|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice,rabbits and NHPs显示文摘The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines.Here,we discovered a new STING agonist,CF501,and found that CF501-adjuvanted RBD-FC vaccine(CF501/RBD-FC)elicited significantly stronger neutralizing antibody(nAb)and T cell responses than Alum-and cGAMP-adjuvanted RBD-FC in mice.Vaccination of rabbits and rhesus macaques(nonhuman primates,NHPs)with CF501/RBD-FC elicited exceptionally potent nAb responses against SARS-CoV-2 and its nine variants and 41 S-mutants,SARS-CoV and bat SARSr-CoVs.CF501/RBD-FC-immunized hACE2-transgenic mice were almost completely protected against SARS-CoV-2 challenge,even 6 months after the initial immunization.NHPs immunized with a single dose of CF501/RBD-FC produced high titers of nAbs.The immunized macaques also exhibited durable humoral and cellular immune responses and showed remarkably reduced viral load in the upper and lower airways upon SARS-CoV-2 challenge even at 108 days post the final immunization.Thus,CF501/RBD-Fc can be further developed as a novel pan-sarbecovirus vaccine to combat current and future outbreaks of sarbecovirus diseases. | Zezhong Liu Jie Zhou Wei Xu Wei Deng Yanqun Wang Meiyu Wang Qian Wang Ming Hsieh Jingming Dong Xinling Wang Weijin Huang Lixiao Xing Miaoling He Chunlin Tao Youhua Xie Yilong Zhang Youchun Wang Jincun Zhao Zhenghong Yuan Chuan Qin Shibo Jiang Lu Lu | 2022 | Cell Research2022，32，3： | 5 |
| 3 | A Novel Approach to Detect the Unresolved Towed Decoy in Terminal Guidance显示文摘 | SONG Zhiyong XIAO Huaitie ZHU Yilong LU Zaiqi | 2012 | Chinese Journal of Electronics2012，21，2： | 5 |
| 4 | Analysis and Simulation of Evolution Induced Catastrophe显示文摘A model of evolution induced catastrophe(EIC)characterized by a nonlocal interaction is proposed.The general feature of the model is its two bias states:explosively catastrophic and globally stable,both consisting in a cascade of locally unstable states.A one-dimensional analysis reveals a transition region from globally stable to catastrophe.A two-dimensional simulation gives a thin fractal fracture profile similar to that observed and also a possible spectrum of fracture fractal.All these are different from percolation.Hence,the EIC model may represent a prototype of natural processes. | BAI Yilong XIA Mengfen KE Fujiu LU Chunsheng LING Zhong | 1993 | Chinese Physics Letters1993，10，3： | 5 |
| 5 | A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant显示文摘Dear Editor,Since the outbreak of Coronavirus Disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,numerous SARS-CoV-2 variants of concern(VOCs),such as Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2),have emerged.Recently,the newly identified SARS-CoV-2 VOC,Omicron(B.1.1.529),has rapidly spread in many countries1 and is expected to replace Delta as the dominant variant circulating in the world.Compared to other VOCs,Omicron contains at least 32 mutations in spike(S)protein,including 15 mutations in the receptor-binding domain(RBD),and these mutations are known to confer resistance to neutralizing antibodies(nAbs)and sera of convalescent patients and people who have received COVID-19 vaccines.2–5 Therefore,vaccines able to induce potent and durable neutralizing antibodies against Omicron and other VOCs are urgently needed. | Zezhong Liu Jasper Fuk-Woo Chan Jie Zhou Meiyu Wang Qian Wang Guangxu Zhang Wei Xu Kenn Ka-Heng Chik Yilong Zhang Youchun Wang Kwok-Yung Yuen Lu Lu Shibo Jiang | 2022 | Cell Research2022，32，5： | 4 |
| 6 | 基于固定WiMAX的被动雷达系统研究显示文摘WiMAX信号作为被动雷达的照射源具有高距离分辨率和大探测距离的优势。率先设计并实现了基于固定WiMAX的被动雷达双通道接收机,提出了基于最小二乘的自适应直达波/杂波干扰消除算法,实现了基于相参体制的运动目标检测算法,并将基于固定WiMAX的被动雷达系统应用于室内运动目标检测。实验结果表明:所设计的实验系统和所提出的算法能准确获得目标的运动轨迹信息,从实验角度进一步证明了固定WiMAX信号作为被动雷达照射源的可行性。 | 汪清 侯春萍 LU Yilong | 2010 | 传感器与微系统2010，29，10： | 4 |
| 7 | Does hukou still matter? The household registration system and its impact on social stratification and mobility in China显示文摘户籍制度是中国社会一项基本的制度安排,它把户口作为资源配置和利益分配的重要凭据,对社会分层和流动产生了较大的影响。在改革开放近三十年后,中国的户口还起不起作用,以及起着怎样的作用?通过对综合社会调查数据的分析,发现中国社会分层具有城乡户口差别和城市户口等级差别并存的特点,户口转变和迁移的开放性程度与个人社会流动机会获得有正相芙关系。市场转型虽带来了较多流动机会,但户口等级差别以及户口对体制内流动所起的结构性影响依然存在。鉴于户籍制度的强粘附性生成了社会差别,改革这一制度的基本方向是推行户口一元化和迁移自主化。 | Lu Yilong | 2008 | Social Sciences in China2008，29，2： | 3 |
| 8 | Awareness intervention for Beijing neurologists regarding secondary prevention of cerebral infarction/transient ischemia Cross-sectional investigation显示文摘BACKGROUND: Stroke prevention guidelines should be made available to neurologists for clinical application to aid in uniformity, timing, preciseness, and acceptance of disease. OBJECTIVE: To investigate the awareness of neurologists in some Beijing hospitals of intervention in secondary prevention of cerebral infarction/transient ischemia. DESIGN: Cross-sectional study. SETTING: Beijing Tiantan Hospital, Beijing Anzhen Hospital, General Hospital of Beijing Military Area, Command of Chinese PLA, Beijing Chuiyangliu Hospital, Beijing 6th Hospital, Beijing Hepingli Hospital, and Beijing Daxing District Hospital. PARTICIPANTS: A total of 28 (associate) chief physicians, 58 attending physicians, and 54 resident physicians who engaged in clinical treatment of cerebrovascular diseases were selected from 8 hospitals in Beijing from March to April 2007. All physicians provided informed consent. METHODS: Self-made closed questionnaires were provided for data collection, consisting of 16 questions that were single choice or multiple choice. Specifically, questions 1-7 focused on awareness of blood pressure regulation in different patients and first choice of decompression drug; questions 8-12 focused on awareness of lipid regulation; and questions 13-16 focused on awareness of anti-blood platelet drugs applied in secondary prevention. The scores ranged from 0-100 points, and each question was worth 6.25 points. The scores positively correlated with the awareness rate. To test leveling real-time, the survey lasted for a maximum of 20 minutes. One questionnaire was independently finished by each subject in the survey. MAIN OUTCOME MEASURES: Awareness intervention among neurologists during secondary prevention of cerebral infarction/transient ischemia and questionnaire scores. RESULTS: 140 subjects were included in the final analysis. ① The awareness rate among neurologists for intervention during secondary prevention of cerebral infarction/transient ischemia ranged from 0.7-57.9%, the scores ranged between 0-56 points, and the mean score was 26 points. ② Scores of resident physicians were 0-56 points with a mean score of 26 points; attending physicians scored 6-50 points, with a mean score of 26 points; and chief physicians scored 6-50 points, with a mean score of 23 points. There were no significant differences among the various physicians (F = 0.771, t = 0.465, P > 0.05). CONCLUSION: Awareness among neurologists of intervention during secondary prevention of cerebral infarction/transient ischemia is not ideal. However, there was no significant difference between professional titles. | Ruihua Ma Chunxue Wang Xianwei Wang Yuhui Zhang Yongjun Wang Yilong Wang Xingquan Zhao Jingjing Li Ying Lu Mingjie Xu Zhuo Zhang Li Wang Weiwei Zhang Lang Lin Jiping Tan Yao Li Ming Wei Hongtao Li | 2008 | Neural Regeneration Research2008，3，3： | 2 |
| 9 | Linearity analysis of closed-loop capacitive accelerometer due to distance mismatch between plates and the influence of compensation capacitor array显示文摘This paper presents mathematical formulae showing that the distance mismatch for an uncentered proof mass in an accelerator sensor does not influence the linearity of the closed-loop accelerometer as a whole.This asymmetry in sensors only introduces an output voltage offset in the readout integrated circuit.Numerical simulation using Matlab/Simulink confirms the mathematical conclusion.The linear response after compensation with a conventional capacitor array is also simulated and analyzed.Results show that there is a loss in linearity.Similar results hold not only for the continuous-time architecture,but also for a time-divided architecture.A readout integrated circuit with a time-divided architecture is designed and fabricated using a 0.35μm HV CMOS process.An accelerometer composed of a microelectromechanical system sensor with severe built-in distance mismatch and the designed readout integrated circuit is tested.Test results show that the nonlinearity of such accelerometer is within 0.3%. | HUANG JingQing ZHAO Meng ZHANG TingTing CHEN ZhongJian HONG LiChen WU Feng ZHANG YaCong LU WenGao GAO ChengChen HAO YiLong | 2014 | Science China(Information Sciences)2014，57，6： | 2 |
| 10 | Anchor-based manifold binary pattern for finger vein recognition显示文摘This paper proposes a novel learning method of binary local features for recognition of the finger vein. The learning methods existing in local features for image recognition intend to maximize the data variance, reduce quantitative errors, exploit the contextual information within each binary code, or utilize the label information, which all ignore the local manifold structure of the original data. The manifold structure actually plays a very important role in binary code learning, but constructing a similarity matrix for large-scale datasets involves a lot of computational and storage cost. The study attempts to learn a map, which can preserve the manifold structure between the original data and the learned binary codes for large-scale situations. To achieve this goal, we present a learning method using an anchor-based manifold binary pattern(AMBP) for finger vein recognition. Specifically, we first extract the pixel difference vectors(PDVs) in the local patches by calculating the differences between each pixel and its neighbors. Second,we construct an asymmetric graph, on which each data point can be a linear combination of its K-nearest neighbor anchors, and the anchors are randomly selected from the training samples. Third, a feature map is learned to project these PDVs into low-dimensional binary codes in an unsupervised manner, where(i) the quantization loss between the original real-valued vectors and learned binary codes is minimized and(ii) the manifold structure of the training data is maintained in the binary space. Additionally, the study fuses the discriminative binary descriptor and AMBP methods at the image representation level to further boost the performance of the recognition system. Finally, experiments using the MLA and PolyU databases show the effectiveness of our proposed methods. | Haiying LIU Gongping YANG Lu YANG Kun SU Yilong YIN | 2019 | Science China(Information Sciences)2019，62，5： | 2 |
| 11 | A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat. | Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang | 2023 | Molecular Plant2023，16，2： | 1 |
| 12 | Clutter rank of STAP in MIMO radar with waveform diversity 显示文摘 | Wang Guohua Lu Yilong | 2010 | IEEE Transactions on Signal Processing2010，58，2： | 1 |
| 13 | Clutter Rank of MIMO Radar with A Speical Class of Waveforms 显示文摘 | Guohua Wang Yilong Lu | 2009 | IEEE Trans Aerospace Electron2009，22，： | 1 |
| 14 | Numerical simulation of evolution-induced catastrophe显示文摘 | Lu Chunsheng Ke Fujiu Bai Yilong | 1995 | Science in China (seties A)1995，38，4： | 1 |
| 15 | Designing single/multiple sparse frequency waveforms with sidelobe constraint 显示文摘 | WANG Guohua LU Yilong | 2011 | Radar Sonar & Navigation IET2011，5，1： | 1 |
| 16 | Maximum likelihood DOA estimation in unknown colored noise fields 显示文摘 | Minghui Li Yilong Lu | 2008 | IEEE Transactions on Aerospace and Electronic Systems2008，44，3： | 1 |
| 17 | An Experimental Study of WiMAX-based Passive Radar 显示文摘 | Wang Qing Hou Chunping Lu Yilong | 2010 | IEEE Transactions on Microwave Theory and Techniques2010，58，12： | 1 |
| 18 | Bounds on generalized integrated sidelobe level in waveforms with stopbands 显示文摘 | WANG Guohua LU Yilong | 2010 | Electronics Letters2010，46，23： | 1 |
| 19 | Coarse-to-Fine Video Instance Segmentation With Factorized Conditional Appearance Flows显示文摘We introduce a novel method using a new generative model that automatically learns effective representations of the target and background appearance to detect,segment and track each instance in a video sequence.Differently from current discriminative tracking-by-detection solutions,our proposed hierarchical structural embedding learning can predict more highquality masks with accurate boundary details over spatio-temporal space via the normalizing flows.We formulate the instance inference procedure as a hierarchical spatio-temporal embedded learning across time and space.Given the video clip,our method first coarsely locates pixels belonging to a particular instance with Gaussian distribution and then builds a novel mixing distribution to promote the instance boundary by fusing hierarchical appearance embedding information in a coarse-to-fine manner.For the mixing distribution,we utilize a factorization condition normalized flow fashion to estimate the distribution parameters to improve the segmentation performance.Comprehensive qualitative,quantitative,and ablation experiments are performed on three representative video instance segmentation benchmarks(i.e.,YouTube-VIS19,YouTube-VIS21,and OVIS)and the effectiveness of the proposed method is demonstrated.More impressively,the superior performance of our model on an unsupervised video object segmentation dataset(i.e.,DAVIS19)proves its generalizability.Our algorithm implementations are publicly available at http://gffzz188fe103f8f1460as05kbkc5v9pcb6uqo.ffgz.tsg.suse.edu.cn/zyqin19/HEVis. | Zheyun Qin Xiankai Lu Xiushan Nie Dongfang Liu Yilong Yin Wenguan Wang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 1 |
| 20 | Sidelohe Reduction in Array- Pattern Synthesis Using Genetic Algorithm显示文摘 | Keen-Keong Yan Yilong Lu | 1997 | IEEE Trans- actions on Antennas and Propagation1997，45，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员