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| 1 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 2 | Preparation and characterization of monodisperse spherical particles of X-ray nano-phosphors based on Gd_2O_2S:Tb显示文摘Monodisperse spherical Gd2O2S:Tb nanoparticles have been prepared using an improved homogeneous precipitation method combined with solid-gas sulfuration technology. The effects of Tb3+-doped concentration on luminescent intensity and color purity of samples were investigated, and the optimal Tb3+-doped concentration was determined. Under the excitation of X-ray, the obtained sample shows excellent luminescent properties, and its luminescent intensity is increased by about 50% under lower sulfuration temperature compared with that of the Gd2O2S:Tb nanoparticles prepared by complex precipitation method. | XING MingMing CAO WangHe PANG Tao LING XiaoQiao CHEN Ning | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 3 | Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice显示文摘Rabies remains a public health threat that kills approximately 59,000 people worldwide each year,most of which are from the developing countries of Africa and Asia where dog rabies are endemic.Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin(IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus(RABV) strain LBNSE(designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated. It was found that mice vaccinated with LBNSEIL15 could induce significantly higher level of virus-neutralizing antibody(VNA) than those immunized with LBNSE, resulting in the higher protection after challenge. Further investigation was performed to find out the possible role of IL-15 plays in the process of antibody induction, and it was found that LBNSE-IL15 could enhance the maturation of dendritic cells(DCs) in immunized mice. Furthermore, the mice immunized with LBNSE-IL15 could promote the T_(FH) cells differentiation and the generation of germinal center B cells and plasma cells. Together, these data indicated that IL-15 could be a potential adjuvant in enhancing the immunogenicity of RABV, contributing to the development of more-efficacious rabies vaccines. | Tiange Chen Yajing Zhang Zhao Wang Jie Yang Mingming Li Kunlun Wang Min Cui Zhen F.Fu Ling Zhao Ming Zhou | 2017 | Virologica Sinica2017，32，4： | 5 |
| 4 | Crustal S-velocity structure and radial anisotropy beneath the southern part of central and western North China Craton and the adjacent Qilian Orogenic Belt from ambient noise tomography显示文摘The crustal S-velocity structure and radial anisotropy along a dense linear portable seismic array with 64 broadband seismic stations were investigated from ambient noise tomography with about one-year-long ambient noise recordings. The array transverses the southern part of the central North China Craton(CNCC) and western NCC(WNCC) from east to west and reaches the adjacent Qilian Orogenic Belt(QOB). The phase velocity structures of Rayleigh waves at 5–35 s and Love waves at 5–30 s were measured. The crustal S-velocity structures(Vsv and Vsh) were constructed from the dispersion data(Rayleigh and Love waves,respectively) from point-wise linear inversion with prior information of the Moho depth and average crustal Vp/Vs ratio. The radial anisotropy along the profile was calculated based on the discrepancies between Vsv and Vsh as 2×(Vsh.Vsv)/(Vsh+Vsv). The results show distinct structural variations in the three major tectonic units. The crustal architecture in the southern CNCC is complicated and featured with wide-distributed low-velocity zones(LVZs), which may be a reflection of crustal modification resulting from Mesozoic-Cenozoic tectonics and magmatic activities. The pronounced positive radial anisotropy in the lower-lowermost crust beneath the Shanxi-Shaanxi Rift and the neighboring areas could be attributed to the underplating of mantle mafic-ultramafic materials during the Mesozoic-Cenozoic tectonic activation. In southern Ordos, the overall weak lateral velocity variations, relative high velocity and large-scale positive radial anisotropy in mid-lower crust probably suggest that the current crustal structure has preserved its Precambrian tectonic characteristics. The low-velocity westward-dipping sedimentary strata in the Ordos Block could be attributed to the Phanerozoic whole-basin tilting and the uneven erosion since late Cretaceous. Integrated with previous studies, the systematic comparison of crustal architecture was made between the southern and northern part of CNCC-WNCC. The similarities and differences may have a relation with the tectonic events and deformation histories experienced before and after the Paleoproterozoic amalgamation of the NCC. The nearly flat mid-crustal LVZ beneath the southern QOB weakens gradually as it extends to the east, which is a feature probably associated with crustal vertical superpositionand ductile shear deformation under the intensive compressional regime due to the northeastward growth and expansion of the Tibetan Plateau. | LING Yuan CHEN Ling WEI ZiGen JIANG MingMing WANG Xu | 2017 | Science China Earth Sciences2017，60，10： | 4 |
| 5 | A Recombinant Rabies Virus Expressing Fms-like Tyrosine Kinase 3 Ligand(Flt3L) Induces Enhanced Immunogenicity in Mice显示文摘Rabies is a zoonotic disease that still causes 59,000 human deaths each year,and rabies vaccine is the most effective way to control the disease.Our previous studies suggested that the maturation of DC plays an important role in enhancing the immunogenicity of rabies vaccine.Flt3L has been reported to own the ability to accelerate the DC maturation,therefore,in this study,a recombinant rabies virus expressing mouse Flt3L,designated as LBNSE-Flt3L,was constructed,and its immunogenicity was characterized.It was found that LBNSE-FU3L could enhance the maturation of DC both in vitro and in vivo,and significantly more TFH cells and Germinal Center B(GC B)cells were generated in mice immunized with LBNSE-FU3L than those immunized with the parent virus LBNSE.Consequently,expressing of Flt3L could elevate the level of virus-neutralizing antibodies(VNA)in immunized mice which provides a better protection from a lethal rabies virus challenge.Taken together,our study extends the potential of Flt3L as a good adjuvant to develop novel rabies vaccine by enhancing the VNA production through activating the DC—Tfh^GC B axis in immunized mice. | Yachun Zhang Jie Yang Mingming Li Min Cui Zhen FFu Ling Zhao Ming Zhou | 2019 | Virologica Sinica2019，34，6： | 3 |
| 6 | Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5′ processing of mitochondrial nad5 messenger RNA and endosperm development显示文摘Pentatricopeptide repeat(PPR) proteins, composing one of the largest protein families in plants,are involved in RNA binding and regulation of organelle RNA metabolism at the posttranscriptional level. Although several PPR proteins have been implicated in endosperm development in rice(Oryza sativa), the molecular functions of many PPRs remain obscure. Here, we identified a rice endosperm mutant named floury endosperm 18(flo18) with pleiotropic defects in both reproductive and vegetative development.Map-based cloning and complementation tests showed that FLO18 encodes a mitochondriontargeted P-type PPR protein with 15 PPR motifs.Mitochondrial function was disrupted in the flo18 mutant, as evidenced by decreased assembly of Complex I in the mitochondrial electron transport chain and altered mitochondrial morphology. Loss of FLO18 function resulted in defective 5′-end processing of mitochondrial nad5 transcripts encoding subunit 5 of nicotinamide adenine dinucleotide hydrogenase. These results suggested that FLO18 is involved in 5′-end processing of nad5 messenger RNA and plays an important role in mitochondrial function and endosperm development. | Mingzhou Yu Mingming Wu Yulong Ren Yihua Wang Jingfang Li Cailin Lei Yinglun Sun Xiuhao Bao Hongming Wu Hang Yang Tian Pan Yongfei Wang Ruonan Jing Mengyuan Yan Houda Zhang Lei Zhao Zhichao Zhao Xin Zhang Xiuping Guo Zhijun Cheng Bing Yang Ling Jiang Jianmin Wan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 2 |
| 7 | Highly water- soluble magnetic nanopartieles as novel draw solutes in forward osmosis for water reuse显示文摘 | Ling Mingming Wang K Y Chung T S | 2010 | Ind Eng Chem Res2010，49，12： | 1 |
| 8 | The impact of lipids on the cancer—immunity cycle and strategies for modulating lipid metabolism to improve cancer immunotherapy显示文摘Lipids have been found to modulate tumor biology,including proliferation,survival,and metastasis.With the new understanding of tumor immune escape that has developed in recent years,the influence of lipids on the cancer—immunity cycle has also been gradually discovered.First,regarding antigen presentation,cholesterol prevents tumor antigens from being identified by antigen presenting cells.Fatty acids reduce the expression of major histocompatibility complex class I and costimulatory factors in dendritic cells,impairing antigen presentation to T cells.Prostaglandin E2(PGE2)reduce the accumulation of tumor-infiltrating dendritic cells.Regarding T-cell priming and activation,cholesterol destroys the structure of the T-cell receptor and reduces immunodetection.In contrast,cholesterol also promotes T-cell receptor clustering and relative signal transduction.PGE2 represses T-cell proliferation.Finally,regarding T-cell killing of cancer cells,PGE2 and cholesterol weaken granule-dependent cytotoxicity.Moreover,fatty acids,cholesterol,and PGE2 can improve the activity of immunosuppressive cells,increase the expression of immune checkpoints and promote the secretion of immunosuppressive cytokines.Given the regulatory role of lipids in the cancer—immunity cycle,drugs that modulate fatty acids,cholesterol and PGE2 have been envisioned as effective way in restoring antitumor immunity and synergizing with immunotherapy.These strategies have been studied in both preclinical and clinical studies. | Mingming Zheng Wenxin Zhang Xi Chen Hongjie Guo Honghai Wu Yanjun Xu Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 9 | Cellular antioxidant activity and cytotoxicity assay of canolol显示文摘To better understand canolol as an efficient intracellular antioxidant agent in food related fields, potential cellular antioxidant activity and cytotoxicity were evaluated using multiple assays, including cellular antioxidant activity(CAA), 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) and methylene blue assay. CAA assay was used to identify the half maximal effective concentration of canolol and other bioactive components, such as sinapic acid, resveratrol and sesamol in oil crops. Results showed that antioxidant capacity(without PBS wash) varies between different compounds. Capacity variation followed the order: sinapic acid > canolol > resveratrol > sesamol. While with PBS wash, the order changed to sinapic acid > resveratrol > canolol > sesamol. Half maximal inhibitory concentration of canolol measured by MTT was 1887.08±1.22 μmol/L, implying that cytotoxicity of canolol was greatly lower than that of resveratrol, sesamol and sinapic acid. Methylene blue assay showed that cell viability was still up to 90% exposed to canolol at a high concentration of 4444 μmol/L. It suggested that canolol had desired antioxidant activity in organism with low cellular cytotoxicity. | Xiaoyang Xia Xia Xiang Fenghong Huang Ling Han Zhen Zhang Mingming Zheng Chang Zheng | 2018 | Oil Crop Science2018，3，2： | 1 |
| 10 | Immobi- lization of Cand/da rugosa lipase on magnetic poly (allyl gly- cidyl ether - co - ethylene glycol dimethacrylate) polymer microsphere for synthesis of phytosterol esters of unsaturated fatty acids 显示文摘 | ZHENG Mingming DONG Ling LU Yong | 2012 | J Mol Catal B Enzym2012，74，： | 1 |
| 11 | Draw solutions for forward osmosis processes: Developments, challenges, and prospects for the future显示文摘 | Qingchun Ge Mingming Ling Tai-Shung Chung | 2013 | Journal of Membrane Science2013，，： | 1 |
| 12 | Effect on the Performance of Drilling Fluids at Downhole Rock Surfaces at Low Temperatures显示文摘To maintain gas hydrate stability, low-temperature drilling fluids and high drilling speeds should be used while drilling in gas hydrate-bearing sediments. The effect of the drilling fluid on downhole rock surfaces at low temperatures is very important to increase the drilling rate. This paper analyzed the action mechanism of the drilling fluid on downhole rock surfaces and established a corresponding evaluation method. The softening effect of six simulated drilling fluids with 0.1 wt.% of four common surfactants and two common organic salts on the downhole rock surface strength was evaluated experimentally using the established method at low temperature. The experimental results showed that the surfactants and organic salts used in the drilling fluids aided in the reduction of the strength of the downhole rock surface, and the established evaluation method was able to quantitatively reveal the difference in the softening effect of the different drilling fluids through comparison with water. In particular, the most common surfactant that is used in drilling fluids, sodium dodecyl sulfate(SDS), had a very good softening effect while drilling under low-temperature conditions, which can be widely applied during drilling in low-temperature formations, such as natural gas hydrate-bearing sediments, the deep seafloor and permafrost. | Mingming Zheng Guosheng Jiang Tianle Liu Fulong Ning Ling Zhang V.F.Chikhotkin | 2016 | Journal of Earth Science2016，27，5： | 1 |
| 13 | Non-dominated Sorting Genetic Algorithms-ⅡBased on Muli-objective Optimization Model in the Water Distribution System显示文摘 | Mingming Li Shuming Liu Ling Zhang | 2012 | Procedia Engineering2012，，37： | 1 |
| 14 | Vanadium-based polyanionic compounds as cathode materials for sodium-ion batteries:Toward high-energy and high-power applications显示文摘Sodium ion batteries(SIBs)have been regarded as one of the alternatives to lithium ion batteries owing to their wide availability and significantly low cost of sodium sources.However,they face serious challenges of low energy&power density and short cycling lifespan owing to the heavy mass and large radius of Na^(+).Vanadium-based polyanionic compounds have advantageous characteristic of high operating voltage,high ionic conductivity and robust structural framework,which is conducive to their high energy&power density and long lifespan for SIBs.In this review,we will overview the latest V-based polyanionic compounds,along with the respective characteristic from the intrinsic crystal structure to performance presentation and improvement for SIBs.One of the most important aspect is to discover the essential problems existed in the present V-based polyanionic compounds for high-energy&power applications,and point out most suitable solutions from the crystal structure modulation,interface tailoring and electrode configuration design.Moreover,some scientific issues of V-based polyanionic compounds shall be also proposed and related future direction shall be provided.We believe that this review can serve as a motivation for further development of novel V-based polyanionic compounds and drive them toward high energy&power applications in the near future. | Zhiqiang Lv Moxiang Ling Meng Yue Xianfeng Li Mingming Song Qjong Zheng Huamin Zhang | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 15 | Highly water-soluble magnetic nanoparticles as novel draw solutes in forward osmosis for water reuse 显示文摘 | Ling Mingming Wang Kaiyu Chung T S | 2010 | Industrial & Engineering Chemistry Research2010，49，12： | 1 |
| 16 | DHD4,a CONSTANS-like family transcription factor,delays heading date by affecting the formation of the FAC complex in rice显示文摘Heading date(or flowering time)is one of the most important agronomic traits in rice,influencing its regional adaptability and crop yield.Many major-effect genes for rice heading date have been identified,but in practice they are difficult to be used for rice molecular breeding because of their dramatic effects on heading date.Genes with minor effects on heading date,which are more desirable for fine-tuning flowering time without significant yield penalty,were seldom reported.In this study,we identified a new minor-effect heading date repressor,Delayed Heading Date 4(DHD4).The dhd4 mutant shows a slightly earlier flowering phenotype without a notable yield penalty compared with wild-type plants under natural long-day conditions.DHD4 encodes a CONSTANS-like transcription factor localized in the nucleus.Molecular,biochemical,and genetic assays show that DHD4 can compete with 14-3-3 to interact with OsFD1,thus affecting the formation of the Hd3a-14-3-3-OsFD1 triprotein FAC complex,resulting in reduced expression of OsMADS14 and OsMADS15,and ultimately delaying flowering.Taken together,these results shed new light on the regulation of flowering time in rice and provide a promising target for fine-tuning flowering time to improve the regional adaptability of rice. | Maohong Cai Shanshan Zhu Mingming Wu Xiaoming Zheng Jiachang Wang Liang Zhou Tianhui Zheng Song Cui Shirong Zhou Chaonan Li Huan Zhang Juntao Chai Xinyue Zhang Xin Jin Zhijun Cheng Xin Zhang Cailin Lei Yulong Ren Qibing Lin Xiuping Guo Lei Zhao Jie Wang Zhichao Zhao Ling Jiang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 1 |
| 17 | Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats显示文摘Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases.The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases(protective effect on cardiomyocytes)is still unclear.In the present study,we identify the role of puerarin in an animal model of experimental heart failure(HF)and explore its underlying mechanisms.The HF rat model is induced by in-traperitoneal injection of adriamycin(ADR),and puerarin is administered intragastrically at low,medium,and high concentrations.We demonstrate that puerarin significantly improves myocardial fibrosis and inflammatory in-filtration and,as a result,improves cardiac function in ADR-induced HF rats.Mechanistically,we find for the first time that puerarin inhibits overactivated Na+/H+exchange isoform 1(NHE1)in HF,which may improve HF by decreasing Na+and Ca2+ion concentrations and attenuating mitochondrial damage caused by calcium overload;on the other hand,puerarin inhibits the activation of the p38 pathway in HF,reduces the expressions of TGF-βand proinflammatory cytokines,and suppresses myocardial fibrosis.In conclusion,our results suggest that Puerarin is an effective drug against HF and may play a protective role in the myocardium by inhibiting the activation of p38 and its downstream NHE1. | Guopin Pan Baoyue Cui Mingming Han Laibiao Lin Yinlan Li Ling Wang Shuang Guo Yaling Yin Heqin Zhan Peng Li | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 18 | 9,10-Bis(diphenylmethylene)-9,10-dihydroanthracene-based metal-organic assemblies with aggregation-induced emission for multiple sensing显示文摘Developing novel emissive supramolecular assemblies with elegant architectures and tunable perfor-mance remains highly desirable yet challenging.Herein,we report the design and synthesis of several 9.10-bis(diphenylmethylene)-9.10-dihydroanthracene-based metal organic assembles with aggregation-induced emission characteristics.Such assemblies feature intriguing thermochromic and mechanochromic properties,ie.,distinguishable fuorescence responses in terms of emission wavelength and intensity un-der variable temperatures and pressures.Moreover,these assemblies can serve as excellent fluorescent sensors for the detection of polysaccharide molecules.Due to the differentiated charge type and den-sity,the assembles display distinct sensing mechanisms toward different polysaccharide molecules.This study provides novel perspectives for the synthesis of buttrfly-like platinum(I)supramolecular coordi-nation complexes with multistimuli-responsiveness for polysaccharide sensing.which will facllitate the development of stimuli-responsive materials. | Qian Feng Nan Li Zeyuan Zhang Kai Gao Kai Wang Sanliang Ling Hongye Yuan Yanmin Zhang Mingming Zhang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 19 | Melatonin restores normal Bax and Bcl-2 protein expression in the subgranular zone of the dentate gyrus in pinealectomized rats显示文摘In this study, we sought to elucidate the effects of melatonin on learning and memory as well as apoptosis and expression of the Bax or Bcl-2 proteins in the subgranular zone of the dentate gyrus in pinealectomized rats. Using the Morris water maze and the olfactory memory tests, we found that the average escape latency in pinealectomized rats was clearly increased compared with sham-operated rats. Moreover, the average escape latency in the melatonin-treated and pinealectomized rats was longer than that in the sham-operated rats and shorter than that in the pinealectomized and untreated rats. Immunohistochemistry and terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) showed that there were fewer Bax immunoreactive cells and TUNEL-positive (apoptotic) cells but more Bcl-2 immunoreactive cells in the melatonin-treated rats compared with the pinealectomized rats. The sham-operated rats showed numbers of these cells similar to the melatonin-treated rats. These experimental findings demonstrate that melatonin treatment may reduce abnormal apoptosis by promoting gene expression of Bax and suppressing gene expression of Bcl-2 in the subgranular zone of the dentate gyrus in pinealectomized rats. These effects appear to result in the inhibition of cellular apoptosis and the improvement of spatial learning and memory in pinealectomized rats. | Shengchang Zhang Shuang Zhao Lu Bai Mingming Guan Jielin Mo Ling Lan | 2011 | Neural Regeneration Research2011，6，27： | 0 |
| 20 | Author correction to‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA'[Acta Pharmaceutica Sinica B 13(2023)2585-2600]显示文摘The authors regret that one author was missed in the author list when preparing the manuscript,while the foundation to him was mentioned in the section of Acknowledgments.Dr.Qinjie Weng should be added to the author list because of his contribution in animal study and his foundation help us to complete this study.The authors sincerely apologize for any inconvenience caused to the journal and readers. | Wenxin Zhang Xiaohui Pan Yanjun Xu Hongjie Guo Mingming Zheng Xi Chen Honghai Wu Fengming Luan Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
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