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| 1 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 2 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 5 | Harvest prediction in ' Algerie' loquat 显示文摘 | Juan J H Mercedes P Frartcisca A | 2007 | International Journal of Biometeorology2007，51，5： | 1 |
| 6 | Harvest prediction in Algerie' loquat 显示文摘 | Hueso J Mercedes P Z Francisca A | 2007 | International Journal of Biomete- orology2007，51，： | 1 |
| 7 | Application of predictive sliding mode controllers to a solar plant 显示文摘 | Mercedes P P Cristina M C Eduardo F C | 2008 | IEEE Transactions on Control System Technology2008，16，4： | 1 |
| 8 | Clusters and entrepreneurship显示文摘 | MERCEDES D P SCOTT S | 2010 | Journal of Economic Geography2010，10，4： | 1 |
| 9 | Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy 显示文摘 | MERCEDES N L CRISTIAN P MARCOS R | 2007 | Invest Ophthalmol- VisSci2007，48，3： | 1 |
| 10 | Predictive factors for mortality in Fournier’s gangrene: A series of 59 cases显示文摘 | Andrés García Marín Fernando Turégano Fuentes Marta Cuadrado Ayuso Juan Antonio Andueza Lillo Juan Carlos Cano Ballesteros Mercedes Pérez López | 2014 | Cirugía Espa?ola (English Edition)2014，，： | 1 |
| 11 | The Bacillus subtilis 168 csn gene encodes a chitosanase with similar properties to a Streptomyces enzyme显示文摘 | Rivas L A Parro V Mercedes M P | 2000 | Microbiology2000，146，： | 1 |
| 12 | Metal-saccharide chemistry and biology: saccharide complexes of zinc and their effect on metallothionein synthesis in mice 显示文摘 | Rajiv P B Mercedes G Juan H | 1996 | Carbohydrate Research1996，284，： | 1 |
| 13 | Disseminated intravascular coagula- tion显示文摘 | MERCEDES P | 2002 | ICS2002，1237，： | 1 |
| 14 | On the role of water in peroxidase catalysis:a theoretical investigation of HRP compound I formation显示文摘 | Pietro V Giacomo F Mercedes A P | 2010 | Journal of Physical Chemistry B2010，114，： | 1 |
| 15 | Fatty acid composition of two new pepper varieties (Capsicum annuum L. cv. Jaranda and Jariza). Effect of drying process and nutritional aspects显示文摘 | Antonio Pérez-Gálvez Juan Garrido-Fernández Ma.Isabel Mínguez-Mosquera Mercedes Lozano-Ruiz Vicente Montero-de-Espinosa | 1999 | Journal of the American Oil Chemists’ Society1999，，2： | 1 |
| 16 | Transition-Metal saccharide chemistry and biology: saccharide complexes of Cu(Ⅱ) and their effect on in vivo metallothionein synthesis in mice显示文摘 | Rajiv P B Chebrolu P R Mercedes G | 1997 | Journal of Inorganic Biochemistry1997，66，： | 1 |
| 17 | Development of reduced fat minced meats using inulin and bovine plasma proteins as fat replacers显示文摘 | Laura T. Rodriguez Furlán Antonio Pérez Padilla Mercedes E. Campderrós | 2014 | Meat Science2014，，2： | 1 |
| 18 | Or- ganochlorine pesticides accumulation and degradation products in vegetation samples of a contaminated area in Galicia (NW Spain)显示文摘 | MERCEDES B P MARI'A J G SOLEDAD M L | 2005 | Chemosphere2005，58，： | 1 |
| 19 | Genistein modulatesoxidative stress in breast cancer cell lines according to ER/ER ra-tio: Effects on mitochondrial functionality, sirtuins, uncouplingprotein 2 and antioxidant enzymes 显示文摘 | Mercedes N S Daniel G P Jorge S S | 2013 | The International Journal ofBiochemistry & Cell Biology2013，45，： | 1 |
| 20 | Organochlorine pesticides accumulation and degradation products in vegetation samples of a contaminated area in Galicia(NW Spain)显示文摘 | Mercedes B P Man'a J G Soledad M L | 2005 | Chemosphere2005，58，： | 1 |
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