocages provided a novel route for boosting the atom utilization efficiency of Pt catalysts. | Yihe Wang Lei Zhang Congling Hu Shengnan Yu Piaoping Yang Dongfang Cheng Zhi-Jian Zhao Jinlong Gong | 2019 | Nano Research2019，12，9： | 3 |
| 5 | The Helicobacter pylori Protein CagM is Located in the Transmembrane Channel That is Required for CagA Translocation显示文摘 | Feng Ling Xiaochun Wang DongFang Dai Min Yu Cheng Chen Jingyi Qian Chang Liu Yuanyuan Zhang Jie Ding Xian Wei Guan Shihe Shao | 2013 | Current Microbiology2013，，5： | 2 |
| 6 | Review on Additive Manufacturing of Single-Crystal Nickel-based Superalloys显示文摘The conventional fabrication process for single-crystal nickel-based superalloy materials is directional solidifica-tion,which is classified as casting.With the rapid development of additive manufacturing(AM)technologies,a novel process for fabricating single-crystal superalloys has become possible.This article reviews recent research on the AM of single-crystal nickel-based superalloys.Laser AM technologies,particularly directed energy deposition,are mainly used to repair single-crystal materials.Electron beam powder bed fusion is an innovative method for the direct fabrication of single-crystal materials.Accordingly,the mechanisms of single-crystal formation during AM are analyzed to elucidate the potential of this process route.Furthermore,this article discusses the challenges faced by AM for single-crystal fabrication,and provides perspectives on the trends of future developments. | Yang Li Xiaoyu Liang Yefeng Yu Dongfang Wang Feng Lin | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 2 |
| 7 | Research on Dielectric Focusing Lens Antenna for HPM Atmospheric Breakdown Experiments显示文摘To distinguish the dielectric surface breakdown from the atmospheric breakdown, one method for atmospheric breakdown experiment by loading dielectric focusing lens is proposed. The focusing characteristics of dielectric focusing lens are investigated for the microwave frequency on the order of 1.3GHz to 9.3GHz, the lens focal length on the order of 0.3m to 0.9m and the dielectric constant on the order of 0.3 to 0.9. Simulations show that higher frequency, shorter focal length, and fitter dielectric constant result in better focus effect that the rising and falling edges of electric field strength change faster near the focus which is closer to the theoretical value. A dielectric focusing lens for the S-band is optimally designed with the polytetrafluoroethylene of 0.32 m thickness, 0.6m diameter,and 0.4m focal length. The focus indicator of dielectric lens is measured and the atmospheric breakdown experiment is carried out. The experimental values of atmospheric breakdown are consistent with the theoretical values. The electric field strength with the lens at the focus is 5–6times greater than that without focusing lens. The image of atmospheric breakdown by the dielectric lens focusing method experiment is clearer than that by the direct radiation method. | YU Daojie CHAI Mengjuan ZHOU Dongfang ZHOU Changlin WEI Jinjin HU Junjie CAI Beibing ZHAO Tongcheng | 2019 | Chinese Journal of Electronics2019，28，1： | 1 |
| 8 | Unraveling Passivation Mechanism of Imidazolium-Based Ionic Liquids on Inorganic Perovskite to Achieve Near-Record-Efficiency CsPbI_(2)Br Solar Cells显示文摘The application of ionic liquids in perovskite has attracted wide-spread attention for its astounding performance improvement of perovskite solar cells(PSCs).However,the detailed mechanisms behind the improvement remain mysterious.Herein,a series of imidazolium-based ionic liquids(IILs)with different cations and anions is systematically investigated to elucidate the passivation mechanism of IILs on inorganic perovskites.It is found that IILs display the following advantages:(1)They form ionic bonds with Cs^(+)and Pb^(2+)cations on the surface and at the grain boundaries of perovskite films,which could effectively heal/reduce the Cs^(+)/I−vacancies and Pb-related defects;(2)They serve as a bridge between the perovskite and the hole-transport-layer for effective charge extraction and transfer;and(3)They increase the hydrophobicity of the perovskite surface to further improve the stability of the CsPbI_(2)Br PSCs.The combination of the above effects results in suppressed non-radiative recombination loss in CsPbI_(2)Br PSCs and an impressive power conversion efficiency of 17.02%.Additionally,the CsPbI_(2)Br PSCs with IILs surface modification exhibited improved ambient and light illumination stability.Our results provide guidance for an indepth understanding of the passivation mechanism of IILs in inorganic perovskites. | Jie Xu Jian Cui Shaomin Yang Yu Han Xi Guo Yuhang Che Dongfang Xu Chenyang Duan Wenjing Zhao Kunpeng Guo Wanli Ma Baomin Xu Jianxi Yao Zhike Liu Shengzhong Liu | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 9 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 10 | Renown Naphazoline Hydrochloride, Chlorphenamine Maleate and Vitamin Bl2 Eye Drops on asthenopia显示文摘 | Liu Zuguo Yu Dongfang Lin Yuesheng | 2005 | Chinese Journal of Optometry & Ophthalmology2005，7，1： | 1 |
| 11 | Online estimation of SOH for lithium-ion battery based on SSA-Elman neural network显示文摘The estimation of state of health(SOH)of a lithium-ion battery(LIB)is of great significance to system safety and economic development.This paper proposes a SOH estimation method based on the SSA-Elman model for the first time.To improve the correlation rates between features and battery capacity,a method combining median absolute deviation filtering and Savitzky-Golay filtering is proposed to process the data.Based on the aging characteristics of the LIB,five features with correlation rates above 0.99 after data processing are then proposed.Addressing the defects of the Elman model,the sparrow search algorithm(SSA)is used to optimize the network parameters.In addition,a data incremental update mechanism is added to improve the generalization of the SSA-Elman model.Finally,the performance of the proposed model is verified based on NASA dataset,and the outputs of the Elman,LSTM and SSA-Elman models are compared.The results show that the proposed method can accurately estimate the SOH,with the root mean square error(RMSE)being as low as 0.0024 and the mean absolute percentage error(MAPE)being as low as 0.25%.In addition,RMSE does not exceed 0.0224 and MAPE does not exceed 2.21%in high temperature and low temperature verifications. | Yu Guo Dongfang Yang Yang Zhang Licheng Wang Kai Wang | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 1 |
| 12 | Derivative Derivative-Based Envelope Design Technique for Wideband Envelope Tracking Power Amplifier with Digital Predistortion显示文摘A novel envelope design for an envelope tracking(ET)power amplifier(PA)based on its derivatives is proposed,which can trade well off between bandwidth reduc-tion and tracking accuracy.This paper theoretically analyzes how to choose an envelope design that can track the original envelope closely and reduce its bandwidth,and then demonstrates an example to validate this idea.The generalized memory polynomial(GMP)model is applied to compensate for the nonlinearity of ET PA with the proposed envelope design.Experiments are carried out on an ET system that is operated with the center fre-quency of 3.5 GHz and excited by a 20 MHz LTE signal,which show that the proposed en-velope design can make a good trade-off between envelope bandwidth and efficiency,and satisfactory linearization performance can be realized. | YI Xueya CHEN Jixin CHEN Peng NING Dongfang YU Chao | 2022 | ZTE Communications2022，20，S01： | 0 |
| 13 | Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis显示文摘The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and metastasis.Photothermal therapy(PTT)triggers the release of tumor-specific antigens and damage associated molecular patterns(DAMPs)in-situ.However,the immunosuppressive tumor microenvironment restrains the activity of the effector immune cells.Therefore,systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic effect.To this end,polyethylene glycol(PEG)-stabilized platinum(Pt)nanoparticles(Pt NPs)conjugated with a PD-L1 inhibitor(BMS-1)through a thermo-sensitive linkage were constructed.Upon near-infrared(NIR)exposure,BMS-1 was released and maleimide(Mal)was exposed on the surface of Pt NPs,which captured the antigens released from the ablated tumor cells,resulting in the enhanced antigen internalization and presentation.In addition,the Pt NPs acted as immune adjuvants by stimulating dendritic cells(DCs)maturation.Furthermore,BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor tissues.Thus,Pt NPs can ablate tumors through PTT,and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration,thereby preventing tumor relapse and metastasis. | Jie Yu Sha Liu Yupeng Wang Xidong He Qingfei Zhang Yanxin Qi Dongfang Zhou Zhigang Xie Xiaoyuan Li Yubin Huang | 2022 | Bioactive Materials2022，7，1： | 0 |
| 14 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 15 | Roadmap for rechargeable batteries:present and beyond显示文摘Rechargeable batteries currently hold the largest share of the electrochemical energy storage market,and they play a major role in the sustainable energy transition and industrial decarbonization to respond to global climate change.Due to the increased popularity of consumer electronics and electric vehicles,lithium-ion batteries have quickly become the most successful rechargeable batteries in the past three decades,yet growing demands in diversified application scenarios call for new types of rechargeable batteries.Tremendous efforts are made to developing the next-generation post-Li-ion rechargeable batteries,which include,but are not limited to solid-state batteries,lithium–sulfur batteries,sodium-/potassium-ion batteries,organic batteries,magnesium-/zinc-ion batteries,aqueous batteries and flow batteries.Despite the great achievements,challenges persist in precise understandings about the electrochemical reaction and charge transfer process,and optimal design of key materials and interfaces in a battery.This roadmap tends to provide an overview about the current research progress,key challenges and future prospects of various types of rechargeable batteries.New computational methods for materials development,and characterization techniques will also be discussed as they play an important role in battery research. | Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu Su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong Su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan | 2024 | Science China Chemistry2024，67，1： | 0 |
| 16 | Deciphering the high-carbonization-temperature triggered enzymatic activity of wool-derived N,S-co-doped carbon nanosheets显示文摘It is well-established that high carbonization temperature will trigger the enzyme-like activity of carbon-based materials.However,the catalytic mechanism is still ambiguous,which hinders the further rational design of nanomaterials as enzyme mimics.Hereby,N,S-rich carbonized wool nanosheets(CWs)were synthesized at different pyrolysis temperatures.As expected,only CWs treated with high-temperature possess intrinsic oxidase-and peroxidase-like activities.Meanwhile,density functional theory(DFT)calculations demonstrate that graphitic nitrogen and the co-existence of nitrogen and sulfur in the carbon matrix serve as the active sites for the enzyme-like process.More importantly,combining theoretical calculations and experimental observations,the high-temperature triggered catalytic mechanism can be ascribed to the fact that an appropriate high-temperature maximizes the graphitization degree to a certain extent,at which most of the catalytic active sites are well retained rather than evaporating.Moreover,coupling with excellent photothermal conversion efficiency and catalytic performance,CWs can be applied to photothermal-catalytic cancer therapy under near-infrared region(NIR)light irradiation.We believe this work will contribute to understanding the catalytic mechanism of carbon-based nanozymes and promote the development of new biomedical and pharmaceutical applications. | Jiachen Zhao Deshuai Yu Jianmin Chen Shihao Lin Yonghua Tang Chaoyu Fan Dongfang Zhou Youhui Lin | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 17 | A Survey on Machine Learning in Chemical Spectral Analysis显示文摘Chemical spectral analysis is contemporarily undergoing a revolution and drawing much attention of scientists owing to machine learning algorithms,in particular convolutional networks.Hence,this paper outlines the major machine learning and especially deep learning methods contributed to interpret chemical images,and overviews the current application,development and breakthrough in different spectral characterization.Brief categorization of reviewed literatures is provided for studies per application apparatus:X-Ray spectra,UV-Vis-IR spectra,Micro-scope,Raman spectra,Photoluminescence spectrum.End with the overview of existing circumstances in this research area,we provide unique insight and promising directions for the chemical imaging field to fully couple machine learning subsequently. | Dongfang Yu Jinwei Wang | 2020 | Journal of Information Hiding and Privacy Protection2020，2，4： | 0 |
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