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| 1 | Evolutionary Modeling of Systems of Ordinary Differential Equations with Genetic Programming显示文摘 | Hongqing Cao Lishan Kang Yuping Chen Jingxian Yu | 2000 | Genetic Programming and Evolvable Machines2000，，4： | 1 |
| 2 | Evolutionary Modeling of Systems of Ordinary Differential Equations with Genetic Programming显示文摘 | Hongqing Cao Lishan Kang Yuping Chen Jingxian Yu | 2000 | Genetic Programming and Evolvable Machines2000，，4： | 1 |
| 3 | Seasonal differences in climatic controls of vegetation growth in the Beijing–Tianjin Sand Source Region of China显示文摘Launched in 2002, the Beiing–Tianjin Sand Source Control Project (BTSSCP) is an ecological restoration project intended to prevent desertification in China. Evidence from multiple sources has confirmed increases in vegetation growth in the BTSSCP region since the initiation of this project. Precipitation and essential climate variable-soil moisture (ECV-SM) conditions are typically considered to be the main drivers of vegetation growth in this region. Although many studies have investigated the inter-annual variations of vegetation growth, few concerns have been focused on the annual and seasonal variations of vegetation growth and their climatic drivers, which are crucial for understanding the relationships among the climate, vegetation, and human activities at the regional scale. Based on the normalized difference vegetation index (NDVI) derived from MODIS and the corresponding climatic data, we explored the responses of vegetation growth to climatic factors at annual and seasonal scales in the BTSSCP region during the period 2000–2014. Over the study region as a whole, NDVI generally increased from 2000 to 2014, at a rate of 0.002/a. Vegetation growth is stimulated mainly by the elevated temperature in spring, whereas precipitation is the leading driver of summer greening. In autumn, positive effects of both temperature and precipitation on vegetation growth were observed. The warming in spring promotes vegetation growth but reduces ECV-SM. Summer greening has a strong cooling effect on land surface temperature. These results indicate that the ecological and environmental consequences of ecological restoration projects should be comprehensively evaluated. | SHAN Lishan YU Xiang SUN Lingxiao HE Bin WANG Haiyan XIE Tingting | 2018 | Journal of Arid Land2018，10，6： | 1 |
| 4 | Evolutionary Modeling of Systems of Ordinary Differential Equations with Genetic Programming显示文摘 | Hongqing Cao Lishan Kang Yuping Chen Jingxian Yu | 2000 | Genetic Programming and Evolvable Machines2000，，4： | 1 |
| 5 | Evolutionary Modeling of Systems of Ordinary Differential Equations with Genetic Programming显示文摘 | Hongqing Cao Lishan Kang Yuping Chen Jingxian Yu | 2000 | Genetic Programming and Evolvable Machines2000，，4： | 1 |
| 6 | Stability analysisof efficient anti- collision protocol for RFID tag identifica-tion显示文摘 | Jia Xiaolin Feng Quanyuan Yu Lishan | 2012 | IEEE Transactions on Communications2012，60，8： | 1 |
| 7 | Electrochemiluminescence Sensor for Cancer Cell Detection Based on H_(2)O_(2)-Triggered Stimulus Response System显示文摘A H_(2)O_(2)-triggered stimulus response electrochemiluminescence(ECL)sensor for sensitive detection of cancer cells using mesoporous silica nanoparticles(MSNs)has been proposed.ECL signal-generating molecules(Ru(phen)32+)were encap-sulated into phenylboronic acid group-functionalized MSNs(PBA-MSNs)porous and capped by polyhydroxy functioned Au nanoparticles(AuNPs)through the interaction of carbohydrate-boronic acid first.Brunauer-Emmett-Teller(BET)and transmission electron microscopy(TEM)were applied to characterize the materials.The proposed controlled release sensing platform shows approximately no leakage from the mesoporrs of MSNs after a long time of storage.Cancer cells are initially incubated with the functionalized MSNs and then treated with ascorbic acid to endogenously produce H_(2)O_(2).Arylboronic esters in the MSNs surface can be oxidized by the produced H_(2)O_(2),causing the releasing of the molecule from MSNs and increased ECL signal.This technique displayed an excellent measurement for the breast cancer cells’sensitive diagnosis with a detection limit of 208 cells/mL.The phenomenon suggests that this sensing platform may be potentially applied for breast cancer sensitive detection in the future. | Yu Chen Zhonghui Chen Lishan Fang Aibin Weng Fang Luo Longhua Guo Bin Qiu Zhenyu Lin | 2020 | Journal of Analysis and Testing2020，4，2： | 0 |
| 8 | Epigenetic modification associated with climate regulates betulin biosynthesis in birch显示文摘The Betula genus contains pentacyclic triterpenoid betulin known for its environmental adaptation and medicinal properties.However,the mechanisms underlying betulin biosynthesis responding to climate change remain unclear.In this study,the role of epigenetic modification(DNA methylation) in betulin biosynthesis was examined and how climatic factors influence it.Whole-genome bisulfite sequencing was performed for greenhouse-grown Chinese white birch(Betula platyphylla Sukaczev) treated with DNA methylation inhibitor zebularine(ZEB) and a natural birch population in Northeast China.ZEB treatment significantly affected the CHH methylation level of transposable elements and betulin content in a hormesis dose-dependent manner.The methylation and expression of bHLH9,a key transcriptional factor controlling betulin biosynthesis,were also consistently affected by ZEB treatment as a hormetic dose-response.In the natural population,there was a positive correlation between promoter methylation of bHLH9 and summer precipitation,while winter temperature was negatively correlated.Thus climate-dependent methylation of bHLH9 regulates the expression of downstream genes involved in betulin biosynthesis.This study highlights the role of environmental signals to induce epigenetic changes that result in betulin production,possibly helping to develop resilient plants to combat ongoing climate change and enhance secondary metabolite production. | Jiang Wang Bowei Chen Shahid Ali Tianxu Zhang Yu Wang He Zhang Lishan Wang Yonglan Zhang Linan Xie Tingbo Jiang Jing Yin Heike W.Sederoff Gaurav Zinta Ronald R.Sederoff Yuhua Li Qingzhu Zhang | 2023 | Journal of Forestry Research2023，34，1： | 0 |
| 9 | mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance显示文摘Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months,and conventional chemotherapeutics are the main treatment strategy.Poly(ADP-ribose)polymerase(PARP)inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer,opening a new era for targeted therapy for this disease.However,most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors.Here,we reported that mammalian target of rapamycin complex 2(mTORC2)kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion.Moreover,we found that knockdown of the mTORC2 obligate subunit Rictor sensitized pancreatic cancer cells to the PARP inhibitor olaparib.Mechanistically,we showed that mTORC2 positively regulates homologous recombination(HR)repair by modulating BRCA1 recruitment to DNA double-strand breaks(DSBs).In addition,we confirmed that combination treatment with the mTORC2 inhibitor PP242 and the PARP inhibitor olaparib synergistically inhibited pancreatic cancer growth in vivo.Thus,this study provides a novel target and strategy for optimizing PARP inhibitor efficiency in pancreatic cancers. | CHIWEN BU LIGANG ZHAO LISHAN WANG ZEQIAN YU JIAHUA ZHOU | 2023 | Oncology Research2023，31，4： | 0 |
| 10 | METTL14 is a chromatin regulator independent of its RNA N^(6)-methyladenosine methyltransferase activity显示文摘METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m^(6)A methyltransferase complex(MTC)that installs m^(6)A.Surprisingly,depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell(mESC).While comparable global hypo-methylation in RNA m^(6)A was observed in Mettl3 or Mettl14 knockout mESCs,respectively.Mettl14 knockout led to a globally decreased nascent RNA synthesis,whereas Mettl3 depletion resulted in transcription upregulation,suggesting that METTL14 might possess an mA-independent role in gene regulation.We found that METTL14 colocalizes with the repressive H3K27me3 modification.Mechanistically,METTL14,but not METTL3,binds H3K27me3 and recruits KDM6B to induce H3K27me3 demethylation independent of METTL3.Depletion of METTL14 thus led to a global increase in H3K27me3 level along with a global gene suppression.The effects of METTL14 on regulation of H3K27me3 is essential for the transition from self-renewal to differentiation of mESCs.This work reveals a regulatory mechanism on heterochromatin by METTL14 in a manner distinct from METTL3 and independently of m^(6)A,and critically impacts transcriptional regulation,stemness maintenance,and differentiation ofmESCs. | Xiaoyang Dou Lulu Huang Yu Xiao Chang Liu Yini Li Xinning Zhang Lishan Yu Ran Zhao Lei Yang Chuan Chen Xianbin Yu Boyang Gao Meijie Qi Yawei Gao Bin Shen Shuying Sun Chuan He Jun Liu | 2023 | Protein & Cell2023，14，9： | 0 |
| 11 | Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein(QPCTL)with antitumor efficacy显示文摘Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various cancers.CD47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and humans.CD47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side effects.In contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy. | Lei Yu Pengcheng Zhao Yaoliang Sun Zening Zheng Wenhao Du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping Wang | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
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