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| 1 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 2 | Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells显示文摘Monoallelic gene expression refers to the phenomenon that all transcripts of a gene in a cell are expressed from only one of the two alleles in a diploid organism. Although monoallelic gene expression has been occasionally reported with bulk transcriptome analysis in plants, how prevalent it is in individual plant cells remains unknown. Here, we developed a single-cell RNA-seq protocol in rice and investigated allelic expression patterns in mesophyll cells of indica(93-11) and japonica(Nipponbare) inbred lines, as well as their F1 reciprocal hybrids. We observed pervasive monoallelic gene expression in individual mesophyll cells, which could be largely explained by stochastic and independent transcription of two alleles. By contrast, two mechanisms that were proposed previously based on bulk transcriptome analyses, parent-oforigin effects and allelic repression, were not well supported by our data. Furthermore, monoallelically expressed genes exhibited a number of characteristics, such as lower expression levels, narrower H3K4me3/H3K9ac/H3K27me3 peaks, and larger expression divergences between 93-11 and Nipponbare. Taken together, the development of a single-cell RNA-seq protocol in this study offers us an excellent opportunity to investigate the origins and prevalence of monoallelic gene expression in plant cells. | Yingying Han Xiao Chu Haopeng Yu Ying-Ke Ma Xiu-Jie Wang Wenfeng Qian Yuling Jiao | 2017 | Science Bulletin2017，62，19： | 5 |
| 3 | Transcriptome Survey of the Contribution of Alternative Splicing to Proteome Diversity in Arabidopsis thaliana显示文摘 | Haopeng Yu Caihuan Tian Yang Yu Yuling Jiao | 2016 | Molecular Plant2016，9，5： | 4 |
| 4 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 5 | RS and GIS-based Analysis of Landscape Pattern Changes in Urban-rural Ecotone:A Case Study of Daiyue District,Tai' an City,China显示文摘Based on RS data of Daiyue District,Tai'an City in 2000,2005 and 2010,changes of land use types in urban-rural ecotone of Tai'an City from 2000 to 2010 were analyzed.Ecological theories,ArcGIS techniques and landscape structure analysis software Fragstats were applied to select relevant landscape pattern indexes and analyze changes of landscape structure,and compare changes in two durations(2000-2005,2005-2010).The results showed that area of natural landscapes in the study area declined from 2000 to 2010,construction land expanded,land use types were mainly transferred from natural landscapes to man-made landscapes.In terms of landscape level,number of patches(NP),patch density(PD),patch shape index(SHAPE),Shannon's diversity index(SHDI) and Shannon's evenness index(SHEI) increased,the largest patch index(LPI) declined.In terms of type level,arable land were influenced by the most human interventions,large-scale patches turned fragmented,and landscape dominance degraded;woodland landscapes were concentrated in mountainous areas,waterscape indexes showed slight changes.Dominance of regional dominant landscape types degraded,landscape fragmentation and landscape heterogeneity increased,and landscape stability declined. | SHI Haopeng YU Kaiqin FENG Yongjun DONG Xiaochang ZHAO Haiyan DENG Xiaomei | 2012 | Journal of Landscape Research2012，4，9： | 2 |
| 6 | 2-Diphenylphosphinoyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis ofβ-Glycosides显示文摘Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining the biological functions and activities of carbohydrate molecules.However,their stereochemistry control in glycosylation represents one of the most challenging tasks in carbohydrate chemistry. | Xianglai Liu Yetong Lin Ao Liu Qianhui Sun Huiyong Sun Peng Xu Guolong Li Yingying Song Weijia Xie Haopeng Sun Biao Yu Wei Li | 2022 | Chinese Journal of Chemistry2022，40，4： | 2 |
| 7 | Object registration using an RGB-D camera for complex product augmented assembly guidance显示文摘Background Augmented assembly guidance aims to help users complete assembly operations more efficiently and quickly through augmented reality technology,breaking the limitations of traditional assembly guidance technology which is single in content and boring in way.Object registration is one of the key technologies in augmented assembly guidance process,which can affect the location and direction of virtual assembly guidance information in real assembly environment.Methods This paper presents an object registration method based on RGB-D camera,which combines Lucas-Kanade(LK)optical flow algorithm and Iterative Closet Point(ICP)algorithm.An augmented assembly guidance system for complex products through this method is built.Meanwhile,in order to compare the effectiveness of the proposed method,we also implemented object registration based on an open source augmented reality SDK Vuforia.Results An engine model and a complex weapon cabin equipment are taken as an case to verify this work.The result shows that the registration method proposed in this paper is more accurate and stable compared with that based on Vuforia and the augmented assembly guidance system through this method greatly improves the user's time compared with the traditional assembly.Conclusions Therefore,we can conclude that the object registration method mentioned in this paper can be well applied in the augmented assembly guidance system,which can do enhance the efficiency of assembly considerably. | Kangkang YANG Yu GUO Pengzhou TANG Haopeng ZHANG Han LI | 2020 | Virtual Reality & Intelligent Hardware2020，2，6： | 2 |
| 8 | QoS-Aware Power Allocation Scheme for Relay Satellite Networks显示文摘This paper investigated a QoS-aware power allocation for relay satellite networks.For the given QoS requirements,we analyzed the signal model of relay transmission and formulated the power minimization problem which is non-convex and difficult to solve.To find the optimal solution to the considered problem,we first analyzed the optimization problem and equivalently turn it into a convex optimization problem.Then,we provided a Lagrangian dual-based method to obtain the closed-form of the power allocation and provided an iterative algorithm to the optimal solution.Moreover,we also extended the results to the cooperative transmission mode.Finally,simulation results were provided to verify the superiority of the proposed algorithm. | Jin’ao Yu Xiaogang Tang Shibing Zhu Haopeng Sun Lunxin Zhong Guangyu Yang | 2021 | Journal of Beijing Institute of Technology2021，30，1： | 1 |
| 9 | Sustainable production of acrolein: investigation of solid acid-base catalysts for gas-phase dehydration of glycerol 显示文摘 | CHAI Songhai WANG Haopeng LIANG Yu | 2007 | Green Chemistry2007，9，： | 1 |
| 10 | Sustainable production of acrolein:investigation of solid acid-base catalysts for gas-phase dehydration of glycerol显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2007 | Green Chemistry2007，9，： | 1 |
| 11 | Sustainable production of acrolein: Investigation of solid acid-base catalysts for gas-phase dehydration of glycerol显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2007 | Green Chem2007，9，10： | 1 |
| 12 | Sustainable production of acrolein:investigation of solid acid base catalysts for gas-phase dehydration of glycerol显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2007 | Green Chemistry2007，，9： | 1 |
| 13 | Sustainable production of acrolein: gas-phase dehydration of glycerol over 12-tungstophosphoric acid supported on ZrO2 and SiO2 显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2008 | Green Chemistry2008，，10： | 1 |
| 14 | Sustainable production of acrolein:Gas-phase dehydration of glycerol over Nb 2 O 5 catalyst显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2007 | J Catal2007，250，2： | 1 |
| 15 | p75 neurotrophin receptor signal pathway influence on apoptosis in anterior horn neurons of the spinal cord in a rat model of cauda equina compression injury显示文摘BACKGROUND: Studies have demonstrated that cauda equina compression results in apoptosis ofmotor neurons in the spinal cord. The combination of p75 neurotrophin receptor (p75NTR) andprecursor of nerve growth factor (pro-NGF) expression initiates the apoptotic pathway and inducesneuronal apoptosis. However, few reports have focused on the p75-mediated mechanism ofneuronal apoptosis following cauda equine compression injuryOBJECTIVE: To determine apoptosis of spinal cord neurons and activation of thepro-NGF-p75NTR-JNK(c-Jun N-terminal kinase) signal pathway in rats following cauda equinacompression, and to verify experimental outcomes.DESIGN, TIME AND SETTING: A randomized, controlled, in vivo experiment was performed at theMedical Experimental Center of Xi'an Jiaotong University between April and November in 2008.MATERIALS: Streptavidin-perosidase kit was purchased from Wuhan Boster, China; in situ endlabeling detection kit was provided by Promega, USA; type AEG-220G electron microscope waspurchased from Hitachi, Japan.METHODS: A total of 48 healthy, adult, female, Sprague Dawley rats were randomly assigned tothree groups: normal (n = 6), sham-surgery (n = 6), and compression (n = 36). The compressiongroup was randomly assigned to six subsets at 1,3, 5, 7, 14, and 28 days, respectively, with 6 rats ineach subset. A cylindrical silica gel stick was implanted into the rats to compress 75% of thevertebral canal in the compression group; in the sham-surgery group, only vertebral resection wasperformed; and no procedures were performed in the normal group.MAIN OUTCOME MEASURES: At 1,3, 5, 7, 14, and 28 days following compression, L_(2-3) spinalcord segments were processed for immunohistochemistry, in situ cell apoptosis detection, andtransmission electron microscopy observation. Nissl staining was used to observe neuronal survivalin the L_2 spinal cord segment. Immunohistochemistry was applied to detect expressions of pro-NGF,p75NTR, and JNK in the L_2 segment. TUNEL fluorometric method was used to observe apoptosis ofneurons in the L_2 segment.RESULTS: In the normal and sham-surgery groups, little neuronal apoptosis was observed in theL_(2-3) spinal cord segment. At 3 days after compression injury, pro-NGF, p75NTR and JNK expressionwas observed in the spinal cord. Expression levels reached a peak at 7 days, and then graduallydecreased. In the compression and sham-surgery groups, neurons primarily expressed pro-NGFand p75NTR. The number of JNK-positive neurons in the compression group was dramaticallyincreased compared with the sham-surgery group (P < 0.05). A few neurons were apoptotic in thespinal cord 1 day after compression injury. The number of apoptotic neurons gradually increasedand reached a peak at 7 days, and subsequently decreased. Apoptosis was still detectable at 28days. There was a positive correlation between p75NTR expression and neuronal apoptosis(r= 0.75, P< 0.05).CONCLUSION: Following cauda equina compression injury, apoptosis of spinal cord neurons wasobserved. The compression-induced neuronal apoptosis was associated with p75NTR expression inthe L_(2-3) spinal cord segment. | Haopeng Li Jie Chen Xijing He Siyue Xu Yu Liu | 2009 | Neural Regeneration Research2009，4，12： | 1 |
| 16 | Sustainable production of acrolein:Gas-phase dehydration of glycerol over 12-tungstophosphoric acid supported on ZrO 2 and SiO 2 显示文摘 | Chai Songhai Wang Haopeng Liang Yu | 2008 | Green Chem2008，10，10： | 1 |
| 17 | Bacteria inactivation by sulfate radical:progress and non-negligible disinfection by-products显示文摘Sulfate radicals have been increasingly used for the pathogen inactivation due to their strong redox ability and high selectivity for electron-rich species in the last decade.The application of sulfate radicals in water disinfection has become a very promising technology.However,there is currently a lack of reviews of sulfate radicals inactivated pathogenic microorganisms.At the same time,less attention has been paid to disinfection by-products produced by the use of sulfate radicals to inactivate microorganisms.This paper begins with a brief overview of sulfate radicals’properties.Then,the progress in water disinfection by sulfate radicals is summarized.The mechanism and inactivation kinetics of inactivating microorganisms are briefly described.After that,the disinfection by-products produced by reactions of sulfate radicals with chlorine,bromine,iodide ions and organic halogens in water are also discussed.In response to these possible challenges,this article concludes with some specific solutions and future research directions. | Xin Zhou Xiaoya Ren Yu Chen Haopeng Feng Jiangfang Yu Kang Peng Yuying Zhang Wenhao Chen Jing Tang Jiajia Wang Lin Tang | 2023 | Frontiers of Environmental Science & Engineering2023，17，3： | 0 |
| 18 | Adenovirus-mediated short hairpin RNA interference against p75 neurotrophin receptor in pheochromocytoma cells显示文摘Previous studies have confirmed that motor neuron apoptosis in the anterior horn of the lumbosacral spinal cord is positively correlated with p75 neurotrophin receptor (p75NTR) expression in rat models of cauda equina syndrome. This study used adenovirus to carry a short hairpin RNA (shRNA) for p75NTR gene silencing, to reduce p75NTR expression in the damaged phase and to decrease motor neuron apoptosis. Three p75 siRNA template oligonucleotide segments (shRNA) were designed, and cloned into the 1.0 CMV shuttle vector. HEK293 cells were cotransfected with shuttle vector (carrying shRNA) and an adenovirus vector framework expressing enhanced green fluorescent protein. Thus, this study successfully obtained adenovirus carrying p75shRNA. The obtained viruses were named Ad.shRNA1, Ad.shRNA2, and Ad.shRNA3. The recombinant adenoviruses were separately used to infect cultured pheochromocytoma cells (PC12). Forty-eight hours later, p75NTR mRNA and total protein were analyzed from the PC12 cells. Compared with the negative controls, RNA interference rates were separately 98.49 ± 0.68%, 95.08 ± 1.79% and 96.60 ± 1.14% at the mRNA level, and 72.89 ± 2.17%, 58.83 ± 1.15% and 59.88 ± 0.44% at the protein level in the Ad.shRNA1, Ad.shRNA2, and Ad.shRNA3 groups, respectively. Thus, recombinant adenovirus shRNA-mediated gene silencing successfully suppressed p75NTR expression. | Dongxu Feng Haopeng Li Siyue Xu YU Liu Xiaofei Hou | 2011 | Neural Regeneration Research2011，6，7： | 0 |
| 19 | Review of advanced road materials, structures, equipment, and detection technologies显示文摘As a vital and integral component of transportation infrastructure,pavement has a direct and tangible impact on socio-economic sustainability.In recent years,an influx of groundbreaking and state-of-the-art materials,structures,equipment,and detection technologies related to road engineering have continually and progressively emerged,reshaping the landscape of pavement systems.There is a pressing and growing need for a timely summarization of the current research status and a clear identification of future research directions in these advanced and evolving technologies.Therefore,Journal of Road Engineering has undertaken the significant initiative of introducing a comprehensive review paper with the overarching theme of“advanced road materials,structures,equipment,and detection technologies”.This extensive and insightful review meticulously gathers and synthesizes research findings from 39 distinguished scholars,all of whom are affiliated with 19 renowned universities or research institutions specializing in the diverse and multidimensional field of highway engineering.It covers the current state and anticipates future development directions in the four major and interconnected domains of road engineering:advanced road materials,advanced road structures and performance evaluation,advanced road construction equipment and technology,and advanced road detection and assessment technologies. | JRE Editorial Office Maria Chiara Cavalli De Chen Qian Chen Yu Chen Augusto Cannone Falchetto Mingjing Fang Hairong Gu Zhenqiang Han Zijian He Jing Hu Yue Huang Wei Jiang Xuan Li Chaochao Liu Pengfei Liu Quantao Liu Guoyang Lu Yuan Ma Lily Poulikakos Jinsong Qian Aimin Sha Liyan Shan Zheng Tong B.Shane Underwood Chao Wang Chaohui Wang Di Wang Haopeng Wang Xuebin Wang Chengwei Xing Xinxin Xu Min Ye Huanan Yu Huayang Yu Zhe Zeng You Zhan Fan Zhang Henglong Zhang Wenfeng Zhu | 2023 | Journal of Road Engineering2023，3，4： | 0 |
| 20 | Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics显示文摘Dear Editor,Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esopha-geal squamous cell carcinoma(ESCC).However,more than half of patients having a partial response to neoadjuvant therapy,which is considered as a therapy-resistant phenotype and the mechan-ism is still unclear.The heterogeneity of the ESCC with surgery alone therapy were characterized by single-cell RNA sequencing(scRNA-seq)previously,but few report was about ESCC patients with neoadjuvant therapy.1 It is emergent to illustrate the comprehensive hallmarks of neoadjuvant therapy-resistance in ESCC at single cell level. | Yushang Yang Yanguo Li Haopeng Yu Zhenyu Ding Longqi Chen Xiaoxi Zeng Shunmin He Qi Liao Yi Zhao Yong Yuan | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
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