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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Active DNA or active histone triggering the production of antinuclear antibodies: inducing the generation of kidney iniury in mice显示文摘 | Wu H S Ma A N Guo L | 2000 | J Allergy Clin Immunol2000，105，1： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Primary duct closure after laparo-scopic common bile bile buct exploration:aretrospective study of302 case显示文摘 | Yin S N Ma H Li Q L | 2001 | Laparoendosco Endo Surgy2001，6，4： | 1 |
| 6 | Effects of Decreasing the Frequency of Ventilator Circuit Changes to Every 7 Days on the Rate of Ventilator-Associated Pneumonia in a Beijing Hospital显示文摘 | Han J N Liu Y P Ma S | 2001 | Respir Care2001，46，9： | 1 |
| 7 | Decentralized robust control of building structures under seismic excitations显示文摘 | Ma T W Xu N S Tang Y | 2008 | Earth- quake Engng Struct Dyn2008，37，1： | 1 |
| 8 | Effect of folic acid supplementation on homocysteine level in postmenopausal women 显示文摘 | Sultan N Khan MA Malik S | 2007 | J Ayub Med Coil Abbottabad2007，19，4： | 1 |
| 9 | Synthesis of uniform microspheres with higher content of 2 - hydroxyethyl methacrylate by employing SPG (Shirasu porous glass)emulsification technique followed by swelling process of droplets 显示文摘 | Masatoshi N Omi S | 1997 | Journal of Applied Polymer Science1997，66，： | 1 |
| 10 | Triterpenes and lignans from Artemisia caruifolia and their eytotoxic effects on meth-A and LLC tumor cell lines 显示文摘 | Ma C M Nakamura N Min B S | 2001 | Chem Pharm Bull2001，49，2： | 1 |
| 11 | Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo显示文摘 | BROWN N J NAKAMURA S MA L | 2000 | Kidney Int2000，58，3： | 1 |
| 12 | Baculovirus-mediated gene transfer into pancreatic islet cells 显示文摘 | Ma L Tamarina N Wang S | 2000 | Diabetes2000，49，12： | 1 |
| 13 | Comparative study of anion polyacrylamide (APAM) adsorption-related fouling o a PVDF UF membrane and a modified PVDF UF membrane 显示文摘 | YiXS Shi W X Yu S L Sun N Jin L M Wang S Zhang B Ma C Sun L P | 2012 | Desalination2012，286，： | 1 |
| 14 | Novel design of short antimicrobial peptides derived from the bacteri- cidal domain of avian β-defensin-4 显示文摘 | DONG N MA Q Q SHAN A S | 2012 | Protein and Peptide Letters2012，19，11： | 1 |
| 15 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 16 | A review of algorithms for medical image segmentation and their applications to the female pelvic cavity 显示文摘 | Ma Zhen Tavares J M R S Jorge R N | 2010 | Computer Methods in Biomechanies and Biomedical Engineering2010，13，2： | 1 |
| 17 | Prostaglandin E receptor EP4 antagonism inhibits breast cancer metas'tasis显示文摘 | Ma X Kundu N Rifat S | 2006 | Cancer Res2006，66，6： | 1 |
| 18 | Improved decentralized method for control of building structures under seismic ex- citation显示文摘 | Ma T W Johansen J Xu N S | 2010 | Journal of Engineering Mechanics2010，136，5： | 1 |
| 19 | Epidermal electronics 显示文摘 | KIM D H LU N S MA R | 2011 | Science2011，333，6044： | 1 |
| 20 | A prototype micro-wheeledrobot using SMA Actuator 显示文摘 | QIN C J MA P S QI N Y | 2004 | Sensors and Actuators: A2004，113，1： | 1 |
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