|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis显示文摘Human glioblastoma is a highly lethal tumor that is known for its immune inhibitory capabilities.B7-homologue l(B7-H 1),a recently identified homologue of B7.1/2(CD80/86),has been described to exert costimulatoryand immune regulatory functions.We investigated the expression and the functional activity of B7-H 1 in humanglioma cells in vitro and in vivo.Although lacking B7.1/2(CD80/86),all 12 glioma cel1 1ines constitutivelyexpressed B7-H1 mRNA and protein.Exposure to IFN-gamma strongly enhanced B7-H 1 expression.Im- | Wintterle S Schreiner B Mitsdoerffer M Schneider D Chen Meyermann R Weller M Wiendl H | 2003 | 中国神经肿瘤杂志2003，1，4： | 37 |
| 3 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 4 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 5 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 6 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 7 | Primary colorectal lymphoma:An overview显示文摘Lymphomas represent common hematological malignancies with increasing incidence in recent years.The major site of extranodal non-Hodgkin lymphoma is the gastrointestinal tract.Involvement of the large intestine is rare in comparison to the stomach or small bowel.The disease appears later in life,predominantly in the male population.Complaints are nonspecific,requiring a high index of suspicion in order to establish the diagnosis.The treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and radiotherapy.The small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal lymphoma.The purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject. | Goran Z Stanojevic Milica D Nestorovic Branko R Brankovic Miroslav P Stojanovic Milan M Jovanovic Milan D Radojkovic | 2011 | World Journal of Gastrointestinal Oncology2011，3，1： | 15 |
| 8 | Biot反演在夏威夷钙质沉积物原位测量声速和衰减中的应用显示文摘对夏威夷檀香山岛的两个站(H3和H4)钙质沉积物进行了20~100kHz的原位纵波声速和声衰减测量.它们均有轻微的频散.随频率的增加H3站位声速从1691m/s增加到1708m/s,H4站位的声速从1579m/s增加到1585m/s.随频率的增加H3站位的有效衰减从15dB/m增加到75dB/m,H4站位的有效衰减从22dB/m增加到62dB/m.运用Biot Stoll模型对所测得的纵波速度和声衰减数据进行了Biot模型未知参数反演,发现粒径较大的H3站的沉积物(孔隙率为45%)比粒径较小的H4站的沉积物(孔隙率为56%)具有曲率小和渗透率及孔隙半径都大的性质. | 陶春辉 BAFFI S WILKENS R H FU S S RICHARDSON M D 金翔龙 | 2005 | 海洋学报2005，27，3： | 15 |
| 9 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 10 | 欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南显示文摘非上皮性卵巢癌是一类少见的卵巢癌,因此,其诊断较难建立。然而,通过仔细观察各种肿瘤的标记物[尤其是人绒毛膜促性腺激素β亚单位(β-hCG)、α-甲胎蛋白(α-AFP)和乳酸脱氢酶(LDH)]、临床体征(如妊娠期体征, | Reed N Millan D Verheijen R Castiglione M On behalf of the ESMO Guidelines Working Group 杨华(译) 郎景和(审校) | 2011 | 国际妇产科学杂志2011，38，4： | 13 |
| 11 | 肺栓塞的影像 应用螺旋CT的新观显示文摘肺栓塞是一种生前常被漏诊的疾病。其死亡率取决于诸多因素,未经治疗患者的年死亡率可高达 30%,是应用抗凝药物患者年死亡率(2.5%)的10倍以上。 | David M Hansell Christopher D R Flower 邢军 | 1998 | 英国医学杂志中文版1998，0，1： | 13 |
| 12 | Podoplanin是一种优于calretinin的较好的诊断肉瘤样间皮瘤免疫标记物显示文摘 | Padgett D M Cathro H P Wick M R 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，1： | 12 |
| 13 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 14 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 15 | 大斜度井和水平井地层评价中的经验、问题和发展方向显示文摘大斜度井和水平井(HA/HZ)测井组合的选择原则主要是指导地质导向钻井。有时(HA/HZ)井所穿过的地层或油藏某部分没有垂直评价井,只能用HA/HZ测井数据评价常规有效厚度/总厚度比、孔隙度和含水饱和度。对同一地层,HA/HZ测井响应与垂直井响应存在很大差异。研究表明,由于视倾角误差,孔隙度值偏差可达6P.u.,含水饱和度误差超过50%,大斜度井中真地层厚度偏差达到200%~300%。垂直井的常规地层评价方法不太适用于HA/HZ井地层和流体性质评价。HA/HZ井与垂直井测井响应差异的主要原因是很多测井仪器是专为探测垂直井地层而设计的,因此在HA/HZ井中,必须对解释方案进行修改,这时需考虑井眼附近地层的几何形状;测量方位;地层各向异性对电阻率、声波和核测井响应的影响;异常侵入剖面;重力引起的仪器偏心以及井眼底部聚积的岩屑。虽然井眼成像测井能有效地测量大斜度井相对地层倾角,但当井斜超过80°时地层倾角的测量仍存在很多问题。中子和密度测井响应又相当程度地受岩屑的影响。这种井的测井难度很大,将差质量测井响应与因几何形状、各向异性以及井眼影响引起的异常测井响应区分开来显得相当重要。HA/HZ井用于地质导向的定性标准测井难以满足未来地层评价的要求。许多地方不能钻垂直评价井,因此利用大位移井信息评价地层很关键。作业公司和测井服务公司必须相互协作,共同解决HA/HZ井仪器响应和数据解释问题,开发出能定量描述HA/HZ井的新仪器。 | Quinn R Passey H Yin C M Rendeiro D E Fitz 唐宇 王昌学 | 2006 | 测井技术2006，30，1： | 10 |
| 16 | 西南天山明尧勒背斜的第四纪滑脱褶皱作用显示文摘通过对明尧勒活动背斜喀浪勾律克河剖面生长前地层和翼部生长地层几何结构的填图以及变形河流阶地的系统测量,结合磁性地层及释光年代学研究,认为该背斜的滑脱褶皱作用起始于距今约1·6Ma,其总体几何结构形成于褶皱作用的早期,但其生长扩展并不完全遵从自相似性特征。持续的缩短作用部分被褶皱翼部陡倾膝折带的加长所吸收(由此导致背斜波幅的增加),另一部分可能是通过不同时期褶皱翼部不同膝折带组的旋转和迁移来实现的。明尧勒背斜的持续构造抬升是背斜区河流下切形成多级基座阶地的主因。晚第四纪褶皱的生长以背斜的垂直抬升为主,主要集中在北翼近核部,背斜宽度变化不大。背斜不同时期的抬升量和抬升速率均大于其缩短量和缩短速率,表明明尧勒背斜的变形以翼旋转为主(Pobletet al.,1996)。背斜自形成以来缩短速率和抬升速率均有减小的趋势。 | 陈杰 Scharer K M Burbank D W Heermance R 王昌盛 | 2005 | 地震地质2005，27，4： | 10 |
| 17 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 18 | 学龄前肺功能轨迹是否延伸至成年期显示文摘成年早期的肺功能是个体死亡率和慢性阻塞性肺疾病(COPD)重要的决定因素。英国布里斯托大学医学院人口健康科学系的Henderson教授团队对3项人群出生队列研究的回顾性分析,探讨了学龄前到成年期肺功能发育的轨迹,及生命早期可能的影响因素。 | BELGRAVE D C M GRANELL R TURNERS W 孙莹(编译) | 2018 | 中国学校卫生2018，39，11： | 8 |
| 19 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 20 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员