|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A multicenter,retrospective.epidemiologic survey of the clinical features and management of bone metastatic disease in China显示文摘Background:Bone metastases are common in patients with advanced cancer.Bisphosphonates(BPs) could prevent or delay the development of skeleton-related events(SREs).The present study aimed to identify the clinical features of and treatment strategies for Chinese patients with bone metastases.Methods:Consecutive cancer patients who had bone metastases and received BP treatment were enrolled.A questionnaire was developed to collect the patients' clinical data,as well as information on the diagnosis and management of bone metastases.Physicians' awareness of the guidelines and knowledge of the application of BP were also assessed.Results:A total of 3223 patients with lung cancer(36.5%),breast cancer(30.9%),prostate cancer(8.5%),and gastrointestinal cancer(5.7%) were included in this study.The sites of bone metastases were the thoracic spine(56.0%),lumbar spine(47.1%),ribs(32.6%),and pelvis(23.2%).The SRE frequency was the highest in patients with multiple myeloma(36.6%),followed by those with lung cancer(25.9%),breast cancer(20.2%),prostate cancer(18.2%),and gastrointestinal cancer(17.3%).Irradiation to the bone was the most frequent SRE(58%in lung cancer patients,45%in breast cancer patients,and 48%in prostate cancer patients).Our survey also showed that 45.5%of patients received BP within 3 months after their diagnosis of bone metastases,whereas the remaining 54.5%of patients did not receive BP treatment until at least 3 months after their diagnosis of bone metastases.The SRE frequency in the former group was significantly lower than that in the latter group(4.0%vs.42.3%,P < 0.05).In patients with more than 6 months of continuous BP treatment,the mean time to the first SRE was significantly longer than that in patients with less than 6 months of continuous BP treatment(7.2 vs.3.4 months,P < 0.05).In addition,12.2%of the physicians were not aware of the efficacy of BP in preventing and delaying SRE.Only half(52.3%) of the physicians agreed that the BP treatment should persist for at least 6 months unless it was intolerable.Conclusions:Our study suggested that prompt and persistent BP treatment was associated with a reduced risk of SREs.However,our survey also revealed that the proper application of BP was not as common as expected in China. | Yunpeng Yang Yuxiang Ma Jin Sheng Yan Huang Yuanyuan Zhao Wenfeng Fang Shaodong Hong Ying Tian Cong Xue Li Zhang | 2016 | Chinese Journal of Cancer2016，35，5： | 13 |
| 2 | Imbalance of Interleukin 18 and Interleukin 18 Binding Protein in Patients with Lupus Nephritis显示文摘评估 interleukin 的平衡地位 18 ( IL-18 )并且 interleukin 在在有豺狼座肾炎(行)和主要肾病的症候群( PNS )的病人的循环的 18 有约束力的蛋白质( IL-18BP ),在 IL-18 和 IL-18BP 的外部血 mononuclear 房间( PBMC )的血浆层次以及 mRNA 表示被 ELISA 和 RT-PCR 分别地测量。IL-18/IL-18BP 的比率也是计算的。当仅仅 IL-18BP 在 PNS 增加了时,当时,血浆 IL-18 和 IL-18BP 在行病人显著地增加了,它在行然而并非在 PNS 病人导致了 IL-18/IL-18BP 的提高的比率与正常控制相比。相反,增加了 IL-18 mRNA 的水平仅仅在行然而并非在 PNS 组被检测,尽管在在两个组的 PBMC 的 IL-18BP mRNA 表情在控制比那高。IL-18 和 IL-18BP 的不平衡可能涉及行,一条治疗学的途径基于是为行要发展的贵重物品的致病。细胞与分子的免疫学。2006; 3 (4 ): 303-306。 | Dong Liang Wenfeng Ma Cuiwei Yao Huafeng Liu Xiaowen Chen | 2006 | Cellular & Molecular Immunology2006，3，4： | 10 |
| 3 | Grinding performance evaluation of porous composite-bonded CBN wheels for Inconel 718显示文摘For high-efficiency grinding of difficult-to-cut materials such as titanium and nickel alloys, a high porosity is expected and also a sufficient mechanical strength to satisfy the function.However, the porosity increase is a disadvantage to the mechanical strength. As a promising pore forming agent, alumina bubbles are firstly induced into the abrasive layer to fabricate porous cubic boron nitride(CBN) wheels. When the wheel porosity reaches 45%, the bending strength is still high up to 50 MPa with modified orderly pore distribution. A porous CBN wheel was fabricated with a total porosity around 30%. The grinding performance of the porous composite-bonded CBN wheel was evaluated in terms of specific force, specific grinding energy, and grinding temperature, which were better than those of the vitrified one under the same grinding conditions. Compared to the vitrified CBN wheel, clear straight cutting grooves and less chip adhesion are observed on the ground surface and there is also no extensive loading on the wheel surface after grinding. | Chen Zhenzhen Xu Jiuhua Ding Wenfeng Ma Changyu | 2014 | Chinese Journal of Aeronautics2014，27，4： | 7 |
| 4 | Differentiation of illicit drugs with THz time-domain spectroscopy显示文摘The terahertz time-domain spectroscopy(THz-TDS) was used for sensing and identifying illicit drugs.The absorption spectra of seven illicit drug samples(morphine and its hydrochloride,cocaine hydrochloride,codeine phosphate,papaverine hydrochloride,pethidine hydrochloride,and thebaine) were studied by THz-TDS at 0.3-2.0 THz at room temperature.The geometric structure and vibration frequencies of morphine were calculated by density functional theory.The four absorption features were dominated by intra-/inter-molecular collective or lattice vibration modes.Each illicit drug has a distinct signature in its THz spectra.The results indicate that the THz-TDS can be used to identify and discriminate illicit drugs by their characteristic fingerprints. | LIU Guifeng MA Shihua JI Te ZHAO Hongwei WANG Wenfeng | 2010 | Nuclear Science and Techniques2010，21，4： | 7 |
| 5 | Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells显示文摘Monoallelic gene expression refers to the phenomenon that all transcripts of a gene in a cell are expressed from only one of the two alleles in a diploid organism. Although monoallelic gene expression has been occasionally reported with bulk transcriptome analysis in plants, how prevalent it is in individual plant cells remains unknown. Here, we developed a single-cell RNA-seq protocol in rice and investigated allelic expression patterns in mesophyll cells of indica(93-11) and japonica(Nipponbare) inbred lines, as well as their F1 reciprocal hybrids. We observed pervasive monoallelic gene expression in individual mesophyll cells, which could be largely explained by stochastic and independent transcription of two alleles. By contrast, two mechanisms that were proposed previously based on bulk transcriptome analyses, parent-oforigin effects and allelic repression, were not well supported by our data. Furthermore, monoallelically expressed genes exhibited a number of characteristics, such as lower expression levels, narrower H3K4me3/H3K9ac/H3K27me3 peaks, and larger expression divergences between 93-11 and Nipponbare. Taken together, the development of a single-cell RNA-seq protocol in this study offers us an excellent opportunity to investigate the origins and prevalence of monoallelic gene expression in plant cells. | Yingying Han Xiao Chu Haopeng Yu Ying-Ke Ma Xiu-Jie Wang Wenfeng Qian Yuling Jiao | 2017 | Science Bulletin2017，62，19： | 5 |
| 6 | The ACTIVE study protocol:apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer(CTONG1706)显示文摘Background:Gefitinib,as the first epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)approved for the treatment of advanced non-small cell lung cancer(NSCLC),has been proved to significantly improve the progression-free survival(PFS)in the first-line setting but suffers from resistance 7-10 months after treatment initia-tion.Apatinib(YN968D1),a potent vascular endothelial growth factor receptor(VEGFR)2-TKI,specifically binds to VEGFR2 and leads to anti-angiogenetic and anti-neoplastic effect.Concurrent inhibition of VEGFR and EGFR path-ways represents a rational approach to improve treatment responses and delay the onset of treatment resistance in EGFR-mutant NSCLC.This ACTIVE study aims to assess the combination of apatinib and gefitinib as a new treatment approach for EGFR-mutant NSCLC as a first-line setting.Methods:This multicenter,randomized,double-blind,placebo-controlled phase III study(NCT02824458)has been designed to assess the efficacy and safety of apatinib or placebo combined with gefitinib as a first-line treatment for patients with EGFR-mutant advanced NSCLC.A total of 310 patients with EGFR-mutation(19del or 21L858R),pathological stage IIIB to IV non-squamous NSCLC were to be enrolled.The primary endpoint is investigator assessment of PFS,and the secondary endpoints include independent radiological central(IRC)-confirmed PFS,overall survival(OS),objective response rate(ORR),disease control rate(DCR),time to progressive disease(TTPD),duration of response(DoR),quality of life(QoL)and safety.The patients are randomized in a 1:1 ratio to receive gefitinib(250 mg,p.o.q.d.)plus apatinib(500 mg,p.o.q.d.)or gefitinib plus placebo,given until disease progression or intolerable adverse events.Exploratory biomarker analysis will be performed.This study is being conducted across China and comprises of 30 participating centers.Enrollment commenced in August 2017 and finished in December 2018,most of the patients are in the follow-up period.Anticipated outcomes and significance:The present study will be the first to evaluate the efficacy and safety profile of the combination of apatinib plus gefitinib as a first-line therapy for patients with EGFR-positive advanced non-squamous NSCLC.Importantly,this trial will provide comprehensive evidence on the treatment of EGFR-TKIs combined with antiangiogenic therapy. | Zhonghan Zhang Fan Luo Yang Zhang Yuxiang Ma Shaodong Hong Yunpeng Yang Wenfeng Fang Yan Huang Li Zhang Hongyun Zhao | 2019 | Cancer Communications2019，39，1： | 5 |
| 7 | Effects of L-lysine·H2SO4 product on the intestinal morphology and liver pathology using broiler model显示文摘Background: Lysine is used widely in livestock production due to the shortage of feed protein resources.Llysine·H2SO4 contains L-lysine sulphate as well as fermentation co-products which contain other amino acids and phosphorus.However,there are few articles about L-lysine·H2SO4 product regarding intestinal morphology and liver pathology of broiler chickens.In this article,we focus on the absorption and metabolism of L-lysine·H2SO4 revealed in the variation of intestinal morphology and liver pathology to determine the tolerance of chicks for L-lysine·H2SO4.Methods: To evaluate the tolerance of broilers for L-lysine·H2SO4,240 one day old broilers were allocated randomly to one of five dietary treatments which included corn-soybean diets containing 0,1%,4%,7% or 10% L-lysine·H2SO4(L-lysine content = 55%).Results: Supplementation of 1% L-lysine·H2SO4 in the diet had no negative effects.However,4%,7% or 10% Llysine·H2SO4 supplementation produced negative responses on broiler performance,carcass characteristics,blood biochemistry,and particularly on intestinal morphology and liver pathology compared with broilers fed the control diet.Conclusion: Our results show that supplementation with 1% L-lysine·H2SO4 had no negative effects on performance,carcass characteristics,blood biochemistry,intestinal morphology and liver pathology in broilers,but supplementation with 4%,7% or 10% L-lysine·H2SO4 produced a negative response,particularly with respect to intestinal morphology and liver pathology. | Hongmin Jia Ting He Haitao Yu Xiangfang Zeng Shihai Zhang Wenfeng Ma Jie Zhang Shiyan Qiao Xi Ma | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 3 |
| 8 | Role of surface defects of carbon nanotubes on catalytic performance of barium promoted ruthenium catalyst for ammonia synthesis显示文摘Carbon nanotubes(CNTs) with abundant surface defects are prepared by a liquid oxidation and thermal annealing method. The defective CNTs-D supported Ba–Ru/CNTs-D catalysts exhibit superior catalytic performance in ammonia synthesis with a TOF be increased up to 0.30 s-1, which is 2.5 times of oxidized CNTs-O supported Ba–Ru/CNTs-O catalysts and 5 times of the Ba–Ru/CNTs. The characterizations by CO chemisorption, transmission electron microscope, Raman, and X-ray photoelectron spectroscopy revealed that the uniformly well dispersed Ru NPs can be stabilized on the defective sites of CNTs-D. The great improvement of the catalytic performance and stability of the Ba–Ru/CNTs-D is contributed to the strong interaction between Ru NPs and surface defect of the CNTs. | Yongcheng Ma Guojun Lan Wenzhao Fu Ying Lai Wenfeng Han Haodong Tang Huazhang Liu Ying Li | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 9 | Selection, identification, and application of Aflatoxin B1 aptamer显示文摘 | Xiaoyuan Ma Wenfeng Wang Xiujuan Chen Yu Xia Shijia Wu Nuo Duan Zhouping Wang | 2014 | European Food Research and Technology2014，，6： | 1 |
| 10 | On the decomposition of an NFSR into the cascade connection of an NFSR into an LFSR显示文摘 | Ma Zhen Qi Wenfeng Tian Tian | | 0，，02： | 1 |
| 11 | Time and fre- quency synchronization for multicarrier transmission on hexagonal time-frequency lattice显示文摘 | Xu Kui Ma Wenfeng Xie Wei | 2013 | IEEE Trans- actions on Signal Processing2013，61，24： | 1 |
| 12 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 13 | Radiation degradation of Congo Red in aqueous solution显示文摘 | Hongjuan Ma Min Wang Rulyuan Yang Wenfeng Wang Jun Zhao Zhongqun Shen Side Yao | 2007 | Chemosphere2007，68，： | 1 |
| 14 | Autonomous bus services:current research status and future recommendations显示文摘Implementing autonomous bus services in several cities has garnered substantial research attention worldwide.However,the benefits and challenges of this emerging mode remain insufficiently understood.Consequently,VOSviewer was employed for a bibliometric analysis involving 300 publications,investigating the associations among authors,journals,and keywords.Subsequently,we comprehensively reviewed the current state of research on two topics and proposed future recommendations.Results indicate that the first document related to autonomous bus services was published in 2009.Most user attitude-related research data are obtained via questionnaires and analyzed using statistical techniques.Autonomous bus services are expected to benefit passengers regarding travel time,cost,safety,etc.,while passenger preferences are inconsistent.However,integrating the service into existing bus systems requires careful consideration of the schedule sequences.Notably,modular autonomous bus services present a new opportunity for the further optimization of bus services.In future studies,standardized data acquisition procedures should be developed to achieve comparable results.Regarding traveler choice behavior,the effect of specific autonomous bus service policies over time and the heterogeneity due to cultural or social contexts across regions should be assessed.To further promote autonomous bus services,based on fluctuating travel demands,the effects of vehicle capacity,speed,and cost of fleet composition should be evaluated comprehensively to optimize the bus network and schedule sequence.Owing to the protracted nature of the transition from conventional to fully autonomous buses,one should prioritize semi-autonomous bus services.Another essential future research direction is to integrate modular autonomous bus assembly or disassembly strategies with different fine-grained operation optimization techniques in various scenarios. | Jinxing Shen Qinxin Liu Zi Ye Wenfeng Jiang Changxi Ma | 2023 | Digital Transportation and Safety2023，2，3： | 1 |
| 15 | Selection,identification,and application of Aflatoxin B1 aptamer 显示文摘 | Ma Xiaoyuan Wang Wenfeng Chen Xiujuan | 2014 | Eoropean Food Research and Technology2014，238，6： | 1 |
| 16 | Fast ISAR imaging method based on scene segmentation显示文摘Although compressed sensing inverse synthetic aperture radar(ISAR) imaging methods are widely used in radar signal processing, its reconstructing time and memory storage space requirements are very high. The main reason is that large scene reconstruction needs a higher dimension of the sensing matrix. To reduce this limitation, a fast high resolution ISAR imaging method,which is based on scene segmentation for random chirp frequencystepped signals, is proposed. The idea of scene segmentation is used to solve the problems aforementioned. In the method,firstly, the observed scene is divided into multiple sub-scenes and then the sub-scenes are reconstructed respectively. Secondly, the whole image scene can be obtained through the stitching of the sub-scenes. Due to the reduction of the dimension of the sensing matrix, the requirement of the memory storage space is reduced substantially. In addition, due to the nonlinear superposition of the reconstructed time of the segmented sub-scenes, the reconstruction time is reduced, and the purpose of fast imaging is achieved.Meanwhile, the feasibility and the related factors which affect the performance of the proposed method are also analyzed, and the selection criterion of the scene segmentation is afforded. Finally,theoretical analysis and simulation results demonstrate the feasibility and effectiveness of the proposed method. | Mingjiu Lü Shaodong Li Wenfeng Chen Jun Yang Xiaoyan Ma | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 1 |
| 17 | Altered brain spontaneous activity and connectivity network in irritable bowel syndrome patients: A resting-state fMRI study显示文摘 | Xiaofen Ma Shumei Li Junzhang Tian Guihua Jiang Hua Wen Tianyue Wang Jin Fang Wenfeng Zhan Yikai Xu | 2014 | Clinical Neurophysiology2014，，： | 1 |
| 18 | Multipair two-way massive MIMO AF relaying with ZFR/ZFT and hardware impairments over high-altitude platforms显示文摘HAPs(High-Altitude Platforms)are one of the most promising alternative infrastructures for providing wireless communications to overcome the shortcomings of terrestrial-tower-based and satellite systems.This paper investigates a multipair two-way MM-AF(Massive MIMO Amplify-and-Forward)relay system over HAPs,where multiple user pairs exchange information within a pair through a relay with a very large number of antennas,and a HAP channel is modeled to follow a Rician fading distribution because of the presence of a line-of-sight path.First,the effect of hardware impairments on a multipair two-way MM-AF system is taken into consideration and is modeled using transmit and receive distortion noises.Then,ZFR/ZFT(Zero-Forcing Reception/Zero-Forcing Transmission)processing matrices of HDR(Half-Duplex Relaying)and FDR(Full-Duplex Relaying)with imperfect channel state information are presented.Finally,the asymptotic expressions of an end-to-end SINR are derived.Theoretical analyses and simulation results show that when the number of relay antennas grows very large,the SE(Spectral Efficiency)of an MM-AF relay system is limited by hardware impairments at the users instead of those at the relay,or by other types of interference.Thus,the quality of the hardware at a relay can be decreased without significantly degrading performance. | SUN Xiaoli XU Kui XU Youyun MA Wenfeng | 2016 | Journal of Communications and Information Networks2016，1，3： | 1 |
| 19 | In situ preparation of gel polymer electrolyte for lithium batteries: Progress and perspectives显示文摘The practical applications of Li-ion batteries(LIBs)are challenged by their safety concerns when using liquid electrolytes(LEs).Solid-state gel polymer electrolytes(GPEs)can address this challenge and have drawn increased attention recently.Normally,GPEs are prepared separately and then assembled into cells,which undoubtedly result in dissatisfactory solid/solid interfacial compatibility and low ionic conductivity.Fortunately,in situ GPEs are proposed to address the above challenges and simplify the preparation process.Typically,LE precursor is injected into the cells and gradually transformed into a quasisolid gel state under the conditions of thermal or chemical initiators.Consequently,the obtained in situ GPEs could fully infiltrate the electrode and better interface contact of gel electrolyte/electrode is thus inherited.In this review,the authors focus on the in situ GPEs used in lithium batteries(LBs),and summarize recent progress of the design,synthesis,and applications of in situ GPEs.Based on the different ways of triggering polymerization,there are mainly three methods:thermochemical gelation,polymerization by additional chemical initiators,and cross-linking initiated by Li O bond.Composite GPEs based on in situ solidification method are introduced as a promising strategy to improve the electrochemical performances.Finally,up-to-date research progresses are discussed,and perspectives are provided on the development and challenges of in situ GPEs to meet the requirements for their practical applications in LBs. | Chao Ma Wenfeng Cui Xizheng Liu Yi Ding Yonggang Wang | 2022 | InfoMat2022，4，2： | 1 |
| 20 | Efficient carrier transport via dual-function interfacial engineering using cesium iodide for high-performance perovskite solar cells based on NiOx hole transporting materials显示文摘As a famous hole transporting material, nickle oxide (NiOx) has drawn enormous attention due to its low cost and superior stability. However, the relatively low conductivity and high-density surface trap states of NiOx severely limit device performance in solar cell applications. Interfacial engineering is an efficient approach to achieve remarkable hole-transporting performance by surface passivation. Herein, the efficient NiOx hole transport layer was prepared by surface passivation engineering strategy via facile solution processes with cesium iodide (CsI). It is demonstrated that CsI plays a super-effective dual-function role in inverted solar cell device: On one hand, the presence of CsI hugely passivates the surface trap states at the NiOx/perovskite interface along with obviously improved conductivity by the incorporated Cs^(+);on the other hand, the ions immigration is significantly suppressed by the presence of I ion for high-quality perovskite films, resulting in a stable contact interface. The ameliorative interface leads to largely reduced carrier non-radiative recombination, attributing to boosted carrier extraction efficiency. As a result, decent power conversion efficiency (PCE) of 18.48% with a noticeable fill factor (FF) beyond 80% was achieved. This facile and efficient surface engineering approach with dual-function shows excellent potential for the design of high-performance functional interfacial modification layer to achieve high-performance solar cells. | Taotao Hu Fu Zhang Hua Yu Meng Zhang Yue Yu Wenfeng Zhang Rui Liu Liuwen Tian Zhu Ma | 2021 | Nano Research2021，14，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员