|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 2 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 3 | Comparison of unenhanced magnetic resonance imaging and ultrasound in detecting very small hepatocellular carcinoma显示文摘BACKGROUND In hepatocellular carcinoma(HCC),detection and treatment prior to growth beyond 2 cm are important as a larger tumor size is more frequently associated with microvascular invasion and/or satellites.In the surveillance of very small HCC nodules(≤2 cm in maximum diameter,Barcelona clinical stage 0),we demonstrated that the tumor markers alpha-fetoprotein and PIVKA-Ⅱare not so useful.Therefore,we must survey with imaging modalities.The superiority of magnetic resonance imaging(MRI)over ultrasound(US)to detect HCC was confirmed in many studies.Although enhanced MRI is now performed to accurately diagnose HCC,in conventional clinical practice for HCC surveillance in liver diseases,unenhanced MRI is widely performed throughout the world.While,MRI has made marked improvements in recent years.AIM To make a comparison of unenhanced MRI and US in detecting very small HCC that was examined in the last ten years in patients in whom MRI and US examinations were performed nearly simultaneously.METHODS In 394 patients with very small HCC nodules,those who underwent MRI and US at nearly the same time(on the same day whenever possible or at least within 14 days of one another)at the first diagnosis of HCC were selected.The detection rate of HCC with unenhanced MRI was investigated and compared with that of unenhanced US.RESULTS The sensitivity of unenhanced MRI for detecting very small HCC was 95.1%(97/102,95%confidence interval:90.9-99.3)and that of unenhanced US was 69.6%(71/102,95%confidence interval:60.7-78.5).The sensitivity of unenhanced MRI for detecting very small HCC was significantly higher than that of unenhanced US(P<0.001).Regarding the location of HCC in the liver in patients in whom detection by US was unsuccessful,S7-8 was identified in 51.7%.CONCLUSION Currently,unenhanced MRI is a very useful tool for the surveillance of very small HCC in conventional clinical follow-up practice. | Kazuo Tarao Akito Nozaki Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Testuo Yoshida Hideki Koyasu Makoto Chuma Kazushi Numata Shin Maeda | 2021 | World Journal of Hepatology2021，13，6： | 3 |
| 4 | Real impact of tumor marker AFP and PIVKA-II in detecting very small hepatocellular carcinoma(≤2 cm,Barcelona stage 0)-assessment with large number of cases显示文摘BACKGROUND In hepatocellular carcinoma(HCC),detection and treatment prior to growth beyond 2 cm are relevant as a larger tumor size is more frequently associated with microvascular invasion and/or satellites.AIM To examine the impact of the tumor marker alpha-fetoprotein(AFP)or PIVKA-II in detecting very small HCC nodules(≤2 cm in maximum diameter,Barcelona stage 0)in the large number of very small HCC.The difference in the behavior of these tumor markers in HCC development was also examined.METHODS A total of 933 patients with single-nodule HCC were examined.They were subdivided into 394 patients with HCC nodules≤2 cm in maximum diameter and 539 patients whose nodules were>2 cm.The rates of patients whose AFP and PIVKA-II showed normal values were examined.RESULTS The positive ratio of the marker PIVKA-II was significantly different(P<0.0001)between patients with nodules≤2 cm in diameter and those with nodules>2 cm,but there was no significant difference in AFP(P=0.4254).In the patients whose tumor was≤2 cm,50.5%showed normal levels in AFP and 68.8%showed normal levels in PIVKA-II.In 36.4%of those patients,both AFP and PIVKA-II showed normal levels.The PIVKA-II-positive ratio was markedly increased with an increase in the tumor size.In contrast,the positivity in AFP was increased gradually and slowly.CONCLUSION In the surveillance of very small HCC nodules(≤2 cm in diameter,Barcelona clinical stage 0)the tumor markers AFP and PIVKA-II are not so useful. | Kazuo Tarao Akito Nozaki Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Makoto Chuma Kazushi Numata Shin Maeda | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 5 | Antithrombotic drugs are risk factors for delayed postoperative bleeding after endoscopic submucosal dissection for gastric neoplasms显示文摘 | Ryonho Koh Kingo Hirasawa Sei Yahara Hiroyuki Oka Kazuya Sugimori Manabu Morimoto Kazushi Numata Atsushi Kokawa Takeshi Sasaki Akinori Nozawa Masataka Taguri Satoshi Morita Shin Maeda Katsuaki Tanaka | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 6 | Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study显示文摘 | Takumi Kawaguchi Atsumasa Komori Masataka Seike Shigetoshi Fujiyama Hiroshi Watanabe Masatoshi Tanaka Shotaro Sakisaka Makoto Nakamuta Yutaka Sasaki Makoto Oketani Toshihiro Hattori Koichi Katsura Michio Sata | 2012 | Journal of Gastroenterology2012，，12： | 1 |
| 7 | IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients显示文摘 | Mayu Ohnishi Masataka Tsuge Tomohiko Kohno Yizhou Zhang Hiromi Abe Hideyuki Hyogo Yuki Kimura Daiki Miki Nobuhiko Hiraga Michio Imamura Shoichi Takahashi Hidenori Ochi C. Hayes Shinji Tanaka Koji Arihiro Kazuaki Chayama | 2012 | Journal of Gastroenterology2012，，7： | 1 |
| 8 | Effect of chain structure on the melt rheology of modified polypropylene显示文摘 | Tadashi Tanaka Yuchi Masubuchi | 1999 | Journal of Applied Polymer Science1999，73，8： | 1 |
| 9 | Surface Modification of Ni-Cr-Mo Steel by Multifunction Cavitation显示文摘 | Masataka Ijiri Daichi Shimonishi Daisuke Nakagawa Kumiko Tanaka Toshihiko Yoshimura | 2017 | 材料科学与工程(中英文A版)2017，7，6： | 1 |
| 10 | A 50-Kilodalton Cry2A Peptide Is Lethal to Bombyx mori and Lymantria dispar显示文摘 | Masataka Ohsawa Miki Tanaka Kenta Moriyama Mitsuaki Shimazu Shin-ichiro Asano Kazuhisa Miyamoto Kohsuke Haginoya Toshiaki Mitsui Tomoaki Kouya Masayuki Taniguchi Hidetaka Hori | 2012 | Applied and Environmental Microbiology2012，，13： | 1 |
| 11 | Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women显示文摘 | Shiro Tanaka Tatsuhiko Kuroda Yasushi Yamazaki Yumiko Shiraki Noriko Yoshimura Masataka Shiraki | 2014 | Journal of Bone and Mineral Metabolism2014，，： | 1 |
| 12 | Effect of interface on the thermal conductivity of carbon nanotube composites显示文摘 | INDRA Vir Singh MASATAKA Tanaka MORINOBU Endo | 2007 | International Journal of Thermal Sciences2007，46，： | 1 |
| 13 | Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice显示文摘 | Kimie Tanaka Daisuke Nagata Yasunobu Hirata Yasuhiko Tabata Ryozo Nagai Masataka Sata | 2011 | Atherosclerosis2011，，2： | 1 |
| 14 | Diagnostic criteria for primary osteoporosis: year 2000 revision显示文摘 | Hajime Orimo Yasufumi Hayashi Masao Fukunaga Teruki Sone Saeko Fujiwara Masataka Shiraki Kazuhiro Kushida Shigehito Miyamoto Satoshi Soen Junji Nishimura Yasuo Oh-hashi Takayuki Hosoi Itsuo Gorai Hiroyuki Tanaka Tetsuo Igai Hideaki Kishimoto | 2001 | Journal of Bone and Mineral Metabolism2001，，6： | 1 |
| 15 | Analytical integration of weakly singular integrals in boundary element analysis of Helmholtz and advection-diffusion equations显示文摘 | KRISHNA M S MASATAKA Tanaka | 2000 | Comput Methods Appl Mech Engrg2000，189，： | 1 |
| 16 | IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients显示文摘 | Mayu Ohnishi Masataka Tsuge Tomohiko Kohno Yizhou Zhang Hiromi Abe Hideyuki Hyogo Yuki Kimura Daiki Miki Nobuhiko Hiraga Michio Imamura Shoichi Takahashi Hidenori Ochi C. Hayes Shinji Tanaka Koji Arihiro Kazuaki Chayama | 2012 | Journal of Gastroenterology2012，，7： | 1 |
| 17 | On exponential variable transformation based boundary element formulation for advection-diffusion problems显示文摘 | KRISHNA M S MASATAKA Tanaka | 2000 | Engineering Analysis with Boundary Elements2000，24，： | 1 |
| 18 | The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures显示文摘 | Masataka Shiraki Tomohiko Urano Tatsuhiko Kuroda Mitsuru Saito Shiro Tanaka Mariko Miyao-Koshizuka Satoshi Inoue | 2008 | Journal of Bone and Mineral Metabolism2008，，6： | 1 |
| 19 | Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures显示文摘 | Masataka Shiraki Tatsuhiko Kuroda Shiro Tanaka Mitsuru Saito Masao Fukunaga Toshitaka Nakamura | 2008 | Journal of Bone and Mineral Metabolism2008，，1： | 1 |
| 20 | Effect of interface on the thermal conductivity of carbon nanotube com- posites 显示文摘 | Indra Vir Singh Masataka Tanaka | 2007 | International Journal of Thermal Sci- ences2007，46，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员