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| 1 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 2 | Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation显示文摘Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone defects.Amongst different kinds of injectable bone cements,bioactive calcium phosphate bone cement(CPC)has been widely studied due to its biological activity.However,its dense structure and poor biodegradability prevent the ingrowth of living tissue,which leads to undesirable bone regeneration and clinical translation.To address this issue,we prepared bone cement based on Magnesium-containing microspheres(MMSs)that can not only be cured into a 3D porous scaffold but also have controllable biodegradability that continuously provides space for desired tissue ingrowth.Interestingly,magnesium ions released from MMSs cement(MMSC)trigger positive immunomodulation via upregulation of the anti-inflammatory genes IL-10 and M2 macrophage polarization with increased expression of CD206,which is beneficial to osteogenesis.Moreover,the physicochemical properties of MMSC,including heat release,rheology and setting time,can be tuned to meet the requirements of injectable bone cement for clinical application.Using a rat model,we have demonstrated that MMSC promoted osteogenesis via mediation of tissue ingrowth and anti-inflammatory immunomodulation.The study provides a paradigm for the design and preparation of injectable bone cements with 3D porous structures,biodegradability and anti-inflammatory immunoregulation to efficiently promote osteogenesis. | Shenglong Tan Yifan Wang Yingying Du Yin Xiao Shengmin Zhang | 2021 | Bioactive Materials2021，6，10： | 9 |
| 3 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 4 | Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP显示文摘胸腺嘧啶 DNA glycosylase (TDG ) ,开始 G/T 和 G/U 的修理的酶错配,最近被发现 crucialin 胚胎维持 epigenetic 稳定性并且便于活跃 DNA demethylation 的开发。这里,我们在作为 -catenin/TCFs 建筑群的 transcriptional 激活剂发信号的 Wnt 报导 TDG 的 novelrole。我们 TDG 绑在 thetranscriptional 因素家庭 LEF1/TCFs 并且加强的数据表演 -catenin/TCFs transactivation,当 TDG 弄空压制 Wnt3a-stimulatedreporter 活动或目标基因抄写时。下次,我们显示出那 CBP,已知的激活剂,也为在目标倡导者上形成合作建筑群的 TDG functionthrough 被要求。而且,有在人的冒号 cancertissue 的 TDG 层次的举起,并且 TDG 击倒禁止冒号房间的增长。总的来说,我们的结果表明作为新激活剂, TDG 支持 -catenin/TCFs transactivation 并且机能上地在正规 Wnt 发信号与 CBP 合作。 | Yingying Jia Fen Nie Aiying Du Zhangcheng Chen Yuanbo Qin Tao Huang Xiaomin Song Lin Li | 2014 | Journal of Molecular Cell Biology2014，8，3： | 5 |
| 5 | Preparation of silver tin oxide powders by hydrothermal reduction and crystallization显示文摘Silver tin oxide composite powders were synthesized by the hydrothermal method with a silver ammine solution and a Na2SnO3 solution as raw materials. H2C2O4 was used as the co-precipitator of silver ions and tin ions. The co-precipitation conditions were investigated. The results show that the co-precipitate of Ag2C2O4 and Sn(OH)4 is available when the pH value of the solution is 4.27-8.36. Using the obtained precipitate as precursor,the reduction of Ag+ and the crystallization of tin oxide were carried out simultaneously by the hydrothermal method and silver tin oxide composite powders were obtained. The composite powders were characterized by X-ray diffraction (XRD) analysis,scanning electron microscope (SEM),and energy spectrum analysis. The results show that the silver tin oxide composite powders are small with a diameter of about 2 μm and with homogeneous distribution of tin. | DU Zuojuan YANG Tianzu GU Yingying QIU Xiaoyong DOU Aichun | 2007 | Rare Metals2007，26，5： | 4 |
| 6 | Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions显示文摘长期的神经病的疼痛的机制不是清楚的。浆液 microRNAs (miRNAs ) 可能为长期的紧张的损害显示出一个特殊特征。然而,很少为神经病的疼痛在传播 miRNAs 对变化被知道。因此,在传播 miRNAs 表示侧面变化因为神经病的疼痛被调查。在针的神经结扎(SNL ) 外科,和 microarray 分析被执行在 miRNA 表示侧面决定变化前后,浆液从老鼠被收集。在从一样的个人的浆液的煽动性的 cytokines 的表示包括 interleukin-6 (IL-6 ) ,肿瘤坏死因素 --(TNF-) ,并且单核白血球趋化性的 protein-1 (MCP-1 ) ,也被测量。结果证明 IL-6, TNF- ,和 MCP-1 的表示层次显著地在显著地与疼痛层次被相关的 SNL 老鼠被提高。有在 SNL 外科前后的显著地不同的表示层次的九 miRNAs 被 microarray 分析识别,它被量的即时聚合酶链反应分析进一步验证。与没有 SNL 外科的天真的老鼠相比,在在 SNL 外科以后的老鼠的浆液的五 miRNAs ( hsa-miR-221 , hsa-miR-34c , hsa-miR-21 , hsa-miR-30a-5p ,和 hsa-miR-206 )的表示被减少,四 miRNAs ( hsa-miR-31-5p , hsa-miR-133b , hsa-miR-22 ,和 hsa-miRPlus-A1087 )被增加,建议变化可以在神经病的疼痛的规定包含的那 miRNA 。TargetScan 被用来为这些 miRNAs 预言 mRNA 目标,并且结果证明有多重预言的目标地点的抄本属于神经病学地重要的小径。生物信息学分析表明几目标基因与房间发信号的激活有关与紧张的损害联系了。在这研究,在在神经病的疼痛条件下面的浆液的 miRNA 侧面的变化第一次被显示出,建议在浆液的那传播 miRNAs 侧面是为神经病的疼痛的一个潜在的预言者。 | Yongming Xu Xin Zhang Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 7 | Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel- evoked neuropathic pain显示文摘 | Yongming Xu Guangxia Cheng Yanrong Zhu Xin Zhang Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 3 |
| 8 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 9 | Si-doping bone composite based on protein template- mediated assembly for enhancing bone regeneration显示文摘 | Qin YANG Yingying DU Yifan WANG Zhiying WANG Jun MA Jianglin WANG Shengmin ZHANG | 2017 | Frontiers of Materials Science2017，11，2： | 3 |
| 10 | Ultra-robust triboelectric nanogenerator for harvesting rotary mechanical energy显示文摘 | Xinyu Du Nianwu Li Yuebo Liu Jiaona Wang Zuqing Yuan Yingying Yin Ran Cao Shuyu Zhao Bin Wang Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，5： | 2 |
| 11 | An Organic Solvent-Assisted Intercalation and Collection (OAIC) for Ti_(3)C_(2)T_(x) MXene with Controllable Sizes and Improved Yield显示文摘A good method of synthesizing Ti_(3)C_(2)T_(x)(MXene)is critical for ensuring its success in practical applications,e.g.,electromagnetic interference shielding,electrochemical energy storage,catalysis,sensors,and biomedicine.The main concerns focus on the moderation of the approach,yield,and product quality.Herein,a modified approach,organic solvent-assisted intercalation and collection,was developed to prepare Ti_(3)C_(2)T_(x) flakes.The new approach simultaneously solves all the concerns,featuring a low requirement for facility(centrifugation speed<4000 rpm in whole process),gram-level preparation with remarkable yield(46.3%),a good electrical conductivity(8672 S cm^(−1)),an outstanding capacitive performance(352 F g^(−1)),and easy control over the dimension of Ti_(3)C_(2)T_(x) flakes(0.47–4.60μm^(2)).This approach not only gives a superb example for the synthesis of other MXene materials in laboratory,but sheds new light for the future mass production of Ti_(3)C_(2)T_(x) MXene. | Danyao Qu Yingying Jian Lihao Guo Chen Su Ning Tang Xingmao Zhang Wenwen Hu Zheng Wang Zhenhuan Zhao Peng Zhong Peipei Li Tao Du Hossam Haick Weiwei Wu | 2021 | Nano-Micro Letters2021，13，11： | 2 |
| 12 | Mechanical Behavior and Failure Mechanism of 2.5D(Shallow Bend-joint, Deep Straight-joint) and 3D Orthogonal UHWMPE Fiber/Epoxy Composites by Vacuum-assistant-resin-infused显示文摘Ultra-high molecular weight polyethylene(UHMWPE) fiber/epoxy composites were fabricated by a vacuum assisted resin infused(VARI) processing technology. The curing condition of composites was at a cure temperature of 80 ℃ for 3h in a drying oven. The characteristics of 2.5D(shallow bend-joint and deep straight-joint) structure and 3D orthogonal structure were compared. The failure behavior, flexural strength, and microstructures of both composites were investigated. It was found that the flexural property was closely related to undulation angle θ. The flexural strength of 3D orthogonal structure composite was superior to the other two structures composites with the same weave parameters and resin. | 赵晓琳 DU Jianhua YANG Hongwei JIA Chengchang GAO Heng WANG Dafeng Lü Yingying | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 2 |
| 13 | MXene-Derived Defect-Rich TiO2@rGO as High-Rate Anodes for Full Na Ion Batteries and Capacitors显示文摘Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavior in electrode materials.Herein,a defective TiO2@reduced graphene oxide(M-TiO2@rGO)self-supporting foam electrode is constructed via a facile MXene decomposition and graphene oxide self-assembling process.The employment of the MXene parent phase exhibits distinctive advantages,enabling defect engineering,nanoengineering,and fluorine-doped metal oxides.As a result,the M-TiO2@rGO electrode shows a pseudocapacitance-dominated hybrid sodium storage mechanism.The pseudocapacitance-dominated process leads to high capacity,remarkable rate ability,and superior cycling performance.Significantly,an M-TiO2@rGO//Na3 V2(PO4)3 sodium full cell and an M-TiO2@rGO//HPAC sodium ion capacitor are fabricated to demonstrate the promising application of M-TiO2@rGO.The sodium ion battery presents a capacity of 177.1 mAh g-1 at 500 mA g-1 and capacity retention of 74%after 200 cycles.The sodium ion capacitor delivers a maximum energy density of 101.2 Wh kg-1 and a maximum power density of 10,103.7 W kg-1.At 1.0 A g-1,it displays an energy retention of 84.7%after 10,000 cycles. | Yongzheng Fang Yingying Zhang Chenxu Miao Kai Zhu Yong Chen Fei Du Jinling Yin Ke Ye Kui Cheng Jun Yan Guiling Wang Dianxue Cao | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 14 | Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis显示文摘The immune microenvironment induced by biomaterials played vital roles in bone regeneration.Hydroxyapatite(HA)and its ion-substituted derivates represent a large class of core inorganic materials for bone tissue engineering.Although ion substitution was proved to be a potent way to grant HA more biological functions,few studies focused on the immunomodulatory properties of ion-doped HA.Herein,to explore the potential osteoimmunomodulatory effects of ion-doped HA,zinc and strontium co-assembled into HA through a collagen template biomimetic way(ZnSr-Col-HA)was successfully achieved.It was found that ZnSr-Col-HA could induce a favorable osteo-immune microenvironment by stimulating macrophages.Furthermore,ZnSr-Col-HA demonstrated a procedural promoting effect on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.Specifically,the osteo-immune microenvironment acted as a dominant factor in promoting osteogenic gene expressions at the early stage through OSM signal pathway.Whereas the direct stimulating effects on BMSCs by Zn^(2+)/Sr^(2+) were more effectively at the later stage with Nfatc1/Maf and Wnt signals activated.In vivo study confirmed strong promoting effects of ZnSr-Col-HA on critical-sized cranial defect repair.The current study indicated that such a combined biomaterial design philosophy of dual ion-doping and biomimetic molecular co-assembly to endow HA applicable osteoimmunomodulatory characteristics might bring up a new cutting-edge concept for bone regeneration study. | Zhenyu Zhong Xiaodan Wu Yifan Wang Mengdie Li Yan Li XuLong Liu Xin Zhang Ziyang Lan Jianglin Wang Yingying Du Shengmin Zhang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 15 | Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation显示文摘许多 G 联合蛋白质的受体(GPCR ) 被报导涉及多重硬化(MS ) 的致病,并且 ~40% 所有识别 GPCR 依靠 Gq/11 G 蛋白质家庭刺激肌醇类脂化合物发信号。然而,在 MS 致病的 G 子单元的功能仍然是未知的。在这研究,我们试图在试验性的自体免疫的脑脊髓炎(EAE ) 的致病决定 Gq 的角色, MS 的一个著名老鼠模型。我们发现与野类型的老鼠相比, Gq 大美人老鼠展出了不太严重的 EAE 症状,与更低的临床的分数,减少的白血球渗入和不太广泛的 demyelination。而且, Th17 房间的一个显著地更低的百分比,在 MS 致病的关键播放器之一,在 Gq 大美人 EAE 老鼠被观察。在 vitro 的研究证明在 CD4 + T 房间的 Gq 的那缺乏直接损害了 Th17 区别。另外, Gq 的缺乏显著地损害了表明 DC 涉及减少的 IL-6 生产的小径的导出 DC 的 IL-6 生产,因此禁止的 Th17 区别和 Gq-PLC-PKC 和 Gq-MAPKs。在摘要,我们的数据在调整 Th17 区别和 MS 致病加亮 Gq 的关键角色。 | Weiming Lai Yingying Cai Jinfeng Zhou Shuai Chen Chaoyan Qin Cuixia Yang Junling Liu Xin Xie Changsheng Du | 2017 | Cellular & Molecular Immunology2017，14，6： | 2 |
| 16 | Studies on prediction of separation percent in electrodialysis process via BP neural networks and improved BP algorithms显示文摘 | Guolin Jing Wenting Du Yingying Guo | 2012 | Desalination2012，，： | 1 |
| 17 | Preparation of AgSnO2 composite powders by hydrothermal process显示文摘 | Yang Tianzu Du Zuojuan Gu Yingying | 2007 | J Central South University of Technology2007，14，2： | 1 |
| 18 | Tamoxifen attenuates reactive astrocyte-induced brain metastasis and drug resistance through the IL-6/STAT3 signaling pathway显示文摘Brain metastasis affects approxim ately 20%-30%of patients w ith triple-negative breast cancers(TNBCs).Even sm all metastatic lesions in the brain can trigg er severe neurological im pairm ents and result in extrem ely short survival time.Recently,active astrocytes were reported to be associated w ith brain metastases.However,how activated astrocytes regulate the behaviors of disseminated breast cancer cells in the brain remains unknown.In this study,human prim ary astrocytes were stim ulated w ith IL-1β to form active astrocytes to study the cross-talk between strom al cells(astrocytes)and TNBC cells in brain metastases.Our results showed that active astrocytes significantly increase the m alignancy of TNBC cells and prevent them from undergoing apoptosis caused by doxorubicin.We also found that the high level of IL-6 secreted by activated astrocytes was responsible for the drug resistance of breast cancer,which could be abolished by treatm ent of astrocytes with tam oxifen(TAM).The blockage of active astrocyte-derived IL-6 by a neutralizing antibody resulted in the attenuation of drug resistance,consequently enhancing the sensitivity of breast cancer cells to doxorubicin.Furthermore,the possible involved TAM-m odulated drug resistance mechanism may be associated with a decrease in IL-6 expression in astrocytes and the downregulation of MAPK and JAK2/STAT3 signaling in cancer cells.Our data suggested that TAMs might reduce drug resistance through the IL-6/JAK2/STAT3 signaling pathway,providing a possible therapy to treat brain metastasis in TNBCs,as estrogen receptor inhibitors(TAMs,etc.)can cross the blood-brain barrier. | Yongming Xu Yanrong Zhu Yong Yue Shaofeng Pu Junzhen Wu Yingying Lv Dongping Du | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 19 | Silica-facilitated proton transfer for high-temperature proton-exchange membrane fuel cells显示文摘High-temperature proton-exchange membrane fuel cells(HT-PEMFCs)have shown a broad prospect of applications due to the enhanced reaction kinetics and simplified supporting system.However,the proton conductor,phosphoric acid,tends to poison the active sites of Pt,resulting in high Pt consumption.Herein,Pt nanoparticles anchored on SiO_(2)-modified carbon nanotubes(CNT@SiO_(2)-Pt)are prepared as high-performance cathode catalysts for HT-PEMFCs.The SiO_(2)in CNT@SiO_(2)-Pt can induce the adsorption of phosphoric acid transferring from Pt active sites in the catalytic layer,avoiding the poisoning of the Pt,and the phosphate fixed by SiO_(2)provide a high-speed proton conduction highway for oxygen reduction reactions.Accordingly,The CNT@SiO_(2)-Pt cathode achieve superior power density of 765 mW cm^(−2)(160℃)and 1,061 mW cm^(−2)(220℃)due to the rapid proton-coupled electron process and outstanding stability in HT-PEMFCs.This result provides a new road to resolve the phosphate poisoning for the commercialization of HT-PEMFCs. | Gen Huang Yingying Li Shiqian Du Yujie Wu Ru Chen Jin Zhang Yi Cheng Shanfu Lu Li Tao Shuangyin Wang | 2021 | Science China Chemistry2021，64，12： | 1 |
| 20 | Novel alternative therapy for spinal tuberculosis during surgery: reconstructing with anti-tuberculosis bioactivity implants显示文摘 | JunFeng Dong ShengMin Zhang HaoMing Liu XinZhi Li YongHui Liu YingYing Du | 2014 | Expert Opinion on Drug Delivery2014，，3： | 1 |
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