|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 2 | Effect of different aged cartilage ECM on chondrogenesis of BMSCs in vitro and in vivo显示文摘Extracellular matrix(ECM)-based biomaterials are promising candidates in cartilage tissue engineering by simulating the native microenvironment to regulate the chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)without exogenous growth factors.The biological properties of ECM scaffolds are primarily depended on the original source,which would directly influence the chondrogenic effects of the ECM materials.Despite the expanding investigations on ECM scaffolds in recent years,the selection of optimized ECM materials in cartilage regeneration was less reported.In this study,we harvested and compared the articular cartilage ECM from newborn,juvenile and adult rabbits.The results demonstrated the significant differences in the mechanical strength,sulphated glycosaminoglycan and collagen contents of the different aged ECM,before and after decellularization.Consequently,different compositional and mechanical properties were shown in the three ECM-based collagen hydrogels,which exerted age-dependent chondrogenic inducibility.In general,both in vitro and in vivo results suggested that the newborn ECM promoted the most chondrogenesis of BMSCs but led to severe matrix calcification.In contrast,BMSCs synthesized the lowest amount of cartilaginous matrix with minimal calcification with adult ECM.The juvenile ECM achieved the best overall results in promoting chondrogenesis of BMSCs and preventing matrix calcification.Together,this study provides important information to our current knowledge in the design of future ECM-based biomaterials towards a successful repair of articular cartilage. | Xiuyu Wang Yan Lu Wan Wang Qiguang Wang Jie Liang Yujiang Fan Xingdong Zhang | 2020 | Regenerative Biomaterials2020，7，6： | 4 |
| 3 | Roles of crystal defects in the persistent luminescence of Eu^(2+), Dy^(3+) co-doped strontium aluminate based phosphors显示文摘The roles of different point defects in persistent luminescence of SrAl2O4:Eu,Dy phosphors were investigated. The research results showed that DySi r plays an important role in the persistent luminescence of SrAl2O4:Eu, Dy phos- phors. It can serve as the electron trap of suitable depth for persistent luminescence. VOii does not serve as the electron trap of suitable depth, but its existence can increase the depth of electron traps. There is interaction between the Dy3+( DySi r) and the Eu2+( Eu×S r), and only if the distance between the Dy3+( DySi r) and the Eu2+( Eu ×Sr) is close enough, the DySi r can work as an effective electron trap. The point defect of VS′′r can be hole trap, but the change of its density in crystal matrix does not arouse the obvious change of persistent luminescence. | LU Xingdong SHU Wangen | 2007 | Rare Metals2007，26，4： | 3 |
| 4 | Highly efficient perovskite solar cells based on symmetric hole transport material constructed with indaceno[1,2-b:5,6-b’]dithiophene core building block显示文摘Two novel hole transport materials (HTMs) with indaceno[1,2-b:5,6-b’]dithiophene (IDT) as core building blocks,termed IDT1 and IDT2,were designed and synthesized.The side alkyl chains were introduced to regulate and control the morphology and stacking behavior of HTMs,and the peripheral triarylamine arms were introduced to adjust the energy levels and to facilitate efficient hole transport.Applied in mesoporous structured perovskite solar cells (PSCs),HTM IDT1 achieved higher power conversion efficiency (PCE,19.55%) and better stability than Spiro-OMeTAD (19.25%) and IDT2 (15.77%) based PSC.These results suggest the potential of IDTl as a promising HTM for PSCs. | Cheng Wu Cheng Chen Li Tao Xingdong Ding Mengmeng Zheng Hongping Li Gongqiang Li Hongfei Lu Ming Cheng | 2020 | Journal of Energy Chemistry2020，29，4： | 2 |
| 5 | Silica encapsulation study on SrA1204 : Eu^2+ , Dy^3+ phosphors显示文摘 | Lu Xingdong | 2005 | Materials Chemistry and Physics2005，93，4： | 1 |
| 6 | Graphene oxide coated three-dimensional printed biphasic calcium phosphate scaffold for angiogenic and osteogenic synergy in repairing critical-size bone defect显示文摘The custom-tailored medicine requires a developmental strategy that integrates excellent osteogene-sis with mechanical stability to enhance the reconstruction of the critical-size bone defect(CSBD)and the healing process in weight-bearing bone.We prepared three-dimensional(3D)printed biphasic cal-cium phosphate(BCP)scaffolds composited with nano-graphene oxide(GO).The biological effects of the GO/BCP composite scaffolds could induce the differentiation of rat bone marrow stem cells(BM-SCs)and the migration of human umbilical vein endothelial cells(HUVECs)for bone repair.The proper ratio of GO in the composite scaffold regulated the composites’surface roughness and hydrophilicity to a suitable range for the adhesion and proliferation of BMSCs and HUVECs.Besides,the GO/BCP composite scaffold increased osteogenesis and angiogenesis by activating BMP-2,RUNX-2,Smad1/4,and VEGF.The customized intramedullary nail combined with GO/BCP scaffold was applied to repair CSBD(2.0 cm in length)in a beagle femur model.This fixation strategy was confirmed by finite element analysis.In vivo,the results indicated that the custom-made internal fixation provided sufficient stability in the early stage,ensuring bone healing in a considerable mechanical environment.At 9 months postoperatively,longitudi-nal bony union and blood vessels in osteon were observed in the CSBD area with partial degradation in the 0.3%GO/BCP group.In the three-point bending test,the ultimate load of 0.3%GO/BCP group reached over 50%of the normal femur at 9 months after repair.These results showed a promising application of osteogenic GO/BCP scaffold and custom-made intramedullary nails in repairing CSBD of the beagle femur.This effective strategy could provide an option to treat the clinical CSBD in weight-bearing bones. | Yitian Wang Yonghao Wu Yuqi Zhang Xiangfeng Li Li Min Quanle Cao Yi Luo Xiao Yang Minxun Lu Yong Zhou Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2023 | Journal of Materials Science & Technology2023，，14： | 1 |
| 7 | Electron beam irradiation modification of collagen membrane显示文摘 | Bo Jiang Zhihong Wu Huichuan Zhao Fangyuan Tang Jian Lu Qingrong Wei Xingdong Zhang | 2005 | Biomaterials2005，，： | 1 |
| 8 | Alumina encapsulated SrAl2O4:Eu^2+,Dy^3+ phosphors 显示文摘 | LU Xingdong ZHONG Minjuan SHU Wangen | 2007 | Powder Technol2007，177，2： | 1 |
| 9 | Silica encapsulation study on SrAl2O4:Eu62+,Dy^3+ phosphors 显示文摘 | LU Xingdong | 2005 | Mater Chem Phys2005，93，23： | 1 |
| 10 | Sihca encapsulation study on SrAI204: Eu2 + Dy3+ phosphor 显示文摘 | Xingdong Lu | 2005 | Material Chemistry and Phys- ics2005，93，： | 1 |
| 11 | Silica encapsulation study on SrAl2O4 : Eu^2+, Dy^3+ phosphors 显示文摘 | Lu Xingdong | 2005 | Mater Chem Phy2005，93，4： | 1 |
| 12 | Alumina encapsulated SrAl2O4 : Eu^2+, Dy^3+ phosphors 显示文摘 | Lu Xingdong Zhong Minjuan Shu Wangen | 2007 | Powder Technology2007，177，4： | 1 |
| 13 | Alumia encapsulated SrAl2O4 : Eu^2+ , Dy^3+ phosphors 显示文摘 | XINGDONG LU MINJUAN ZHONG WANGEN SHU | 2007 | Powder Technology2007，，177： | 1 |
| 14 | Silica encapsulation study on SrAl2O4:Eu^2+、Dy^3+ phosphors显示文摘 | XINGDONG LU | 2005 | Material Chemistry and Physics2005，，93： | 1 |
| 15 | Advanced application of collagen-based biomaterials in tissue repair and restoration显示文摘In tissue engineering,bioactive materials play an important role,providing structural support,cell regulation and establishing a suitable microenvironment to promote tissue regeneration.As the main component of extracellular matrix,collagen is an important natural bioactive material and it has been widely used in scientific research and clinical applications.Collagen is available from a wide range of animal origin,it can be produced by synthesis or through recombinant protein production systems.The use of pure collagen has inherent disadvantages in terms of physico-chemical properties.For this reason,a processed collagen in different ways can better match the specific requirements as biomaterial for tissue repair.Here,collagen may be used in bone/cartilage regeneration,skin regeneration,cardiovascular repair and other fields,by following different processing methods,including cross-linked collagen,complex,structured collagen,mineralized collagen,carrier and other forms,promoting the development of tissue engineering.This review summarizes a wide range of applications of collagen-based biomaterials and their recent progress in several tissue regeneration fields.Furthermore,the application prospect of bioactive materials based on collagen was outlooked,aiming at inspiring more new progress and advancements in tissue engineering research. | Jiayi Zhu Zhulian Li Yaping Zou Gonggong Lu Alfredo Ronca Ugo D’Amora Jie Liang Yujiang Fan Xingdong Zhang Yong Sun | 2022 | Journal of Leather Science and Engineering2022，4，1： | 0 |
| 16 | Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype显示文摘Collagen made a tremendous impact in the field of regenerative medicine as a bioactive material.For decades,collagen has been used not only as a scaffolding material but also as an active component in regulating cells’biological behavior and phenotype.However,animal-derived collagen as a major source suffered from problems of immunogenicity,risk of viral infection,and the unclear relationship between bioactive sequence and function.Recombinant humanized collagen(rhCol)provided alternatives for regenerative medicine with more controllable risks.However,the characterization of rhCol and the interaction between rhCol and cells still need further investigation,including cell behavior and phenotype.The current study preliminarily demonstrated that recombinant humanized collagen type III(rhCol III)conformed to the theoretical amino acid sequence and had an advanced structure resembling bovine collagen.Furthermore,rhCol III could facilitate basal biological behaviors of human skin fibroblasts,such as adhesion,proliferation and migration.rhCol III was beneficial for some extracellular matrix-expressing cell phenotypes.The study would shed light on the mechanism research of rhCol and cell interactions and further understanding of effectiveness in tissue regeneration. | Jing Wang Hong Hu Jian Wang He Qiu Yongli Gao Yang Xu Zhanhong Liu Yajun Tang Lu Song John Ramshaw Hai Lin Xingdong Zhang | 2022 | Journal of Leather Science and Engineering2022，4，1： | 0 |
| 17 | Cardiovascular toxicity with CTLA-4 inhibitors in cancer patients:A meta-analysis显示文摘Background:With the emergence of cytotoxic T lymphocyte-associated protein-4(CTLA-4)inhibitors,the outcomes of patients with malignant tumors have improved significantly.However,the incidence of cardiovascular adverse events has also increased,which can affect tumor treatment.In this study,we evaluated the incidence and severity of adverse cardiovascular events caused by CTLA-4 inhibitors by analyzing reported trials that involved CTLA-4 inhibitor therapy.Methods:Randomized clinical trials published in English from January 1,2013,to November 30,2022,were searched using the Cochrane Library and PubMed databases.All included trials examined all grade and grades 3–5 cardiac and vascular adverse events.These involved comparisons of CTLA-4 inhibitors to placebo,CTLA-4 inhibitors plus chemotherapy to chemotherapy alone,CTLA-4 inhibitors combined with PD-1/PD-L1 inhibitors to PD-1/PD-L1 inhibitors alone,and CTLA-4 inhibitors plus target agent to PD-1/PD-L1 inhibitors plus target agent.The odds ratio(OR)and corresponding 95%confidence intervals(CIs)were calculated using the Mantel-Haenszel method.Results:Overall,20 trials were included.CTLA-4 inhibitors significantly increased the incidence of all-grade cardiovascular toxicity(OR=1.33,95%CI:1.00–1.75,p=0.05).The incidence of all-grade cardiovascular toxicity increased in malignant tumor patients who received single-agent CTLA-4 inhibitors(OR=1.73,95%CI:1.13–2.65,p=0.01),as well as the incidence rate of grades 3–5 cardiovascular adverse events(OR=2.00,95%CI:1.08–3.70,p=0.03).Compared with the non-CTLA-4 inhibitor group,CTLA-4 inhibitors plus chemotherapy,PD-1/PD-L1 inhibitors,or target agent did not significantly affect the incidence of cardiac and vascular toxicity.The incidence of grades 3–5 cardiac failure,hypertension,pericardial effusion,myocarditis,and atrial fibrillation were much higher among patients exposed to CTLA-4 inhibitor,but the data were not statistically significant.Conclusion:Our findings suggest that the incidence rate of all cardiovascular toxicity and severe cardiovascular toxicity increased in patients who were administered CTLA-4 inhibitors.In addition,the risk of serious cardiovascular toxic events was independent of the type of adverse event.From these results,physicians should assess the benefits and risks of CTLA-4 inhibitors when treating malignancies. | Huiyi Liu Lu Fu Shuyu Jin Xingdong Ye Yanlin Chen Sijia Pu Yumei Xue | 2024 | Cancer Innovation2024，3，3： | 0 |
| 18 | Regulatory perspectives of combination products显示文摘Combination products with a wide range of clinical applications represent a unique class of medical products that are composed of more than a singular medical device or drug/biological product.The product research and development,clinical translation as well as regulatory evaluation of combination products are complex and challenging.This review firstly introduced the origin,definition and designation of combination products.Key areas of systematic regulatory review on the safety and efficacy of device-led/supervised combination products were then presented.Preclinical and clinical evaluation of combination products was discussed.Lastly,the research prospect of regulatory science for combination products was described.New tools of computational modeling and simulation,novel technologies such as artificial intelligence,needs of developing new standards,evidence-based research methods,new approaches including the designation of innovative or breakthrough medical products have been developed and could be used to assess the safety,efficacy,quality and performance of combination products.Taken together,the fast development of combination products with great potentials in healthcare provides new opportunities for the advancement of regulatory review as well as regulatory science. | Jiaxin Tian Xu Song Yongqing Wang Maobo Cheng Shuang Lu Wei Xu Guobiao Gao Lei Sun Zhonglan Tang Minghui Wang Xingdong Zhang | 2022 | Bioactive Materials2022，7，4： | 0 |
| 19 | A novel approach to estimate and control denitrification performance in activated sludge systems with respirogram technology显示文摘Respirogram technology has been widely applied for aerobic process, however, the response of respirogram to anoxic denitrification is still unclear. To reveal such response may help to design a new method for the evaluation of the performance of denitrification. The size distribution of flocs measured at different denitrification moments demonstrated a clear expansion of flocs triggered by denitrification, during which higher specific endogenous and quasi-endogenous respiration rates(SOUReand SOURq) were also observed. Furthermore,SOURqincreases exponentially with the specific denitrification rate(SDNR), suggesting that there should be a maximum SDNR in conventional activated sludge systems. Based on these findings, an index Rq/t, defined as the ratio of quasi-endogenous(OURq) to maximum respiration rate(OURt), is proposed to estimate the denitrification capacity that higher Rq/tindicates higher denitrification potential, which can be readily obtained without complex measurement or analysis, and it offers a novel and promising respirogram-based approach for denitrification estimation and control by taking measures to extend anoxic time to maintain its value at a high level within a certain range. | Zhihua Li Yali Zhang Zhenyu Hang Meng Lu Haiguang Wang Xingdong Gao Ruina Zhang | 2022 | Journal of Environmental Sciences2022，34，11： | 0 |
| 20 | Size effect on optical performance of blue light-emitting diodes显示文摘In this paper,size effects on optical performance of blue light-emitting diodes(LEDs)are investigated.The essential physical mechanism is studied by fabricating LEDs with various sizes of the active area and testing optical characteristics.It is found that micro-LEDs have better light extracting efficiency and thermal dissipation compared with broad-area LEDs,which is likely due to the small ratio of perimeter and active area.Furthermore,micro-LEDs are more beneficial for displays due to the stable wavelength under the low pulse width modulation(PWM)current density. | Chang Ge Jing Li Guohong Wang Kang Su Xingdong Lu | 2019 | Journal of Semiconductors2019，40，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员