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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 3 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 4 | Inverted Meckel's diverticulum as a cause of occult lower gastrointestinal hemorrhage显示文摘Meckel's diverticulum is a common asymptomatic congenital gastrointestinal anomaly,but rarely it can present with hemorrhage.Over the last few years inverted Meckel's diverticulum has been reported in the literature with increasing frequency as an occult source of lower gastrointestinal hemorrhage.Here,we report a case of a 54-year-old male,who was referred for surgical evaluation with persistent anemia and occult blood per rectum after a work up which failed to localize the source over 12 mo,including upper and capsule endoscopy,colonoscopy,enteroclysis,Meckel scan,and tagged nuclear red blood cell scan.An abdominal computed tomography scan showed a possible mid-ileal intussusception and intraluminal mass.During the abdominal exploration,inverted Meckel's diverticulum was diagnosed and resected.We review the literature,discuss the forms in which the disease presents,the diagnostic modalities utilized,pathological findings,and treatment.Although less than 40 cases have been reported in the English literature from 1978 to 2005,19 cases have been reported in the last 6 years alone(2006-2012) due to improved diagnostic modalities.Successful diagnosis and treatment of this disease requires a high index of clinical suspicion,which is becoming increasingly relevant to general gastroenterologists. | Omar M Rashid Joseph K Ku Masayuki Nagahashi Akimitsu Yamada Kazuaki Takabe | 2012 | World Journal of Gastroenterology2012，18，42： | 7 |
| 5 | Preoperative Gemcitabine-Based Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer显示文摘 | Hidenori Takahashi Hiroaki Ohigashi Kunihito Gotoh Shigeru Marubashi Terumasa Yamada Masayuki Murata Tatsuya Ioka Hiroyuki Uehara Masahiko Yano Osamu Ishikawa | 2013 | Annals of Surgery2013，，6： | 3 |
| 6 | Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer显示文摘 | Jie Liang Masayuki Nagahashi Eugene Y. Kim Kuzhuvelil B. Harikumar Akimitsu Yamada Wei-Ching Huang Nitai C. Hait Jeremy C. Allegood Megan M. Price Dorit Avni Kazuaki Takabe Tomasz Kordula Sheldon Milstien Sarah Spiegel | 2013 | Cancer Cell2013，，： | 3 |
| 7 | Outcomes of gastrointestinal defect closure with an overthe-scope clip system in a multicenter experience: An analysis of a successful suction method显示文摘AIM To demonstrate the clinical outcomes of a multicenter experience and to suggest guidelines for choosing a suction method. METHODS This retrospective study at 5 medical centers involved 58 consecutive patients undergoing over-the-scope clips(OTSCs) placement. The overall rates of technical success (TSR), clinical success (CSR), complications, and procedure time were analyzed as major outcomes. Subsequently, 56 patients, excluding two cases that used the Anchor device, were divided into two groups: 14 cases of simple suction (SS-group) and 42 cases using the Twin Grasper (TG-group). Secondary evaluation was performed to clarify the predictors of OTSC success.RESULTS The TSR, CSR, complication rate, and median procedure time were 89.7%, 84.5%, 1.8%, and 8 (range 1-36) min, respectively, demonstrating good outcomes. However, significant differences were observed between the two groups in terms of the mean procedure time (5.9 min vs 14.1 min). The CSR of the SS- and TG-groups among cases with a maximum defect size ≤ 10 mm and immediate or acute refractory bleeding was 100%, which suggests that SS is a better method than TG in terms of time efficacy. The CSR in the SS-group (78.6%), despite the technical success of the SS method (TSR, 100%), tended to decrease due to delayed leakage compared to that in the TG-group (TSR, CSR; 88.1%), indicating that TG may be desirable for leaks and fistulae with defects of the entire layer. CONCLUSION OTSC system is a safe and effective therapeutic option for gastrointestinal defects. Individualized selection of the suction method based on particular clinical conditions may contribute to the improvement of OTSC success. | Hideki Kobara Hirohito Mori Shintaro Fujihara Noriko Nishiyama Taiga Chiyo Takayoshi Yamada Masao Fujiwara Keiichi Okano Yasuyuki Suzuki Masayuki Murota Yoshitaka Ikeda Makoto Oryu Mohamed Abo Ellail Tsutomu Masaki | 2017 | World Journal of Gastroenterology2017，23，9： | 3 |
| 8 | Extrapancreatic neural plexus invasion by carcinomas of the pancreatic head region: evaluation using thin-section helical CT显示文摘 | Hui Tian Hiromu Mori Shunro Matsumoto Yasunari Yamada Hiro Kiyosue Masayuki Ohta Seigo Kitano | 2007 | Radiation Medicine2007，，4： | 2 |
| 9 | Clinicopathology of pancreaticobiliary maljunction: relationship between alterations in background biliary epithelium and neoplastic development显示文摘 | Makoto Seki Akio Yanagisawa Eiji Ninomiya Yasuro Ninomiya Hirotoshi Ohta Akio Saiura Junji Yamamoto Toshiharu Yamaguchi Akiko Aruga Keiko Yamada Koichi Takano Rikiya Fujita Masayuki Ikeda Keiko Sasaki Yo Kato | 2005 | Journal of Hepato - Biliary - Pancreatic Surgery2005，，3： | 2 |
| 10 | Tumor‐suppressive micro RNA ‐135a inhibits cancer cell proliferation by targeting the c‐ MYC oncogene in renal cell carcinoma显示文摘 | Yasutoshi Yamada Hideo Hidaka Naohiko Seki Hirofumi Yoshino Takeshi Yamasaki Toshihiko Itesako Masayuki Nakagawa Hideki Enokida | 2012 | Cancer Sci2012，，3： | 2 |
| 11 | G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation显示文摘 | Keiji Tanese Mariko Fukuma Taketo Yamada Taisuke Mori Tsutomu Yoshikawa Wakako Watanabe Akira Ishiko Masayuki Amagai Takeji Nishikawa Michiie Sakamoto | 2008 | The American Journal of Pathology2008，，： | 1 |
| 12 | Effects of outside air temperature on the preparation of antineoplastic drug solutions in biological safety cabinets显示文摘 | Masayuki Umemura Akio Itoh Yuichi Ando Kiyofumi Yamada Yoshifumi Wakiya Toshitaka Nabeshima | 2015 | Journal of Oncology Pharmacy Practice2015，，： | 1 |
| 13 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 14 | Charge and discharge performance of lithiated metal oxide cathodes in organic electrolyte solutions with different compositions 显示文摘 | Masayuki Morita Otoo Yamada Masashi Ishikawa | 1999 | Journal of Power Sources1999，8182，： | 1 |
| 15 | Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development显示文摘 | Ryo Aizawa Atsushi Yamada Dai Suzuki Tadahiro Iimura Hidetoshi Kassai Takeshi Harada Masayuki Tsukasaki Gou Yamamoto Tetsuhiko Tachikawa Kazuki Nakao Matsuo Yamamoto Akira Yamaguchi Atsu Aiba Ryutaro Kamijo | 2012 | Mechanisms of Development (-)2012，，1： | 1 |
| 16 | Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone显示文摘 | Akihide Nampei Jun Hashimoto Kenji Hayashida Hideki Tsuboi Kenrin Shi Isamu Tsuji Hideaki Miyashita Takao Yamada Naomichi Matsukawa Masayuki Matsumoto Shigeto Morimoto Toshio Ogihara Takahiro Ochi Hideki Yoshikawa | 2004 | Journal of Bone and Mineral Metabolism2004，，3： | 1 |
| 17 | Rhodopsin Gene Codon 106 Mutation (Gly-to-Arg) in a Japanese Family with Autosomal Dominant Retinitis Pigmentosa显示文摘 | Budu Masayuki Matsumoto Seiji Hayasaka Tetsuya Yamada Yoriko Hayasaka | 2000 | Japanese Journal of Ophthalmology2000，，6： | 1 |
| 18 | Synchronous double cancers of the remnant stomach and pancreas: Report of a case显示文摘 | Takao Miyaguni Yoshihiro Muto Toshiomi Kusano Mamoru Yamada Mitsuyuki Matsumoto Masayuki Shiraishi | 1995 | Surgery Today1995，，12： | 1 |
| 19 | Evaluation of the lateral sentinel node by indocyanine green for rectalcancer based on micrometastasis determined by reverse transcriptase-polymerasechain reaction显示文摘 | Shingo Noura Masayuki Ohue Yosuke Seki Takashi Yamamoto Atsushi Idota Junko Fujii Tomoyuki Yamasaki Hiromu Nakajima Kohei Murata Masao Kameyama Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa Shingi Imaoka | 2008 | Oncology Reports2008，，4： | 1 |
| 20 | Efficacy of subcutaneous penrose drains for surgical site infections in colorectal surgery显示文摘AIM: To investigate whether a subcutaneous penrose drain would decrease the superficial surgical site infection (s-SSI) rate in elective colorectal surgery. METHODS: This is a comparative study of the historical control type. Intervention consisted of the use of penrose drain in elective open colorectal surgical wounds. The outcome was an incidence of s-SSI. The patients were risk stratified according to the depth of subcutaneous tissue.RESULTS: There were 131 patients (40 patients with high s-SSI risk) in the prior period (from July 2008 to June 2009, when no penrose drains were inserted) and 151 patients (75 patients with high s-SSI risk) in the latter period (from June 2010 to November 2011, when penrose drains were inserted). The overall s-SSI rate was 6.1% and 5.3% during the two periods (P = 0.770), and the s-SSI rate in the high s-SSI risk group was 15.0% and 8.0% (P = 0.242).CONCLUSION: Although penrose drain was not observed to significantly reduce s-SSI, there tended to be a reduced risk of s-SSI in the high s-SSI risk group. | Shinya Imada Shingo Noura Masayuki Ohue Tatsushi Shingai Toshinori Sueda Kentaro Kishi Terumasa Yamada Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 1 |
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