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| 1 | Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population显示文摘BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still inconclusive.AIM To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA expression.METHODS A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length polymorphism.All samples were tested for the H.pylori infection using Hpx1 and Hpx2 primers.Quantitative polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,P<0.0001],and the CG(recessive model OR=4.63;95%CI:2.44-8.79,P<0.0001)groups.For TLR9-1486,an association between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C group.Moreover,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the samples were grouped according to the polymorphic genotypes and the presence of H.pylori infection,an influence of TLR9-1237 TC+CC polymorphic genotypes(P=0.0083)and H.pylori infection(P<0.0001)was observed on the upregulation of mRNA expression.CONCLUSION Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric,and that TLR9 mRNA levels can be modulated by TLR9-1237 TC+CC variant genotypes and H.pylori infection. | Manoela Dias Susi de Matos Lourenco Caroline Lucas Trevizani Rasmussen Spencer Luis Marques Payao Ana Flavia Teixeira Rossi Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo | 2019 | World Journal of Gastrointestinal Oncology2019，11，11： | 9 |
| 2 | A systematic review of the accuracy and indications for diagnostic laparoscopy prior to curative-intent resection of gastric cancer显示文摘 | Pierre-Anthony Leake Roberta Cardoso Rajini Seevaratnam Laercio Lourenco Lucy Helyer Alyson Mahar Calvin Law Natalie G. Coburn | 2012 | Gastric Cancer2012，，1： | 5 |
| 3 | Cirrhotic cardiomyopathy:Isn't stress evaluation alwaysrequired for the diagnosis?显示文摘AIM:To describe the proportion of patients with cirrhotic cardiomyopathy(CCM) evaluated by stress echocardiography and investigating its association with the severity of liver disease.METHODS:A cross-sectional study was conducted.Cirrhotic patients without risk factors for cardiovascular disease were included.Data regarding etiology and severity of liver disease(Child-Pugh score and model for end-stage liver disease),presence of ascites and gastroesophageal varices,pro-brain natriuretic peptide(proBNP) and corrected QT(QTc) interval were collected.Dobutamine stress echocardiography(conventional and tissue Doppler imaging) was performed.CCM was considered present when diastolic and/or systolic dysfunction was diagnosed at rest or after pharmacological stress.Therapy interfering with cardiovascular system was suspended 24 h before the examination.RESULTS:Twenty-six patients were analyzed,17(65.4%) Child-Pugh A,mean model for end-stage liver disease(MELD) score of 8.7.The global proportion of patients with CCM was 61.5%.At rest,only 2(7.7%)patients had diastolic dysfunction and none of the patients had systolic dysfunction.Dobutamine stress echocardiography revealed the presence of diastolic dysfunction in more 6(23.1%) patients and of systolic dysfunction in 10(38.5%) patients.QTc interval prolongation was observed in 68.8%of the patients and increased pro-BNP levels in 31.2%of them.There was no association between the presence of CCM and liver impairment assessed by Child-Pugh score or MELD(P= 0.775,P= 0.532,respectively).Patients with QTc interval prolongation had a significant higher rate of gastroesophageal varices comparing with those without QTc interval prolongation(95.0%vs 50.0%,P= 0.028).CONCLUSION:CCM is a frequent complication of cirrhosis that is independent of liver impairment.Stress evaluation should always be performed,otherwise it will remain an underdiagnosed condition. | mara barbosa joana guardado carla marinho bruno rosa isabel quelhas antónio lourenco josécotter | 2016 | World Journal of Hepatology2016，8，3： | 5 |
| 4 | A systematic review and meta-analysis of the utility of EUS for preoperative staging for gastric cancer显示文摘 | Roberta Cardoso Natalie Coburn Rajini Seevaratnam Rinku Sutradhar Laercio Gomes Lourenco Alyson Mahar Calvin Law Elaine Yong Jill Tinmouth | 2012 | Gastric Cancer2012，，1： | 3 |
| 5 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 6 | 三维网络结构氧化铜纳米线锂离子电池负极材料的制备和性能研究显示文摘通过阳极氧化法和后退火处理在铜箔上合成了三维网络结构氧化铜纳米线,将其作为负极材料制备了无需添加粘结剂的锂离子电池。研究了恒压氧化时间对材料形貌和电化学性能的影响。在1C的倍率下,氧化1000 s制备的CuO纳米线表现出最高的1172 mAh/g首圈放电比容量和594 mAh/g的可逆比容量,500圈循环可逆比容量为607.6 mAh/g,可逆容量保留率为102.3%。交联的三维网络结构CuO纳米线相互支撑,提供稳定的结构,有效缓解了CuO纳米线作为锂离子电池负极材料中的体积膨胀问题,表现出了优异的倍率性能和循环寿命。 | 曹宇光 肖煌 周佳盈 高云 Manon D'Assuncao Lourenco Kevin Peter Homewood 鲍钰文 夏晓红 | 2020 | 功能材料2020，51，4： | 3 |
| 7 | Defining Surgical Quality in Gastric Cancer: A RAND/UCLA Appropriateness Study显示文摘 | Savtaj Brar Calvin Law Robin McLeod Lucy Helyer Carol Swallow Lawrence Paszat Rajini Seevaratnam Roberta Cardoso Matthew Dixon Alyson Mahar Laercio G. Lourenco Lavanya Yohanathan Alina Bocicariu Tanios Bekaii-Saab Ian Chau Neal Church Daniel Coit Christop | 2013 | Journal of the American College of Surgeons2013，，2： | 3 |
| 8 | How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis显示文摘 | Rajini Seevaratnam Roberta Cardoso Caitlin Mcgregor Laercio Lourenco Alyson Mahar Rinku Sutradhar Calvin Law Lawrence Paszat Natalie Coburn | 2012 | Gastric Cancer2012，，1： | 3 |
| 9 | T cells in sputum of asthmatic patients are activated independently of disease severity or control 显示文摘 | Lourenco O Mafalda Fonseca A Taborda-Barata L | 2009 | Allergol hnmunopathol2009，37，6： | 1 |
| 10 | Nervous output from the respiratory center during obstructed breathing显示文摘 | Lourenco RV Cherniack NS Malm JR | 1966 | J Appl Physiol1966，21，2： | 1 |
| 11 | How do young children determine location? Evidence from disorientation tasks显示文摘 | Lourenco S.F Huttenlocher J | | 0，，： | 1 |
| 12 | An investigation of single-event transients in C- SiGe HBT on SO1 current mirror circuits 显示文摘 | SEUNGWOO J LOURENCO N E ICKHYUN S | 2014 | IEEE Trans Nucl Sci2014，61，6： | 1 |
| 13 | Homogenised limit analysis of masonry walls, Part I: Failure surfaces 显示文摘 | Milani G Lourenco P B Tralli A | 2006 | Composites & Structures2006，84，34： | 1 |
| 14 | Pulsed-field gel electrophoresis(PFGE) analysis of Listeria monocytogenes isolates from different sources and geographical origins and representative of the twelve serovars 显示文摘 | Neves E Lourenco A Silva A C | 2008 | Syst Appl Microbiol2008，31，5： | 1 |
| 15 | Stone fruit injuries and damage at the wholesale market of Sao Paulo Brazil显示文摘 | Amorim L Martins M C Lourenco S A | 2008 | Postharvest Biology and Technology2008，47，： | 1 |
| 16 | Early sex differences in weighting geometric cues显示文摘 | Lourenco S.F Addy D Huttenlocher J Fabian L | | 0，，06： | 1 |
| 17 | Activated status of basophils in chronic urticaria leads to interleukin-3 hyperresponsiveness and enhancement of histamine release induced by anti-IgE stimulus显示文摘 | Lourenco FD Azor MH Santos JC | | 0，，5： | 1 |
| 18 | Minimally invasive treat- ments for benign prostatic enlargement:systematic review of randomised controlled trials 显示文摘 | Lourenco T Pickard R Vale L | 2008 | The British Medical Journal2008，337，7676： | 1 |
| 19 | Homogenised limit analysis of masonry walls, Part Ⅱ: Structural examples 显示文摘 | Milani G Lourenco P B Tralli A | 2006 | Composites & Structures2006，84，34： | 1 |
| 20 | Job shop scheduling: computational study of local search and large step optimization methods显示文摘 | LOURENCO H | 1995 | European Journal of Operations Research1995，83，： | 1 |
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