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| 1 | Engineering Broad-Spectrum Bacterial Blight Resistance by Simultaneously Disrupting Variable TALE-Binding Elements of Multiple Susceptibility Genes in Rice显示文摘Xanthomonas oryzae pv.oryzae(Xoo),the causal agent of bacterial blight of rice,employs the transcription activator-like effectors(TALEs)to induce the expression of the OsSWEET family of putative sugar transporter genes,which function in conferring disease susceptibility(S)in rice plants.To engineer broadspectrum bacterial blight resistance,we used CRISPR/Cas9-mediated gene editing to disrupt the TALEbinding elements(EBEs)of two S genes,OsSWEETH and OsSWEET14,in rice cv.Kitaake,which harbors the recessive resistance allele of Xa25/OsSWEET13.The engineered rice line MS14K exhibited broadspectrum resistance to most Xoo strains with a few exceptions,suggesting that the compatible strains may contain new TALEs.We identified two PthXo2-like TALEs,Tal5LN18 and Tal7PX061,as major virulence factors in the compatible Xoo strains LN18 and PX061,respectively,and found that Xoo encodes at least five types of PthXo2-like effectors.Given that PthXo2/PthXo2.1 target OsSlVEETf3 for transcriptional activation,the genomes of 3000 rice varieties were analyzed for EBE variationsin the OsSWEET13 promoter,and 10Xa25-like haplotypes were identified.We found that Tal5LN18 and Tal7PX〇6i bind slightly different EBE sequences in the OsSWEET13 promoter to activate its expression.CRISPR/Cas9 technology was then used to generate InDels in the EBE of the OsSWEET13 promoter in MS14K to creat a new germplasm with three edited OsSWEET EBEs and broad-spectrum resistance against all Xoo strains tested.Collectively,our findings illustrate how to disarm TALE-S co-evolved loci to generate broad-spectrum resistance through the loss of effector-triggered susceptibility in plants. | Zhengyin Xu Xiameng Xu Qiang Gong Ziyang Li Ying Li Sai Wang Yangyang Yang Wenxiu Ma Longyu Liu Bo Zhu Lifang Zou Gongyou Chen | 2019 | Molecular Plant2019，12，11： | 29 |
| 2 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 3 | Microstructure and Mechanical Properties of 45 vol.%SiC_p/7075Al Composite显示文摘Microstructure and mechanical behavior of high volume content Si Cp/7xxx Al composites have not been explored yet. Therefore, in the present work, 45 vol.% SiC p/7075 Al composite has been prepared by pressure infiltration method. High density dislocations were found around Si C/Al interface in SiC p/7075 Al composite after water-quenching and aging treatment. Fine dispersed nano-η′ phases were observed after the aging treatment. Adverse to other Si Cp/Al composites prepared by the pressure infiltration method,an interface layer was observed between SiC particles and Al matrix. Furthermore, high-resolution transmission electron microscopy(HRTEM) observation indicated that this interface layer was coherent/semicoherent with that of the SiC particles. 45 vol.% SiC p/7075 Al composite demonstrated high tensile strength(630 MPa) and micro-ductility. Compared to aged Si Cp/2024 Al composite, the aged Si Cp/7075 Al composite showed an increase of about 200% in the tensile strain and 90% in the tensile strength, respectively.It is speculated that nano-η′ phases in the Al matrix significantly contributed to the strengthening effect while the interface layer between Si C and Al matrix might be beneficial to the strength and plasticity of Si Cp/7075 Al composite. | Ziyang Xiu Wenshu Yang Ronghua Dong Murid Hussain Longtao Jiang YongXing Liu Gaohui Wu | 2015 | Journal of Materials Science & Technology2015，31，9： | 7 |
| 4 | Enhanced photodynamic therapy of mixed phase TiO2(B)/anatase nanofibers for killing of HeLa cells显示文摘光力学的治疗(太平洋夏季时间) 是使用使药具有感光性有选择地使用治疗指向地点的一个过程,被证明了是为可以发展成癌症的癌症和条件的安全治疗。缩放 Nano 的 TiO < 潜水艇 class= “ a-plus-plus ” > 2 为紫外轻驾驶太平洋夏季时间被认为是潜在的 photosensitizer。在这研究, TiO 的四种类型<潜水艇class=“ a-plus-plus ”> 2 nanofibers 从质子 tri-titanate 被准备( H <潜水艇class=“ a-plus-plus ”> 2 T <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 7 ) nanofiber 。同样获得的 nanofibers 为太平洋夏季时间杀死 HeLa 房间作为有效 photosensitizers 被表明。MTT 试金和流动 cytometry (FCM ) 被执行评估 biocompatibility, apoptotic 房间的百分比,和房间生存能力。同样准备的 TiO 的 non-cytotoxicity < 潜水艇 class= “ a-plus-plus ” > 当紫外照耀不在时的 2 nanofibers 也被表明了。在紫外轻照耀下面, TiO < 潜水艇 class= “ a-plus-plus ” > 2 nanofibers,特别地混合阶段 nanofibers,比 Pirarubicin (THP ) 显示了高得多的杀死房间的效率,它是普通的药导致 HeLa 房间的 apoptosis。我们归功于混合阶段 nanofibers 的高 cellkilling 效率到在 TiO 之间的 bandgap 边比赛和稳定的接口 < 候补选手 class= “ a-plus-plus ” > 2 (B) 和锐钛矿在单个 nanofiber 分阶段执行,它能禁止 photogenerated 电子和洞的再结合。这支持费用分离和转移过程和罐头生产负责杀死 HeLa 房间的更多的反应的氧种类(ROS ) 。 | Shuchao Zhang Dongjiang Yang Dengwei Jing Hongwei Liu Long Liu Yi Jia Meihua Gao Liejin Guo Ziyang Huo | 2014 | Nano Research2014，7，11： | 6 |
| 5 | A genome-wide analysis of SWEET gene family in cotton and their expressions under different stresses显示文摘Background: The SWEET(Sugars will eventually be exported transporters) gene family plays multiple roles in plant physiological activities and development process. It participates in reproductive development and in the process of sugar transport and absorption, plant senescence and stress responses and plant-pathogen interaction. However,thecomprehensive analysis of SWEET genes has not been reported in cotton.Results: In this study, we identified 22, 31, 55 and 60 SWEET genes from the sequenced genomes of Gossypium arboreum, G. raimondii, G. hirsutum and G. barbadense, respectively. Phylogenetic tree analysis showed that the SWEET genes could be divided into four groups, which were further classified into 14 sub-clades. Further analysis of chromosomal location, synteny analysis and gene duplication suggested that the orthologs showed a good collinearity and segmental duplication events played a crucial role in the expansion of the family in cotton. Specific MtN3_slv domains were highly conserved between Arobidopsis and cotton by exon-intron organization and motif analysis. In addition, the expression pattern in different tissues indicated that the duplicated genes in cotton might have acquired new functions as a result of sub-functionalization or neo-funtionalization. The expression pattern of SWEET genes showed that the different genes were induced by diverse stresses. The identification and functional analysis of SWEET genes in cotton may provide more candidate genes for genetic modification.Conclusion: SWEET genes were classified into four clades in cotton. The expression patterns suggested that the duplicated genes might have experienced a functional divergence. This work provides insights into the evolution of SWEET genes and more candidates for specific genetic modification, which will be useful in future research. | ZHAO Lanjie YAO Jinbo CHEN Wei LI Yan L Youjun GUO Yan WANG Junyi YUAN Li LIU Ziyang ZHANG Yongshan | 2018 | Journal of Cotton Research2018，1，2： | 6 |
| 6 | Distributed Cooperative Control Algorithm for Multi-UAV Mission Rendezvous显示文摘Multiple unmanned aerial vehicles(UAVs)cooperative operation is the main form for UAVs fighting in battlefield,and multi-UAV mission rendezvous is the premise of cooperative reconnaissance and attack missions.We propose a rendezvous control strategy,which divides the rendezvous process into two parts:The loose formation rendezvous and the close formation rendezvous.In the first stage,UAVs are supposed to reach the specific target locations simultaneously and form a loose formation.A distributed control strategy based on first-order consensus algorithm is presented to achieve this goal.Then the second stage is designed based on the second-order consensus algorithm to complete the transition from the loose formation to the close formation.This process needs the speeds and heading angles of UAVs to reach an agreement.Besides,control algorithms with a virtual leader are proposed,by which the formation states can reach a specific value.Finally,simulation results show that the control algorithms are capable of realizing the mission rendezvous of multi-UAV and the consistence of UAVs′final states,which verify the effectiveness and feasibility of the designed control strategy. | Liu Guoliang Xing Dongjing Hou Jianyong Jin Guting Zhen Ziyang | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，6： | 5 |
| 7 | Visual Object Tracking and Servoing Control of a Nano-Scale Quadrotor:System,Algorithms,and Experiments显示文摘There are two main trends in the development of unmanned aerial vehicle(UAV)technologies:miniaturization and intellectualization,in which realizing object tracking capabilities for a nano-scale UAV is one of the most challenging problems.In this paper,we present a visual object tracking and servoing control system utilizing a tailor-made 38 g nano-scale quadrotor.A lightweight visual module is integrated to enable object tracking capabilities,and a micro positioning deck is mounted to provide accurate pose estimation.In order to be robust against object appearance variations,a novel object tracking algorithm,denoted by RMCTer,is proposed,which integrates a powerful short-term tracking module and an efficient long-term processing module.In particular,the long-term processing module can provide additional object information and modify the short-term tracking model in a timely manner.Furthermore,a positionbased visual servoing control method is proposed for the quadrotor,where an adaptive tracking controller is designed by leveraging backstepping and adaptive techniques.Stable and accurate object tracking is achieved even under disturbances.Experimental results are presented to demonstrate the high accuracy and stability of the whole tracking system. | Yuzhen Liu Ziyang Meng Yao Zou Ming Cao | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 4 |
| 8 | Tea eggs-inspired high-strength natural polymer hydrogels显示文摘Natural polymer(NP)hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety;however,the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds.Inspired by the stiffening albumen gel of tea eggs,a traditional Chinese snack,high-strength NP hydrogels are constructed by simply soaking in aqueous solution of tea polyphenols(TP),an active ingredient extracted from tea.The TP-treated representative NP hydrogels exhibit considerably enhanced multifaceted mechanical properties with maximum 19-/30-,8.4-,6.1-,72-fold increases in tensile/compressive strengths,Young’s modulus,elongation at break and facture toughness,respectively,compared with pristine hydrogels,primarily due to the hydrogen bonding interactions between TP and NP chains.The TP-treated NP hydrogels can resist different large deformations,which cannot be achieved by their original species at all.In aqueous solution,the TP-treated NP hydrogels can still maintain robust mechanical performances,in spite of somewhat decline in strengths with release of TP,which just favorably affords increased water contents,antibacterial and antioxidant activities.GelMA-TP hydrogel is shown to facilitate wound healing in a full-thickness skin defect model.Importantly,the weak 3D printed GelMA scaffolds are significantly strengthened by TP treatment,broadening the possibility for customizing individualized bioscaffolds. | Tengling Wu Chunyan Cui Chuanchuan Fan Ziyang Xu Yang Liu Wenguang Liu | 2021 | Bioactive Materials2021，6，9： | 3 |
| 9 | 彩色多普勒超声与磁共振成像在胎脑发育异常中的临床应用研究显示文摘目的探讨彩色多普勒超声联合磁共振检查在胎脑发育异常中的临床应用价值。方法收集本院围产保健门诊孕妇中筛选出符合条件者1 118名,于妊娠16、24、32周进行超声或磁共振检查,观察胎儿脑发育情况,异常者进行干预,出生后的婴儿进行发育随访。结果从1 118名符合条件的观察对象中共检出胎儿脑发育异常者34例。超声或磁共振检出典型脑发育畸形23例,其中15例终止妊娠,8例失去联系;11例轻度脑积水无典型畸形者经干预后,出生胎儿7例发育正常,另4例中2例智力和运动发育稍落后,2例运动落后者经康复治疗达正常水平。结论 MRI是超声发现胎脑异常的重要验证和补充诊断手段。典型的胎脑发育畸形可及时终止妊娠以减少出生缺陷;仅有轻度脑积水不合并脑发育畸形者可以在严密观察中继续妊娠;出生婴儿可以正常发育,部分会有发育落后经康复治疗可达正常儿发育水平。 | 王存强 王爱华 贺顺岭 申国琴 谷丽萍 顾韵泽 Yuan Ziyang Wang Wenna Liu Xiaokun | 2016 | 实用医技杂志2016，23，5： | 3 |
| 10 | Study on the quality evaluation metrics for compressed spaceborne hyperspectral data显示文摘Based on the raw data of spaceborne dispersive and interferometry imaging spectrometer,a set of quality evaluation metrics for compressed hyperspectral data is initially established in this paper.These quality evaluation metrics,which consist of four aspects including compression statistical distortion,sensor performance evaluation,data application performance and image quality,are suited to the comprehensive and systematical analysis of the impact of lossy compression in spaceborne hyperspectral remote sensing data quality.Furthermore,the evaluation results would be helpful to the selection and optimization of satellite data compression scheme. | LI Xiaohui ZHANG Jing LI Chuanrong LIU Yi LI Ziyang ZHU Jiajia ZENG Xiangzhao | 2015 | Instrumentation2015，2，1： | 3 |
| 11 | Full-spectrum cell-free RAN for 6G systems:system design and experimental results显示文摘With distributed transceivers and scalable cooperative transmission,cell-free massive multipleinput multiple-output(CF-mMIMO)technology eliminates the“cells”of traditional mobile communications,thereby significantly improving the performance of wireless networks.CF-mMIMO is considered as a major technical tool for achieving the key performance indicators of sixth generation(6G)mobile communication systems.In this paper,a scalable implementation architecture for CF-mMIMO is proposed,based on which potential key technologies such as channel information acquisition,transceiver design,dynamic user and access point association,and novel duplexing are introduced.Finally,based on low-cost commercial access points,a CF-mMIMO testbed with 64 transmit and receive antennas is developed,and the performance of the distributed receiver design is evaluated. | Dongming WANG Xiaohu YOU Yongming HUANG Wei XU Jiamin LI Pengcheng ZHU Yanxiang JIANG Yang CAO Xinjiang XIA Ziyang ZHANG Qingji JIANG Pan WANG Dongjie LIU Kang ZHENG Mengting LOU Jing JIN Qixing WANG Jiangzhou WANG | 2023 | Science China(Information Sciences)2023，66，3： | 3 |
| 12 | A highly selective catalyst of Co/La_(4)Ga_(2)O_(9) for CO_(2) hydrogenation to ethanol显示文摘A new catalyst of Co/La_(4)Ga_(2)O_(9) for CO_(2) hydrogenation to produce ethanol was prepared by reducing LaCo^(0).5 Ga0.5 O3,which showed excellent selectivity to ethanol(%35 C-mol%)at mild reaction conditions(270°C,3.5 MPa,3000 m L g-1 h-1).The catalysts were characterized by N_(2) adsorption/desorption,XRD,XAFS,CO and CO_(2)-TPD,H2 chemisorption,XPS and TEM techniques.The interaction between Co nanoparticles(NPs)and La2+4 Ga_(2)O_(9) oxide resulted in Co^(0)-Coon the surface of Co NPs.It was proposed that La_(4)Ga_(2)O_(9) could catalyze reverse water gas shift reaction(r-WGS),which converted CO_(2) to CO.Then,the CO migrated to Co^(0)-Co^(2+)on Co NPs,where it was hydrogenated to form ethanol like higher alcohols synthesis from syngas.The results suggest that by controlling the oxidation state of cobalt,and combined with a kind of active site for activating CO_(2) to form CO,a catalyst with excellent selectivity to ethanol could be obtained for CO_(2) hydrogenation,which means that the complex reaction may be proceed with high selectivity using only one active metal component. | Kang An Siran Zhang Jiaming Wang Qiang Liu Ziyang Zhang Yuan Liu | 2021 | Journal of Energy Chemistry2021，30，5： | 3 |
| 13 | Reaction procedure of a graphite fiber reinforced Ti-Al composite produced by squeeze casting-in situ reaction显示文摘The in situ reaction procedure and microstructure evolution of a graphite fiber reinforced Ti-Al composite (Grf/Ti-Al) was investigated, and the stability of TiAl3 at high temperature was discussed. As-cast material was prepared by pressing molten pure aluminum into a preform, which was composed of titanium particles and graphite fibers. The in situ reaction procedure of the as-cast material was investigated by differential scanning calorimetry (DSC), and phases in the products were detected by X-ray diffraction (XRD). Experimental results showed that TiAl3 was formed first. With an increase in temperature, TiC and Al4C3 were observed, but TiAl3 decreased. In the final product, Al2O3 and TiO2 were observed. It was considered that the previous forming TiAl3 decomposed, then TiC precipitated, and subsequently, oxidation resulted in the formation of Al2O3 and TiO2. | WU Gaohui LIU Yanmei XIU Ziyang JIANG Longtao YANG Wenshu | 2010 | Rare Metals2010，29，1： | 2 |
| 14 | A robust visual SLAM system in dynamic man-made environments显示文摘This paper presents a robust visual simultaneous localization and mapping(SLAM) system that leverages point and structural line features in dynamic man-made environments. Manhanttan world assumption is considered and the structural line features in such man-made environments provide rich geometric constraint, e.g., parallelism. Such a geometric constraint can be therefore used to rectify 3 D maplines after initialization. To cope with dynamic scenarios, the proposed system are divided into four main threads including 2 D dynamic object tracking, visual odometry, local mapping and loop closing. The 2 D tracker is responsible to track the object and capture the moving object in bounding boxes. In such a case, the dynamic background can be excluded and the outlier point and line features can be effectively removed. To parameterize 3 D lines, we use Pl ¨ucker line coordinates in initialization and projection processes, and utilize the orthonormal representation in unconstrained graph optimization process. The proposed system has been evaluated in both benchmark datasets and real-world scenarios, which reveals a more robust performance in most of the experiments compared with the existing state-of-the-art methods. | LIU JiaCheng MENG ZiYang YOU Zheng | 2020 | Science China(Technological Sciences)2020，63，9： | 2 |
| 15 | Insight into the adsorption of tetracycline onto amino and amino–Fe^(3+) gunctionalized mesoporous silica: Effect of functionalized groups显示文摘In order to study the influences of functionalized groups onto the adsorption of tetracycline,we prepared a series of amino and amino–Fe^(3+)complex mesoporous silica adsorbents with diverse content of amino and Fe^(3+)groups(named N,N-SBA15 and Fe-N,N-SBA15).The resulting mesoporous silica adsorbents were fully characterized by X-ray powder diffraction(XRD),Fourier transform infrared spectrometer(FTIR)and N_2adsorption/desorption isotherms.Furthermore,the effects of functionalized groups on the removal of TC were investigated.The results showed that the periodic ordered structure of SBA-15 was maintained after modification of amino/Fe^(3+)groups.The functionalized amino groups decreased the adsorption capacity while the coordinated Fe^(3+)increased the adsorption capacity.The adsorption kinetics of TC fitted pseudo-second-order model well and the equilibrium was achieved quickly.The adsorption isotherms fitted the Langmuir model well and with the Fe^(3+)content increased from 3.93%to 8.26%,the Q_(max)of the adsorbents increased from 102 to 188 mmol/kg.The solution p H affected the adsorption of TC onto amino complex adsorbents slightly while influenced the adsorption onto Fe-amine complex adsorbents greatly.The adsorption of TC on SBA15 and N,N-SBA15 may be related to the formation of outer-sphere surface complexes,while the adsorption of TC onto Fe-N,N-SBA15 was mainly attributed to the inner-sphere surface complexes.This study could offer potential materials that have excellent adsorption behavior for environmental remediation and suggested useful information for the preparing other adsorbents in environmental applications. | Ziyang Zhang Haiyan Li Huijuan Liu | 2018 | Journal of Environmental Sciences2018，30，3： | 2 |
| 16 | Coherence-enhancing line drawing for color images显示文摘Line drawing plays an important role in many image-based non-photorealistic applications.However,most existing approaches use a grayscale edge detector for line extraction,so that only luminance diferences between nearby image pixels is taken into account,but the chrominance diferences is ignored.This leads to the undesirable consequence that visually signifcant edges in adjacent regions with diferent colors of similar luminance cannot be detected.To address this limitation,we present a novel enhanced line drawing method based on a flow-based diference-of-Gaussians(FDoG)flter.Because of an inherent property of the thresholded DoG edge model,captured lines may appear dislodged from the true edges in the image.To this end,we provide a gradient-guided warping technique so that smooth and coherent lines can be extracted in the correct location.The GPU implementation of the proposed algorithms allows real-time performance,and experimental examples with various color images demonstrate the method’s superior qualitative performance over previous approaches. | WANG ShanDong MA ZiYang LIU XueHui CHEN YanYun WU EnHua | 2013 | Science China(Information Sciences)2013，56，11： | 2 |
| 17 | An MPC-based manoeuvre stability controller for full drive-by-wire vehicles显示文摘Aiming at the actuator time delay caused by the drive-by-wire technology,a novel manoeuvre stability controller based on model predictive control is proposed for full drive-by-wire vehicles.Firstly,the future vehicle dynamics are predicted by a twodegree-of-freedom vehicle model with input delay.Secondly,in order to prevent the vehicle from destabilizing due to excessive side slip angles,the determined ideal yaw rate and side slip angle are tracked simultaneously by optimizing the front wheel angle and additional yaw moment.Moreover,in order to improve the trajectory tracking ability,a side slip angle constraint determined by phase plane stability boundaries is added to the cost function.The results of Matlab and veDYNA co-simulation show that the regulated yaw rate can track the reference value well and the side slip angle decreases.Meanwhile,the trajectory tracking ability is improved obviously by compensating the time delay. | Ping WANG Ziyang LIU Qifang LIU Hong CHEN | 2019 | Control Theory and Technology2019，17，4： | 2 |
| 18 | Current advances in design and engineering strategies of industrial enzymes显示文摘Enzymes are considered as functional proteins,also known as biocatalysts,which are required for normal cellular function.The commercial production of enzymes with distinct features always remains the top priority of researchers for industrial biocatalysis.However,the insufficient yield,low stability,low activity,formation of by-products,complex purification pro-cess,and many other factors are challenging for the enzyme production industry.Novel advancements in protein engineering,especially the combination of multidisciplinary techniques including post-translational enzyme modification,structured assisted protein tailoring and computational modeling approaches,open a new horizon to more efficient production of bio-catalysts.In this review,we focus on the development process of enzyme modification design strategies,such as rational design,semi-rational design and de novo design.Selected examples for each strategy,which are particularly useful for novel enzyme design,are given.We hope this review is helpful for the development of biocatalysts for industrial application. | Tanatarov Dinmukhamed Ziyang Huang Yanfeng Liu Xueqin Lv Jianghua Li Guocheng Du Long Liu | 2021 | Systems Microbiology and Biomanufacturing2021，1，1： | 2 |
| 19 | Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis显示文摘The immune microenvironment induced by biomaterials played vital roles in bone regeneration.Hydroxyapatite(HA)and its ion-substituted derivates represent a large class of core inorganic materials for bone tissue engineering.Although ion substitution was proved to be a potent way to grant HA more biological functions,few studies focused on the immunomodulatory properties of ion-doped HA.Herein,to explore the potential osteoimmunomodulatory effects of ion-doped HA,zinc and strontium co-assembled into HA through a collagen template biomimetic way(ZnSr-Col-HA)was successfully achieved.It was found that ZnSr-Col-HA could induce a favorable osteo-immune microenvironment by stimulating macrophages.Furthermore,ZnSr-Col-HA demonstrated a procedural promoting effect on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.Specifically,the osteo-immune microenvironment acted as a dominant factor in promoting osteogenic gene expressions at the early stage through OSM signal pathway.Whereas the direct stimulating effects on BMSCs by Zn^(2+)/Sr^(2+) were more effectively at the later stage with Nfatc1/Maf and Wnt signals activated.In vivo study confirmed strong promoting effects of ZnSr-Col-HA on critical-sized cranial defect repair.The current study indicated that such a combined biomaterial design philosophy of dual ion-doping and biomimetic molecular co-assembly to endow HA applicable osteoimmunomodulatory characteristics might bring up a new cutting-edge concept for bone regeneration study. | Zhenyu Zhong Xiaodan Wu Yifan Wang Mengdie Li Yan Li XuLong Liu Xin Zhang Ziyang Lan Jianglin Wang Yingying Du Shengmin Zhang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 20 | Realization of high-performance tri-layer graphene saturable absorber mirror fabricated via a one-step transfer process显示文摘Graphene,as a saturable absorber(SA),has attracted much attention for its application in ultrashort pulse fiber lasers due to its ultrafast interband carrier relaxation and ultra-broadband wavelength operation.Nevertheless,during the stacking process of monolayer graphene layer,the induced nonuniform contact at the interface of graphene layers deteriorate the device performance.Herein,we report the fabrication of graphene saturable absorber mirrors(SAMs)via a one-step transfer process and the realization of the much enlarged modulation depth and the much reduced nonsaturable loss with tri-layer graphene(TLG)than single-layer graphene(SLG)due to the improved uniform contact at the interface.Moreover,the operation of 1550 nm mode-locked Er-doped fiber laser with the TLG SAM exhibits excellent output characteristics of the maximum output power of 9.9 mW,a slope efficiency of 2.4%and a pulse width of 714 fs.Our findings are expected to pave the way toward high-performance ultrashort pulse fiber lasers based on graphene SAs. | Cheng Jiang Xu Wang Jian Liu Jiqiang Ning Changcheng Zheng Xiaohui Li Ziyang Zhang | 2020 | Journal of Semiconductors2020，41，1： | 2 |
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