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| 1 | Optical vortices 30 years on:OAM manipulation from topological charge to multiple singularities显示文摘Thirty years ago,Coullet et al.proposed that a special optical field exists in laser cavities bearing some analogy with the superfluid vortex.Since then,optical vortices have been widely studied,inspired by the hydrodynamics sharing similar mathematics.Akin to a fluid vortex with a central flow singularity,an optical vortex beam has a phase singularity with a certain topological charge,giving rise to a hollow intensity distribution.Such a beam with helical phase fronts and orbital angular momentum reveals a subtle connection between macroscopic physical optics and microscopic quantum optics.These amazing properties provide a new understanding of a wide range of optical and physical phenomena,including twisting photons,spin–orbital interactions,Bose-Einstein condensates,etc.,while the associated technologies for manipulating optical vortices have become increasingly tunable and flexible.Hitherto,owing to these salient properties and optical manipulation technologies,tunable vortex beams have engendered tremendous advanced applications such as optical tweezers,high-order quantum entanglement,and nonlinear optics.This article reviews the recent progress in tunable vortex technologies along with their advanced applications. | Yijie Shen Xuejiao Wang Zhenwei Xie Changjun Min Xing Fu Qiang Liu Mali Gong Xiaocong Yuan | 2019 | Light(Science & Applications)2019，8，1： | 77 |
| 2 | Engineering Broad-Spectrum Bacterial Blight Resistance by Simultaneously Disrupting Variable TALE-Binding Elements of Multiple Susceptibility Genes in Rice显示文摘Xanthomonas oryzae pv.oryzae(Xoo),the causal agent of bacterial blight of rice,employs the transcription activator-like effectors(TALEs)to induce the expression of the OsSWEET family of putative sugar transporter genes,which function in conferring disease susceptibility(S)in rice plants.To engineer broadspectrum bacterial blight resistance,we used CRISPR/Cas9-mediated gene editing to disrupt the TALEbinding elements(EBEs)of two S genes,OsSWEETH and OsSWEET14,in rice cv.Kitaake,which harbors the recessive resistance allele of Xa25/OsSWEET13.The engineered rice line MS14K exhibited broadspectrum resistance to most Xoo strains with a few exceptions,suggesting that the compatible strains may contain new TALEs.We identified two PthXo2-like TALEs,Tal5LN18 and Tal7PX061,as major virulence factors in the compatible Xoo strains LN18 and PX061,respectively,and found that Xoo encodes at least five types of PthXo2-like effectors.Given that PthXo2/PthXo2.1 target OsSlVEETf3 for transcriptional activation,the genomes of 3000 rice varieties were analyzed for EBE variationsin the OsSWEET13 promoter,and 10Xa25-like haplotypes were identified.We found that Tal5LN18 and Tal7PX〇6i bind slightly different EBE sequences in the OsSWEET13 promoter to activate its expression.CRISPR/Cas9 technology was then used to generate InDels in the EBE of the OsSWEET13 promoter in MS14K to creat a new germplasm with three edited OsSWEET EBEs and broad-spectrum resistance against all Xoo strains tested.Collectively,our findings illustrate how to disarm TALE-S co-evolved loci to generate broad-spectrum resistance through the loss of effector-triggered susceptibility in plants. | Zhengyin Xu Xiameng Xu Qiang Gong Ziyang Li Ying Li Sai Wang Yangyang Yang Wenxiu Ma Longyu Liu Bo Zhu Lifang Zou Gongyou Chen | 2019 | Molecular Plant2019，12，11： | 29 |
| 3 | Changes of activated circulating endothelial cells and survivin in patients with non-small cell lung cancer after antiangiogenesis therapy显示文摘背景尽管 antiangiogenesis 治疗与它的公认的功效和细微不利效果在反肿瘤的治疗起一个重要作用,没有未来的临床的试用为预言 antiangiogenic therapy.This 学习的功效被承担在预言非小的 cel 的 therapy.Methods 病人的功效在 anti-angiogenesis 治疗和他们的意义以后调查激活的传播 endothelial 房间( aCECs )和 survMn | WANG Jing HUANG Chun WEI Xi-yin QI Da-liang GONG Li-qun MU Hai-yu YAO Qiang LI Kai | 2008 | Chinese Medical Journal2008，，22： | 24 |
| 4 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 5 | Minimally invasive percutaneous compression plating versus dynamic hip screw for intertrochanteric fractures: a randomized control trial显示文摘ObjectiveIntertrochanteric 腿节骨折是在老病人的普通损害。动态新潮的螺丝钉(DHS ) 为固定用作标准选择;然而,它有几个缺点。经皮的压缩板(PCCP ) 的研究关于它的功效和安全仍然是不确定的。由比较二个方法,我们与 intertrochanteric 腿节破裂估计了他们 121 个老病人的临床的治疗学的 outcome.MethodsA 总数(类型 AO/OTA 31 .A1-A2 , Evans 类型 1 )随机被划分成经历一个最低限度地侵略的 PCCP 过程或操作持续时间是的一个常规 DHS fixation.ResultsThe 平均数的二个组在 PCCP 组显著地更短( 55.2 ; min 对 88.5 ; min , P ;< ; 0.01 )。血损失是 156.5 ml ± 18.3 在 PCCP 组和 513.2 的 ml; ml ± 66.2 在 DHS 组的 ml (P < 0.01 ) 。在与 PCCP 对待的病人之中, 3.1% 需要输血,与 44.6% 那些那有的 DHS 外科相比(P < 0.01 ) 。PCCP 组显示了不太手术后的复杂并发症(P < 0.05 ) 。在 PCCP 组的麻醉学者分数和哈里斯臀部分数的吝啬的美国社会比在 DHS 组的那些好。在到几个优点的吝啬的医院停留,死亡率,或骨折 healing.ConclusionDue 没有重要差别, PCCP 有潜力为对待 intertrochanteric 破裂成为理想的选择(类型 AO/OTA 31 .A1-A2, Evans 类型 1 ) ,在特别地老。 | Cheng Qiang Huang Wei Gong Xuan Wang Changdong Liang Xi Hu Ning | 2014 | Chinese Journal of Traumatology2014，17，5： | 20 |
| 6 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 7 | Process analysis of PM_(2.5) pollution events in a coastal city of China using CMAQ显示文摘US EPA's Community Multiscale Air Quality modeling system(CMAQ) with Process Analysis tool was used to simulate and quantify the contribution of individual atmospheric processes to PM_(2.5) concentration in Qingdao during three representative PM_(2.5) pollution events in the winter of 2015 and 2016. Compared with the observed surface PM_(2.5) concentrations, CMAQ could reasonably reproduce the temporal and spatial variations of PM_(2.5) during these three events. Process analysis results show that primary emissions accounted for 72.7%–93.2% of the accumulation of surface PM_(2.5) before and after the events.When the events occurred, primary emissions were still the major contributor to the increase of PM_(2.5) in Qingdao, however the contribution percentage reduced significantly,which only account for 51.4%–71.8%. Net contribution from horizontal and vertical transport to the accumulation of PM_(2.5) was also positive and its percentage increased when events occurred. Only 1.1%–4.6% of aerosol accumulation was due to PM processes and aqueous chemical processes before and after events. When the events occurred,contribution from PM processes and aqueous chemistry increased to 6.0%–11.8%. Loss of PM_(2.5) was mainly through horizontal transport, vertical transport and dry deposition, no matter during or outside the events. Wet deposition would become the main removal pathway of PM_(2.5), when precipitation occurred. | Qiang Zhang Di Xue Xiaohuan Liu Xiang Gong Huiwang Gao | 2019 | Journal of Environmental Sciences2019，31，5： | 17 |
| 8 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 9 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 10 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 11 | Identification of Festuca arundinacea Schreb Cat1 Catalase Gene and Analysis of its Expression Under Abiotic Stresses显示文摘不能生活的压力例如干旱,高咸度,和 cold/freezing,导致植物生产过量反应的氧种类。过氧化氢酶,唯一的氢 peroxide-scavengingenzyme,在植物起一个很重要的作用。为了描绘过氧化氢酶,在对不能生活的压力的工厂反应包含了,我们从 4 度构造了一个 cDNA 图书馆对待 C 的 Festucaarundinacea Schreb 幼苗并且从这个图书馆孤立过氧化氢酶基因。cDNA (FaCat1, 1 735bp ) 包含了 1 479 bp 的一个开的读物框架。强风分析显示推出的氨基酸顺序从 maizeZmCat2 与那从小麦 TaCat1 和 87% 身份与那显示出 96% 身份。北弄污分析与根在对比在叶子显示出 FaCat1 抄本的明显的增加。在 F 的 FaCat1 的表示的时间功课分析。arundinacea 叶子证明那 FaCat1 表情起来在强调寒冷、强调盐的叶子调整了,与分别地主要在在冷或咸的应力以后的 4 或 2 h 积累的 FaCat1transcripts。在 FaCat1 抄写的重要变化都没在弄干的叶子被观察, FaCat1 抄写的抑制在对待的酸(骆驼毛的织物) 离开的 abscisic 被发现,显示 FaCat1 基因是在在 F 的寒冷,高盐,干旱,和骆驼毛的织物处理期间表示的差别。arundinacea 离开…… | Wen-Long Yang Jing-Mei Liu Fan Chen Qiang Liu Yan-Dao Gong Nan-Ming Zhao | 2006 | Journal of Integrative Plant Biology2006，48，3： | 14 |
| 12 | Relationship of chemical properties of different peanut varieties to peanut butter storage stability显示文摘This study examined the effect of peanut quality on the storage stability of peanut butter. The quality of 17 varieties of peanuts was analyzed, and each was used to prepare peanut butter. For different storage temperatures and durations, stability of the peanut butter was measured according to three indicators: peroxide value, acid value, and centrifugal rate. The correlation between peanut components and peanut butter storage stability was also investigated. The results indicated significant differences in fatty acid composition between different varieties of peanut. Peanut butter prepared with high oleic peanuts(Kainong 17-15) had a significantly longer shelf life than that of other varieties. The significant correlation between the stability of peanut butter and peanut quality suggests that oleic acid and linoleic acid were the main influencing factors on stability. This study finds that the high oleic peanuts(HOP) is the most suitable variety for making peanut butter, which can allow farmers and processors to choose the specific variety for better product and shelf life. | GONG A-na SHI Ai-min LIU Hong-zhi YU Hong-wei LIU Li LIN Wei-jing WANG Qiang | 2018 | Journal of Integrative Agriculture2018，17，5： | 14 |
| 13 | Determination of Forchlorfenuron Dissipation and Residue in Cucumbers and Red Soil显示文摘To assess the risks of forchlorfenuron after application, a residue analysis method for ferchlorfenuron in cucumbers and the red soil of Southern China was established, and the dissipation behavior and residue characteristics of forchlorfenuron were studied under field conditions. The field trials, including dissipation and residue experiments, were conducted in Hunan, Yunnan and Hainan Provinces. Forchlorfenuron was applied at 32 a.i.g ha-1 rate for the dissipation study and both 21 and 32 a.i.g ha-1 for the residue study. Representative cucumbers and soil samples were collected at predetermined intervals for HPLC for UV-detector analysis. The average recoveries of the method were 80.8%-92.0% with coefficients variation (CV) between 0.4% and 11.8%. The detection limit of forchlorfenuron in cucumbers and soil samples was 0.003 mg · kg-1 and the minimum detectable amount was 3.0×10-10 g. The half life of forchlorfenuron in cucumbers in the three provinces changed as: Yunnan (5.50 days), Hunan (5.88 days), and Hainan (6.53 days) and in the soil was observed: Hainan (6.54 days), Hunan (7.64 days), and Yunnan (8.39 days). The maximum terminal residue in cucumbers at 32 a.i.g ha-1 rate after 5 days was 0.009 mg · kg-1 (Yunnan) followed by 0.0085 mg · kg-1 (Hainan) and 0.0082 mg · kg-1 (Hunan) which was below MRL value of 0.01 mg · kg-1 established by the USA, EPA. So a waiting period of 5 days should be established after spaying on cucumbers to avoid hazard to human beings. | LIU Qiang GONG Daoxin PENG Xiaochun YAN Xiaojun | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，1： | 11 |
| 14 | Preparation and modification of activated carbon for benzene adsorption by steam activation in the presence of KOH显示文摘A series of activated carbons from Taixi anthracite were prepared by steam activation in the presence of KOH and then they were modified by different methods. The regulation of porosity and the modification of surface chemistry were carried out with the aim to improve the benzene adsorption capacity of activated carbon. The influences of KOH and activation process parameters including activation temperature, activation time and steam flow rate on porosity of activated carbon were evaluated, and the effect of modification methods on surface chemistry was investigated. Also, the relationship between benzene adsorption capacity and porosity and surface chemistry was analyzed. Results show that activation temperature is the dominant factor in the activation process; the introduction of KOH into the raw material can enhance the reactivity of char in activation process, meanwhile it shows a negative effect on the porosity development, especially on the mesopore development. Results of FTIR analysis indicate that anthracite-based activated carbon with condensed aromatics and chemically inert oxygen does not present the nature to be surface modified. Besides, benzene adsorption capacity has an approximate linear relationship with surface area and in our preparation, benzene adsorption capacity and surface area of activated carbon are up to 1210 m 2 /g and 423 mg/g, respectively. | Yao Xin Liu Jinchang Gong Guozhuo Jiang Yu Xie Qiang | 2013 | International Journal of Mining Science and Technology2013，23，3： | 10 |
| 15 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 16 | Postoperative complications in patients with portal vein thrombosis after liver transplantation:Evaluation with Doppler ultrasonography显示文摘AIM: To study the postoperative complications in patients with preoperative portal vein thrombosis (PVT) undergoing liver transplantation (LT) and to evaluate the complications with Doppler ultrasonography. METHODS: Retrospective studies were performed on 284 patients undergoing LT (286 LT) with respect to pre-and postoperative clinical data and Doppler ultrasonography. According to the presence and grade of preoperative PVT, 286 LTs were divided into three groups: complete PVT (c-PVT), partial PVT (p-PVT) and non-PVT, with 22, 30 and 234 LTs, respectively. Analyses were carried out to compare the incidence of early postoperative complications. RESULTS: PVT, inferior vena cava (IVC) thrombosis, hepatic artery thrombosis (HAT) and biliary complications were found postoperatively. All complications were detected by routine Doppler ultrasonography and diagnoses made by ultrasound were confirmed by clinical data or/and other imaging studies. Nine out of 286 LTs had postoperative PVT. The incidence of the c-PVT group was 22.7%, which was higher than that of the p-PVT group (3.3%, P < 0.05) and non-PVT group (1.3%, P < 0.005). No difference was found between the p-PVT and non-PVT groups (P > 0.25). Of the 9 cases with postoperative PVT, recanalizations were achieved in 7 cases after anticoagulation under the guidance of ultrasound, 1 case received portal vein thrombectomy and 1 case died of acute injection. Ten LTs had postoperative IVC thrombosis. The c-PVT group had a higher incidence of IVC thrombosis than the non-PVT group (9.1% vs 2.6%, P < 0.05); no significant difference was found between either the c-PVT and p-PVT groups (9.1% vs 6.7%, P > 0.5) or between the p-PVT and non-PVT groups (P > 0.25). Nine cases with IVC thrombosis were cured by anticoagulation under the guidance of ultrasound, and 1 case gained natural cure without any medical treatment after 2 mo. HAT was found in 2 non-PVT cases, giving a rate of 0.7% among 286 LTs. Biliary complications were seen in 12 LTs. The incidence of biliary complications in the c-PVT, p-PVT and non-PVT groups was 9.1%, 3.3% and 4.3%, respectively (P > 0.25 for all), among which 2 stenosis led retransplantations and others were controlled by relative therapy. CONCLUSION: C-PVT patients tend to have a higher incidence of PVT and IVC thrombosis than non-PVT patients after LT. The incidence of postoperative complications in p-PVT patients does not differ from that of non-PVT patients. A relatively low incidence of HAT was seen in our study. Doppler ultrasonography is a convenient and efficient method for detecting posttransplant complications and plays an important role in guiding treatment. | Yi-Ping Jia Qiang Lu Shu Gong Bu-Yun Ma Xiao-Rong Wen Yu-Lan Peng Ling Lin Hong-Yan Chen Li Qiu Yan Luo | 2007 | World Journal of Gastroenterology2007，13，34： | 10 |
| 17 | New triterpenoid sapoin from Ardisia gigantifolia Stapf.显示文摘One new triterpenoid sapoin with two known triterpenoid sapoins:3β-O-{α-L-rhamnopyranosyl-(1→3)-[β-D-xylopyranose-(1→2)]-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-oleanan-16-oxo-30-al(1),3β-O-{α-L-rhamnopyranosyl-(1→3)-[(β-D-xylopyranosyl-(1→2)]-β-D-galactopyranosyl-(1→4)-[(β-D-glucopyranosyl-(1→2)]-α-L-ara-binopyranoside}-16α-hydroxy-13,28-epoxy-oleanane(2) and cyclamiretin A 3β-O-α-L-rhamnopyranosyl-(l→3)-[P-D-xylopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosy... | Gong, Qiang Qiang Mu, Li Hua Liu, Ping Yang, Shi Lin Wang, Bo Feng, Yu Lin | 2010 | Chinese Chemical Letters2010，21，4： | 10 |
| 18 | Heavy Ion Beams Induce Survivin Expression in Human Hepatoma SMMC-7721 Cells More Effectively than X-rays显示文摘高线性的精力转移(让)重离子放射在导致生物损坏比是更有效的低--让的X光或 y-rays.Heavy 离子横梁在批评癌症织物提供好剂量本地化(布拉格山峰)并且在房间越过剂量山峰杀死给更高相对的生物有效性,那么高--让的重离子横梁比在癌症 treatment.Survivin 的 low-LETradiation 优异作为 apoptosis 蛋白质家庭的禁止者的一个成员,可能帮助癌的房间克服 G_2/M apoptotic 检查点并且在暴露以后在人的 hepatoma SMMC-7721cell 线通过 mitosis.Survivin 表示赞成转变房间的异常前进到低--让的X光检查和高度--让的碳离子照耀在这研究被调查。与X光检查照耀相比,清楚地引起 G_2/M 拘捕并且在剂量依赖者 manner.Clonogenic 幸存试金支持了 survivin 基因的表示的碳离子横梁证明 SMMC-7721 房间对高度更对射线敏感--比到theX光线让碳离子,并且放射敏感度与特定的 survivin 在治疗以后被支持在 transcriptional 和翻译层次的短介入 RNA.Differential survivin 表示被作出对 SMMC-7721 房间列在后面有利的裁决低--并且高--让的照耀。过去 survivinin SMMC-7721 房间的表示可能是癌的房间有辐射抵抗到象高的稠密的电离那样的强壮的刺激的一个重要原因 -- 让的放射。然而,由高度的癌的房间上的直接杀死效果 -- 让的放射可能是比 apoptosis 抑制通过更重要的过去 survivin 的表示后面的重离子照耀。 | Li GONG Xiaodong JIN Qiang LI Jiangtao LIU Lizhe AN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 9 |
| 19 | Use of suppression subtractive hybridization strategy for cloning and identifying specifically expressed genes of renal cell carcinoma显示文摘Using suppression subtractive hybridization, a renal cell carcinoma (RCC) cDNA subtractive library which only contains differently expressed cDNAs between human RCC and normal kidney has been constructed. 200 clones were picked out randomly to perform enzyme digest analysis, a part of them underwent sequence analysis and Northern blot to identify RCC specially expressed genes. Results showed that 190 clones contain 50-400 bp inserts respectively. Sequence analysis was performed in 10 clones. All the 10 sequences were unknown before and derived from 6 unique novel genes among which the cDNA insert RCC18 has five copies. Northern blot analysis showed that RCC18 cDNA expressed highly in RCC, but there was no signal detected in normal kidney, and the full length of RCC18 was about 2.5 kb. The constructed cDNA subtractive library of human RCC is a highly efficient one and lays the solid foundation for large-scale screening and cloning new and specific oncogenes or tumor suppressor genes of RCC. The novel | ZHANG Qiang ZHANG Zhiwen GONG Kan XIN Dianqi NA Yanqun GUO Yinlu | 2001 | Chinese Science Bulletin2001，46，3： | 8 |
| 20 | Versatile on-chip light coupling and(de)multiplexing from arbitrary polarizations to controlled waveguide modes using an integrated dielectric metasurface显示文摘Metasurfaces have found broad applicability in free-space optics,while its potential to tailor guided waves remains barely explored.By synergizing the Jones matrix model with generalized Snell’s law under the phase-matching condition,we propose a universal design strategy for versatile on-chip mode-selective coupling with polarization sensitivity,multiple working wavelengths,and high efficiency concurrently.The coupling direction,operation frequency,and excited mode type can be designed at will for arbitrary incident polarizations,outperforming previous technology that only works for specific polarizations and lacks versatile mode controllability.Here,using silicon-nanoantenna-patterned silicon-nitride photonic waveguides,we numerically demonstrate a set of chip-scale optical couplers around 1.55μm,including mode-selective directional couplers with high coupling efficiency over 57%and directivity about 23 d B.Polarization and wavelength demultiplexer scenarios are also proposed with 67%maximum efficiency and an extinction ratio of 20 d B.Moreover,a chip-integrated twisted light generator,coupling free-space linear polarization into an optical vortex carrying 1 h orbital angular momentum(OAM),is also reported to validate the mode-control flexibility.This comprehensive method may motivate compact wavelength/polarization(de)multiplexers,multifunctional mode converters,on-chip OAM generators for photonic integrated circuits,and high-speed optical telecommunications. | YUAN MENG ZHOUTIAN LIU ZHENWEI XIE RIDE WANG TIANCHENG QI FUTAI HU HYUNSEOK KIM QIRONG XIAO XING FU QIANG WU SANG-HOON BAE MALI GONG XIAOCONG YUAN | 2020 | Photonics Research2020，8，4： | 8 |
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