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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Postoperative haemorrhage following transurethral resection of theprostate (TURP) and photoselective vaporisation of the prostate(PVP) 显示文摘 | Mark Lynch Seshadri Sriprasad Kesavapillai Subramonian | 2010 | AnnR Coll Surg Engl2010，92，7： | 1 |
| 3 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 4 | Strategies for developing decellularized corneal scaffolds显示文摘 | Amy P. Lynch Mark Ahearne | 2012 | Experimental Eye Research2012，，： | 1 |
| 5 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 6 | Atom-economic synthesis of an oligomeric P/N-containing fire retardant towards fire-retarding and mechanically robust polylactide biocomposites显示文摘Renewable and biodegradable polylactide (PLA) has excellent mechanical strength but is highly flammable which restricts its practical applications. Many phosphorus/nitrogen (P/N)-based flame retardants are ef- fective in PLA, but their high addition loading usually decreases the mechanical strength of the PLA bulk. For polyphosphoramides, despite high fire-retardant efficiency, their chemical synthesis often generates chemical wastes as byproducts. Herein, we report an atom-economic and highly efficient oligomeric P/N fire retardant (APN) prepared using a mild Michael addition polymerization with no byproducts. Using only 3 wt% APN, the resulting PLA exhibits desired fire retardancy including a UL-94 V-0 rating and a limiting oxygen index of 37.6%. Furthermore, the toughness of the fire-retardant PLA increases by 85% compared to pure PLA, with both tensile strength and thermal stability preserved. This work offers an atom-economic strategy for synthesizing highly efficient P/N fire retardants for use in the creation of fire-resistant PLA with robust mechanical properties. | Jiabing Feng Yixia Lu Hongyan Xie Yan Zhang Siqi Huo Xiaohuan Liu Matt Flynn Zhiguang Xu Paulomi Burey Mark Lynch Hao Wang Pingan Song | 2023 | Journal of Materials Science & Technology2023，，29： | 1 |
| 7 | Effect of biomaterial surface properties on fibronectin– α 5 β 1 integrin interaction and cellular attachment显示文摘 | Mark H. Lee Paul Ducheyne Laura Lynch David Boettiger Russell J. Composto | 2005 | Biomaterials2005，，9： | 1 |
| 8 | Postoperative haemorrhage following transurethral resection of the prostate (TURP) and photoselective vaporisation of the prostate (PVP)显示文摘 | Mark Lynch Seshadri Sriprasad Kesavapillai Subramonian | 2010 | Ann R Coll Surg Engl2010，92，7： | 1 |
| 9 | Inverse Relationship between Microsatellite Instability and K- ras and p53 Gene Alterations in Colon Cancer显示文摘 | Wade S. Samowitz Joseph A. Holden Karen Curtin Sandra L. Edwards Adrianne R. Walker Heather A. Lin Margaret A. Robertson Melanie F. Nichols Kristin M. Gruenthal Beverly J. Lynch Mark F. Leppert Martha L. Slattery | 2001 | The American Journal of Pathology2001，，4： | 1 |
| 10 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 11 | Postoperative haemorrhage following transurethral resection of the prostate and photoselective vaporization of the prostate 显示文摘 | Mark Lynch Seshadri Sriprasad Kesavapillai Subramonian | 2010 | Ann R Coil Surg Engl2010，92，7： | 1 |
| 12 | Cumulative incidence of colorectal and extracolonic cancers in mlh1 and msh2 mutation carriers of hereditary nonpolyposis colorectal cancer显示文摘 | Kevin M. Lin M.D. M. Shashidharan M.D. Alan G. Thorson M.D. Charles A. Ternent M.D. Garnet J. Blatchford M.D. Mark A. Christensen M.D. Patrice Watson Ph.D. Stephen J. Lemon M.D. M.PH. Barbara Franklin B.S.N. Beth Karr B.S.N. Jane Lynch B.S.N. Henry T. Ly | 1998 | Journal of Gastrointestinal Surgery1998，，1： | 1 |
| 13 | Inverse Relationship between Microsatellite Instability and K- ras and p53 Gene Alterations in Colon Cancer显示文摘 | Wade S. Samowitz Joseph A. Holden Karen Curtin Sandra L. Edwards Adrianne R. Walker Heather A. Lin Margaret A. Robertson Melanie F. Nichols Kristin M. Gruenthal Beverly J. Lynch Mark F. Leppert Martha L. Slattery | 2001 | The American Journal of Pathology2001，，4： | 1 |
| 14 | Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells显示文摘Background: Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linagedifferentiation capabilities. While much work has been done to optimize the differentiation media, few studies havefocused on examining the influence of different expansion media on cell behavior. In this study, three basal media(low glucose Dulbecco’s modified Eagle’s medium (DMEM), high glucose DMEM and DMEM-F12) supplementedwith or without fibroblast growth factor 2 (FGF) were examined to assess their suitability for expanding ASCs.Findings: Flow cytometry, colony-forming unit assays (CFU-Fs) and differentiation assays were utilized to study cellbehavior. High glucose media CFU-Fs produced fewest colonies while the addition of FGF increased colony size.By passage 2, the majority of cells were positive for CD44, 45, 73, 90 and 105 and negative for CD14, 31 and 45,indicating a mesenchymal phenotype. A sub-population of CD34 positive cells was present among passage 2 cells;however, by passage 4 the cells were negative for CD34. FGF has a negative effective on passage 4 ASC adipogenesisand high glucose media plus FGF-enhanced osteogenic capacity of passage 4 ASCs. FGF supplemented basal mediawere most suitable for chondrogenesis. High glucose media plus FGF appeared to be the most beneficial for primingASCs to induce a keratocyte phenotype.Conclusions: These findings demonstrate the reciprocal effect FGF and basal media have on ASCs. This research hasimplications for those interested regenerating bone, cartilage, cornea or adipose tissues. | Mark Ahearne Joanne Lysaght Amy P Lynch | 2014 | Cell Regeneration2014，3，1： | 0 |
| 15 | Fire-retardant, anti-dripping, biodegradable and biobased polyurethane elastomers enabled by hydrogen-bonding with cellulose nanocrystals显示文摘Thermoplastic polyurethane(PU)elastomers have attracted significant attention because of their many important industrial applications.However,the creation of fire-retardant and anti-dripping PU elastomers has remained a grant challenge due to the lack of crosslinking and weak interchain interactions.Herein,we report a mechanically robust,biodegradable,fire-retardant,and anti-dripping biobased PU elastomer with excellent biodegradability using an abietic acid-based compound as hard segments and polycaprolactone diol(PCL)as soft segments,followed by physically crosslinking with cellulose nanocrystals(CNC)through dynamic hydrogen-bonding.The resultant elastomer shows the balanced mechanical and fire-retardant properties,e.g.,a tensile strength and break strain of 9.1 MPa and 560%,a self-extinguishing ability(V-0 rating in UL-94 testing),and an anti-dripping behavior.Moreover,the as-developed PU can be completely degraded in 1.0 wt.%lipase solution at 37℃ in 60 days,arising from the catalytic and wicking effect of CNC on PU chains.This work provides an innovative and versatile strategy for constructing robust,fire-retardant,anti-dripping,and biodegradable PU elastomers,which hold great promise for practical applications in electronic and automobile sectors. | Yijiao Xue Tianchen Zhang Hong Peng Zhewen Ma Meng Zhang Mark Lynch Toan Dinh Zhezhe Zhou Yonghong Zhou Pingan Song | 2024 | Nano Research2024，17，3： | 0 |
| 16 | 一个只在有理点处可微的连续函数显示文摘给出了一个函数的显式构造,此函数是在一个区间中的连续函数,它只在有理点处可微. | Mark Lynch 陆柱家(译) 陈凌宇(校) | 2014 | 数学译林2014，，1： | 0 |
| 17 | π日显示文摘1932年,Stanislaw证明了:对于平面中的一大类度量,单位圆盘的周长可以在6—8之间变动.因而,相应于π的比值可以在3~4之间变动.我们通过定义一族易于被学过线性代数的学生理解的度量来解释这个结果. | Mark Lynch 陆柱家 陈凌宇 | 2014 | 数学译林2014，0，3： | 0 |
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