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| 1 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 2 | 不同终板准备方法对ProDisc-C颈椎人工椎间盘假体稳定性的影响显示文摘目的:探讨不同颈椎终板准备方法对颈椎人工椎间盘置换术后金属-骨界面刚度的影响,了解终板准备方法与人工椎间盘假体稳定性的关系。方法:取6具新鲜成人尸体颈椎标本,分离出C3~T1共35个椎体(1例C6~C7融合),剔除每个椎体上下面的椎间盘组织,显露出骨性终板,分为:去终板组17个,完全去除骨性终板;保留终板组18个,完整保留骨性终板。在所有椎体的上面安放相应大小的颈椎人工椎间盘(ProDisc-C)后用MTS-858生物力学实验机进行疲劳测试和屈服测试,得到金属-骨界面的刚度、位移和最大屈服压力,从其中1具颈椎标本取出4个椎体(每组各2个)切片行HE染色后用光镜观察金属-骨性界面。结果:疲劳前测试金属-骨界面刚度去终板组为1470±180N/mm,高于保留终板组的1260±170N/mm(P<0.0001);疲劳后测试两组刚度均有上升,去终板组刚度为1990±110N/mm,仍高于保留终板组的1680±140N/mm(P<0.0001)。疲劳前测试两组的终板位移分别为0.45±0.09mm和0.41±0.10mm,无显著性差异(P=0.15),疲劳后测试去终板组位移0.53±0.12mm小于保留终板组的0.66±0.14mm(P=0.005)。去终板组最大屈服压力为1110±350N,略小于保留终板组的1250±230N,但无显著性差异(P=0.27)。组织切片显示去终板组金属-骨界面贴合良好,而保留终板组金属-骨界面有明显的缝隙。结论:不同的终板准备方法会影响到假体金属-骨界面的刚度和稳定性。去终板组金属-骨界面的刚度和稳定性优于保留终板组,良好的金属-骨界面接触是颈椎人工椎间盘假体稳定的关键因素之一。 | 谭荣 邹德威 Hansen Yuan Amir H.Fayyazi Nathaniel R.Ordway Matthew J.Allen | 2007 | 中国脊柱脊髓杂志2007，17，9： | 3 |
| 3 | A review of large area monitoring of land cover change using Landsat data显示文摘 | Matthew C. Hansen Thomas R. Loveland | 2012 | Remote Sensing of Environment2012，，： | 2 |
| 4 | First-principles-based Monte Carlo simulation of ethylene hydrogenation kinetics on Pd 显示文摘 | EricW Hansen Matthew Neurock | 2000 | Journal of Catalysis2000，196，： | 1 |
| 5 | Prevalence of renovascular disease in the elderly: A population-based study显示文摘 | Kimberley J. Hansen Matthew S. Edwards Timothy E. Craven Gregory S. Cherr Sharon A. Jackson Richard G. Appel Gregory L. Burke Richard H. Dean | 2002 | Journal of Vascular Surgery2002，，3： | 1 |
| 6 | Prevalence of renovascular disease in the elderly: A population-based study显示文摘 | Kimberley J. Hansen Matthew S. Edwards Timothy E. Craven Gregory S. Cherr Sharon A. Jackson Richard G. Appel Gregory L. Burke Richard H. Dean | 2002 | Journal of Vascular Surgery2002，，3： | 1 |
| 7 | Computational simulations of the trichoderma reesei cel- lobiohydrolase I acting on microcrystalline cellulose I3: the enzyme-substrate complex 显示文摘 | ZHONG L MATTHEWS J F HANSEN P I | 2009 | Carbohydrate Re- search2009，344，15： | 1 |
| 8 | The Coxsackievirus and Adenovirus Receptor: A new adhesion protein in cochlear development显示文摘 | Katherine J.D.A. Excoffon Matthew R. Avenarius Marlan R. Hansen William J. Kimberling Hossein Najmabadi Richard J.H. Smith Joseph Zabner | 2006 | Hearing Research2006，，1： | 1 |
| 9 | Arteriovenous Malformations of the Head and Neck: Natural History and Management显示文摘 | Mark P. Kohout Matthew Hansen Julian J. Pribaz John B. Mulliken | 1998 | Plastic and Reconstructive Surgery1998，，3： | 1 |
| 10 | Global discrimination of land cover types from metrics derived from AVHRR pathfinder data 显示文摘 | Ruth DeFries Matthew Hansen John Townshend | 1995 | Remote Sensing of Environment1995，54，： | 1 |
| 11 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 12 | Atheroemboli during renal artery angioplasty: An ex vivo study显示文摘 | Jade Hiramoto Kimberley J. Hansen Xian Mang Pan Matthew S. Edwards Rajiv Sawhney Joseph H. Rapp | 2005 | Journal of Vascular Surgery2005，，： | 1 |
| 13 | Simultaneous two-dimensional laser-induced-fluorescence measurements of argon ions显示文摘 | A K Hansen Matthew Galante Dustin McCarren | | 0，，10： | 1 |
| 14 | A comparison of sampling designs for estimating deforestation from Landsat imagery: A case study of the Brazilian Legal Amazon显示文摘 | Mark Broich Stephen V. Stehman Matthew C. Hansen Peter Potapov Yosio E. Shimabukuro | 2009 | Remote Sensing of Environment2009，，11： | 1 |
| 15 | Adapting a global stratified random sample for regional estimation of forest cover change derived from satellite imagery显示文摘 | Stephen V. Stehman Matthew C. Hansen Mark Broich Peter V. Potapov | 2010 | Remote Sensing of Environment2010，，2： | 1 |
| 16 | A method for integrating MODIS and Landsat data for systematic monitoring of forest cover and change in the Congo Basin显示文摘 | Matthew C. Hansen David P. Roy Erik Lindquist Bernard Adusei Christopher O. Justice Alice Altstatt | 2007 | Remote Sensing of Environment2007，，5： | 1 |
| 17 | Output-only modal analysis of linear time-periodic systems with application to wind turbine simulation data显示文摘 | Matthew S. Allen Michael W. Sracic Shashank Chauhan Morten Hartvig Hansen | 2011 | Mechanical Systems and Signal Processing2011，，4： | 1 |
| 18 | A method for integrating MODIS and Landsat data for systematic monitoring of forest cover and change in the Congo Basin显示文摘 | Matthew C. Hansen David P. Roy Erik Lindquist Bernard Adusei Christopher O. Justice Alice Altstatt | 2007 | Remote Sensing of Environment2007，，5： | 1 |
| 19 | Color of scents:Chromatic stimuli modulate odor responses in the human brain显示文摘 | (O)sterbauer R.A Matthews P.M Jenkinson M Beckmann C.F Hansen P.C & Calvert G.A | | 0，，： | 1 |
| 20 | Baseline Map of Carbon Emissions from Deforestation in Tropical Regions显示文摘 | Nancy L. Harris Sandra Brown Stephen C. Hagen Sassan S. Saatchi Silvia Petrova William Salas Matthew C. Hansen Peter V. Potapov Alexander Lotsch | 2012 | Science2012，，6088： | 1 |
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