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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 3 | 6–100 GHz research progress and challenges from a channel perspective for fifth generation(5G)and future wireless communication显示文摘Radio frequency is a valuable resource for wireless communication systems. The high-frequency band from 6 GHz up to 100 GHz, where continuous and broad spectra exist, is promising to meet the high spectrum requirement of fifth generation(5G) mobile communication systems by 2020. To date, many groups from academia and industry have contributed to devising approaches to allocate and utilize frequency resources from 6 GHz to 100 GHz for 5G and future wireless communication systems. In this paper, we present global efforts to allocate potential frequency bands and field trial progress from 6 GHz to 100 GHz for 5G. From a channel perspective, we summarize research progress and challenges, including channel measurement platforms and channel parameter analysis, both of which are important to extract the inherent channel characteristics and use a high-frequency band for 5G and future wireless communication systems. | Jianhua ZHANG Pan TANG Lei TIAN Zhixue HU Tan WANG Haiming WANG | 2017 | Science China(Information Sciences)2017，60，8： | 14 |
| 4 | A new perturbation algorithm and enhancing security of SFLASH signature scheme显示文摘This paper introduces the concept of noise factor and noise operation, and constructs a noise group. We present a new perturbation algorithm for enhancing security of multivariate public key cryptosystems (MPKCs). European Consortium SFLASH which derives from Matsumoto-Imai scheme is a fast signature scheme intended for low cost smart cards. It was broken with the differential cryptanalysis by Dubois et al. in 2007. Taking Matsumoto-Imai system as an example, security analysis shows that the new algorithm can powerfully demolish its potential mathematical properties of the public key, and effectively avoid differential cryptanalysis without lowering the effciency of the original algorithm. | WANG HouZhen ZHANG HuanGuo GUAN HaiMing HAN HaiQing | 2010 | Science China(Information Sciences)2010，53，4： | 12 |
| 5 | Radio Propagation and Wireless Coverage of LSAA-Based 5G Millimeter-Wave Mobile Communication Systems显示文摘Millimeter-wave(mm Wave) communications will be used in fifth-generation(5G) mobile communication systems, but they experience severe path loss and have high sensitivity to physical objects, leading to smaller cell radii and complicated network architectures. A coverage extension scheme using large-scale antenna arrays(LSAAs) has been suggested and theoretically proven to be cost-efficient in combination with ultradense small cell networks. To analyze and optimize the LSAA-based network deployments, a comprehensive survey of recent advances in statistical mmWave channel modeling is first presented in terms of channel parameter estimation, large-scale path loss models, and small-scale cluster models. Next, the measurement and modeling results at two 5G candidate mmWave bands(e.g., 28 GHz and 39 GHz) are reviewed and compared in several outdoor scenarios of interest, where the propagation characteristics make crucial contributions to wireless network designs. Finally, the coverage behaviors of systems employing a large number of antenna arrays are discussed, as well as some implications on future mmWave cellular network designs. | Haiming Wang Peize Zhang Jing Li Xiaohu You | 2019 | China Communications2019，16，5： | 12 |
| 6 | Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice显示文摘Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis,M. vaccae was injected into Mycobacterium tuberculosis(M. tuberculosis) infected mice. The optimal dose of M. vaccae(22.5 μg/mouse) treated mice showed lower pathological change index,spleen weight index,lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells,IFN-γ+CD4+ T cells,innate immune cells including NK cells,NK1.1+ T cells and γδ T cells,and reduced the percentage of IL-4+CD4+ T cells. Therefore,M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity,suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis. | Lijun Xu Yanyan Wang Xiaodong Zheng Xiangdong Gui Lifeng Tao Haiming Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 11 |
| 7 | IEEE 802.11aj(45GHz):A New Very High Throughput Millimeter-Wave WLAN System显示文摘This paper presents an overview of a new very high throughput millimeterwave WLAN system operating at 45 GHz band. We begin by reviewing standards process of IEEE 802.11aj(45GHz). Then the frequency spectrum allocation at 45 GHz band is introduced. Next, the channel measurement and mod-eling is given. Specifically, the millimeter-wave MIMO for physical layer enhancement is given in detail. | WANG Haiming HONG Wei CHEN Jixin SUN Bo PENG Xiaoming | 2014 | China Communications2014，11，6： | 10 |
| 8 | Assessment of the Ecological Security in the Three Gorges Reservoir Area by Using the Ecological Footprint Method显示文摘The ecological footprint concept and its calculation models are useful for the measurement of the sustainable level of social and economic development.The ecological security situation of the Three Gorges Reservoir Area(TGRA) was evaluated using this concept in this study.The construction of the Three Gorges Reservoir has led to the change in the ecology and immigration status of TGRA.The ecological footprint method is an important means to study the regional ecological security.Our results suggested that,by excluding the areas for biodiversity conservation(12% of the total land),the ecological footprint per capita was 0.57895 ha,which exceeded the ecological carrying capacity in TGRA.The total ecological deficit was found to be 11,522,193.34 ha,accounting for 95.02% of the ecological carrying capacity.These findings suggested that the ecological security of TGRA was not good.In order to compensate for the ecological deficit,it was essential to introduce natural resources from other regions. | WANG Haiming WANG Hai'e SUN Hongyang WANG Xiaolan LIAO Xiaoyong CHEN Zhijian LI Xianwei | 2012 | Journal of Mountain Science2012，9，6： | 9 |
| 9 | Trichosanthin Induced Th2 Polarization Status显示文摘Trichosanthin 从中国药用的植物 Trichosanthes kirilowii maximowicz (Tian Hua 分) 的根 tuber 被提取。TCS 有堕胎药,反肿瘤, anti-HIV 和 immunoregulatory 功能。它能禁止有免疫力的反应并且唤醒一个 T 助手,这被证明了在排干的淋巴节点的 2 反应。在当前的学习,老鼠 splenocytes 上的 TCS 的效果被调查。我们在 vivo 并且在 vitro 与 TCS 刺激了 C57BL/6 老鼠并且在老鼠 splenocytes 分析了类型 1 和类型 2 cytokines 的变化。结果证明 TCS 能导致 IL-4 的表示,主要 T 助手之一 2 (Th2 ) cytokines,并且禁止 IFN- 的表示,在在 vivo 并且在 vitro 的怒气淋巴细胞的重要 Th1 cytokine。它也在 C57BL/6 老鼠在 vivo 在 TCS 刺激以后被看 Th1-to-Th2 转变的动力学。我们发现那种类型 2 cytokines,例如 IL-10, TGF-4 和 IL-4 定期被增加,但是 IFN- 在白天 3 点被减少然后增加。然而,为 cytokine 变化的机制不是清楚的。细胞与分子的免疫学。2006; 3 (4 ): 297-301。 | Shuying Zhao Yanyan Wang Haiming Wei | 2006 | Cellular & Molecular Immunology2006，3，4： | 6 |
| 10 | Artificial periosteum in bone defect repair--A review显示文摘Periosteum is a thin membrane that encases the surfaces of most bones.It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells(MSCs)and osteogenic progenitor cells.Periosteum has a function of regulating cell and collagen arrangement,which is important to the integrity,modelling and remodelling of bone,particularly during bone defect repair.Apart from autograft and allograft,artificial periosteum,or tissue-engineered periosteum mimicking native periosteum in structure or function,made up of small intestinal submucosa,acellular dermis,induced membrane,cell sheets,and polymeric scaffolds,and so on,has been developed to be used in bone defect repair.In this review,we classify the artificial periosteum into three approaches based on the material source,that is,native tissues,scaffoldfree cell sheets and scaffold-cell composites.Mechanisms,methods and efficacy of each approach are provided.Existing obstacles and enabling technologies for future directions are also discussed. | Quan Wang Jianxiang Xu Haiming Jin Wenhao Zheng Xiaolei Zhang Yixing Huang Zhiyong Qian | 2017 | Chinese Chemical Letters2017，28，9： | 6 |
| 11 | Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy显示文摘Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)therapy.Recently,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA effectively.In this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of MOF.The collagen II-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser irritation.Briefly,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain extent.Meanwhile,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte protection.RB@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling pathway.Additionally,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS imaging.More significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat model.Overall,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy. | Song Xue Xiaojun Zhou Weilin Sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma | 2021 | Bioactive Materials2021，6，8： | 5 |
| 12 | High Expression of NKG2A/CD94 and Low Expression of Granzyme B Are Associated with Reduced Cord Blood NK Cell Activity显示文摘Human umbilical cord blood (CB) has recently been used as a source of stem cells in transplantation. NK cells derived from CB are the key effector cells involved in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). It was reported that the activity of CB NK cells was lower than that of adult peripheral blood (PB) NK cells. In this study,we analyzed the expression of some NK cell receptors and cytotoxicity-related molecules in CB and PB NK cells. The expressions of activating NK receptors,CD16,NKG2D and NKp46,did not show significant difference between CB and PB NK cells. But the expression of inhibitory receptor NKG2A/CD94 was significantly higher on CB NK cells. As to the effector function molecules,granzyme B was expressed significantly lower in CB NK cells,but the expressions of intracellular perforin,IFN-γ,TNF-α and cell surface FasL and TRAIL did not show difference between CB and PB NK cells. The results indicated that the high expression of NKG2A/CD94 and low expression of granzyme B may be related with the reduced activity of CB NK cells. | Yanyan Wang1,2,Han Xu1,2,Xiaodong Zheng1,Haiming Wei1,Rui Sun1 and Zhigang Tian1,31Institute of Immunology,Hefei National Laboratory for Physical Materials at Microscale and School of Life Sciences,University of Science and Technology of China,Hefei 230027,China 2Yanyan Wang and Han Xu equally contributed to the present study | 2007 | Cellular & Molecular Immunology2007，4，5： | 5 |
| 13 | Observed oceanic feedback to the atmosphere over the Kuroshio Extension during spring time and its possible mechanism显示文摘High-resolution satellite measurements are used to study the air-sea interaction over the Kuroshio Extension (KE) region during spring time. There are two oceanic fronts in the KE region off the east coast of Japan. These fronts are generally associated with strong ocean currents, which may display unstable meander, resulting in remarkable warm sea surface temperature (SST) ridges and cold SST troughs. Analyses of these satellite observations reveal a significantly positive correlation between sea surface wind speed and its underlying SST along these fronts. This positive SST-wind correlation be-comes even more significant when strong meanders occur along the fronts. This positive SST-wind correlation indicates an ocean-to-atmosphere feedback over the KE region during spring time. A high-resolution regional atmospheric model is used to investigate the atmospheric response to SST changes along the two fronts. | XU HaiMing WANG LinWei HE JinHai | 2008 | Chinese Science Bulletin2008，53，12： | 5 |
| 14 | Geochemistry of Pyrite from the Gangcha Gold Deposit, West Qinling Orogen, China: Implications for Ore Genesis显示文摘The Gangcha gold deposit was discovered in 2011 in the Xiahe-Hezuo region, West Qinling Orogen, China. Five types of pyrite have been identified in the ore according to the detailed mineral paragenetic studies. Geochemical data are presented for type I pyrite(py1) rim-core zonation and for the different types of pyrite based on in-situ laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and electron probe microanalysis(EPMA). The results show that pyrites are characterized with heterogeneous Au concentrations, which indicate that Au occurs mainly as micro-or nano-particle native inclusions. Time-resolved depth profiles demonstrate that As, Co and Ni occur as solid solutions in pyrite, whereas Cu, Pb, Zn and Ag occur mainly as inclusions. Trace element concentrations differ between rims and cores in py1, and the differences also exist within different pyrite types. These differences indicate complex chemical evolution of the ore-forming fluids, and the overall geology, geochronology, and stable isotope and pyrite data suggest that the ore-forming fluids were closely linked to magmatic activity during the Triassic Period in West Qinling orogenic belt. | NIE Xiao SHEN Junfeng LIU Haiming DU Baisong WANG Shuhao LI Jie XU Liwei WANG Ran | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 5 |
| 15 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 16 | Research on practical power system stability analysis algorithm based on modified SVM显示文摘Stable and safe operation of power grids is an important guarantee for economy development.Support Vector Machine(SVM)based stability analysis method is a significant method started in the last century.However,the SVM method has several drawbacks,e.g.low accuracy around the hyperplane and heavy computational burden when dealing with large amount of data.To tackle the above problems of the SVM model,the algorithm proposed in this paper is optimized from three aspects.Firstly,the gray area of the SVM model is judged by the probability output and the corresponding samples are processed.Therefore the clustering of the samples in the gray area is improved.The problem of low accuracy in the training of the SVM model in the gray area is improved,while the size of the sample is reduced and the efficiency is improved.Finally,by adjusting the model of the penalty factor in the SVM model after the clustering of the samples,the number of samples with unstable states being misjudged as stable is reduced.Test results on the IEEE 118-bus test system verify the proposed method. | Kaiyuan Hou Guanghui Shao Haiming Wang Le Zheng Qiang Zhang Shuang Wu Wei Hu | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 5 |
| 17 | Gas stunning with CO_2 affected meat color,lipid peroxidation, oxidative stress, and gene expression of mitogen-activated protein kinases, glutathione S-transferases,and Cu/Zn-superoxide dismutase in the skeletal muscles of broilers显示文摘Background: Meat color and lipid peroxidation are important traits related to meat quality. CO_2 concentration is a critical factor that can affect meat quality in the commercial use of gas stunning(GS). However, the effect and mechanism of CO_2 stunning on meat color and lipid peroxidation during long-term storage remain poorly studied. We aimed to study the effects of GS methods, especial y CO_2 concentration, on meat color and meat lipid peroxidation in broilers during long-term storage at 4 °C and to explore the potential mechanism of meat color change via lipid peroxidation and the inner lipid peroxide scavenging system.Methods: Eighteen broilers were sacrificed after exposure to one of the following gas mixtures for 90 s: 40% CO_2+21% O_2+ 39% N2(G40%), 79% CO_2+ 21% O_2(G79%), or no stunning(0% CO_2, control). Meat color, serum variables,enzyme activities, and the gene expression of mitogen-activated protein kinase(MAPK), nuclear factor-erythroid2-related factor 2(Nrf2), glutathione S-transferase(GST) and superoxide dismutase(SOD) were determined.(Continued on next page)Results: The concentrations of serum triiodothyronine(T3, P = 0.03) and the ratio of serum free triiodothyronine/free thyroxine(FT3/FT4, P < 0.01) were decreased, whereas levels of serum cortisol(P < 0.01) were increased in the 40%CO_2 group compared with the control group. Additionally, the thiobarbituric acid-reactive substances(TBARS)3 d(P < 0.01) and TBARS6 d(P = 0.01) in breast meat and the TBARS3 din thigh meat(P < 0.01) were increased in the40% CO_2 group compared with the control group. Serum T3 was negatively correlated with TBARS6 dboth in the breast and thigh meat(r =-0.63, P < 0.01 and r =-0.47, P = 0.05 respectively). T3/T4 was negatively correlated with TBARS6 din the breast meat and in the thigh meat(r =-0.57, P = 0.01; and r =-0.53, P = 0.03 respectively). Compared with the control group, Lightness(L*)1 d(P = 0.03) and L*9 d(P < 0.01) were increased, whereas total chromatic aberration(E*)1 d(P = 0.05) and E*3 d(P < 0.01) were decreased in the breast meat of both the G40% and G79% groups. The values of yel owness(b*)3 d(P = 0.01), b*6 d(P < 0.01) and E*6 d(P < 0.01) in the thigh meat were lower in both the G40% and G79% groups than in the control group. In the breast muscle, the m RNA levels of c-Jun N-terminal kinase 2(JNK2, P = 0.03),GSTT1(P = 0.04), and SOD1(P = 0.05) were decreased, and the m RNA levels of JNK1(P = 0.07), Nrf2(P = 0.09), and GSTA3(P = 0.06) were slightly lower in both the G40% and G79% groups compared with the control group. However, among these genes, only the m RNA level of JNK1 was decreased in the G40% group compared with the control group and the G79% group(P = 0.03) in the thigh muscle.Conclusions: Compared with the control group, meat color quality in the breast meat was decreased, and the expression of genes in the MAPK/Nrf2/ARE(antioxidant responsive element) antioxidant pathway in breast muscle was partly suppressed by GS of both 40% and 79% CO_2. However, oxidative stress and meat lipid peroxidation during storage were aggravated by GS with 40% CO_2 compared to GS with 79% CO_2 and no GS. | Lei Xu Haijun Zhang Hongyuan Yue Shugeng Wu Haiming Yang Zhiyue Wang Guanghai Qi | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 18 | Effects of soil nutrients and climate factors on belowground biomass in an alpine meadow in the source region of the Yangtze-Yellow rivers, Tibetan Plateau of China显示文摘Improving our knowledge of the effects of environmental factors(e.g.soil conditions,precipitation and temperature) on belowground biomass in an alpine grassland is essential for understanding the consequences of carbon storage in this biome.The object of this study is to investigate the relative importance of soil nutrients and climate factors on belowground biomass in an alpine meadow in the source region of the Yangtze and Yellow rivers,Tibetan Plateau.Soil organic carbon(SOC),total nitrogen(TN) and total phosphorous(TP) contents and belowground biomass were measured at 22 sampling sites across an alpine meadow on the Tibetan Plateau.We analyzed the data by using the redundancy analysis to determine the main environmental factors affecting the belowground biomass and the contribution of each factor.The results showed that SOC,TN and TP were the main factors that influenced belowground biomass,and the contribution of SOC,TN and TP on biomass was in the range of 47.87%–72.06% at soil depths of 0–30 cm.Moreover,the combined contribution of annual mean temperature(AMT) and mean annual precipitation(MAP) on belowground biomass ranged from 0.92% to 4.10%.A potential mechanism for the differences in belowground biomass was caused by the variations in soil nitrogen and phosphorous,which were coupled with SOC.A significant correlation was observed between MAP and soil nutrients(SOC,TN and TP) at the soil depth of 0–10 cm(P<0.05).We concluded that precipitation is an important driving force in regulating ecosystem functioning as reflected in variations of soil nutrients(SOC,TN and TP) and dynamics of belowground biomass in alpine grassland ecosystems. | WANG Haiming SUN Jian LI Weipeng WU Jianbo CHEN Youjun LIU Wenhui | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 19 | Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors显示文摘The spatiotemporal distribution of cytokines orchestrates immune responses in vivo,yet the underlying mechanisms remain to be explored.We showed here that the spatial distribution of interleukin-4(IL4)in invariant natural killer T(iNKT)cells regulated crosstalk between iNKT cells and dendritic cells(DCs)and controlled iNKT cell-mediated T-helper type 1(Th1)responses.The persistent polarization of IL4 induced by strong lipid antigens,that is,α-galactosylceramide(αGC),caused IL4 accumulation at the immunological synapse(IS),which promoted the activation of the IL4R-STAT6(signal transducer and activator of transcription 6)pathway and production of IL12 in DCs,which enhanced interferon-γ(IFNγ)production in iNKT cells.Conversely,the nonpolarized secretion of IL4 induced by Th2 lipid antigens with a short or unsaturated chain was incapable of enhancing this iNKT cell-DC crosstalk and thus shifted the immune response to a Th2-type response.The nonpolarized secretion of IL4 in response to Th2 lipid antigens was caused by the degradation of Cdc42 in iNKT cells.Moreover,reduced Cdc42 expression was observed in tumorinfiltrating iNKT cells,which impaired IL4 polarization and disturbed iNKT cell-DC crosstalk in tumors. | Lu Wang Zhilan Liu Lili Wang Qielan Wu Xiang Li Di Xie Huimin Zhang Yongdeng Zhang Lusheng Gu Yanhong Xue Ting Yue Gang Liu Wei Ji Haiming Wei Tao Xu Li Bai | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 20 | Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer显示文摘 | Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao | 2018 | Nano Research2018，11，5： | 4 |
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