|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 2 | Synthesis and DNA Adsorption of Poly(2-Vinyl-4,6-Diamino-1,3,5-Triazine)Coated Polystyrene Microspheres显示文摘To take advantage of the polymer's special properties, we synthesized PVDAT coated polystyrene(PVDAT@PS) microspheres through semi-continuous precipitation polymerization, and demonstrated the possibility of controlling the size of microspheres by using different sized PS cores. Mechanism of the microsphere synthesis was investigated. Preliminary application studies indicated that the synthesized microspheres adsorbed double-stranded DNAs(dsDNAs) comprising A-T base pairs in pH7.4 phosphate buffered saline, and the adsorption capacity was in a range of 3.28 mg to 5.58 mg per gram PVDAT@PS microspheres depending on A-T base pair percentage and chain length of the dsDNAs. | 黄雷 王小涛 XIE Xun XIE Weihong LI Xuefeng GONG Xinghou LONG Shijun GUO Huiling 刘最芳 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 3 |
| 3 | A transformer-based Siamese network and an open optical dataset for semantic change detection of remote sensing images显示文摘Recent change detection(CD)methods focus on the extraction of deep change semantic features.However,existing methods overlook the fine-grained features and have the poor ability to capture long-range space–time information,which leads to the micro changes missing and the edges of change types smoothing.In this paper,a potential transformer-based semantic change detection(SCD)model,Pyramid-SCDFormer is proposed,which precisely recognizes the small changes and fine edges details of the changes.The SCD model selectively merges different semantic tokens in multi-head self-attention block to obtain multiscale features,which is crucial for extraction information of remote sensing images(RSIs)with multiple changes from different scales.Moreover,we create a well-annotated SCD dataset,Landsat-SCD with unprecedented time series and change types in complex scenarios.Comparing with three Convolutional Neural Network-based,one attention-based,and two transformer-based networks,experimental results demonstrate that the Pyramid-SCDFormer stably outperforms the existing state-of-the-art CD models and obtains an improvement in MIoU/F1 of 1.11/0.76%,0.57/0.50%,and 8.75/8.59%on the LEVIR-CD,WHU_CD,and Landsat-SCD dataset respectively.For change classes proportion less than 1%,the proposed model improves the MIoU by 7.17–19.53%on Landsat-SCD dataset.The recognition performance for small-scale and fine edges of change types has greatly improved. | Panli Yuan Qingzhan Zhao Xingbiao Zhao Xuewen Wang Xuefeng Long Yuchen Zheng | 2022 | International Journal of Digital Earth2022，15，1： | 2 |
| 4 | A micro photocatalytic fuel cell with an air-breathing, membraneless and monolithic design显示文摘在这研究,有呼吸空气的阴极的一个无膜的、整体的微 photocatalytic 燃料房间为同时的废水治疗和电产生被开发。在这个最新开发的微 photocatalytic 燃料房间, photoanode 和阴极与一个 shoulder-to-shoulder 图案被安排,形成二个平面电极。提高的质量的几个优点转移的如此的设计提议,一致轻分发,短轻转移路径,膜消除和容易的制造,集成,和与另外的 microdevices 的相容性。这个类型燃料房间的表演被在碱的条件下面把甲醇用作一种模型污染物质评估。试验性的结果显示发达微 photocatalytic 燃料房间能象耐久性一样显示出好相片反应到照明和令人满意的性能。房间表演上的参量的学习也被执行。增加轻紧张,甲醇集中和 KOH 集中能改进房间表演,这被发现。要不是液体流动率的效果,房间表演第一与增加液体流动率增加了然后与进一步增加液体流动率减少了,这被显示出。这研究不仅为微 photocatalytic 燃料房间的设计打开一条新大街而且对操作条件的优化有用。 | Ming Xia Rong Chen Xun Zhu Qiang Liao Liang An Zhibin Wang Xuefeng He Long Jiao | 2016 | Science Bulletin2016，61，21： | 2 |
| 5 | Nanomaterial-based strategies in antimicrobial applications:Progress and perspectives显示文摘The dramatic increase of microbial resistances against conventional available antibiotics is a huge challenge to the effective treatment of infectious disease and thus becoming a daunting global threat of major concern,which necessitates the development of innovative therapeutics.Nanomaterial-based antimicrobial strategies have emerged as novel and promising tools to combat lethal bacteria and recalcitrant biofilm,featuring the abilities to evade existing drug resistance-related mechanisms.In this review,recent advances in“state-of-the-art”nanosystems which acting either as inherent therapeutics or nanocarriers for the precise delivery of antibiotics,are comprehensively summarized.Those nanosystems can effectively accumulate at the infectious sites,achieve multifunctional synergistic antibacterial efficacy,and provide controlled release of antibiotics in response to endogenous or exogenous stimulus(e.g.,low pH,enzymes,or illumination).Especially,the nanoplatform that integrated with photothermal/photodynamic therapy(PTT/PDT)can enhance the bacterial destruction and biofilm penetration or ablation.In addition,nanoparticle-based approaches with enzymatically promoting bacterial killing,anti-virulence,and other mechanisms were also involved.Overall,this review provides crucial insights into the recent progress and remaining limitations of various antimicrobial nanotherapeutic strategies,and enlightens the further developments in this field simultaneously,which eventually benefiting public health. | Yi Zhao Long Chen Yanan Wang Xinyu Song Keyang Li Xuefeng Yan Liangmin Yu Zhiyu He | 2021 | Nano Research2021，14，12： | 1 |
| 6 | Effects of sound field on the growth of Chrysanthemum callus 显示文摘 | Li Yiyao Wang Bochu Long Xuefeng | 2002 | Colloids and Surfaces B: Biointerfaces2002，24，34： | 1 |
| 7 | Preliminary study on resin transfer molding of highly- toughened graphite laminates hy ex-situ method 显示文摘 | Long Wei Xu Yahong Yi Xiaosu An Xuefeng | 2004 | Journal of Materials Science2004，39，6： | 1 |
| 8 | Effects of sound field on the growth of Chrysanthemum callus 显示文摘 | Li Yiyao Wang Bochu Long Xuefeng | 2002 | Colloids and Surfaces B: Biointerfaces2002，24，34： | 1 |
| 9 | Effect of sound field on the growth of Chrysanthemum callus 显示文摘 | Liu Yi Wang Bochu Long Xuefeng | 2002 | Colloids and Surfaces B: Biointerfaces2002，24，34： | 1 |
| 10 | Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway显示文摘 | Qing Xie Linlin Chen Xuefeng Shan Xiaoliang Shan Jia Tang Fan Zhou Qingmei Chen Huiqin Quan Dan Nie Wenlu Zhang Ai‐Long Huang Ni Tang | 2014 | Int. J. Cancer2014，，3： | 1 |
| 11 | Effects of Wetland Utilization Change on Spatial Distribution of Soil Nematodes in Heihe River Basin, Northwest China显示文摘The first account of the effects of wetland reclamation on soil nematode assemblages were provided, three sites in Heihe River Basin of Northwest China, that is grass wetland(GW), Tamarix chinensis wetland(TW) and crop wetland(CW) treatments, were compared. Results showed that the majority of soil nematodes were presented in the 0–20 cm soil layers in CW treatments, followed by in the 20–40 cm and 40–60 cm layers in GW treatments. Plant-feeding nametodes were the most abundant trophic groups in each treatment, where GW(91.0%) > TW(88.1%) > CW(53.5%). Generic richness(GR) was lower in the TW(16) than that in GW(23) and CW(25). The combination of enrichment index(EI) and structure index(SI) showed that the soil food web in GW was more structured, and those in TW was stressed, while the enrichment soil food web was presented in the CW treatment. Several ecological indices which reflected soil community structure, diversity, Shannon-Weaver diversity(H′), Evenness(J′), Richness(GR) and modified maturity index(MMI) were found to be effective for assessing the response of soil namatode communities to soil of saline wetland reclamation. Furthermore, saline wetland reclamation also exerted great influence on the soil physical and chemical properties(p H, Electric conductivity(EC), Total organic carbon(TOC), Total nitrogen(Total-N) and Nitrate Nitrogen(N-NO3–)). These results indicated that the wetland reclamation had significantly effects on soil nematode community structure and soil properties in this study. | ZHU Hongqiang MAO Zhixia LONG Zhangwei WANG Yan SU Yongzhong WANG Xuefeng | 2016 | Chinese Geographical Science2016，26，3： | 0 |
| 12 | Molten salt synthesis,morphology modulation,and lithiation mechanism of high entropy oxide for robust lithium storage显示文摘High entropy oxides(HEOs)with ideal element tunability and enticing entropy-driven stability have exhibited unprecedented application potential in electrochemical lithium storage.However,the general control of dimension and morphology remains a major challenge.Here,scalable HEO morphology modulation is implemented through a salt-assisted strategy,which is achieved by regulating the solubility of reactants and the selective adsorption of salt ions on specific crystal planes.The electrochemical properties,lithiation mechanism,and structure evolution of composition-and morphology-dependent HEO anode are examined in detail.More importantly,the potential advantages of HEOs as electrode materials are evaluated from both theoretical and experimental aspects.Benefiting from the high oxygen vacancy concentration,narrow band gap,and structure durability induced by the multi-element synergy,HEO anode delivers desirable reversible capacity and reaction kinetics.In particular,Mg is evidenced to serve as a structural sustainer that significantly inhibits the volume expansion and retains the rock salt lattice.These new perspectives are expected to open a window of opportunity to compositionally/morphologi cally engineer high-performance HEO electrodes. | Xuefeng Liu Honghong Wang Long Dong Kezhuo Li Haijun Zhang Quanli Jia Shaowei Zhang Wen Lei | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 13 | Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents显示文摘Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raised concern about the efficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B cell response.To this end,a study on a long-term cohort of 208 participants who have recovered from COVID-19 was conducted,and the participants were followed up at 3.3(Visit 1),9.2(Visit 2),and 18.5(Visit 3)months after SARS-CoV-2 infection.They were classified into three groups(no-vaccination(n=54),one-dose(n=62),and two-dose(n=92)groups)on the basis of the administration of inactivated vaccination.The neutralizing antibody(NAb)titers against the wild-type virus continued to decrease in the no-vaccination group,but they rose significantly in the one-dose and two-dose groups,with the highest NAb titers being observed in the two-dose group at Visit 3.The NAb titers against the Delta variant for the no-vaccination,one-dose,and two-dose groups decreased by 3.3,1.9,and 2.3 folds relative to the wild-type virus,respectively,and those against the Omicron variant decreased by 7.0,4.0,and 3.8 folds,respectively.Similarly,the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the second vaccine dose.Results showed that the convalescents benefited from the administration of the inactivated vaccine(one or two doses),which enhanced neutralization against highly mutated SARS-CoV-2 variants and memory B cell responses.Two doses of inactivated vaccine among COVID-19 convalescents are therefore recommended for the prevention of the COVID-19 pandemic,and vaccination guidelines and policies need to be updated. | Hao Wang Yu Yuan Bihao Wu Mingzhong Xiao Zhen Wang Tingyue Diao Rui Zeng Li Chen Yanshou Lei Pinpin Long Yi Guo Xuefeng Lai Yuying Wen Wenhui Li Hao Cai Lulu Song Wei Ni Youyun Zhao Kani Ouyang Jingzhi Wang Qi Wang Li Liu Chaolong Wang An Pan Xiaodong Li Rui Gong Tangchun Wu | 2023 | Frontiers of Medicine2023，17，4： | 0 |
| 14 | Molecular Markers of Fat and Inosinic Acid Content in Sheep Muscle and Application显示文摘This study was conducted to speed up the process of improving the quality of lamb breeds in China,and to solve the problems that restrict the development of lamb breeds in China,such as low quality of lamb breeds,low meat production rate,and poor meat quality.By studying molecular markers of fat content in sheep muscles,we searched for polymorphic loci related to fat content in sheep muscles on the ANGPTL4 gene.Among the 9 polymorphic loci retrieved,ANGPTL4 was found.Two polymorphic sites,C724 A and A601 G,were significantly associated with intramuscular fat in mutton.In summary,these two molecular markers can be used as a molecular marker reference when breeding high-quality meat or hair and meat using German Merino sheep breeds. | Guizhi TONG Xuefeng LIU Xintao LI Gui ZHU Weixia WANG Long HAI | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 15 | Study on the Relationship Between CAPN Gene Peptide and Fat Content in Sheep Muscle显示文摘[Objectives] This study was conducted to speed up the process of improving the quality of lamb breeds in China,and to solve the problems that restrict the development of lamb breeds in China,such as low quality of lamb breeds,low meat production rate,and poor meat quality. [Methods]By studying molecular markers of fat content in sheep muscle,the CAPN gene was used to find polymorphic sites related to fat content in sheep muscle,and the correlation between two polymorphic sites C724 A and A601G on CAPN1 and CAPN2 and fat content in sheep muscle was analyzed. [Results] The two polymorphic sites,C724 A on CAPN1 and A601G on CAPN2 were significantly related to intramuscular fat in mutton. [Conclusions] These two molecular markers can be used as a molecular marker reference when breeding high-quality meat or hair and meat using German Merino sheep breeds. | Guizhi TONG Xuefeng LIU Gui ZHU Xintao LI Long HAI Weixia WANG | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
| 16 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员