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| 1 | The role of the orphan nuclear receptor COUP-TFII in tumorigenesis显示文摘The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms. | Mafei XU lun QIN Sophia Y TSAI Ming-jer TSAI | 2015 | Acta Pharmacologica Sinica2015，36，1： | 6 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Positional cloning of the mouse obese gene and it human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，6505： | 1 |
| 4 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | | 0，，6505： | 1 |
| 5 | Managing the job shop:Simulating the effects of flexibility,order release mechanisms and sequencing rules显示文摘 | Newman W R Mafei M J | 1999 | Integrated Manufacturing Systems1999，10，5： | 1 |
| 6 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | PROENCA R MAFEI M | 1994 | Nature1994，372，： | 1 |
| 7 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
| 8 | Positional cloning of the mouseobese gene and its human homologue 显示文摘 | Zhang Y Proenca R Mafei M etal | 1994 | Nature1994，372，6505： | 1 |
| 9 | Positional cloning of the mouse obese gene and its humanhomoligue显示文摘 | PROENEA R MAFEI M | 1994 | Nature1994，372，： | 1 |
| 10 | Position cloning of the mouse obese gene and its human homologue显示文摘 | Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
| 11 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | ZHANG Y PROENCE R MAFEI M | 1994 | Nature1994，372，： | 1 |
| 12 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
| 13 | Positional Cloming of the mouse chase gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，6505： | 1 |
| 14 | Positional cloning of the mouse obese gene and its human homologue 显示文摘 | Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
| 15 | Positional cloning of the mouse bese gene and its human homologue 显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，6505： | 1 |
| 16 | Prevalence of deep vein thrombosis and pulmonary embolism in superficial thrombophlebitis of the lower limbs: prospective study of 60 cases显示文摘 | Sobreira ML Mafei FH Yoshida WB | 2010 | Clin Epidemiol2010，63，7： | 1 |
| 17 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
| 18 | Positional cloning of the mouse bese gene and its human homologue显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，6505： | 1 |
| 19 | Expression and function on embryonic development of lissencephaly-1 genes in zebrafish显示文摘Lissencephaly,严重疾病被大脑畸形性描绘。主要原因的基因 lissencephaly 是 LIS1。LIS1 的变化或删除在大脑开发导致增长和神经原的迁居缺乏。然而,很少在胚胎的开发对它的生物函数被知道。在这篇文章,我们识别了 zebrafish LIS1 基因的表达式模式并且在胚胎的开发调查了它的函数。我们证明 zebrafish 由二 LIS1 基因, LIS1a 和 LIS1b 组成了。生物信息学分析表明 LIS1 基因在蛋白质序列和 genomic 结构两个都在进化被保存。zebrafish LIS1a 和 LIS1b 的表示模式证明两个抄本无所不在地被表示根本胚胎的发展阶段并且在检验的成年纸巾。在蛋白质水平, LIS1 产品主要在由西方的弄污显示出分析的早阶段在大脑织物并且在胚胎存在。整个山的 immunostaining 数据证明 LIS1 蛋白质在整个从 1 房间舞台的胚胎是分布式的到 5 白天授精以后。通过 morpholino antisense oligonucleotides 的 LIS1 蛋白质表示击倒在 zebrafish,包括的大脑畸形性,发行量反常,和身体导致了许多发展缺乏卷屈。一起拿,我们的学习建议 zebrafish LIS1 在胚胎的开发起一个很重要的作用。 | Chengfu Sun Mafei Xu Zhen Xing Zhili Wu Yiping Li Tsaiping Li Mujun Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 1 |
| 20 | Positional cloning of the mouse obese gene and its human homologue 显示文摘 | Zhang Y Proenca R Mafei M | 1994 | Nature1994，372，： | 1 |
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