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| 1 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 2 | Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV显示文摘淋巴的系统在在人和动物模型装有免疫力的回答到外国抗原和肿瘤是重要的。肝生产大量淋巴,和它的淋巴的系统被划分成三个主要部件:门, sublobular 和表面的淋巴管。尽管老鼠是最通常使用的实验室动物,对解剖地点的详细描述和排干肝的淋巴节点(行) 的功能是令人惊讶地不在的。在这研究,我们发现门和邻近老鼠肝的腹的行在 5-8min 以内与 Evans 蓝色被染色。从肝的积极房间也排干进二上述的行的提高的绿荧光蛋白质(EGFP ) 。这些数据显示门和腹的行排干鼠标肝。识别的排干肝的行的 Lymphadenectomy 导致了肝炎 B 在免疫能力的老鼠的病毒(HBV ) 坚持与假冒的组相比。另外, CD8 + T 房间的频率和树枝状的房间(DC ) 在 HBV plasmid 的水动力学注射以后在排干肝的行显著地增加了。在 HBV 注射 plasmid 的老鼠的排干肝的行房间也在 vitro 与 recombinant 肝炎 B 核心抗原响应刺激显示出重要抗原特定的增长。进 Rag1 −/− 老鼠的这些房间的采纳转移在 uninjected 老鼠与排干肝的行房间相比在肝炎 B 表面抗原(HBsAg ) 的浆液集中导致了减小。总的来说我们的数据描绘排干肝的行并且提供排干肝的行导致为 HBV 负责的 anti-HBV-specific 免疫者回答的证据清理。 | Meijuan Zheng Jiali Yu Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，2： | 2 |
| 3 | A study of third-order nonlinear optical propertes for anthraquinone derivatives显示文摘 | Wenfan Yan Meijuan Yu | 2003 | Dyes and Pigments2003，56，： | 1 |
| 4 | Heat conduc tion in fractal tree like branched networks显示文摘 | Peng Xu Boming Yu Meijuan Yun | 2006 | Internation al Journal of Heat and Mass Transfer2006，49，： | 1 |
| 5 | Proteomic Analysis of Pancreatic Ductal Adenocarcinoma Compared with Normal Adjacent Pancreatic Tissue and Pancreatic Benign Cystadenoma显示文摘 | Yazhou Cui Mei Tian Meijuan Zong Mujian Teng Yu Chen Jun Lu Jinbo Jiang Xiaoyong Liu Jinxiang Han | 2009 | Pancreatology . 2009 (1-2)2009，，1： | 1 |
| 6 | A fractal model for the starting pressure gradient for Bingham fluids in porous media显示文摘 | Meijuan Yun Boming Yu Jianchao Cai | 2007 | International Journal of Heat and Mass Transfer2007，，5： | 1 |
| 7 | A fractal model for the starting pressure gradient for Bingham fluids in porous media显示文摘 | Yun Meijuan Yu Boming Cai Jianchao | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
| 8 | A fractal model for the starting pressure gradient for Bingham fluids in porous media显示文摘 | Yun Meijuan Yu Boming Cal Jianchao | 2008 | International Journal of Heat and Mass Transfer2008，51，56： | 1 |
| 9 | Diabetes education in mainland China—A systematic review of the literature显示文摘 | Qingqing Lou Liaofang Wu Xia Dai Meijuan Cao Yu Ruan | 2011 | Patient Education and Counseling2011，，3： | 1 |
| 10 | Diabetes education in mainland China—A systematic review of the literature显示文摘 | Qingqing Lou Liaofang Wu Xia Dai Meijuan Cao Yu Ruan | 2011 | Patient Education and Counseling2011，，3： | 1 |
| 11 | Identification of microRNAs regulating grain filling of rice inferior spikelets in response to moderate soil drying post-anthesis显示文摘The grain filling of inferior spikelets is much less complete than that of superior spikelets in rice cultivars with large panicles and numerous spikelets and is promoted by moderate soil drying(MD)post-anthesis.A growing body of evidence has shown that microRNAs function in regulating grain development.However,little is known about the mechanism of microRNA control of grain filling of inferior spikelets in response to MD.In this study,grain filling of inferior spikelets was promoted by MD treatment in Nipponbare.Small-RNA profiling at the most active grain-filling stage was conducted in inferior spikelets under control(CK)and MD treatment.Of 521 known and 128 novel miRNAs,38 known and 9 novel miRNAs were differentially expressed between the CK and MD treatments.Target genes of differentially expressed miRNAs were involved in multiple developmental and signaling pathways associated with catalytic activity,carbohydrate metabolism,and other functions.Both miR1861 and miR397 were upregulated by MD,leading to a decrease in OsSBDCP1 and OsLAC,two negative regulators of SSIIIa activity and BR signaling,respectively.In contrast,miR1432 abundance was reduced by MD,resulting in upregulation of OsACOT and thus an elevated content of both ABA and IAA.These results suggest that both starch synthesis and phytohormone biosynthesis are regulated by differentially expressed miRNAs in inferior spikelets in response to MD treatment.Our results suggest the molecular mechanisms by which miRNAs regulate grain filling in inferior spikelets of rice under moderate soil drying,providing potential application in agriculture to increase rice yields by genetic approaches. | Zhenning Teng Yinke Chen Youqing Yuan Yaqiong Peng Yake Yi Huihui Yu Zhenxie Yi Jianchang Yang Yan Peng Meijuan Duan Jianhua Zhang Nenghui Ye | 2022 | The Crop Journal2022，10，4： | 1 |
| 12 | A Fractal model for the starting pressure gradient 显示文摘 | Meijuan Yun Boming Yu Jiaochao Cai | 2008 | Heat and mass transfer2008，51，： | 1 |
| 13 | Peripheral body temperature rhythm is associated with suicide risk in major depressive disorder:a case-control study显示文摘Background Patients with major depressive disorder(MDD)may have an abnormal peripheral body temperature rhythm,but its relationship with suicidal risk and the response to treatment with antidepressants remain unknown.Aims This study aimed to investigate the feature of peripheral body temperature in patients with MDD and its relationship with suicide risk before and after treatment with antidepressants.Methods This is a prospective case-control study.Patients diagnosed as MDD were enrolled into MDD group.Healthy subjects who matched in terms of gender,age and body mass index were enrolled into normal control(NC)group.The 24-hour peripheral body temperatures were monitored by TM’Holter the next day after assessment.Patients with MDD were re-assessed after a 2-week treatment with antidepressants.All temperature data were fitted into cosine curves by Python.Result There were 41 patients with MDD,and 21 NC participants enrolled and completed the baseline assessments before the treatment.Patients with MDD were further divided into subgroup of with suicide risk or without suicide risk.In patients with MDD,the mesor of peripheral body temperature rhythm was higher in both patients with(36.17(0.30))and without suicide risk(36.22(0.27))than the mesor in NC participants before treatment(35.84(0.38),Z=11.82,p=0.003,Kruskal-Wallis test).The phase-delay of temperature before treatment was greater in patients with MDD with suicidal risk(4.71(1.68))in comparison with those without suicidal risk(3.05(2.19))and NC participants(3.19(1.82),Z=9.68,p=0.008,Kruskal-Wallis test).Moreover,phase-delay of temperature was associated with suicide risk in patients with MDD before treatment(OR=1.046,95%CI:1.009 to 1.085,p=0.015,unadjusted;OR=1.080,95%CI:1.020 to 1.144,p=0.009,adjusted by age and sex).Conclusion Patients with MDD might have abnormal peripheral body temperature.The abnormal phase-delay of peripheral body temperature may indicate suicide risk in patients with MDD,depending on validation in large-scale cohorts. | Xin Ma Jing Cao Hailin Zheng Xinchun Mei Meijuan Wang Haoran Wang Yu Shuai Yuan Shen | 2021 | General Psychiatry2021，34，1： | 1 |
| 14 | Air pollution and children’s respiratory symptoms in six cities of Northern China显示文摘 | Guowei Pan Shujuan Zhang Yiping Feng Ken Takahashi Jun Kagawa Lianzheng Yu Ping Wang Meijuan Liu Qinan Liu Shuwen Hou Bailing Pan Jianping Li | 2010 | Respiratory Medicine2010，，12： | 1 |
| 15 | Fabrication of W@Cu Composite Powders by Direct Electroless Plating Using a Dripping Method显示文摘A direct electroless copper (Cu) coating on tungsten powders method requiring no surface treatment or stabilizing agent and using glyoxylic acid (C2H2O3) as a reducing agent was reported. The effects of copper sulfate concentration and the pH of the plating solution on the properties of the prepared W@Cu composite powders were assessed. The content of Cu in the composite powders was controlled by adjusting the concentration of copper sulfate in the electroless plating solution. A uniform, dense, and consistent Cu coating was obtained under the established optimum conditions (flow rate of C2H2O3 = 5.01 mL/min, solution pH = 12.25 and reaction temperature 45.35 ℃) by using central composite design method. In addition, the crystalline Cu coating was evenly dispersed within the W@Cu composite powders and Cu element in the coating existed as Cu0. The formation mechanism for the W@Cu composite powders by electroless plating in the absence of surface treatment and stabilizing agent was also proposed. | 刘树龙 YU Kan 沈强 LI Meijuan CHEN Wenshu LUO Guoqiang ZHANG Lianmeng | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，4： | 0 |
| 16 | Promoted surface charge density from interlayer Zn–N_(4) configuration in carbon nitride for enhanced CO_(2) photoreduction显示文摘The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy crises.However,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCN)photocatalyst with Zn single atoms(Zn1/CN)was designed and synthesized for CO_(2) photoreduction.The results of the CO_(2) photoreduction studies show that the CO and CH_(4) yields of Zn1/CN increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified PCN.Ar+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCN in the Zn–N_(4) configuration.Photoelectrochemical characterizations indicate that the interlayer Zn–N_(4) configuration can amplify light absorption and establish an interlayer charge transfer channel.Light-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–N_(4) configuration,which increases its surface charge density.Further,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) conversion.This work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts. | Xianjin Shi Yu Huang Gangqiang Zhu Wei Peng Meijuan Chen | 2024 | Nano Research2024，17，4： | 0 |
| 17 | Recent progress on two-dimensional materials confining single atoms for CO_(2) photoreduction显示文摘Photoreduction of CO_(2) into value-added products offers a promising approach to overcome both climate change and energy crisis.However,low conversion efficiency,poor product selectivity,and unclear mechanism limit the further advancement of CO_(2) photoreduction.The development of two-dimensional(2D)materials and construction of single atom sites are two frontier research fields in catalysis.Combining the advantages of 2D materials and single atom sites is expected to make a breakthrough in CO_(2) photoreduction.In this review,we summarized the design and application,proposed challenges and opportunities,and laid a foundation for further research and application of 2D materials confining single atoms(SACs@2D)for CO_(2) photoreduction. | Xianjin Shi Leo NYCao Meijuan Chen Yu Huang | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 18 | Features of animal models of complex partial epilepsy established through unilateral,bilateral and alternate-side kindling at hippocampus of rats显示文摘BACKGROUND: Electrical stimulation kindling model, having epilepsy-inducing and spontaneous seizure and other advantages, is a very ideal experimental animal model. But the kindling effect might be different at different sites. OBJECTIVE: To compare the features of animal models of complex partial epilepsy established through unilateral, bilateral and alternate-side kindling at hippocampus and successful rate of modeling among these 3 different ways. DESIGN: A randomized and controlled animal experiment. SETTING: Department of Neurology, Qilu Hospital, Shandong University. MATERIALS: Totally 60 healthy adult Wistar rats, weighing 200 to 300 g, of either gender, were used in this experiment. BL-410 biological functional experimental system (Taimeng Science and Technology Co.Ltd, Chengdu) and SE-7102 type electronic stimulator (Guangdian Company, Japan) were used in the experiment. METHODS: This experiment was carried out in the Experimental Animal Center of Shandong University from April to June 2004. After rats were anesthetized, electrode was implanted into the hippocampus. From the first day of measurement of afterdischarge threshold value, rats were given two-square-wave suprathreshold stimulation once per day with 400 μA intensity, 1ms wave length, 60 Hz frequency for 1 s duration. Left hippocampus was stimulated in unilateral kindling group, bilateral hippocampi were stimulated in bilateral kindling group, and left and right hippocampi were stimulated alternately every day in the alternate-side kindling group. Seizure intensity was scored: grade 0: normal, 1: wet dog-like shivering, facial spasm, such as, winking, touching the beard, rhythmic chewing and so on; 2: rhythmic nodding; 3: forelimb spasm;4: standing accompanied by bilateral forelimb spasm;5: tumbling, losing balance, four limbs spasm. Modeling was successful when seizure intensity reached grade 5. t test was used for the comparison of mean value between two samples. MAIN OUTCOME MEASURES: Comparison of the successful rate of modeling, the times of stimulation to reach intensity of grade 5, the lasting time of seizure of grade 3 of rats in each group. RESULTS: Four rats of alternate-side kindling group dropped out due to infection-induced electrode loss, and 56 rats were involved in the result analysis. The successful rate of unilateral kindling group, bilateral kindling group and alternate-side kindling group was 55%(11/20),100%(16/16)and 100%(20/20), respectively. The stimuli to reach the grade 5 spasm were significantly more in the bilateral kindling group than in the unilateral kindling group [(30.63±3.48),(19.36±3.47)times,t=8.268,P < 0.01], and those were significantly fewer in the alternate-side kindling group than in the unilateral kindling group [(10.85±1.98)times,t=8.744,P < 0.01]. The duration of grade 3 spasm was significantly longer in the bilateral kindling group than in the unilateral kindling group [(9.75±2.59),(3.21 ±1.58)days,t=8.183,P < 0.01]. Among 20 successful rats of alternate-side kindling group, grade 5 spasm was found in the left hippocampi of 11 rats, but grade 3 spasm in their right hippocampi; Grade 5 spasm was found in the right hippocampi of the other 9 rats, grade 4 spasm in the left hippocampus of 1 rat and grade 3 of 8 rats. CONCLUSION: The speed of establishing epilepsy seizure model by alternate-side kindling is faster than that by unilateral kindling, while that by bilateral kindling is slower than that by unilateral kindling. The successful rate is very high to establish complex partial epilepsy with alternate-side or bilateral kindling. Epilepsy seizure established by alternate-side kindling has antagonistic effect of kindling and the seizure duration of grade 3 spasm is prolonged. | Dongjun Zhang Guangrun Xu Shengnian Zhou Meijuan Yu | 2006 | Neural Regeneration Research2006，1，2： | 0 |
| 19 | Studies on the Compositional Properties of Main Miben Series Pumpkin Varieties in Southern China显示文摘Pumpkin is among the most popular agricultural products in Southern China. To determine the important analytical properties(dry matter, total soluble sugar,dissolvable polysaccharides, mineral content, electricity conductivity, soluble solid content, fruit weight, fat, protein, fiber, pectin, β-carotene and edible rate) of pumpkin in Southern China, this study investigated the physical and chemical properties and texture of raw and steamed pumpkins of 13 Miben series varieties. Miben pumpkins were frozen at-40 ℃ for 24 h, or at-4 ℃ for 24 h, or were steamed for 15 min in boiling water to investigate the effect of different treatments on the textural change, and to reveal the texture and sensory properties of the different varieties. A total of 13 pumpkin varieties of Miben series CP1578, CP2116, XM2-2,Baimi II, Guangmi I, Guangzhouluxia, Jintong, Laojinhanzaoshu, Quanguanjixiang,Newzuhe III, V pumpkin, Zaoshutianmi and Daguomiben were involved in this study.The results showed that the Miben series pumpkins had significant difference in physical properties. The editable rate of Miben series pumpkins was higher than77%. Chemical properties varied among different varieties. Textures of pumpkin flesh after different processes were different. In the sensory assessment of Miben pumpkins, the varieties with overall quality scores more than 50 were Guangmi I, Laojinhanzaoshu, V pumpkin and Daguomiben, indicating that the four varieties all had excellent properties. | Qun ZHANG Wenhua ZHOU Gaoyang LI Yonghong LIU Hanjun TANG Meijuan YU Guizhi LU Jianwen SU | 2014 | Agricultural Science & Technology2014，15，6： | 0 |
| 20 | Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases显示文摘As a ligand-dependent transcription factor,retinoid-associated orphan receptor gt(RORγt)that controls T helper(Th)17 cell differentiation and interleukin(IL)-17 expression plays a critical role in the progression of several inflammatory and autoimmune conditions.An emerging novel approach to the therapy of these diseases thus involves controlling the transcriptional capacity of RORγt to decrease Th17 cell development and IL-17 production.Several RORγt inhibitors including both antagonists and inverse agonists have been discovered to regulate the transcriptional activity of RORγt by binding to orthosteric-or allosteric-binding sites in the ligand-binding domain.Some of small-molecule inhibitors have entered clinical evaluations.Therefore,in current review,the role of RORγt in Th17 regulation and Th17-related inflammatory and autoimmune diseases was highlighted.Notably,the recently developed RORγt inhibitors were summarized,with an emphasis on their optimization from lead compounds,efficacy,toxicity,mechanisms of action,and clinical trials.The limitations of current development in this area were also discussed to facilitate future research. | Jiuping Zeng Mingxing Li Qianyun Zhao Meijuan Chen Long Zhao Shulin Wei Huan Yang Yueshui Zhao Anqi Wang Jing Shen Fukuan Du Yu Chen Shuai Deng Fang Wang Zhuo Zhang Zhi Li Tiangang Wang Shengpeng Wang Zhangang Xiao Xu Wu | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 0 |
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