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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | A necessary and sufficient condition for a surface sum of two handlebodies to be a handlebody显示文摘The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2. | Fengchun Lei He Liu Fengling Li Andrei Vesnin | 2020 | Science China Mathematics2020，63，10： | 2 |
| 5 | The impact of biofuel plantation on biodiversity: a review显示文摘Because plants convert solar energy into chemical energy stored in organisms, biomass production as an energy source can help to reduce the world's reliance on fossil energy and mitigate global warming. Biofuel production is a fast-growing industry that represents a new type of large-scale human disturbance on ecosystems. Thus, the benefits of biofuel production bring environmental risks that include its potential impact on biodiversity, which is still an open question. In this review, we start first with a brief overview of the evolution of biofuel concept; second, we review the state of biofuel production across the continents,with a major emphasis on the main species used and their major feedstock. For which, we found significant differences for land use and environmental cultural management of biofuel plantation between tropical and temperate regions.Third, we summarize the impacts of biofuel plantation on biodiversity at multiple scales, based on the case studied with respect to the corresponding issues. At the genetic level,introgression and contamination by aggressive genotypes are a primary risk. At the species level, habitat pollution, degradation, and disturbance caused by intensive managementof biofuel plantation significantly raise the risk of habitat fragmentation, native extinction, and bio-invasion. At the ecosystem level, the large-scale homogeneous landscape of biofuel plantation results in simplified community and food web that severely damage ecosystem services, including ecosystem diversity. Finally, we compare the current and potential benefits and risks of biofuel plantations for the practical application of a biofuel industry of China. We emphasize the land use constraint from food security and biodiversity conservation, and the need for scientific research and systematic monitoring as a critical support for the sustainable development of biofuel production in China. | Ye Liu Yue Xu Fengchun Zhang Jinqi Yun Zehao Shen | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 6 | Hydrolytic dynamics of pesticide N'-(2,4-dimethylphenyl)-N-methylformamidine in aquatic solution显示文摘HydrolyticdynamicsofpesticideN'-(2,4-dimethylphenyl)-N-methylformamidineinaquaticsolution￥MoHanhong;YangKewu;AnFengchun;LiuYe... | Mo Hanhong Yang Kewu An Fengchun Liu Ye (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 7 | Ultrahigh-temperature ferromagnetism in MoS_(2) Moirésuperlattice/graphene hybrid heterostructures显示文摘Realizing high-temperature ferromagnetism in two-dimensional(2D)semiconductor nanosheets is significant for their applications in next-generation magnetic and electronic nanodevices.Herein,this goal could be achieved on a MoS_(2) Moirésuperlattice grown on the reduced graphene oxide(RGO)substrate by a hydrothermal approach.The as-synthesized bilayer MoS_(2) superlattice structure with rotating angle(ϕ=13°±1°)of two hexagonal MoS_(2) lattices,possesses outstanding ferromagnetic property and an ultra-high Curie temperature of 990 K.The X-ray absorption near-edge structure and ultraviolet photoelectron spectroscopies combined with density functional theory calculation indicate that the covalent interactions between MoS_(2) Moirésuperlattice and RGO substrate lead to the formation of interfacial Mo-S-C bonds and complete spin polarization of Mo 4d electrons near the Fermi level.This design could be generalized and may open up a possibility for tailoring the magnetism of other 2D materials. | Liang Cai Hengli Duan Qinghua Liu Chao Wang Hao Tan Wei Hu Fengchun Hu Zhihu Sun Wensheng Yan | 2021 | Nano Research2021，14，11： | 1 |
| 8 | Advances in graphene oxide membranes for water treatment显示文摘Graphene oxide(GO),a derivative of graphene,is a novel carbon material that has attracted a lot of attention in the field of membrane materials as its ability to achieve layer-by-layer stacking and the formation of nanochannels between the lamellae makes it excellent for selective separation of substances.In this paper,the separation mechanism of the GO membrane is summarized.According to the different separation substances,the separation mechanism of graphene oxide membrane is reviewed from two aspects of metal ions and organic pollutants.Next,the preparation methods of graphene oxide membranes is introduced,such as spin-coating,vacuum filtration,dip-coating,spraying,and layer-by-layer self-assembly,followed by a review on the structural regulation of GO.Finally,this paper concludes with an overview of the potential development prospects and challenges of GO membranes. | Fengchun Jia Xiao Xiao Ardo Nashalian Sophin Shen Liu Yang Zhenyang Han Huaijiao Qu Tianmei Wang Zhi Ye Zhijun Zhu Linjun Huang Yanxin Wang Jianguo Tang Jun Chen | 2022 | Nano Research2022，15，7： | 1 |
| 9 | Speckle reduction by adaptive window anisotropic dif-fusion显示文摘 | LIU Guojin ZENG Xiaoping TIAN Fengchun | 2009 | Signal Processing2009，89，： | 1 |
| 10 | [lamda] Operations on Packet Sets and the Significance of Application显示文摘 | Fengchun Liu Chunying Zhang Ruitao Liang Jing Wang | 2012 | EN2012，，15： | 1 |
| 11 | Speckle reduction by adaptive window anisotropic diffusion显示文摘 | Liu Guojin Zeng Xiaoping Tian Fengchun | 2009 | Signal Processing2009，89，11： | 1 |
| 12 | Evaluation of dynamic fracture toughness by Hopkinson pressure bar loaded instrumented Charpy impact test显示文摘 | Jiang Fengchun Liu Ruitang Zhang Xiaoxin | 2004 | Engineering Fracture Mechanics2004，71，： | 1 |
| 13 | A novel inverter-output passive filter for reducing both differential-and common-mode dv/dt at the motor terminals in PWM drive systems 显示文摘 | CHEN Xiyou XU Dianguo LIU Fengchun | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 14 | A novel representation approach to DNA sequence and its application显示文摘 | Wang Shiyuan Tian Fengchun Liu Xiao | | 0，，04： | 1 |
| 15 | Novel systemic lupus erythematosus autoantigens identified by human protein microarray technology显示文摘 | Wei Huang Chaojun Hu Haipan Zeng Ping Li Lei Guo Xiaofeng Zeng Guozhen Liu Fengchun Zhang Yongzhe Li Lin Wu | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 16 | Fluid Inclusion and Carbon-Oxygen Isotope Studies of the Hujiayu Cu Deposit,Zhongtiao Mountains,China:Implications for Synmetamorphic Copper Remobilization显示文摘The Hujiayu Cu deposit,representative of the 'HuBi-type' Cu deposits in the Zhongtiao Mountains district in the southern edge of the North China Craton,is primarily hosted in graphitebearing schists and carbonate rocks.The ore minerals comprise mainly chalcopyrite,with minor sphalerite,siegenite[(Co,Ni)_3S_4],and clausthalite[Pb(S,Se)].The gangue minerals are mainly quartz and dolomite,with minor albite.Four fluid inclusion types were recognized in the chalcopyrite-pyrite-dolomite-quartz veins,including CO_2-rich inclusions(type Ⅰ),low-salinity,liquid-dominated,biphase aqueous inclusions(type Ⅱ),solid-bearing aqueous inclusions(type Ⅲ),and solid-bearing aqueous-carbonic inclusions(type Ⅳ).Type I inclusion can be further divided into two sub-types,i.e.,monophase CO_2 inclusions(type Ⅰa) and biphase CO_2-rich inclusions(with a visible aqueous phase),and type Ⅲ inclusion is divided into a subtype with a halite daughter mineral(type Ⅲa) and a subtype with multiple solids(type Ⅲb).Various fluid inclusion assemblages(FIAs) were identified through petrographic observations,and were classified into four groups.The group-1 FIA,consisting of monophase CO_2 inclusions(type Ⅰa),homogenized into the liquid phase in a large range of temperatures from-1 to 28℃,suggesting post-entrapment modification.The group-2 FIA consists of type Ⅰb,Ⅲb and Ⅳ inclusions,and is interpreted to reflect fluid immiscibility.The group-3 FIA comprises type Ⅱ and Ⅲa inclusions,and the group-4FIA consists of type Ⅱ inclusions with consistent phase ratios.The group-1 and group-2 FIAs are interpreted to be entrapped during mineralization,whereas group-3 and group-4 FIAs probably represent the post-mineralization fluids.The solid CO_2 melting temperatures range from-60.6 to56.6℃ and from-66.0 to-63.4℃ for type Ⅰa and type Ⅳ inclusions,respectively.The homogenization temperatures for type Ⅱ inclusions range from 132 to 170℃ for group-3 FIAs and115 to 219℃ for group-4 FIAs.The halite melting temperatures range from 530 to 562℃ for typeⅢ b and Ⅳ inclusions,whereas those for type Ⅲa inclusions range from 198 to 398℃.Laser Raman and SEM-EDS results show that the gas species in fluid inclusions are mainly CO_2 with minor CH_4,and the solids are dominated by calcite and halite.The calcite in the hosting marble and dolomite in the hydrothermal veins have δ^(13)C_(V-pdb) values of-0.2 to 1.2‰ and-1.2 to-6.3‰,and δ^(18)O_(v-smow) values of 14.0 to 20.8 ‰ and 13.2 to 14.3‰,respectively.The fluid inclusion and carbon-oxygen isotope data suggest that the ore-forming fluids were probably derived from metamorphic fluids,which had reacted with organic matter in sedimentary rocks or graphite and undergone phase separation at 1.4-1.8 kbar and 230-240℃,after peak metamorphism.It is proposed that the Hujiayu Cu deposit consists of two mineralization stages.The early stage mineralization,characterized by disseminated and veinlet copper sulfides,probably took place in an environment similar to sediment-hosted stratiform copper mineralization.Ore minerals formed in this precursor mineralization stage were remobilized and enriched in the late metamorphic hydrothermal stage,leading to the formation of thick quartz-dolomite-sulfides veins. | QIU Zhengjie FAN Hongrui LIU Xuan WEN Bojie HU Fangfang YANG Kuifeng GUO Shuanglong ZHAO Fengchun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 1 |
| 17 | COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer显示文摘 | Huidong Liu Jianbing Xiao Yanmei Yang Yan Liu Ruijin Ma Yuhang Li Fengchun Deng Yafang Zhang | 2011 | Microvascular Research2011，，： | 1 |
| 18 | A Novel InverterOutput Passive Filter for Reducing Both Differential-and CommonMode dv/dt at the Motor Terminals in PWM Drive Systems显示文摘 | Chen Xiyou Xu Dianguo Liu Fengchun | 2007 | IEEE Transactions on Industrial Electronics2007，54，1： | 1 |
| 19 | In-situ oxidized tungsten disulfide nanosheets achieve ultrafast photocatalytic extraction of uranium through hydroxyl-mediated binding and reduction显示文摘Photoreduction of hexavalent uranium(U(VI))by semiconductor provides a novel and effective avenue for uranium extraction.Unfortunately,the traditional metal oxide and sulfide semiconductors suffer from the lack of confinement sites to U(VI),which resulted in the long period(~1 h)to achieve a high U(VI)extraction efficiency of>90%.Herein,we successfully constructed WS2 nanosheets and created in-situ oxidized domains on the surfaces(O-WS_(2))to promote the uranium extraction and the corresponding removal kinetics.In this system,the O_(7.7-)WS_(2) nanosheets exhibited a considerable U(VI)extraction efficiency of>90%within 20 min in 8 mg·L^(–1) U(VI)-containing solution,which represented the highly efficient U(VI)removal performance.In 200 mg·L^(–1) U(VI)-containing solution,the O7.7-WS2 nanosheets exhibited an extraction capacity of 652.4 mg·g^(-1).The mechanism study revealed that the oxidized surface tended to trap hydrogen atom and in-situ form hydroxyl groups in defect sites.Evidenced by a series of experiment,such as kinetic isotope effect,1H nuclear magnetic resonance(NMR)spectra,and X-ray absorption near-edge structure(XANES)spectra,the in-situ formed hydroxyl groups participated in the uranium reduction,which dramatically enhanced uranium extraction kinetics and efficiency. | Huanhuan Liu Jia Lei Changyao Gong Ye Li Huimei Chen Jiali Chen Fengchun Wen Dengjiang Fu Yan Liu Wenkun Zhu Rong He | 2022 | Nano Research2022，15，10： | 0 |
| 20 | Dynamically-evolved surface heterojunction in iridium nanocrystals boosting acidic oxygen evolution and overall water splitting显示文摘Simultaneously realizing improved activity and stability of acidic oxygen evolution reaction(OER) electrocatalysts is highly promising for developing cost-effective sustainable energy in the splitting of water technique.Herein,we report iridium nanocrystals embedded into 3D conductive clothes(Ir-NCT/CC) as a low iridium electrocatalyst realizing ultrahigh acidic OER activity and robust stability.The well-designed Ir-NCT/CC requires a low overpotential of 202 mV to reach the current density of 10 mA cm^(-2)with a high mass activity of 1754 A g^(-1).Importantly,in acidic overall water splitting,Ir-NCT/CC merely delivers a cell voltage of 1.469 V at a typical current density of 10 mA cm^(-2)and also maintains robust durability under continuous operation.We identify that a low working voltage drives the formation of a highly stable amorphous IrOxactive phase over the surface of Ir nanocrystals(surface heterojunction IrOx/Ir-NCT) during operating conditions,which contributes to an effective and durable OER process. | Chenyu Yang Xiuxiu Zhang Qizheng An Meihuan Liu Wanlin Zhou Yuanli Li Fengchun Hu Qinghua Liu Hui Su | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
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