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| 1 | A stretchable,asymmetric,coaxial fiber-shaped supercapacitor for wearable electronics显示文摘Nano Research volume 13,pages1686–1692(2020)Cite this article 210 Accesses 1 Citations Metrics details Abstract Fiber-shaped supercapacitors(FSCs),owing to their high-power density and feasibility to be integrated into woven clothes,have drawn tremendous attentions as a key device for flexible energy storage.However,how to store more energy while withstanding various types of mechanical deformation is still a challenge for FSCs.Here,based on a magnetron sputtering method,different pseudocapacitive materials are conformally coated on self-supported carbon nanotube aligned films.This fabrication approach enables a stretchable,asymmetric,coaxial fiber-shaped supercapacitors with high performance.The asymmetric electrode configuration that consists of CNT@NiO@MnOx cathode and CNT@Fe2O3 anode successfully extends the FSC’s electrochemical window to 1.8 V in an aqueous electrolyte.As a result,a high specific capacitance of 10.4 F·cm^−3 is achieved at a current density of 30 mA·cm^−3 corresponding to a high energy density of 4.7 mWh·cm^−3.The mechanical stability of the stretchable FSC is demonstrated with a sustainable performance under strains up to 75%and a capacitance retention of 95%after 2,000 cycles under 75%strain. | Hua Yuan Guang Wang Yuxing Zhao Yang Liu Yang Wu Yuegang Zhang | 2020 | Nano Research2020,13,6: | 7 |
| 2 | Extensive Inter-plant Protein Transfer between Cuscuta Parasites and Their Host Plants显示文摘Cuscuta species(dodders)are holoparasites that totally rely on host plants to survive.Although various mobile proteins have been identified to travel within a plant,whether and to what extent protein transfer between Cuscuta and host plants remain unclear.We found that hundreds to more than 1500 proteins were transferred between Cuscuta and the host plants Arabidopsis and soybean,and hundreds of interplant mobile proteins were even detected in the seeds of Cuscuta and the host soybean.Different hosts bridge-connected by dodder were also found to exchange hundreds of proteins.Quantitatively,the mobile proteins represent a few to more than 10%of the proteomes of foreign plants.Using Arabidopsis plants expressing different reporter proteins,we further showed that these reporter proteins could travel between plants and,importantly,retained their activity in the foreign plants.Comparative analysis between the interplant mobile proteins and mRNAs indicated that the majority of mobile proteins were not de novo synthesized from the translocated mRNAs,but bona fide mobile proteins.We propose that large-scale inter-plant protein translocation may play an important role in the interactions between host plants and dodder and even among the dodder bridge-connected hosts. | Nian Liu Guojing Shen Yuxing Xu Hui Liu Jingxiong Zhang Shalan Li Jing Li Cuiping Zhang Jinfeng Qi Lei Wang Jianqiang Wu | 2020 | Molecular Plant2020,13,4: | 3 |
| 3 | 3D printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration显示文摘Three-dimensional(3D)-printed scaffolds have attracted considerable attention in recent years as they provide a suitable environment for bone cell tissue regeneration and can be customized in shape.Among many other challenges,the material composition and geometric structure have major impacts on the performance of scaffolds.Hydroxyapatite and tricalcium phosphate(HA/TCP),as the major constituents of natural bone and teeth,possess attractive biological properties and are widely used in bone scaffold fabrication.Many fabrication methods have been investigated in attempts to achieve HA/TCP scaffolds with microporous structure enabling cell growth and nutrient transport.However,current 3D printing methods can only achieve the fabrication of HA/TCP scaffolds with certain range of microporous structure.To overcome this challenge,we developed a slurry-based microscale mask image projection stereolithography,allowing us to form a HA/TCP-based photocurable suspension with complex geometry including biomimetic features and hierarchical porosity.Here,the curing performance and physical properties of the HA/TCP suspension were investigated,and a circular movement process for the fabrication of highly viscous HA/TCP suspension was developed.Based on these investigations,the scaffold composition was optimized.We determined that a 30 wt%HA/TCP scaffold with biomimetic hierarchical structure exhibited superior mechanical properties and porosity.Cell proliferation was investigated in vitro,and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells.The results showed our 3D-printed HA/TCP scaffold with biomimetic hierarchical structure is biocompatible and has sufficient mechanical strength for surgery. | Xiangjia Li Yuan Yuan Luyang Liu Yuen‑Shan Leung Yiyu Chen Yuxing Guo Yang Chai Yong Chen | 2020 | Bio-Design and Manufacturing2020,3,1: | 3 |
| 4 | Effects of electro-acupuncture on brain tissue norepinephrine contents in a morphine withdrawal anxiety mouse model显示文摘BACKGROUND: Following morphine withdrawal, anxiety is associated with abnormal norepinephrine content change. However, increasing blood lactic acid content can induce anxiety or panic in patients with anxiety disorder or endogenous opioid peptide functional disorder. OBJECTIVE: This study was designed to observe the effects of electro-acupuncture, at the 'Sanyinjiao' point (SP 6), on brain tissue norepinephrine and blood lactic acid content in anxiety-model mice after morphine withdrawal. DESIGN: A randomized controlled animal experiment. SETTING: This study was performed in the Laboratory of Acupuncture, Electro-acupuncture & Tuina College, Chengdu University of Traditional Chinese Medicine, from June to September 2001. MATERIALS: A total of 50 healthy Kunming male mice were provided by the Laboratory Animal Center of Chengdu University of Traditional Chinese Medicine. The protocol was performed in accordance with ethical guidelines stated in the Guide for the use and care of laboratory animals, approved by the Committee on the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council, China (1985). Experimental reagents and equipment used were as follows: morphine hydrochloride (Lot No. 930503, Shenyang No.1 Pharmaceutical Factory, China), norepinephrine (Sigma Chemical Company, USA), fluorospectrophotometer (RF-510, Shimadzu Corporation, Japan), Han electro-acupuncture apparatus (WQ 1002, No. zun (91)-227270-588, Beijing Anlong Photoelectricity-Technique Company, China), and T-maze (self-made). METHODS: A total of 50 mice were randomly divided into 5 groups, with 10 mice in each group: blank control, T-maze, model, model + electro-acupuncture, and electro-acupuncture groups. Establishment of anxiety model after morphine withdrawal: the mouse hot plate assay was used to detect the activity of morphine. The median effective dose of morphine, 2.95 mg/kg, was defined as the base. Mice were subcutaneously administered morphine, 3 times a day, for 4 days successively (initially 2.95 mg/kg, then increased day by day, as described below). Interventions: In the model + electro-acupuncture group, after model induction, mice were subjected electro-acupuncture at bilateral 'Sanyinjiao' (SP6) points using a Han electro-acupuncture apparatus with sparse-dense waves and frequency of 2-100 Hz, once a day, for 6 days. In the model group, after anxiety-model induction, mice were subjected to fixation as same as model + electro-acupuncture group within 6 days of model induction. In the electro-acupuncture group, the anxiety model was not induced and mice were subjected to fixation, electro-acupuncture and the T-maze test. In the T-maze group, the anxiety model was not induced and mice were subjected to fixation. The T-maze test was performed in the 4 groups after experiment. In the blank control group, the anxiety model was not induced and mice were subjected to fixation only. MAIN OUTCOME MEASURES: Brain tissue norepinephrine content of morphine-withdrawal anxiety mice was detected by fluorospectrophotometry after 6 days of electro-acupuncture. Blood lactic acid content was detected by visible spectrophotometry. RESULTS: A total of 50 mice were included in the final analysis. Brain norepinephrine content was significantly greater in the model group compared to the T-maze, blank control, electro-acupuncture and model + electro-acupuncture groups, (P < 0.05-0.01). Brain norepinephrine content was similar between the model + electro-acupuncture and the blank control groups (P > 0.05). There was no significant difference in blood lactic acid content among the groups (P > 0.05). CONCLUSION: Electro-acupuncture lowers brain norepinephrine content but does not influence peripheral blood lactic acid content in morphine-withdrawn, anxiety-modeled mice. These results demonstrate that anxiety-inhibiting effects of electro-acupuncture, after morphine withdrawal, might be related to regulation of norepinephrine release. | Qizhi Zhou Yuxing Liu Xuguang Liu Jiaolu Wei Yong Tang Junmei Wu Yi Pu | 2008 | Neural Regeneration Research2008,3,4: | 2 |
| 5 | Vision-Based Hand Gesture Recognition for Human-Computer Interaction——A Survey显示文摘Recently,vision-based gesture recognition(VGR)has become a hot research spot in human-computer interaction(HCI).Unlike other gesture recognition methods with data gloves or other wearable sensors,vision-based gesture recognition could lead to more natural and intuitive HCI interactions.This paper reviews the state-of-the-art vision-based gestures recognition methods,from different stages of gesture recognition process,i.e.,(1)image acquisition and pre-processing,(2)gesture segmentation,(3)gesture tracking,(4)feature extraction,and(5)gesture classification.This paper also analyzes the advantages and disadvantages of these various methods in detail.Finally,the challenges of vision-based gesture recognition in haptic rendering and future research directions are discussed. | GAO Yongqiang LU Xiong SUN Junbin TAO Xianglin HUANG Xiaomei YAN Yuxing LIU Jia | 2020 | Wuhan University Journal of Natural Sciences2020,25,2: | 2 |
| 6 | Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection显示文摘Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury(SCI).Antioxidant therapies that reduce the reactive oxygen and nitrogen species(RONS)overgeneration and inflammation are proved promising for improving the outcomes.However,efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging.Here,a single-atom cobalt nanozyme(Co-SAzyme)with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI.Among SAzymes featuring different single metal-N sites(e.g.,Mn,Fe,Co,Ni,and Cu),this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide(H_(2)O_(2)),superoxide anion(O_(2)·^(-)),hydroxyl radical(·OH),nitric oxide(·NO),and peroxynitrite(ONOO^(-))that overexpressed in the early stage of SCI.The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy.In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress.In addition,the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. | Yuxing Jiang Hongtao Rong Yifan Wang Shange Liu Peng Xu Zhen Luo Lamei Guo Tao Zhu(✉) Hongpan Rong Dingsheng Wang Jiatao Zhang Yu Yi Hao Wang | 2023 | Nano Research2023,16,7: | 2 |
| 7 | Effects of cerium salts on corrosion behaviors of Si–Zr hybrid sol–gel coatings显示文摘The present work examines the effects of cerium salts on corrosion behaviors of Si–Zr hybrid sol–gel coatings. The Si–Zr hybrid sol–gel coatings on a 2A12 aluminum substrate were prepared through hydrolysis and condensation of glycidoxypropyl-trimethoxy-silane(GTMS) and zirconium(IV) n-propoxide(TPOZ). Used as inhibitors for corrosion, three types of cerium salts(Ce(NO_3)_3, CeCl_3, and Ce(CH_3COO)_3) were doped into the sol–gel coatings. Fourier transform infrared(FTIR) and scanning electron microscopy(SEM) were employed to investigate the structures and morphologies of various coatings, and the corrosion resistances of the coatings were evaluated by electrochemical methods and neutral salt spray tests. Experimental results indicate that the addition of cerium salts can hinder the process of corrosion due to their self-healing abilities. Furthermore, the sol–gel coating doped with Ce(CH_3COO)_3 has the best corrosion resistance because of the promotions of hydrolysis and condensation provided by CH_3COO. | Yu Mei Liu Yuxing Liu Jianhua Li Songmei Xue Bing Zhang You Yin Xiaolin | 2015 | Chinese Journal of Aeronautics2015,28,2: | 2 |
| 8 | Small-signal modeling and parameter extraction method for a multigate GaAs pHEMT switch显示文摘This paper presents an accurate small-signal model for multi-gate GaAs pHEMTs in switching-mode.The extraction method for the proposed model is developed.A 2-gate switch structure is fabricated on a commercial 0.5μm AlGaAs/GaAs pHEMT technology to verify the proposed model.Excellent agreement has been obtained between the measured and simulated results over a wide frequency range. | Lin Luo Jun Liu Guofang Wang Yuxing Wu | 2020 | Journal of Semiconductors2020,41,3: | 2 |
| 9 | Superscalar communication: A runtime optimization for distributed applications显示文摘Building distributed applications is difficult mostly because of concurrency management. Existing approaches primarily include events and threads. Researchers and developers have been debating for decades to prove which is superior. Although the conclusion is far from obvious, this long debate clearly shows that neither of them is perfect. One of the problems is that they are both complex and error-prone. Both events and threads need the programmers to explicitly manage concurrencies, and we believe it is just the source of difficulties. In this paper, we propose a novel approach—superscalar communication, in which concurrencies are automatically managed by the runtime system. It dynamically analyzes the programs to discover potential concurrency opportunities; and it dynamically schedules the communication and the computation tasks, resulting in automatic concurrent execution. This approach is inspired by the idea of superscalar technology in modern microprocessors, which dynamically exploits instruction-level parallelism. However, hardware superscalar algorithms do not fit software in many aspects, thus we have to design a new scheme completely from scratch. Superscalar communication is a runtime extension with no modification to the language, compiler or byte code, so it is good at backward compatibility. Superscalar communication is likely to begin a brand new research area in systems software, which is characterized by dynamic optimization for networking programs. | LI HuiBa , LIU ShengYun, PENG YuXing, LI DongSheng, ZHOU HangJun & LU XiCheng National Laboratory for Parallel and Distributed Processing, National University of Defense Technology, Changsha 410073, China | 2010 | Science China(Information Sciences)2010,53,10: | 2 |
| 10 | Impact of Initial Storm Intensity and Size on the Simulation of Tropical Cyclone Track and Western Pacific Subtropical High Extent显示文摘Typhoon Megi, the 13 th typhoon of the 2010 typhoon season, was selected for case study by utilizing the Weather Research and Forecasting(WRF) model. Twelve sensitivity experiments with various initial tropical cyclone(TC) intensities and sizes were conducted to investigate their impacts on the simulation of typhoon track. Interaction between TC and the western Pacific subtropical high(WPSH) was also analyzed to explore the mechanism for the impact on TC track of the initial TC intensity and size. Numerical results indicate that the simulated TC size and TC track are sensitive to initial TC intensity and size. Stronger initial TC intensity and larger initial TC size often lead to larger simulated TC size and make TC turn northward earlier. Further analysis suggests that, with the increase of initial TC intensity and size, more air mass enters into the TC region, which subsequently reduces the extent of WPSH.As a result, the steering flow changes significantly and eventually causes the TC to turn northward earlier. The present study confirms that the initial TC intensity and size have certain influences on the TC track simulation, which demonstrates the importance of accurate initial condition for successful simulation of the TC intensity and TC track.Moreover, it also deepens our understanding of the interaction between TC and WPSH, provides helpful clues for the TC track change study, and discusses the future directions for improvement of TC track forecast. | Yuxing WANG Yuan SUN Qianfeng LIAO Zhong ZHONG Yijia HU Kefeng LIU | 2017 | Journal of Meteorological Research2017,31,5: | 2 |
| 11 | Leak Detection of Gas Pipelines Based on Characteristics of Acoustic Leakage and Interfering Signals显示文摘When acoustic method is used in leak detection for natural gas pipelines,the external interferences including operation of compressor and valve,pipeline knocking,etc.,should be distinguished with acoustic leakage signals to improve the accuracy and reduce false alarms.In this paper,the technologies of extracting characteristics of acoustic signals were summarized.The acoustic leakage signals and interfering signals were measured by experiments and the characteristics of time-domain,frequency-domain and time-frequency domain were extracted.The main characteristics of time-domain are mean value,root mean square value,kurtosis,skewness and correlation function,etc.The features in frequency domain were obtained by frequency spectrum analysis and power spectrum density,while time-frequency analysis was accomplished by short time Fourier transform.The results show that the external interferences can be removed effectively by the characteristics of time domain,frequency domain and time-frequency domain.It can be drawn that the acoustic leak detection method can be applied to natural gas pipelines and the characteristics can help reduce false alarms and missing alarms. | Lingya Meng Cuiwei Liu Liping Fang Yuxing Li Juntao Fu | 2019 | Sound & Vibration2019,53,4: | 2 |
| 12 | Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex显示文摘The development and plasticity of central auditory system can be influenced by the change of peripheral neuronal activity. However, the molecular mechanism participating in the process remains elusive. Brain-derived neurotrophic factor(BDNF) binding with its functional receptor tropomyosin receptor kinase B(TrkB) has multiple effects on neurons. Here we used a rat model of auditory deprivation by bilateral cochlear ablation, to investigate the changes in expression of BDNF and Trk B in the auditory cortex after auditory deprivation that occurred during the critical period for the development of central auditory system. Reverse transcription-quantitative polymerase chain reaction(RTqPCR) and immunohistochemistry methods were adopted to detect the m RNA and protein expression levels of BDNF and TrkB in the auditory cortex at 2, 4, 6 and 8 weeks after surgery, respectively. The change in the expression of BDNF and TrkB mRNAs and proteins followed similar trend. In the bilateral cochlear ablation groups, the BDNF-TrkB expression level initially decreased at 2 weeks but increased at 4 weeks followed by the reduction at 6 and 8 weeks after cochlear removal, as compared to the age-matched sham control groups. In conclusion, the BDNF-TrkB signaling is involved in the plasticity of auditory cortex in an activity-dependent manner. | Yuxing Wang Ou Xu Yanxing Liu Hong Lu | 2017 | Journal of Otology2017,12,1: | 2 |
| 13 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016,43,11: | 2 |
| 14 | 24-h residual urine volume at hemodialysis initiation: A possible predictor for acute ischemic stroke incurrence in hemodialyis patients显示文摘 | Yuemei Chen Hong Liu Jianzhou Zou Yuxing Ge Jie Teng ShaoWei Xu WenLv Lv Zhonghua Liu Yan Xu XueSen Cao Bo Shen XiaoQiang Ding | 2012 | Clinical Neurology and Neurosurgery2012,,: | 1 |
| 15 | Experimenta1, study on effect of loading rate on mode I delamination of Z- pin rein- forced laminates 显示文摘 | Liu H Y YanW Y YuX Y | 2007 | Composites Science and Technology2007,67,78: | 1 |
| 16 | Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation显示文摘 | Wenbo Liu Qi Long Keshi Chen Shengbiao Li Ge Xiang Shen Chen Xiyin Liu Yuxing Li Liang Yang Delu Dong Cheng Jiang Zhenhua Feng Dajiang Qin Xingguo Liu | 2013 | Biochemical and Biophysical Research Communications2013,,: | 1 |
| 17 | Wave propagation in graphene reinforced piezoelectric sandwich nanoplates via high-order nonlocal strain gradient theory显示文摘Αn analytical method is developed to explore the wave propagation characteristics of piezoelectric sandwich nanoplates in the present work.The sandwich nanoplates are composed of a graphene reinforced composite core layer with two piezoelectric surface layers exposed to electric field.The material properties of the nanocomposite layer are given by the Halpin–Tsai model and mixture’s rule.The Euler–Lagrange equation of the nanoplates is obtained by Hamilton's principle and first-order shear deformation theory.Then,combining the high-order nonlocal strain gradient theory with the hygrothermal constitutive relationship of composite nanoplates,the nonlocal governing equations are presented.Finally,numerical studies are conducted to demonstrate the influences of scale parameters,applied external voltage,temperature variation,moisture variation,graphene size,and weight fraction on wave frequency.The results reveal that low-order and high-order nonlocal parameters and length scale parameters have different effects on wave frequency.The wave frequency can be reduced by increasing temperature and the thickness of graphene.This could facilitate the investigation of the dynamic properties of graphene nanocomposite structures. | Biao Hu Juan Liu Yuxing Wang Bo Zhang Huoming Shen | 2021 | Acta Mechanica Sinica2021,37,9: | 1 |
| 18 | Deep postbuckling and nonlinear bending behaviors of nanobeams with nonlocal and strain gradient effects显示文摘In this paper, multi-scale modeling for nanobeams with large deflection is conducted in the framework of the nonlocal strain gradient theory and the Euler-Bernoulli beam theory with exact bending curvature. The proposed size-dependent nonlinear beam model incorporates structure-foundation interaction along with two small scale parameters which describe the stiffness-softening and stiffness-hardening size effects of nanomaterials, respectively. By applying Hamilton's principle, the motion equation and the associated boundary condition are derived. A two-step perturbation method is introduced to handle the deep postbuckling and nonlinear bending problems of nanobeams analytically. Afterwards, the influence of geometrical, material, and elastic foundation parameters on the nonlinear mechanical behaviors of nanobeams is discussed. Numerical results show that the stability and precision of the perturbation solutions can be guaranteed, and the two types of size effects become increasingly important as the slenderness ratio increases. Moreover, the in-plane conditions and the high-order nonlinear terms appearing in the bending curvature expression play an important role in the nonlinear behaviors of nanobeams as the maximum deflection increases. | Bo ZHANG Huoming SHEN Juan LIU Yuxing WANG Yingrong ZHANG | 2019 | Applied Mathematics and Mechanics(English Edition)2019,40,4: | 1 |
| 19 | Antimicrobial resistance among clinical isolates from the Chinese Meropenem Surveillance Study (CMSS), 2003–2008显示文摘 | Hui Wang Minjun Chen Yuxing Ni Yudong Liu Hongli Sun Yunsong Yu Xiujuan Yu Yaning Mei Min Liu Ziyong Sun Yunzhuo Chu Zhidong Hu Xinhong Huang | 2009 | International Journal of Antimicrobial Agents2009,,: | 1 |
| 20 | The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke显示文摘Ischemic stroke is a major public health problem worldwide.Although the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear.In the present study,we determined that environmental circadian disruption(ECD)increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model,by measuring the infarct volume,neurological tests,and angiogenesis-related protein.We further report that Bmal1 plays an irreplaceable role in angiogenesis.Overexpression of Bmal1 promoted tube-forming,migration,and wound healing,and upregulated the vascular endothelial growth factor(VEGF)and Notch pathway protein levels.This promoting effect was reversed by the Notch pathway inhibitor DAPT,according to the results of angiogenesis capacity and VEGF pathway protein level.In conclusion,our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway. | Yuxing Zhang Xin Zhao Chun Guo Ying Zhang Fukang Zeng Qian Yin Zhong Li Le Shao Desheng Zhou Lijuan Liu | 2023 | Neuroscience Bulletin2023,39,9: | 1 |