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| 1 | The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients显示文摘Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications.This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion,including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).All subjects were evaluated with a number of accepted cognitive function tests,including themini‐mental status examination (MMSE).The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated,likewise with the correlation between MODD and MMSE.Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age,sex,glycemic control,hypertension,smoking,or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients.Elevated glucose excursion decreased the MMSE score,which reflects general cognitive function.Thus,therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients. | ZHONG Yuan ZHANG Xiao Yan MIAO Ya ZHU Jie Hua YAN Hong WANG Bei Yun JIN Jun HU Ting Jun JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 34 |
| 2 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 3 | Hyperinsulinemia,Insulin Resistance and Cognitive Decline in Older Cohort显示文摘Objective Type 2 diabetes has been recently recognized as an important risk factor for cognitive decline of patients with Alzheimer's disease (AD).But the roles of hyperinsulinemia (HI) and insulin resistance (IR) in the development of AD are still controversial.This study was designed to evaluate whether HI or IR influenced the cognitive functions of older cohort.Methods The cognitive functions of 328 consecutive elderly patients were evaluated with a battery of cognitive rating scales.Their fasting blood glucose (FBG) and fasting insulin (FINS) were analyzed and IR was calculated with modified‐Homa.The cognitive scores in different groups and the correlation of cognitive functions with HI or IR were analyzed.Results In our study,there were 180 participants with HI and 148 without HI,and 192 with IR and 136 without IR.The participants with HI showed worse cognitive functions than those without HI in MMSE,MOCA,CDR,orientation,delayed memory,and attention/calculation domains.Similarly,the elderly with IR had lower cognitive scores than those without IR in MMSE,MOCA,CDR,GDS,orientation,delayed memory,and attention/calculation domains.The insulin levels and Homa IR had negative correlation with the scores of MMSE and delayed memory,not only in the model 1 adjusted for FBG and diabetes history,but also in the model 2 adjusted for all nine demographic characteristics.Conclusion HI and IR are important risk factors for cognitive decline of the elderly,especially for the dysfunctions in delayed memory domains. | ZHONG Yuan MIAO Ya JIA Wei Ping YAN Hong WANG Bei Yun JIN Jun | 2012 | Biomedical and Environmental Sciences2012，25，1： | 11 |
| 4 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 5 | TNF-αTNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms显示文摘Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha(TNF-a) and its receptors TNF receptor subtype-1(TNFR1) and TNFR2 in acute and chronic itch in mice.Compared to wild-type(WT) mice, TNFR1-knockout(TNFR1-KO) and TNFR1/R2 double-KO(DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine(CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-αantagonist etanercept dose-dependently suppressed acute itch. Intradermal injection of TNF-α was not sufficient to evoke scratching, but potentiated itch induced by compound 48/80, but not CQ. In addition, compound 48/80 induced TNF-α mRNA expression in the skin, while CQ induced its expression in the dorsal root ganglia(DRG) and spinal cord. Furthermore, chronic itch induced by dry skin was reduced by administration of thalidomide and etanercept and in TNFR1/R2 DKO mice. Dry skin induced TNF-α expression in the skin, DRG, and spinal cord and TNFR1 expression only in the spinal cord. Thus, our findings suggest that TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch via peripheral and central mechanisms, and targeting TNFR1 may be beneficial for chronic itch treatment. | Xiuhua Miao Ya Huang Teng-Teng Liu Ran Guo Bing Wang Xue-Long Wang Li-Hua Chen Yan Zhou Ru-Rong Ji Tong Liu | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 6 | In situ decomposition of metal-organic frameworks into ultrathin nanosheets for the oxygen evolution reaction显示文摘氧进化反应(OER ) 是一个枢轴的过程为切开水并且包含氧电极的许多另外的精力技术。此处,新合成策略被建议准备 OER 催化剂基于一简单在共同基于的醋酸盐氢氧化物的 situ 分解还灵活金属器官的框架(MOF ) 。这个过程与优秀部件可控制性允许各种各样的 2D 氢氧化物 ultrathin nanosheets (UNS ) 的直接制造。同样获得的共同基于的氢氧化物 UNS 由于众多的活跃地点的暴露为 OER 表明优异催化活动。特别地, CoNi 氢氧化物 UNS 展出低过电位() 在 10 和 100 妈的当前的密度的 324 和 372 mV ? 沬? | Kai He Zhen Cao Ruirui Liu Ya Miao Yi Ding | 2016 | Nano Research2016，9，6： | 7 |
| 7 | A network security entity recognition method based on feature template and CNN-BiLSTM-CRF显示文摘By network security threat intelligence analysis based on a security knowledge graph(SKG), multi-source threat intelligence data can be analyzed in a fine-grained manner. This has received extensive attention. It is difficult for traditional named entity recognition methods to identify mixed security entities in Chinese and English in the field of network security, and there are difficulties in accurately identifying network security entities because of insufficient features extracted. In this paper, we propose a novel FT-CNN-BiLSTM-CRF security entity recognition method based on a neural network CNN-BiLSTM-CRF model combined with a feature template(FT). The feature template is used to extract local context features, and a neural network model is used to automatically extract character features and text global features. Experimental results showed that our method can achieve an F-score of 86% on a large-scale network security dataset and outperforms other methods. | Ya QIN Guo-wei SHEN Wen-bo ZHAO Yan-ping CHEN Miao YU Xin JIN | 2019 | Frontiers of Information Technology & Electronic Engineering2019，20，6： | 5 |
| 8 | Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues显示文摘九外消旋的 homocamptothecin 衍生物被综合,在 vitro antitumor,活动被标准 MTT 方法评估。结果比 iritecan 显示出复合有的更高的 antitumor 活动的那一些。 | Liang You Wan Nian Zhang Zhen Yuan Miao Wei Guo Xiao Ying Che Wen Ya Wang Chun Quan Sheng Jiang Zhong Yao Ting Zhou | 2008 | Chinese Chemical Letters2008，19，7： | 3 |
| 9 | Bio-inspired design of hierarchical FeP nanostructure arrays for the hydrogen evolution reaction显示文摘由 FeP nanopetals 组成的层次 FeP nanoarray 电影成功地经由 phosphorization 跟随的一条启发简历的热水的线路被综合。作为一个水晶生长修饰词,甘油在控制 FeO 的形态学和结构起一个重要作用(哦) 先锋在 biomineralization 过程期间,当时 FeO 的下列转移和 pseudomorphic 转变(哦) 电影成功地产生 FeP 数组电影。同样准备的 FeP 电影电极展出优秀的氢进化反应(她的) 在一个宽 pH 范围上的性能。理论计算表明在 FeP 电影的混合 P/Fe 结束为 nanostructured 电极的高催化的活动负责。这新卓见将支持有效金属的进一步的探索为 HER 的基于 phosphoride 的催化剂。更重要地,这研究衔接在生物、无机的自我装配的 nanosystems 之间的差距并且可以在精力设备用申请为功能的 nanostructures 的准备开创一条新大街。 | Ya Yan Xue Rong Shi Mao Miao Ting He Ze Hua Dong Ke Zhan Jun He Yang Bin Zhao Bao Yu Xia | 2018 | Nano Research2018，11，7： | 2 |
| 10 | Calcineurin B-like protein 5(SiCBL5)in Setaria italica enhances salt tolerance by regulating Na^(+)homeostasis显示文摘Salinity,a major abiotic stress,reduces plant growth and severely limits agricultural productivity.Plants regulate salt uptake via calcineurin B-like proteins(CBLs).Although extensive studies of the functions of CBLs in response to salt stress have been conducted in Arabidopsis,their functions in Setaria italica are still poorly understood.The foxtail millet genome encodes seven CBLs,of which only SiCBL4 was shown to be involved in salt response.Overexpression of SiCBL5 in Arabidopsis thaliana sos3-1 mutant rescued its salt hypersensitivity phenotype,but that of other SiCBLs(SiCBL1,SiCBL2,SiCBL3,SiCBL6,and SiCBL7)did not rescue the salt hypersensitivity of the Atsos3-1 mutant.SiCBL5 harbors an N-myristoylation motif and is located in the plasma membrane.Overexpression of SiCBL5 in foxtail millet increased its salt tolerance,but its knockdown increased salt hypersensitivity.Yeast two-hybrid and firefly luciferase complementation imaging assays showed that SiCBL5 physically interacted with SiCIPK24 in vitro and in vivo.Cooverexpression of SiCBL5,SiCIPK24,and SiSOS1 in yeast conferred a high-salt-tolerance phenotype.Compared to wild-type plants under salt stress conditions,SiCBL5 overexpressors showed lower accumulations of Na^(+) and stronger Na^(+) efflux,whereas RNAi-SiCBL5 plants showed higher accumulations of Na^(+) and weaker Na^(+) efflux.These results indicate that SiCBL5 confers salt tolerance in foxtail millet by modulating Na^(+) homeostasis. | Jingwei Yan Lan Yang Ya Liu Yingdi Zhao Tong Han Xingfen Miao Aying Zhang | 2022 | The Crop Journal2022，10，1： | 1 |
| 11 | Global Burden of Cardiovascular Disease Attributable to High Temperature in 204 Countries and Territories from 1990 to 2019显示文摘Objective This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease(CVD)burden from 1990 to 2019.Methods Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study 2019.Deaths and disability-adjusted life years(DALYs)were used to quantify heat-induced CVD burden.We calculated the age-standardized mortality rate(ASMR)and DALY rate(ASDR)per 100,000population to compare this burden across regions.Generalized linear models were applied to evaluate estimated annual percentage changes(EAPC)for temporal trends from 1990 to 2019.The correlation between the socio-demographic index(SDI)and age-standardized rate was measured using the Spearman rank test.Results Heat-induced CVD caused approximately 90 thousand deaths worldwide in 2019.Global ASMR and ASDR of heat-related CVD in 2019 were 1.17[95%confidence interval(CI):0.13-1.98]and 25.59(95%CI:2.07-44.17)per 100,000 population,respectively.The burden was significantly increased in middle and low-SDI regions and slightly decreased in high-SDI regions from 1990 to 2019.ASMR showed an upward trend,with the most considerable increase in low-latitude countries.We observed a negative correlation between SDI and EAPC in ASMR(rs=-0.57,P<0.01)and ASDR(rs=-0.59,P<0.01)among204 countries.Conclusion Heat-attributable CVD burden substantially increased in most developing countries and tropical regions. | HONG Le YAN Miao Miao ZHANG Yun Quan WANG Kai WANG Ya Qi LUO Si Qi WANG Fang | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 12 | A novel approach to large-scale formation of through-hole porous anodic aluminum template显示文摘一台新奇阳极的氧化设备被设计制作在一个的模板预定的很多多孔的阳极的氧化铝(泛美航空公司) 。这条途径在一个正常实验室显著地改进了 PAA 模板的准备的效率并且被期望以后被用于大规模生产。 | Ya Nan Zhang Miao Chen Zhi Lu Liu Yan Chun Zhao | 2008 | Chinese Chemical Letters2008，19，11： | 1 |
| 13 | The effectiveness of a health promotion programmme for women in southern Taiwan显示文摘 | SU - Hsien Chang Miao - ehun Fang Ya - Shu Yang | 2006 | International Journal of Nursing Practice2006，12，： | 1 |
| 14 | Investigation of geothermal structure of the Sulawesi,using gravity and magnetic method显示文摘The Sulawesi Sea and Sulawesi Island are located in the western Pacific area where volcanic activity,plate subduction,and seismic activity are very active.The Sulawesi basin formed during the Middle Eocene-Late Eocene and nearly half of the Eocene oceanic crust has subducted below the North Sulawesi Trench.The Sulawesi Island was spliced and finalized in the Early Pliocene-Pleistocene during volcanic activity and is recently very active.This area is an optimal location to study volcanic geothermal conditions and subduction initiation mechanisms in the southern part of the western Pacific plate margin,which are important in geothermal and geodynamic research.In this study,we combined 133 heat flow data with gravity and magnetic data to calculate the Moho structure and Curie point depth of the Sulawesi Sea and periphery of the Sulawesi Island,and analyze the distribution characteristics of the geothermal gradient and thermal conductivity.The results show that the average depths of the Moho and Curie surfaces in this area are 18.4 and 14.3 km,respectively,which is consistent with the crustal velocity layer structure in the Sulawesi Basin previously determined by seismic refraction.The average geothermal gradient is 4.96°C(100 m)-1.The oceanic area shows a high geothermal gradient and low thermal conductivity,whereas the land area shows a low geothermal gradient and high thermal conductivity,both of which are consistent with statistical results of the geothermal gradient at the measured heat flow points.The highest geothermal gradient zone occurs in the transition zone from the Sulawesi Sea to Sulawesi Island,corresponding to the spreading ridge of the southward-moving Sulawesi Basin.Comprehensive gravity,magnetic,and geothermal studies have shown a high crustal geothermal gradient in the study area,which is conducive to the subduction initiation.The northern part of the Palu-koro fault on the western side of Sulawesi is likely the location where subduction initiation is occurring.During the process of moving northwest,the northern and eastern branches of Sulawesi Island have different speeds;the former is slow and the latter is fast.These branches also show different deep tectonic dynamic directions;the northern branch tilts north-up and the eastern branch tilts north-down. | Jian ZHANG Tianyao HAO Miao DONG Ya XU Beiyu WANG Yifei AI Gui FANG | 2021 | Science China Earth Sciences2021，64，2： | 1 |
| 15 | Low-temperature synthesis of nano-crystalline magnesium titanate materials by the sol-gel method 显示文摘 | Miao Ya mei Zhang Qi-long Yang Hui | 2006 | Materials Scienee and Engineering B2006，128，： | 1 |
| 16 | Highly efficient synthesis and application of aryl diazonium salts via femtosecond laser-tailored 3D flow microfluidic chips显示文摘The first example of the microfluidic chips(MFCs) consisting of centimeter-level 3D channels with highdensity and large-volume fabricated by femtosecond laser micromachining were utilized to develop a time-saving, economical and hazardless flow synthesis process, and its advantages have been proved by in situ formation of aryldiazonium salts and subsequent borylation with bis(pinacolato)diboron. There are several important advantages in our 3D MFC-based flow synthesis technology, including the following:(1) the reaction temperature was altered from ice bath to room temperature;(2) the residence time was reduced by 10 times;(3) the yield was greatly improved, that is, several arylboronates were successfully obtained with higher yield compared to traditional batch process. Therefore, it can be envisioned that a novel, simplified flow synthetic protocol will be developed toward green organic synthesis via MFCs. | Jing Ren Miao Wu Kaiwu Dong Min Zhang Ya Cheng Guoyue Shi | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 17 | Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris显示文摘 | Hong Li Lin Gao Zhu Shen Chun Ying Li Kai Li Miao Li Ya Jie Lv Cheng Xin Li Tian Wen Gao Yu Feng Liu | 2008 | Archives of Dermatological Research2008，，8： | 1 |
| 18 | A contact angle measurement by laser glancing incidence method显示文摘 | ZHU Feng MIAO Run cai ZHANG Ya ni | 2008 | J Appl Phys2008，104，06： | 1 |
| 19 | Electroactive chitosan-aniline pentamer hydrogel for peripheral nerve regeneration显示文摘Electroactive hydrogels could guide the regeneration of nerves and promote their functional recovery.An aniline pentamer-crosslinked chitosan(CS-AP)hydrogel with better electroactivity and degradation was fabricated by the carbodiimide method,and then injected into the repair site of sciatic nerve damage,with its gelation time,tensile strength,and conductivity reaching 35 min,5.02-6.69 MPa,and from 2.97×10^(-4) to 3.25×10^(-4) S-cm^(-1),respectively,due to the cross-linkage and well-distribution of AP.There was better cytocompativility of CS-AP hydrogel on nerve cells.The results of the in vivo repair indicated that CS-AP10 hydrogel induced the capillaries formation and the repair of sciatic nerve defect,and re-innervated gastrocnemius muscle in the CS-AP10 group were obviously better than other experimental groups,due to the electroactivity of CS-AP and its degradation into fragments.These results indicated the potential application of CS-AP hydrogel in the regeneration and function recovery of peripheral nerve injury. | Deqiang MIAO Ya Li Zhongbing HUANG Yulin WANG Min DENG Xiaohui LI | 2022 | Frontiers of Materials Science2022，16，3： | 0 |
| 20 | The Combined Effect of Dyslipidemia on the Incidence of Type 2 Diabetes:A Prospective Cohort Study in Northwest of China显示文摘Type 2 diabetes mellitus(T2DM)is a major noncommunicable chronic disease in the population and is a major threat to global public health.According to the International Diabetes Federation[1],there were at least 463 million patients with diabetes between the ages of 20 and 79 in 2019,and this number will rise to 700 million by 2045.Dyslipidemia is the most important factor that influences T2DM.At present,cross-sectional studies are mainly used to determine the correlation between single lipid index,lipid ratio,and T2DM and its complications[2].Few studies have focused on dyslipidemia and its aggregation patterns in relation to T2DM. | WANG Min Zhen DAI Tian ZHENG Shan YU Cheng XIA Miao YANG Hong Yan ZHANG De Sheng YIN Chun JIN Ya Fei CHENG Ning BAI Ya Na | 2021 | Biomedical and Environmental Sciences2021，34，10： | 0 |
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