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| 1 | Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats显示文摘AIM: To investigate the mechanism of resveratrol underlying the microcirculation disorder and lung injury following severe acute pancreatitis (SAP).METHODS: Twenty-four rats were divided into 3 groups (SAP, sham and resveratrol groups) randomly. SAP model was established by injecting 4% sodium taurocholate 1 mL/kg through puncturing pancreatic ducts. Sham (control) group (8 rats) was established by turning over the duodenum.Resveratrol was given at 0.1 mg/kg b.m. intraperitoneally.Rats were sacrificed 9 h after SAP was induced. Blood samples were obtained for hemorrheological examination.Lung tissues were used for pathological observation, and examination of microvascular permeability, dry/wet ratio and myeloperoxidase (MPO) activity. Gene expression of intercellular adhesion molecule-1 (ICAM-1) was detected by RT-PCR.RESULTS: Compared with SAP group, resveratrol relieved the edema and infiltration of leukocytes in the lungs. Resveratrol improved markers of hemorrheology:high VTB (5.77±1.18 mPas vs9.49±1.34 mPas), low VTB (16.12±3.20 mPas vs30.91±7.28 mPas), PV (4.69±1.68 mPas vs8.00±1.34 mPas), BSR (1.25±0.42 mm/h vs 0.03±0.03mm/h), VPC (54.67±3.08% vs 62.17±3.39%), fibrinogen (203.2±87.8 g/L vs 51.3±19.1 g/L), original hemolysis (0.45±0.02 vs 0.49±0.02), and complete hemolysis (0.41±0.02 vs0.43±0.02) (P<0.05). Resveratrol decreased the OD ratio of ICAM-1 gene (0.800±0.03 vs 1.188±0.10),dry/wet ratio (0.74±0.02 vs 0.77±0.03), microvascular permeability (0.079±0.006 vs 0.112±0.004) and MPO activity (4.42±0.32 vs 5.03±0.51) significantly (P<0.05).CONCLUSION: Resveratrol can improve the microcirculation disorder of the lung by decreasing leukocyte-endothelial interaction, reducing blood viscosity, improving the decrease of blood flow, and stabilizing erythrocytes in SAP rats. It may be a potential candidate to treat SAP and its severe complications (ALI). | YongMeng MeiZhang JunXu Xue-MinLiu Qing-YongMa | 2005 | World Journal of Gastroenterology2005，11，3： | 19 |
| 2 | MTERF1 regulates the oxidative phosphorylation activity and cell proliferation in HeLa cells显示文摘mitochondrial 抄写结束因素(MTERF ) 家庭是一组高度保存的 DNA 有约束力的蛋白质 composedof 四个关键成员, MTERF14。迄今为止,几研究在 mitochondrial genomeand 上调查了 MTERF1 的有约束力的地点 mitochondrial 基因抄写的规定,而是在 mitochondrial 基因 transcriptionregulation 之间的更复杂的连接, mitochondrial 氧化 phosphorylation (OXPHOS ) ,和房间增长仍然糟糕被理解。在这研究,我们构造了在表示上和是进 HeLa 房间的 transfected 调查 MTERF1 的功能的 MTERF1 的击倒的向量。结果证明尽管 MTERF1 是 mitochondrial 基因抄写的一个 positiveregulatory 因素,它没在 MTERF1 的 mitochondrial DNA.Over表示的复制上有重要效果增加的 mitochondrial 氧化 phosphorylation 活动和支持的 ATP 合成, cyclin D1expression ,和房间增长它的击倒的禁止的 ATP 合成,减少的 cyclin D1 表示,并且 slowedthe 房间生长。这些结果建议 MTERF1 可以由在 HeLa 房间调整氧化 phosphorylationactivity 支持房间增长。最终,这些调查结果由提供新奇卓见进位于房间增长下面的潜在的机制在 MTERF 家庭的 physiologicalfunctions 上为进一步、更最后的研究创造一个基础规定。 | Guiyuan Chen Jie Dai Shirui Tan Shengke Meng Zhongjian Liu Meizhang Li Qinghua Cui Min Yu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 10 |
| 3 | Harmonic moments and large deviations for supercritical branching processes with immigration显示文摘我们与在文学为非移民盒子扩大以前的结果的移民 Z n , 为 supercritical 分叉过程学习泛音时刻的集中率。作为一个副产品,为 Z n+1 /Z n 的大偏差也被学习。我们能看到在集成取决于分叉和移民的产生功能的率有阶段转变。 | Qi SUN MeiZHANG | 2017 | Frontiers of Mathematics in China2017，12，5： | 8 |
| 4 | STRUCTURE,MOLECULAR WEIGHT AND BIOACTIVITIES OF(1→3)-β-D-GLUCANS AND ITS SULFATED DERIVATIVES FROM FOUR KINDS OF LENTINUS EDODES显示文摘Lentinan samples, (1→3)-β-D-glucans containing 4.6-15.2 wt% proteins, coded as L-I1, L-I2, L-I3 and L-I4 (L-I)were isolated from four kinds of Lentinus edodes. These glucans were treated with acetone to remove the protein in order to obtain free protein glucans coded as LNP-I1, LNP-I2, LNP-I3 and LNP-I4 (LNP-I). The free-protein polysaccharides were sulfated to give derivatives (S-LNP-I) with degree of substitution (DS) from 0.4-0.8. The structural features and weight- average molecular weight (Mw) of the samples were investigated by using infrared spectroscopy, elemental analysis,13C-NMR, size exclusion chromatography combined with laser light scattering (SEC-LLS) and viscometry. The effects of structure and conformation of the polysaccharides on antitumor activities were assayed in vivo (Sarcoma 180 solid tumors)and in vitro (Sarcoma 180, HL-60, MCF-7 and Vero tumors). The results indicated that the predominant species of the samples L-I and LNP-I in 0.2 mol/L NaCl aqueous solution existed as triple-helical chains with high rigidity and in dimethyl sulfoxide (DMSO) as single-flexible chains. Interestingly, the antitumor activities of LNP-I are lower than those of the native glucans (L-I), whereas their sulfated derivatives have higher inhibition ratio against Sarcoma 180 than LNP-I. The results reveal that the binding of protein, sulfated modification and the triple helix conformation are important factors in the enhancement of the antitumor activities of polysaccharides on the whole. | UnursaikhanSurenjav 张俐娜 Xiao-juanXu MeiZhang PeterChiKeungCheung Fan-boZeng | 2005 | Chinese Journal of Polymer Science2005，23，3： | 5 |
| 5 | The Study on the Expression of Keratin Proteins in Pterygial Epithelium显示文摘Purpose:To evaluate the expression patterns of several keratin proteins in pteygial epithelium.Methods:The proteins of K8,K10,K14,K16andAE3 in the epithelium of 8pterygia and 4normal conjunctiva were detected using immunofluorescent staining.Results:In pterygial epithelium,the staining patterns of 5keratin proteins were different with normal conjunctiva.No staining of K8,K10and K16was detected in normal conjunctival epithelium,but in pterygial epithelium,K8and K16were present in full thickness and K10was present in superficial cells.In normal conjunctiva.only base layer of epithelium showed positive staining with antibody of K14and AE3proteins,but they were present in the full thickness in pterygial epithelium and the antibody of AE3 protein stained the superficial cells heavily comparing with base cells.Conclusion:The Abnormal expression of keratin proteins(K8,K10,K14,K16andAE3)in pterygia indicates that the epithelial cells in pterygia are in the state of hyperproliferation and keratinization,which may,be the cause of the abnormal tear function in patients with pterygia,Eye Science2000;16:48-52. | MeiZhang YuhuanXie | 2000 | 眼科学报2000，16，1： | 3 |
| 6 | Gold(Ⅰ)-Catalyzed Diastereo- and Enantioselective Synthesis of Polysubstituted Pyrrolo[3,4-d][1,2 ]oxazines显示文摘 | MeiZhang Xiaoyu Di Mingrui Zhang Junliang Zhang | 2018 | Chinese Journal of Chemistry2018，36，6： | 3 |
| 7 | Research and Suggestions on the Coordinated Management and Protection of Intellectual Property in China显示文摘From two aspects of intellectual property management, namely the subject and the object,this article discusses the development and im-provement of intellectual property system in China and the gap and problems existed compared with developed countries. Based on this, the issue ofhow to improve the coordinated management of intellectual property is studied and the relevant proposals are put forward. | Chen Meizhang(Teaching and Research Centre of Intellectual Property, PKU, Beijing 100871) | 2003 | Science Foundation in China2003，11，1： | 2 |
| 8 | Intelligent predicting approach of peritoneal fluid absorption rate based-on neural network显示文摘This paper addresses the important intelligent predicting problem of peritoneal absorption rate in the peritoneal dialysis treament process of renal failure. As the index of dialysis adequacy, KT/V and Ccr are widely used and accepted. However,growing evidence suggests that the fluid balance may play a critical role in dialysis adequacy and patient outcome. Peritoneal fluid absorption decreases the peritoneal fluid removal. Understanding the peritoneal fluid absorption rate will help clinicians to opthnize the dialysis dwell time. The neural network approach is applied to the prediction of peritoneal absorption rate. Compared with multivariable regression method, the experimental results showed that neural network method has an advantage over multivariable regression. The application of this predicting method based-on neural network in clinic is instructive. | MeiZHANG YuemingHU TaoWANG | 2003 | 控制理论与应用(英文版)2003，1，1： | 1 |
| 9 | Structural and functional diversity in the PAR1b/MARK2‐binding region of Helicobacter pylori CagA显示文摘 | Huai‐ShengLu YasuhiroSaito MayumiUmeda NaokoMurata‐Kamiya Hong‐MeiZhang HideakiHigashi | 2008 | Cancer Science2008，，： | 1 |
| 10 | The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis显示文摘 | Meizhang LI Richard M | 2009 | Sem Cancer Biol2009，19，： | 1 |
| 11 | Digital gene expression profiling analysis of DNA repair pathways in colon cancer stem population of HT29 cells显示文摘癌症干细胞(CSC ) 贡献新瘤损害的恶化和发展。当很可得到的临床的途径例如化学药品和放射治疗,将杀死癌症房间的多数时,他们都不杀死他们。一些抵抗房间象 CSC 一样,能由于他们的优秀自我维持的能力幸存,甚至在挑战性的环境。在现在的学习,我们响应单个海滨的损坏和双海滨从 HT29 房间线调查了冒号 CSC 的 DNA 修理基因的 mRNA 水平裂缝,以及在基础切除的关键基因的明显的 upregulation 修理,失配修理,非相应加入结束,并且在这些房间的相应再结合小径。数字基因表示分析在可以在 DNA 修理起重要作用的 CD44 + HT29 房间识别了 upregulated 基因。我们的结果表明冒号 CSC 忍受有效 DNA 修理能力,它可能在重复化学药品和放射治疗以后解释冒号 CSC 的幸存。 | Wenxue Wang Guoxiu Zhang Jing Yang Huan Gu Lei Ding Haijing Yu Min Yu Qinghua Cui Xinglai Ji Meizhang Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 12 | Reflection-type surface lattice resonances in all-metal metasurfaces for refractive index sensing显示文摘Surface lattice resonance(SLR)is a pretty effective mechanism to realize ultranarrow linewidths in the spectrum.Herein,we propose and demonstrate reflection-type SLRs in all-metal metasurfaces experimentally,compared with the traditional transmission-type SLR,which can avoid the refractive index(RI)mismatch problem and are more suitable for high-efficiency RI sensing due to direct contact and strong light–matter interaction.The measured SLR linewidth is 13.5 nm influenced by the meta-atom size,which needs a compromise design to keep a balance between the narrow linewidth and noise immunity.Notably,the SLR sensitivity is determined by the lattice period along the polarization direction with regularity,which establishes an intuitive link between structures and optical responses and provides a theoretical guide for metasurface designs.Additionally,incident angle multiplexing will make the resonance wavelength red shift or blue shift in the case of orthogonal polarization.The rectangular array metasurface can realize dual SLRs with different sensing performances.Flexibly,the SLR can also be formed by the different meta-atoms and arrays.This research supports SLR multifarious applications involving not only RI sensing but also nonlinear optics,nano-lasers,etc. | LIYE LI YIFAN OUYANG LIJUN MA HONGSHUN SUN YUSA CHEN MEIZHANG WU ZHIMEI QI WENGANG WU | 2023 | Photonics Research2023，11，12： | 0 |
| 13 | Study of the immunoisolating effects of barium-alginate microencapsu lation on rat islets allograft survival显示文摘Objective: To evaluate the immunoisola ti ng effects of barium-alginate microencapsulation on islets allograft survival. Methods: The nonmicroencapsulated and microencapsulated islets w ere transplanted under the kidney capsule or intraperitoneally into Wistar rat w ith STZ-induced diabetes. The blood glucose and insulin secretion of grafts wer e observed. Graft function was tested by oral glucose tolerance test (OGTT). Results: ①Five diabetic rats became normoglycemic for 48 to 72 h after microencapsulated islets transplantation. The survival of transplanted i slets was on an average of 6 W. ②The normalization of the glycemia and insulin in the transplanted rats was associated with normal glucose and insulin profiles in response to OGTT. Conclusion: Microencapsulation with barium -alginate membrane can prolong islet survival and protect islets against allore jection. | MeiZhang ChaoLiu CuipingLiu YouwenQin ZhaosunZhen | 2005 | Journal of Nanjing Medical University2005，19，2： | 0 |
| 14 | The Study on the Eapression of Keratin Protins in Pterygial Epithelium显示文摘Purpose:To evaluate the expression patterns of several keratin proteins in pterygial epithelium.Methods:The proteins of K8,K10,K14,K16 and AE3 in the epithelium of 8 pterygia and 4 normal conjunctiva were detected using immunofluorescent staining.Results:In pterygial epithelium,the staining patterns of 5 keratin proteins were different with normal conjunctiva.No staining of K8,K10 and K16 was detected in normal conjunctival epithelium,but in pterygial epithelium,K8 and K16 were present in full thickness and K10 was present in superficial cells.In normal conjunctiva, only base layer of epithelium showed positive staining with antibody of K14 and AE3 proteins,but they were present in the full thickness in pterygial epithelium and the antibody of AE3 protein stained the superficial cells heavily comparing with base cells.Conclusion:The abnormal expression of keratin proteins (K8,K10,K14,K16 and AE3) in pterygia indicates that the epithelial cells in pterygia are in the state of hyperproliferation and keratinization,which may be the cause of the abnormal tear function in patients with pterygia.Eye Science 2000;16:48-52. | MeiZhang YuhuanXie | 2002 | 眼科学报2002，18，1： | 0 |
| 15 | Thermodynamic study of K_2CrO_4-KAlO_2-KOH-H_2O and Na_2CrO_4-NaAlO_2-NaOH-H_2O systems显示文摘Phase diagrams of complex multi-component aqueous chromium salt system are the important theoretical bases for increasing the recovery ratio of chromium and reducing the poisonous waste in the chromate production process. Phase equilibrium of multi-component system has been calculated from the limited known data with thermodynamic models. The phase equilibriums of KOH-K2CrO4-H2O, KOH-KAlO2-H2O, NaOH-Na2CrO4-H2O and NaOH-NaAlO2-H2O systems were calculated with thermodynamic models. The solubilities of Cr and Al was measured in the systems at different temperatures. The results were compared with experimental data and they are consistent with each other. It shows that the lower concentration of KOH (or NaOH) is favorable for thecrystallization of KAlO2 (or NaAlO2) and higher concentration of KOH (or NaOH) is favorable for the crystallization of K2CrO4(Na2CrO4). Therefore, K2CrO4 (or Na2CrO4) can be separated from KAlO2 (or NaAlO2) with controlling the KOH concentration in solutions of KOH-K2CrO4-KAlO2-H2O or NaOH-Na2CrO4-NaAlO2-H2O systems. | XidongWang JinlanCui XinleiGe ShiliZheng MeiZhang YiZhang | 2004 | Journal of University of Science and Technology Beijing2004，11，6： | 0 |
| 16 | Pneumatic separation system for collected seedlings using subdivided air streams显示文摘To adhere to the needs of automated supply of collected seedlings for mechanized grafting and cutting machines for enhancing their operational efficiency,herein,a separation system that uses subdivided air streams to separate the collected seedlings is developed.The separation system comprises a feeder for supplying collected seedlings,a seedling separator that uses subdivided air streams,a picking belt for the separated seedlings,a delivery unit for the separated seedlings,a pneumatic unit,and a control unit.To investigate the complete performance of separation,picking,and delivery of the separation system,several separation experiments were conducted to separate the collected Anthurium seedlings.The results show that the consistency of the moving direction of seedlings floated by subdivided air streams in the separation container and the moving direction of the picking belt have a significant effect on the picking of the separated seedlings by the picking belt.Moreover,the seedling supply timing of the feeder has a significant effect on the stability of the collected seedling separation rate during continuous separation.When this timing is such that the percentage of separated seedlings is 70%,the separation rate of continuous separation operation is 2.24 plant/s(the separation productivity is 8060 plants/h)with 0.12 CV.The operating conditions are 0.5 MPa separation pressure,0.5 s nozzle operation time,and 60 mm seedling thickness in the separation container.Moreover,the staying times of the collected seedlings separated in the separation container are less than 2.5 min. | Delong Jiang Song Gu Qi Chu Yanli Yang Meizhang Gu Yi Yang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 0 |
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