|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 2 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 3 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 4 | RNA-Directed DNA Methylation Is Involved in Regulating Photoperiod-Sensitive Male Sterility in Rice显示文摘光周期敏感的男绝育(PSMS ) 是为混合米饭繁殖的珍贵 germplasm。最近,我们克隆 pms3,控制 PSMS 的一个地点,它编码称为在长天的条件下面为米饭植物的正常男富饶要求的 LDMAR 的长非编码的 RNA。在在 PSMS 米饭(Nongken 58S ) 相对的 LDMAR 的倡导者的增加的 methylation 野类型(Nongken 58 ) 减少了在长天的条件下面导致男绝育的 LDMAR 的表示。在这研究,我们鉴别 siRNA 在比在 Nongken 58 更充满 Nongken 58S 的 LDMAR 倡导者区域说出 PsiLDMAR。我们证明 PsiLDMAR 多半从 AK111270 被导出,与它让 110 底与 LDMAR 的 5 结束重叠的 3 结束从 LDMAR 倡导者的感觉海滨获得的一个抄本。在 Nongken 58S 的 Overexpressing AK111270 极大地充实 PsiLDMAR,它在 LDMAR 倡导者导致了指导 RNA 的 DNA methylation 并且镇压 LDMAR 的表示。在 Nongken 58S 的 LDMAR 的减小为富饶恢复改变了批评的天长度并且在短天的条件下面推迟了富饶恢复。这结果为 PSMS 增加了我们分子的机制的理解。 | Jihua Ding Jianqiang Shen Hailiang Mao Weibo Xie Xianghua Li Qifa Zhang | 2012 | Molecular Plant2012，5，6： | 33 |
| 5 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 6 | Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia显示文摘Background Vascular endothelial growth factor (VEGF) is well known as a hypoxia-induced protein. That it markedly increased expression of VEGF and improvement of rat motor function after spinal cord injury suggested that VEGF could play a neuroprotective role in ischaemic tolerance. This study investigated whether vascular endothelial growth factor has direct neuroprotective effects on rat spinal cord neurons. Methods We employed primary cultures of embryonic rat spinal cord neurons, then administrated different concentrations of VEGF164 in the culture medium before hypoxia when the number of neurons was counted and the cell viability was detected by MTT. The neuronal apoptosis and expression of VEGF and its receptor genes were evaluated by terminal deoxynucleotidyl transferase mediated dUTP nick-end labelling (TUNEL) and immunohistochemistry. The VEGFR2/FLK-1 inhibitor, SU1498, was used to confirm whether the neuroprotective effect of VEGF was mediated through VEGFR2/Flk-1 receptors. Result In hypoxic conditions,the number and viability of neurons decreased progressively, while the number of TUNEL-positive cells increased along with the prolongation of hypoxic exposure. When the concentration of VEGF in cell culture medium reached 25 ng/ml, the cell viability increased 11% and neuronal apoptosis reduced to half, this effect was dose dependent and led to an approximately 25% increase in cell viability and about threefold decrease in TUNEL-positive cells at a maximally effective concentration of 100 ng/ml. In normal conditions, VEGF/Flk-1 but not VEGF/Flt-1 gene expressed at a low level: after hypoxia, the expression of VEGF/Flk-1, but not VEGF/Flt-1 was significantly increased. The protective effect of VEGF was blocked by the VEGFR2/Flk-1 receptor tyrosine kinase inhibitor, SU1498. Conclusions VEGF has direct neuroprotective effects on rat spinal cord neurons, which may be mediated in vitro through VEGFR2/Flk-1 receptors. | DING Xin-min MAO Bo-yong JIANG Shu LI Sheng-fu DENG Yi-ling | 2005 | Chinese Medical Journal2005，，19： | 20 |
| 7 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 8 | Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model显示文摘 | De-gang YU Hui-feng DING Yuan-qing MAO Ming LIU Bo YU Xin ZHAO Xiao-qing WANG Yang LI Guang-wang LIU Shao-bo NIE Shen LIU Zhen-an ZHU | 2013 | Acta Pharmacologica Sinica2013，34，3： | 13 |
| 9 | Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration显示文摘Shenfu Injection(SFI) is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides(ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rc) and aconitum alkaloids(benzoylmesaconine and fuziline) were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC–MS/MS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of2–8 m L/kg. | Yuqiao Zhang Dali Tian Yuyou Huang Ling Li Juan Mao Juan Tian Jinsong Ding | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 12 |
| 10 | Intelligent modeling and control for nonlinear systems with rate-dependent hysteresis显示文摘A new modeling approach for nonlinear systems with rate-dependent hysteresis is proposed. The approach is used for the modeling of the giant magnetostrictive actuator,which has the rate-dependent nonlinear property. The models built are simpler than the existed approaches. Compared with the experiment result,the model built can well describe the hysteresis nonlinear of the actuator for input signals with complex frequency. An adaptive direct inverse control approach is proposed based on the fuzzy tree model and inverse learning and special learning that are used in neural network broadly. In this approach,the inverse model of the plant is identified to be the initial controller firstly. Then,the inverse model is connected with the plant in series and the linear parameters of the controller are adjusted using the least mean square algorithm by on-line manner. The direct inverse control approach based on the fuzzy tree model is applied on the tracing control of the actuator by simulation. The simulation results show the correctness of the approach. | MAO JianQin DING HaiShan | 2009 | Science in China(Series F)2009，52，4： | 11 |
| 11 | A controlled study of positron-emission-tomography and positron-emission-tomography/computed tomography in differential diagnosis of solitary pulmonary nodules—report of 60 cases显示文摘The differential diagnosis of solitary pulmonary nodules (SPNs) remains a challenge. It is acknowledged that combining positron-emission tomography (PET) and computed tomography (CT) offers the most reliable noninvasive method for the diagnosis of SPNs. Since Townsend et al1 developed integrated PET/CT in 1999, this technique has increasingly been introduced into clinical practice. To date, nuclear medicine physicians have usually undertaken PET/CT diagnosis, but the question is surfacing as how to make full use of the information of CT image to improve the accuracy of SPN diagnosis. To answer this question, we performed a retrospective study on 60 patients with SPNs. METHODS Patients Between October 2003 and October 2004, 60 consecutive patients with SPNs (age range 26-85 years; median 56 years) underwent PET/CT examination, including 30 with benign and 30 with malignant lesions. Most of the patients had undergone CT scan before PET/CT. None of the patients received chemotherapy or radiation therapy previously. | DING Qi-yong HUA Yan-qing ZHANG Guo-zhen ZHAO Jun GUAN Yi-hui GE Xiao-jun MAO Ding-biao ZUO Chuan-tao | 2005 | Chinese Medical Journal2005，，18： | 10 |
| 12 | A new multi-wavelength solar telescope: Optical and Near-infrared Solar Eruption Tracer (ONSET)显示文摘A new multi-wavelength solar telescope,the Optical and Near-infrared Solar Eruption Tracer(ONSET)of Nanjing University,has been constructed.It was fabricated at the Nanjing Institute of Astronomical Optics&Technology,and the operation is jointly administered with Yunnan Astronomical Observatory.ONSET is able to observe the Sun in three wavelength windows:He I 10830?A,Hαand white-light at3600?A and 4250?A,which are selected in order to simultaneously record the dynamics of the corona,chromosphere and photosphere respectively.Full-disk or partial-disk solar images with a field of 10 at three wavelengths can be obtained nearly simultaneously.It is designed to trace solar eruptions with high spatial and temporal resolutions.This telescope was installed at a new solar observing site near Fuxian Lake in Yunnan Province,southwest China.The site is located at E102N24,with an altitude of 1722 m.The seeing is stable and has high quality.We give a brief description of the scientific objectives and the basic structure of ONSET.Some preliminary results are also presented. | Cheng Fang Peng-Fei Chen Zhen Li Ming-De Ding Yu Dai Xiao-Yu Zhang Wei-Jun Mao Jun-Ping Zhang Ting Li Yong-Jun Liang Hai-Tian Lu | 2013 | Research in Astronomy and Astrophysics2013，13，12： | 9 |
| 13 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 14 | Optimized design and test for a pendulum suspension of the crop spray boom in dynamic conditions based on a six DOF motion simulator显示文摘Spray deposit distribution from a field sprayer is mainly affected by the boom movements when the tractor is driven over a rough soil surface,the pendulum suspension that used to reduce and control the movement of spray boom by isolating the boom from vibrations of the tractor will directly enhance uniform deposition of chemicals.However,how to match the parameters of the suspension with the properties of the boom is the key problem.The dynamic rigid-flexible coupling model of the virtual prototype of the spray boom suspension system was established by using ADAMS and ABAQUS software.An optimization of the suspension parameters for a large spay boom was carried out based on the optimal Latin hypercube design,radial basis function neural network,and multi-objective genetic algorithm NSGA-II.After modified parameters of the suspension,the travel of the sprayer on a typical field motion track was simulated based on a six DOF motion simulator,and the dynamic behavior of the boom suspension was measured.The results show that RMS of the measured boom roll angle and the boom center displacement for optimized solution were reduced by 14.76%and 12.43%compared with the original suspension.Finally,the inertial measurement unit(IMU)was used to measure the movements of the sprayer vehicle during the pesticide application on the Hongze Lake Farm,the experiment of field condition reproduced by using the six DOF motion simulator,the standard deviation of the roll angle and vibration displacement for the optimized sprayer boom are only 0.6382°and 62.279 mm respectively.The research provides theoretical basis and experimental method for parameter optimization of large scale boom suspension. | Longfei Cui Hanping Mao Xinyu Xue Suming Ding Baiyu Qiao | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 9 |
| 15 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 16 | Differentiation of embryoid-body cells derived from embryonic stem cells into hepatocytes in alginate microbeads in vitro显示文摘目的: 胚胎的茎(ES ) 细胞广泛地与他们的增生的、可更新、多能的能力作为 hepatocytes 的有希望的来源正在被调查。然而,控制了并且进功能的 hepatocytes 的可伸缩的 ES 细胞分化文化是挑战性的。在这研究,我们检验了细胞从进在藻朊的 hepatocytes 的细胞吃了微祷告包含的 ES 导出的胚胎植物或动物身体的区分的潜力在 vitro.Methods 的外长的生长因素: 胚胎植物或动物身体被暂停方法从 ES 细胞形成。为 5 d 有教养的胚胎植物或动物身体与 trypsin-EDTA.The disaggregated 细胞被对待在藻朊被包含吃了微祷告并且与外长的生长因素刺激了导致肝的区别。在细胞分化期间,细胞形态学和生存能力被观察,并且 hepatocyte 的一些基因的表示模式被 RT-PCR.An 免疫证实萤光分析揭示了白朊(白长袍的)和 cytokeratin-18 ( CK18 ) .Hepatocyte 的表示功能的试金被白长袍的和 urea.Results 的分泌物证实:我们证明胚胎植物或动物身体细胞能坚持说在藻朊的细胞生存能力吃了微祷告在也发现那指导的 vitro.We ,区分的细胞表示了几 hepatocyte 基因包括 alpha-fetoprotein (法新社),白长袍的, Cyp7al , CK18 , transthyretin ( TTR )和酷氨酸 aminotransferase (梭织)并且在藻朊的生产白长袍的和脲吃了指导区分的细胞表示了的 microbeads.The d 上的白长袍的和 CK18 蛋白质 14 。然而,没有在藻朊的因素吃了的外长的生长,胚胎植物或动物身体细胞不能形成 hepatocytes microbeads.Conclusion : 进在藻朊包含外长的生长因素的 hepatocytes 的胚胎植物或动物身体细胞的区别吃了微祷告产生功能的 hepatocytes 并且可以为简历 artificial 肝和 hepatocyte 移植开发可伸缩的干细胞区别策略。 | Sheng FANG Yu-dong QIU Liang MAO Xiao-lei SHI De-cai YU Yi-tao DING | 2007 | Acta Pharmacologica Sinica2007，28，12： | 8 |
| 17 | Primary resonance of traveling viscoelastic beam under internal resonance显示文摘Under the 3:1 internal resonance condition,the steady-state periodic response of the forced vibration of a traveling viscoelastic beam is studied.The viscoelastic behaviors of the traveling beam are described by the standard linear solid model,and the material time derivative is adopted in the viscoelastic constitutive relation.The direct multi-scale method is used to derive the relationships between the excitation frequency and the response amplitudes.For the first time,the real modal functions are employed to analytically investigate the periodic response of the axially traveling beam.The undetermined coefficient method is used to approximately establish the real modal functions.The approximate analytical results are confirmed by the Galerkin truncation.Numerical examples are presented to highlight the effects of the viscoelastic behaviors on the steady-state periodic responses.To illustrate the effect of the internal resonance,the energy transfer between the internal resonance modes and the saturation-like phenomena in the steady-state responses is presented. | Hu DING Linglu HUANG Xiaoye MAO Liqun CHEN | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，1： | 8 |
| 18 | Non-image diagnosis of bile duct injury during laparoscopic cholecystectomy显示文摘Objective: To evaluate the role of simple non-imagetechnique in intraoperative diagnosis of bile duct in-jury (BDI).Methods: BDI was highly suspected at the original la-paroscopic cholecystectomy (LC) when the following 3abnormal findings were noted: the 'cystic duct' stump(the common bile duct stump actually) markedly re-tracted down to the duodenum; bile leakage from theporta hepatis; abnormal mucosal patch attached to the'cystic duct' stump of the removed gallbladder. Allcases of suspected BDI were converted to have laparo-tomy. Image techniques such as intraoperative cholan-giography or ultrasonography were not utilized forrecognition of BDI in all 9 patients.Results: BDI in 4 of the 9 patients was suspected ac-cording to 1-3 abnormal intraoperative findings de-scribed above. The four patients were subjected imme-diately to converted laparotomy. Abnormal findingswere not observed or misinterpreted in the other 5misdiagnosed patients.Conclusions: Timely recognizing whether BDI occursshould be considered as a routine procedure ofLC. Negligence of operators to the abnormalities of theoriginal LC, is the main cause of misdiagnosis forBDL. Simple non-image approaches such as close ob-servation of these abnormalities can make timely diag-nosis for most BDIs during the original LC. | Ding Luo Xun-Ru Chen Shen-Hong Li Jing-Xi Mao Shao-Ming Yu From the Department of Hepatobiliary Surgery, Kunming General Hospital, Kunming 650032, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 7 |
| 19 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 20 | Effects of Niaoduqing Particles(尿毒清颗粒)on Delaying Progression of Renal Dysfunction:A Post-trial,Open-Label,Follow-up Study显示文摘Objective: To follow up the participants of the randomized clinical trial 'Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction', and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function. | ZHENG Ying WANG Nian-song LIU Yu-ning HE Li-qun JIAN Gui-hua LIU Xu-sheng NI Zhao-hui CHENG Xiao-hong LIN Hong-li ZHOU Wen-hua WANG Ya-ping FANG Jing-ai HE Ya-ni YANG Hong-tao ZHAO Li-juan DING Han-lu WANG Li-hua YU Ren-huan LI Wen-ge YE Zhi-ming GUO Wang ZHAN Yong-li MAO Hui-juan HU Zhao YAO Chen CAI Guang-yan CHEN Xiang-mei | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员