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| 1 | Anchor Self-Localization Algorithm Based on UWB Ranging and Inertial Measurements显示文摘Localization systems utilizing Ultra-WideBand(UWB) have been widely used in dense urban and indoor environments. A moving UWB tag can be located by ranging to fixed UWB anchors whose positions are surveyed in advance. However, manually surveying the anchors is typically a dull and time-consuming process and prone to artificial errors. In this paper, we present an accurate and easy-to-use method for UWB anchor self-localization,using the UWB ranging measurements and readings from a low-cost Inertial Measurement Unit(IMU). The locations of the anchors are automatically estimated by freely moving the tag in the environment. The method is inspired by the Simultaneous Localization And Mapping(SLAM) technique used by the robotics community. A tightly-coupled Error-State Kalman Filter(ESKF) is utilized to fuse UWB and inertial measurements, producing UWB anchor position estimates and six Degrees of Freedom(6 DoF) tag pose estimates. Simulated experiments demonstrate that our proposed method enables accurate self-localization for UWB anchors and smooth tracking of the tag. | Qin Shi Sihao Zhao Xiaowei Cui Mingquan Lu Mengdi Jia | 2019 | Tsinghua Science and Technology2019，24，6： | 11 |
| 2 | FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway). | Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang | 2020 | Molecular Plant2020，13，3： | 8 |
| 3 | Effects of phosvitin phosphopeptide-Ca complex prepared by efficient enzymatic hydrolysis on calcium absorption and bone deposition of mice显示文摘Phosvitin(PV)was treated with high-temperature,mild pressure(HTMP),and enzyme combination,and then phosvitin phosphopeptides-calcium(PPP-Ca)complexes were prepared.The low-calcium specific pathogen free-Kunming(SPF-KM)mice were used to determine the effect of PPP-Ca complexes on intestinal calcium absorption and their utilization for bone formation.The serum calcium content was the highest with the HTMP-Enz-PPP-Ca treatment(2.19 mmol/L),and it significantly down-regulated the abnormal elevation of serum alkaline phosphatase(AKP)caused by calcium deficiency.The low-calcium control group had the lowest calcium deposited to the femur(80.41 mg/g)and the lowest femur bone mineral density(BMD)(0.17 g/cm^(3)),while HTMP-Enz-PPP-Ca significantly improved bone calcium content(94.33 mg/g)and BMD(0.29 g/cm^(3)).The micro-computed tomography(MCT)images showed that the femur with the normal control,PV-Ca,and HTMP-Enz-PPP-Ca treatments had a more compact,complete,and thicker trabecular network than the low-calcium and CaCl_(2)treatments.These results indicated that the organic calcium(HTMP-Enz-PPP-Ca)promoted calcium absorption and bone deposition,and the effect of HTMP-Enz-PPP-Ca was better than the inorganic CaCl_(2). | Mengdie Zhao Dong Uk Ahn Songming Li Wei Liu Shengwei Yi Xi Huang | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 4 | A cubic triboelectric generator as a self-powered orientation sensor显示文摘Recently, triboelectric generator(TEG) has attracted a lot of attention due to its high output voltage and low-cost fabrication process. Here, a novel cubic TEG box is designed, which has separated electrodes on different surfaces. Thanks to the specially designed structure, it can scavenge vibration energy from all directions. Firstly the device is investigated through finite element method(FEM) simulation. Then the device is evaluated by experiments. The measuremental results show that this device can generate an amount of 25 n C charge during once shake by charging a 10 n F capacitor. Besides, an output voltage about 100 V is obtained, which is able to directly light up several light-emitting diodes(LEDs) simultaneously. At last, the device is utilized as a self-powered orientation sensor, which shows explicit directivity. This work extends the applications of TEG for ambient vibration energy harvesting techniques and the self-powered orientation sensor. | QIU GuoLin LIU Wen HAN MengDi CHENG XiaoLiang MENG Bo SMITHA Ankanahalli Shankaregowda ZHAO JiangMing ZHANG HaiXia | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 5 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 6 | Nd-doped structurally disordered YSr_(3)(PO_(4))_(3) single crystal:Growth and laser performances显示文摘Disordered-structure crystals have drawn increasing attention as promising ultrashort laser material hosts owing to their broad linewidth.Herein,a novel disordered Nd:YSr_(3)(PO_(4))_(3)(Nd:YSP)crystal with good quality was successfully grown via the Czochralski pulling technique.The absorption and fluorescence spectra of the Nd:YSP single crystal were recorded at ambient temperature.The maximum absorption cross section for Nd:YSP single crystal is found to be approximately 3.89×10^(-20) cm^(2).The stimulated emission cross section for Nd:YSP crystal at~1060 nm was determined to be 7.64×10^(20) cm^(2) with the full width half maximum value of 22 nm.The fluorescence lifetime of the Nd3+ions in the Nd:YSP crystal is fitted to be 288μs.Diode-pumped continuous-wave laser operation is firstly realized at approximately 1060 nm.The maximum output power value from the Nd:YSP crystal is 714 mW,corresponding to a slope efficiency of-12.8%.The results indicate that the Nd:YSP crystal with a disordered structure may be a promising disordered laser host. | Guangda Wu Xiaoqin Yin Mengdi Fan Fapeng Yu Shuzhen Fan Zhengping Wang Xian Zhao | 2021 | Journal of Rare Earths2021，39，12： | 2 |
| 7 | Anti-arthritic effects of microneedling with bee venom gel显示文摘Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and mice to construct the model.Bee venom gelemicroneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.Results:Compared with the model group,the bee venom gelemicroneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate,and on LPS induced mouse model of acute inflammation effect and the micro.Conclusions:Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction.Choose the 750 mm microneedle with 10N force on skin about 3 minutes,bee venom can play the optimal role,and the anti-inflammatory effect is obvious.Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 8 | QTL mapping of quality traits in peanut using whole-genome resequencing显示文摘Oil and protein content and fatty acid composition are quality traits in peanut.Elucidating the genetic mechanisms underlying these traits may help researchers to obtain improved cultivars by molecular breeding.Whole-genome resequencing of a recombinant inbred population of 318 lines was performed to construct a high-density linkage map and identify QTL for peanut quality.The map,containing 4561 bin markers,covered 2032 c M with a mean marker density of 0.45 c M.A total of 110 QTL for oil and protein content,and fatty acid composition were mapped on the 18 peanut chromosomes.The QTL q A05.1 was detected in four environments and showed a major phenotypic effect on the contents of oil,protein,and six fatty acids.The genomic region spanned by q A05.1,corresponding to a physical interval of approximately 1.5 Mb,contains two SNPs polymorphic between the parents that could cause missense mutations.The two SNP sites were employed as KASP markers and validated using lines with extremely high and low oil contents.These sites may be useful in the marker-assisted breeding of peanut cultivars with high oil contents. | Ziqi Sun Feiyan Qi Hua Liu Li Qin Jing Xu Lei Shi Zhongxin Zhang Lijuan Miao Bingyan Huang Wenzhao Dong Xiao Wang Mengdi Tian Jingjing Feng Ruifang Zhao Xinyou Zhang Zheng Zheng | 2022 | The Crop Journal2022，10，1： | 2 |
| 9 | Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network显示文摘Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly cancers.Methods:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug Bank.We performed additional experimental validation for the dominant repurposed drugs in cancer.Results:The overall performance of the model was well supported by cross-validation and literature mining.Focusing on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity experiments.Because of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative proteomics.Our analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA transport.Moreover,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft model.Conclusions:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs. | Xi Cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang Xiaoyun Yang Yuqi Huang Minjia Tan Jing Li | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 10 | Recycled Aggregate Pervious Concrete: Analysis of Influence of Water-Cement Ratio and Fly Ash under Single Action and Optimal Design of Mix Proportion显示文摘Pervious concrete is recommended,which is of great benefit to the ecological environment and human living environment.In this paper,the influences of five water-cement ratios and four fly ash contents to replace the cement by mass with a water-cement ratio of 0.30 on the properties of Recycled Aggregate Pervious Concrete(RAPC)were studied.Following this,based on the Grey relational-Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)optimization method,the strength,permeability,abrasion loss rate,and material costs of RAPC were adopted as evaluation indices to establish a mix proportion optimization model.The results show that the increase of water-cement ratio and fly ash replacement level of RAPC leads to decreased compres-sive strength while an increase in the permeability and abrasion loss rate.According to test results based on the optimal model 0.30 was identified as the best mix proportion.In addition,ecological-economic analysis of RAPC raw materials was carried out by comparing different natural aggregates.The results of EE(embodied energy)and ECO 2e(embodied CO_(2) emission)pointed out that the combination of recycled aggregate and fly ash leads to sig-nificant ecological and economic benefits. | Shoukai Chen Chunpeng Xing Mengdie Zhao Junfeng Zhang Lunyan Wang Qidong He | 2022 | Journal of Renewable Materials2022，10，3： | 1 |
| 11 | Lighted up by hydrogen-bonding: luminescence behavior and applications of AIEgen-doped interpenetrating network hydrogel显示文摘The interaction between the aggregation-induced emissive(AIE) luminogens(AIEgen) and the polymer is the key scientific question in the design of functional AIE hydrogels. In this study, we report the AIE behavior of a poly(acrylic acid)(PAAc) and poly(acrylamide)(PAAm) interpenetrating network(IPN) hydrogel doped with tetra-cationic tetraphenylethene(TCTPE). The cationic AIEgen can bind with PAAc through ionic interaction, while PAAc and PAAm chains can associate with each other through hydrogen-bonds(H-bonds). These two interactions can restrict the intramolecular rotation and thus activate the luminescence of the AIEgen. The PAAc-PAAm H-bonds can be broken by increasing temperature or p H, restoring the intramolecular rotation of the AIEgen and quenching the fluorescence of the hydrogel. Therefore, the TCTPE-doped IPN hydrogel is designed as temperature-and p H-sensitive displayers which can record information imprinted by photo-printing or iono-printing with good switchability and reversibility. Another application of this TCTPE-doped hydrogel is demonstrated as a luminescent soft actuator, which has fast shape deformation and editable fluorescence pattern. The above results reveal a pathway to tune the emission behavior through tuning polymer-polymer and polymer-AIEgen interactions, which may inspire new design strategies of aggregation-induced emissive polymers and broaden their applications. | Mengdi Xu Luqin Hua Lihao Gong Jianlei Lu Jinhui Wang Chuanzhuang Zhao | 2021 | Science China Chemistry2021，64，10： | 1 |
| 12 | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials显示文摘The back-propagating action potential(bpAP)is crucial for neuronal signal integration and synaptic plasticity in dendritic trees.Its properties(velocity and amplitude)can be affected by dendritic morphology.Due to limited spatial resolution,it has been difficult to explore the specific propagation process of bpAPs along dendrites and examine the influence of dendritic morphology,such as the dendrite diameter and branching pattern,using patch-clamp recording.By taking advantage of Optopatch,an all-optical electrophysiological method,we made detailed recordings of the real-time propagation of bpAPs in dendritic trees.We found that the velocity of bpAPs was not uniform in a single dendrite,and the bpAP velocity differed among distinct dendrites of the same neuron.The velocity of a bpAP was positively correlated with the diameter of the dendrite on which it propagated.In addition,when bpAPs passed through a dendritic branch point,their velocity decreased significantly.Similar to velocity,the amplitude of bpAPs was also positively correlated with dendritic diameter,and the attenuation patterns of bpAPs differed among different dendrites.Simulation results from neuron models with different dendritic morphology corresponded well with the experimental results.These findings indicate that the dendritic diameter and branching pattern significantly influence the properties of bpAPs.The diversity among the bpAPs recorded in different neurons was mainly due to differences in dendritic morphology.These results may inspire the construction of neuronal models to predict the propagation of bpAPs in dendrites with enormous variation in morphology,to further illuminate the role of bpAPs in neuronal communication. | Wu Tian Luxin Peng Mengdi Zhao Louis Tao Peng Zou Yan Zhang | 2022 | Neuroscience Bulletin2022，38，11： | 0 |
| 13 | Electro-elastic features of YBa3(PO_(4))3 and YbBa3(PO_(4))3 crystals with pure face-shear mode for acoustic wave sensor applications显示文摘The fundamental shear horizontal(SH0)waves have been proved to be a very useful method for nondestructive testing due to their non-dispersive characteristics.Currently,although several methods have been proposed to generate SH0 waves,it is still a challenge to obtain pure SH0 wave mode efficiently.Herein,in this study,non-centrosymmetric YBa3(PO_(4))3(YBP)and YbBa3(PO_(4))3(YbBP)crystals with pure face-shear mode were grown via the traditional Czochralski pulling method at temperatures above 1800℃.High resolution X-ray diffraction was carried out to evaluate the crystalline quality.Results showed that the YBP and YbBP crystals were of good quality,with the full width at half-maxima being on the order of 42.500 and 52.300,respectively.Moreover,the full set of electro-elastic constants for the YBP and YbBP crystals were determined and collated using a combination of impedance and pulse-echo methods.The piezoelectric coefficient(d14)of the YBP and YbBP crystals were determined to be 10.6 pC/N and 11.4 pC/N,respectively,corresponding to the electromechanical coupling coefficient(k14)equal to 15.4%and 15.9%,exhibiting large and pure face-shear vibration mode.Collectively,these results indicate that the YBP and YbBP crystals are promising for acoustic wave sensing application. | Guangda Wu Lingkai Kong Mengdi Fan Fapeng Yu Chao Jiang Xiufeng Cheng Xian Zhao | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 14 | Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures显示文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare. | Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
| 15 | Carbon nanomaterial addition changes soil nematode community in a tall fescue mesocosm显示文摘Carbon nanomaterials have been widely used in industry and inevitably enter the environment.However,there is little information about their influence on the abundance and diversity of soil nematode community.We evaluated the impact of three kinds of carbon nanomaterials(graphene,graphene oxide,and carbon nanotubes)on the abundance and diversity of soil nematodes after growing tall fescue for 130 d using a laboratory pot experiment.A total of 29 genera of nematodes were identified in all the treatments.Carbon nanomaterials significantly increased the abundance of total nematodes and plant parasites.The presence of graphene and graphene oxide increased the numbers of bacterivores,and graphene benefited fungivores.The total nematode abundance was1.9-2.9 times greater in the carbon nanomaterial treatments than in the control with no carbon nanomaterial addition.However,graphene oxide and carbon nanotubes decreased the values of nematode community parameters,e.g.,diversity,species richness,and structure index.Compared with the control,the addition of graphene resulted in a community with a higher plant-parasitic index(i.e.,the maturity index of the plant-parasitic nematodes).Overall,our findings highlight that the addition of carbon nanomaterials has a negative influence on the composition and diversity of the nematode community,simplifying the community structure. | Shulan ZHAO Xue BAI Mengdi MOU Lian DUO | 2022 | Pedosphere2022，32，5： | 0 |
| 16 | Patent Applications of Pharmaceutical Industry in Liaoning: Current Situation and Suggestions显示文摘Objective To analyze the current situation of pharmaceutical patents in Liaoning Province with the background of increasing emphasis on intellectual property rights in the pharmaceutical industry and the application of pharmaceutical-related patents having taken shape in Liaoning Province.Methods The invention patent information applied by Liaoning pharmaceutical manufacturers before December 31,2018 was obtained from Qixinbao APP,and then the retrieval data was also obtained through detailed search on patent information inquiry websites in China and other countries.The types of drug patents were separately extracted by Excel.Data analysis was carried out according to drug category,applicant type,legal status and transfer situation.Results and Conclusion A thorough discussion on the current situation of patent applications in pharmaceutical industry of Liaoning Province reveals that the number of patent applications is large but they are lack of creativity.Meanwhile,few patent applications are made by individual.Besides,there are fewer international patent applications for pharmaceutical patents in Liaoning Province.The problems in patent applications include the followings,such as insufficient patent applications and unbalanced proportion of patent applications.In order to promote the stable development of pharmaceutical market in Liaoning Province,some suggestions are raised. | Zhao Zhe Sheng Mengdi Fan Junyan Liu Yanwen Dong Li | 2019 | Asian Journal of Social Pharmacy2019，14，4： | 0 |
| 17 | Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo显示文摘Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies.To exploit the synthetic lethality concept in the design of chemical anti-cancer agents,we developed a bio-orthogonally catalyzed lethality(BCL)strategy to generate targeting anti-tumor metallodrugs both in vitro and in vivo.Metallodrug Ru-rhein was generated from two non-toxic species Ru-N_(3)and rhein-alkyne via exclusive endogenous copper-catalyzed azide alkyne cycloaddition(Cu AAC)reaction without the need of an external copper catalyst.The non-toxic species Ru-arene complex Ru-N_(3)and rhein-alkyne were designed to perform this strategy,and the mitochondrial targeting product Ru-rhein was generated in high yield(>83%)and showed high anti-tumor efficacy in vitro.This BCL strategy achieved a remarkable tumor suppression effect on the tumor-bearing mice models.It is interesting that the combination of metal-arene complexes with rhein via Cu AAC reaction could transform two non-toxic species into a targeting anti-cancer metallodrug both in vitro and in vivo,while the product Ru-rhein was non-toxic towards normal cells.This is the first example that exclusive endogenous copper was used to generate metal-based anti-cancer drugs for cancer treatment.The anti-cancer mechanism of Ru-rhein was studied and autophagy was induced by increased reactive oxygen species and mitochondrial damage.The generality of this BCL strategy was also studied and it could be extended to other metal complexes such as Os-arene and Ir-arene complexes.Compared with the traditional methods for cancer treatment,this work presented a new approach to generating targeting metallodrugs in vivo via the BCL strategy from non-toxic species in metal-based chemotherapy. | Xuling Xue Chenggen Qian Qin Tao Yuanxin Dai Mengdi Lv Jingwen Dong Zhi Su Yong Qian Jing Zhao Hong-Ke Liu Zijian Guo | 2021 | National Science Review2021，8，9： | 0 |
| 18 | Seismic activities before and after the impoundment of the Xiangjiaba and Xiluodu reservoirs in the lower Jinsha River显示文摘The lower Jinsha River basin is located at the junction of Sichuan and Yunnan provinces in Southwest China,a region with intense tectonic movements and frequent moderate to strong seismic activities.Cascade hydropower stations have been constructed along the lower Jinsha River since 2012.However,research on the effect of the impoundment of large-scale cascade reservoirs in a river basin on local seismic activities is currently lacking.Accurately identifying earthquake locations is essential for studying reservoir-induced earthquakes.Analyzing the spatiotemporal migration process of seismic activities based on complete and precise earthquake relocation is fundamental for determining the fluid diffusion coefficient,constructing fault models for reservoir areas,identifying earthquake types,exploring earthquake mechanisms,and evaluating seismic hazards.The seismicity pattern in the Xiangjiaba and Xiluodu reservoir areas,where seismic activities had been weak for a long time,has changed with the successive impoundment of the two reservoirs,showing microseismic events and seismic clusters.We investigated the spatiotemporal characteristics of seismic activities in the Xiangjiaba and Xiluodu reservoir areas using the waveform cross-correlation-based double-difference relocation technique and the b-value analysis method.We discovered that seismic events after the impoundment of these two reservoirs exhibited different characteristics in different regions.The seismic activities at the Xiluodu dam quickly responded to the rising water level,with the seismic intensity decaying rapidly afterward.These events were concentrated in the limestone strata along both sides of the Jinsha River,with a shallow focal depth,generally within 5 km,and a high b-value of approximately 1.2.Such features are close to those of karst-type earthquakes.Microseismic activities frequent occur on the eastern bank of the Yongshan reservoir section downstream of the Xiluodu dam,with two parallel NW-trending earthquake strips visible after precise earthquake relocation.The M_(S)5.2 earthquake near Wuji town on August 17,2014,had prominent foreshocks and aftershocks distributed in a clear NW-trending 20-km-long strip,perpendicular to the riverbank.These seismic events had a low b-value of approximately 0.7.The orientation of the node plane revealed by the strike-slip focal mechanism of the mainshock is consistent with that of the strip formed by the foreshock-mainshock-aftershock sequence,indicating the existence of a NW-striking concealed fault.Seismic activities near the Yanjin-Mabian fault upstream of the Xiangjiaba reservoir area since 2013 were concentrated in a NW-trending strip,with several near EW-trending seismic clusters on its western side,and with the largest event having a magnitude of M_(L)3.7.So far,the impoundment of the Xiangjiaba and Xiluodu reservoirs has not triggered seismic activities on the large Jinyang-Ebian and Yanjin-Mabian faults nearby. | Ce Zhao Cuiping Zhao Hongfu Lei Mengdi Yao | 2022 | Earthquake Science2022，35，5： | 0 |
| 19 | Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors显示文摘Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy.In this study,we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives.Kinase inhibition,cell proliferation,and whole blood stability assays were used to evaluate their activity on FGFR,allowing us to explore structureàactivity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors’selectivity and reactivity.Among them,compound 10h exhibited potent enzymatic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation,and suppressed FGFR signaling pathway in cancer cells by the immunoblot analysis.Moreover,10h displayed highly potent antitumor efficacy (TGI Z 91.6%,at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. | Xiaowei Wu Mengdi Dai Rongrong Cui Yulan Wang Chunpu Li Xia Peng Jihui Zhao Bao Wang Yang Dai Dan Feng Tianbiao Yang Hualiang Jiang Meiyu Geng Jing Ai Mingyue Zheng Hong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 0 |
| 20 | Response of MaHMA2 gene expression and stress tolerance to zinc stress in mulberry(Morus alba L.)显示文摘HMA2(heavy metal ATPase 2)plays a crucial role in extracellular and intracellular Zn^(2+)transport across biomembranes,maintaining ion homeostasis,and playing an important role in the normal physiological metabolism,growth,and development of plants.In our study,a novel HMA2 gene,named MaHMA2,was isolated and cloned from white mulberry(Morus alba L.).The gene sequence obtained was 1,342 bp long,with an open reading frame of 1,194 bp,encoding a protein of 397 amino acids,with a predicted molecular mass of 42.852 kD and an isoelectric point of 7.53.This protein belonged to the PIB-type ATPase transport protein family.We analyzed the expression of the MaHMA2 gene by quantitative real-time PCR.The results showed that the level of MaHMA2 gene expression decreased to a Zn concentration of 800 mg/kg.Malondialdehyde and proline levels increased and responded to increasing Zn when the MaHMA2 gene was silenced,whereas the activities of peroxidase and superoxide dismutase tended to increase in response to increasing Zn^(2+)ion stress concentrations but were lower in the gene-silenced plants.These findings suggested that the MaHMA2 gene played an active role in the tolerance response of mulberry to Zn stress. | LEI WANG QIUXIA DU YISU SHI MICHAEL ACKAH PENG GUO DANYAN ZHENG MENGMENG WU XIN JIN PEILAN LI QIAONAN ZHANG RUIXUE LI ZHI YIN MENGDI ZHAO WEIGUO ZHAO | 2022 | BIOCELL2022，46，10： | 0 |
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