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| 1 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 2 | Research on heart sound identification technology显示文摘In this article,both the basic principles and the experimental methods of identity recognition technology based on heart sounds are addressed.First,the characteristics of heart sounds and the feasibility of heart sounds as a biometric were analyzed.A synthetic model of heart sounds was then developed based on a family of wavelets;Finally,the characteristic parameters of heart sounds were extracted by using the heart sounds linear band frequency cepstra(HS-LBFC)with a specified configuration,and the similarity distance was adopted for heart sound identification.To highlight the difference in two heart sound signals between the time and frequency domains,a construction method of the heart sound wavelet,a calculation method of the parameters of a synthetic model,selection of the characteristic parameters of heart sounds and the corresponding data processing technology were examined.The experimental results showed that the proposed method exhibited excellent performance and practicability. | CHENG XieFeng MA Yong LIU Chen ZHANG XueJun GUO YuFeng | 2012 | Science China(Information Sciences)2012，55，2： | 20 |
| 3 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 4 | In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31显示文摘The performance of biodegradable magnesium alloy requires special attention to rapid degradation and poor biocompatibility, which can cause the implant to fail. Here, a sodium montmorillonite(MMT)/bovine serum albumin(BSA) composite coating was prepared upon magnesium alloy AZ31 via hydrothermal synthesis, followed by dip coating. We evaluated the surface characterization and corrosion behavior in vitro, and the biocompatibility in vitro and in vivo. Biodegradation progress of the MMT-BSA coated Mg pieces was examined through hydrogen evolution, immersion tests, and electrochemical measurements in Hank’s solution. In vitro biocompatibility studies were evaluated via hemolysis tests, dynamic cruor time tests, platelet adhesion, MTT testing and live-dead stain of osteoblast cells(MC3 T3-E1). It was found that the MMT-BSA coating had good corrosion resistance and a marked improvement in biocompatibility in comparison to bare Mg alloy AZ31. in vivo studies were carried out in rat model and the degradation was characterized by computed tomography scans. Results revealed that the MMT-BSA coated Mg alloy AZ31 implants maintained their structural integrity and slight degradation after 120 d of post-implantation. A100% survival rate for the rats was observed with no obvious toxic damages on the organs and tissues.Additionally, we proposed a sound coating formation mechanism. Considering the good corrosion protection and biocompatibility, the MMT-BSA coated Mg alloy AZ31 is a promising candidate material for biomedical implants. | Jian Wang Lanyue Cui Yande Ren Yuhong Zou Jinlong Ma Chengjian Wang Zhongyin Zheng Xiaobo Chen Rongchang Zeng Yufeng Zheng | 2020 | Journal of Materials Science & Technology2020，47，12： | 7 |
| 5 | Toxic effects of arsenic trioxide on Echinococcus granulosus protoscoleces through ROS production, and Ca^2+-ER stress-dependent apoptosis显示文摘 | Jiajie Li Guangyao Tang Wenjuan Qin Rentan Yang Rongji Ma Bin Ma Jianfeng Wei Hailong Lv Yufeng Jiang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 6 |
| 6 | Energy-Efficient Architecture and Technologies for Device to Device(D2D) Based Proximity Service显示文摘Considering that modern mobile terminals possess the capability to detect users' proximity,and offer means to directly communicate and share content with the people in close area,Device-to-Device(D2D) based Proximity Services(ProSe) have recently witnessed great development,which enable users to seek for and utilize relevant value in their physical proximity,and are capable to create numerous new mobile service opportunities.However,without a breakthrough in battery technology,the energy will be the biggest limitation for ProSe.Through incorporating the features of ProSe(D2D communication technologies,abundant built-in sensors,localization-dependent,and context-aware,etc.),this paper thoroughly investigates the energy-efficient architecture and technologies for ProSe from the following four aspects:underlying networking technology,localization,application and architecture features,context-aware and user interactions.Besides exploring specific energy-efficient schemes pertaining to each aspect,this paper offers a perspective for research and applications.In brief,through classifying,summarizing and optimizing the multiple efforts on studying,modeling and reducing energy consumption for ProSe on mobile devices,the paper would provide guide for developers to build energy-efficient ProSe. | ZHANG Bo WANG Yufeng JIN Qun MA Jianhua | 2015 | China Communications2015，12，12： | 5 |
| 7 | Effects of trigonelline inhibition of the Nrf2 transcription factor M vitro on Echmococcus granulosus显示文摘 | Wenjuan Qin Dongfang Guan Rongji Ma Rentan Yang Guoqiang Xing Hongjuan Shi Guangyao Tang Jiajie Li Hailong Lv Yufeng Jiang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 4 |
| 8 | Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging显示文摘Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole collimator.However the ideal pinhole collimator must keep a compromise between spatial resolution and sensitivity.In order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole diameters.The results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 cm.We chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution. | ZHU Jie MA Wenyan ZHU Yufeng MA Hongguang WU Yuelei HU Huasi ZHANG Boping HUO Yonggang LIU Silu JIAN Bin WANG Zhaomin | 2009 | Nuclear Science and Techniques2009，20，1： | 4 |
| 9 | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications:Process optimization,in vitro and in vivo investigation显示文摘Laser powder bed fusion(L-PBF)of magnesium(Mg)alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects.However,one of the key technical difficulties lies in the poor L-PBF process performance of Mg,contributed by the high susceptibility to oxidation,vaporization,thermal expansion,and powder attachment etc.This work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder,and characterized the microstructure,mechanical properties,biocompatibility,biodegradation and osteogenic effect of the as-built WE43 porous scaffolds.With the customized energy input and scanning strategy,the relative density of struts reached over 99.5%,and the geometrical error between the designed and the fabricated porosity declined to below 10%.Massive secondary phases including intermetallic precipitates and oxides were observed.The compressive strength(4.37-23.49 MPa)and elastic modulus(154.40-873.02 MPa)were comparable to those of cancellous bone.Good biocompatibility was observed by in vitro cell viability and in vivo implantation.The biodegradation of as-built porous scaffolds promoted the osteogenic effect,but the structural integrity devastated after 12 h by the immersion tests in Hank’s solution and after 4 weeks by the implantation in rabbits’femur,indicating an excessively rapid degradation rate. | Jinge Liu Bingchun Liu Shuyuan Min Bangzhao Yin Bo Peng Zishi Yu Caimei Wang Xiaolin Ma Peng Wen Yun Tian Yufeng Zheng | 2022 | Bioactive Materials2022，7，10： | 4 |
| 10 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 11 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 12 | METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most prevalent cancers in the world,with a high likelihood of metastasis and a dismal prognosis.The reprogramming of glucosemetabolism is critical in the development ofHCC.TheWarburg effect has recently been confirmed to occur in a variety of cancers,including HCC.However,little is known about the molecular biological mechanisms underlying the Warburg effect in HCC cells.In this study,we sought to better understand how methyltransferase 5,N6-adenosine(METTL5)controls the development of HCC and theWarburg effect.Methods:In the current study,quantitative real-time polymerase chain reaction and Western blotting were used to detect the expression of METTL5 in HCC tissues and cell lines.Several different cell models and animal models were established to determine the role of METTL5 in glucose metabolism reprogramming and the underlying molecularmechanism of HCC.Glutathione-S-transferase pulldown,coimmunoprecipitation,RNA sequencing,non-targeted metabolomics,polysome profiling,and luciferase reporter assays were performed to investigate the molecular mechanisms of METTL5 in HCC cells.Results:We discovered that METTL5 drove glucose metabolic reprogramming to promote the proliferation and metastasis of HCC.Mechanistically,upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A(LDHA),enolase 1(ENO1),triosephosphate isomerase 1(TPI1),solute carrier family 2 member 1(SLC2A1),and pyruvate kinase M2(PKM2).The c-Box and ubiquitin binding domain(UBA)regions of ubiquitin specific peptidase 5(USP5)binded to c-Myc protein and inhibited K48-linked polyubiquitination of c-Myc.Further study revealed that METTL5 controled the USP5 translation process,which in turn regulated the ubiquitination of c-Myc.Furthermore,we identified cAMP responsive element binding protein 1(CREB1)/P300 as a critical transcriptional regulator ofMETTL5 that promoted the transcription of METTL5 in HCC.In patient-derived tumor xenograft(PDX)models,adenovirus-mediated knockout of METTL5 had a good antitumor effect and prolonged the survival of PDX-bearing mice.Conclusions:These findings point to a novel mechanism by which CREB1/P300-METTL5-USP5-c-Myc controls abnormal glucose metabolism and promotes tumor growth,suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC. | Peng Xia Hao Zhang Haofeng Lu Kequan Xu Xiang Jiang Yuke Jiang Xiangdong Gongye Zhang Chen Jie Liu Xi Chen Weijie Ma Zhonglin Zhang Yufeng Yuan | 2023 | Cancer Communications2023，43，3： | 3 |
| 13 | Multiscale Nonlinear Thermo-Mechanical Coupling Analysis of Composite Structures with Quasi-Periodic Properties显示文摘This paper reports a multiscale analysis method to predict the thermomechanical coupling performance of composite structures with quasi-periodic properties.In these material structures,the configurations are periodic,and the material coefficients are quasi-periodic,i.e.,they depend not only on the microscale information but also on the macro location.Also,a mutual interaction between displacement and temperature fields is considered in the problem,which is our particular interest in this study.The multiscale asymptotic expansions of the temperature and displacement fields are constructed and associated error estimation in nearly pointwise sense is presented.Then,a finite element-difference algorithm based on the multiscale analysis method is brought forward in detail.Finally,some numerical examples are given.And the numerical results show that the multiscale method presented in this paper is effective and reliable to study the nonlinear thermo-mechanical coupling problem of composite structures with quasiperiodic properties. | Zihao Yang Liang Ma Qiang Ma Junzhi Cui Yufeng Nie Hao Dong Xiaohong An | 2017 | Computers, Materials & Continua2017，，3： | 2 |
| 14 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 2 |
| 15 | Genetic analysis of porcine circovirus type 2 (PCV2) strains isolated between 2001 and 2009: genotype PCV2b predominate in postweaning multisystemic wasting syndrome occurrences in eastern China显示文摘 | Wenliang Li Xianwei Wang Tao Ma Zhixin Feng Yufeng Li Ping Jiang | 2010 | Virus Genes2010，，2： | 2 |
| 16 | Energy-Aware Scheduling of Parallel Application in Hybrid Computing System显示文摘Energy management is emerging as an important issue for High performance computing(HPC)owning to high operational cost and low reliability. Compared with low-power architectural approach, energyaware scheduling based on Dynamic voltage scaling(DVS)and Dynamic power management(DPM) is regarded as a promising way since it is practical and low-cost. At present,most studies focus on pure DVS or non-DVS environment, while most high performance computing systems are hybrid non-DVS/DVS platforms. We propose an energyaware scheduling algorithm for parallel application to consider both DVS and non-DVS characteristics of hybrid system. We present the rule of task assignment, make analysis on DVS and DPM technique and give their mathematical formulation, which maintains makespan optimization and energy conservation. The clustering and merging algorithm, and priority computation method consider the situation of resource constraints. The extensive simulations demonstrate that the proposed algorithm has stronger ability of energy saving and time optimization than Heterogeneous earliest finish time(HEFT), Energy-efficient task duplication scheduling(EETDS) and Heterogeneous energy-aware duplication scheduling(HEADUS) algorithm no matter for synthetic workload or realistic workload. | MA Yan GONG Bin GUO Zhihong CHEN Yufeng ZOU Lida | 2014 | Chinese Journal of Electronics2014，23，4： | 2 |
| 17 | An Integrated Incentive Framework for Mobile Crowdsourced Sensing显示文摘Currently,mobile devices(e.g.,smartphones)are equipped with multiple wireless interfaces and rich builtin functional sensors that possess powerful computation and communication capabilities,and enable numerous Mobile Crowdsourced Sensing(MCS)applications.Generally,an MCS system is composed of three components:a publisher of sensing tasks,crowd participants who complete the crowdsourced tasks for some kinds of rewards,and the crowdsourcing platform that facilitates the interaction between publishers and crowd participants.Incentives are a fundamental issue in MCS.This paper proposes an integrated incentive framework for MCS,which appropriately utilizes three widely used incentive methods:reverse auction,gamification,and reputation updating.Firstly,a reverse-auction-based two-round participant selection mechanism is proposed to incentivize crowds to actively participate and provide high-quality sensing data.Secondly,in order to avoid untruthful publisher feedback about sensing-data quality,a gamification-based verification mechanism is designed to evaluate the truthfulness of the publisher’s feedback.Finally,the platform updates the reputation of both participants and publishers based on their corresponding behaviors.This integrated incentive mechanism can motivate participants to provide high-quality sensed contents,stimulate publishers to give truthful feedback,and make the platform profitable. | Wei Dai Yufeng Wang Qun Jin Jianhua Ma | 2016 | Tsinghua Science and Technology2016，21，2： | 2 |
| 18 | Development and Validation of an RNA Binding Proteinassociated Prognostic Model for Hepatocellular Carcinoma显示文摘Background and Aims:The survival rate of patients with hepatocellular carcinoma is variable.The abnormal expression of RNA-binding proteins(RBPs)is closely related to the occurrence and development of malignant tumors.The primary aim of this study was to identify RBPs related to the prognosis of liver cancer and to construct a prognostic model of liver cancer.Methods:We downloaded the hepatocellular carcinoma gene sequencing data from The Cancer Genome Atlas(cancergenome.nih.gov/)database,constructed a protein-protein interaction network,and used Cytoscape to realize the visualization.From among 325 abnormally expressed genes for RBPs,9(XPO5,enhancer of zeste 2 polycomb repressive complex 2 subunit[EZH2],CSTF2,BRCA1,RRP12,MRPL54,EIF2AK4,PPARGC1A,and SEPSECS)were selected for construction of the prognostic model.Then,we further verified the results through the Gene Expression Omnibus(www.ncbi.nlm.nih.gov/geo/)database and in vitro experiments.Results:A prognostic model was constructed,which determined that the survival time of patients in the high-risk group was significantly shorter than that of the low-risk group(p<0.01).Univariate and multivariate Cox regression analysis suggested that the risk score was an independent prognostic factor(p<0.01).We also constructed a nomogram based on the risk score,survival time,and survival status.At the same time,we verified the high expression and cancer-promoting effects of EZH2 in tumors.Conclusions:Survival,receiver operating characteristic curve and independent prognostic analyses demonstrated that we constructed a good prognostic model,which might be useful for estimating the survival of patients with hepatocellular carcinoma. | Hao Zhang Peng Xia Weijie Ma Yufeng Yuan | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 2 |
| 19 | Synthesis and Characterization of DOPO-g-CNSL and Its Effect on the Properties of Phenolic Foams显示文摘In order to improve the mechanical properties without reducing its flame retardancy of phenolic foams(PFs),9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide(DOPO)was introduced in the structure of cashew nut shell liquid(CNSL)to improve its flame retardant,and the product of DOPO grafting CNSL(DOPO-g-CNSL)was obtained to modify phenolic resin,and to prepare DOPO-g-CNSL modified PFs(DCMPFs).The structures of DOPO-g-CNSL were verified by Fourier transform infrared spectroscopy(FT-IR)and nuclear magnetic resonance(1H-NMR).Compared with CNSL,thermal stability of DOPO-g-CNSL was decreased and Ti decreased by 3.53%,but the residual carbon(800°C)was increased by 35.05%.Compared with pure PF,the mechanical properties,toughness and flame retardancy of DCMPFs were increased when the ratio of DOPO-g-CNSL to phenol(DOPO-g-CNSL/P)was no more than 10%.With the dosage of DOPO-g-CNSL/P increased,Ti of DCMPFs was slightly increased,but the carbon residues(800°C)were almost unchanged.And the cell sizes of DCMPFs were basically the same as the pure PF.By comprehensive analysis,the suitable dosage of DOPO-g-CNSL/P was no more than 10%. | Yufeng Ma Xuanang Gong Bing Xie Xiang Geng Puyou Jia | 2019 | Journal of Renewable Materials2019，7，10： | 2 |
| 20 | “Extreme utilization”development of deep shale gas in southern Sichuan Basin,SW China显示文摘To efficiently develop deep shale gas in southern Sichuan Basin,under the guidance of“extreme utilization”theory,a basic idea and solutions for deep shale gas development are put forward and applied in practice.In view of multiple influencing factors of shale gas development,low single-well production and marginal profit of wells in this region,the basic idea is to establish“transparent geological body”of the block in concern,evaluate the factors affecting shale gas development through integrated geological-engineering research and optimize the shale gas development of wells in their whole life cycle to balance the relationship between production objectives and development costs.The solutions are as follows:(1)calculate the gold target index and pinpoint the location of horizontal well drilling target,and shale reservoirs are depicted accurately by geophysical and other means to build underground transparent geological body;(2)optimize the drilling and completion process,improve the adaptability of key tools by cooling,reducing density and optimizing the performance of drilling fluid,the“man-made gas reservoir”is built by comprehensively considering the characteristics of in-situ stress and fractures after the development well is drilled;(3)through efficient management,establishment of learning curve and optimization of drainage and production regime,the development quality and efficiency of the well are improved across its whole life cycle,to fulfil“extreme utilization”development of shale gas.The practice shows that the estimated ultimate recovery of single wells in southern Sichuan Basin increase by 10%-20%than last year. | MA Xinhua WANG Hongyan ZHAO Qun LIU Yong ZHOU Shangwen HU Zhiming XIAO Yufeng | 2022 | Petroleum Exploration and Development2022，49，6： | 2 |
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