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| 1 | Low-frequency wide-band hybrid energy harvester based on piezoelectric and triboelectric mechanism显示文摘Recently,hybrid energy harvester has been considered as an attractive potential approach to response the worldwide energy crisis due to the combination of advantages from different harvesting mechanism.In this paper,a novel low-frequency wide-band hybrid energy harvester based on piezoelectric and triboelectric mechanism is presented and systematically studied including structural design,fabrication process,working principle simulation and measurement.With a vibrational excitation,the polyvinylidene fluoride(PVDF) cantilevers will vibrate and impact the polydimethylsiloxane(PDMS) film on the substrate,producing a piezoelectric output as well as a triboelectric output.The structural parameters of each cantilever are optimized using finite element simulation,and the well-designed PVDF cantilevers with controllable PDMS mass not only reduce the device working frequency but also enlarge the bandwidth.Under a sweep-frequency test,three voltage peaks induced by the piezoelectric part are observed at 15,32.5 and 47.5 Hz,with the value of 320,288 and 264 mV,respectively.With the combined triboelectric part,a 20 V peak-peak voltage is generated at 15 Hz.The electrical driving ability of this hybrid energy harvester also has been demonstrated by lighting up a commercial light emitting diode(LED). | HAN MengDi ZHANG XiaoSheng LIU Wen SUN XuMing PENG XuHua ZHANG HaiXia | 2013 | Science China(Technological Sciences)2013，56，8： | 17 |
| 2 | Low frequency wide bandwidth MEMS energy harvester based on spiral-shaped PVDF cantilever显示文摘In this paper,a piezoelectric energy harvester based on spiral-shaped polyvinylidene fluoride(PVDF)cantilever is designed and fabricated for harvesting low frequency vibration energy in the environment.In this design,the spiral-shaped PVDF cantilever is major for lowering the resonant frequency by increasing the length of the cantilever;Copper and silicon proof masses on both sides are working on further decreasing the resonant frequency and widen its bandwidth.Due to the high flexibility of the PVDF cantilever,this device is extremely sensitive to vibration and can harvest weak vibration energy.Both simulation and experimental results have approved that this device can operate at very low frequency which is about 20 Hz and can effectively harvest energy from 15–50 Hz.The peak of the output voltage can reach 1.8 V with the acceleration of 0.2 g.This is a promising harvester for powering the wireless sensors in the future. | LIU Wen HAN MengDi MENG Bo SUN XuMing HUANG XianLiang ZHANG HaiXia | 2014 | Science China(Technological Sciences)2014，57，6： | 13 |
| 3 | Reservoir characteristics and well-logging evaluation of the Lower Cambrian shales in southeast Chongqing, China显示文摘To accurately identify the reservoir characteristics and main controlling factors of the Cambrian Niutitang black shale in the southeast Chongqing,a series of systematic measurements were conducted on core samples from Well Yuke-1 and Well Youke-1.The measurements include clay mineral analysis,XRD analysis,petrophysical properties,specific surface area,pore diameter and TOC,as well as R_(o) and maceral compositions.The Niutitang shale reservoir contains detrital minerals and clay minerals averagely of 51.34%and 32.74%,respectively.The average effective porosity and permeability are 1.2%and 8.0×10^(-3)mD,respectively,typically of ultra-low porosity and permeability.Mesopores are dominant,accounting for approximately 73%of the total pore volume.The average BET specific surface area is 7.75m^(2)/g and the average pore diameter is 5.3nm.The average TOC is 2.29%and the average R_(o) is 3.12%,indicating that the organic matter is in over-maturity stage.Statistical analyses of the measurements show that the micropore volume is positively correlated with TOC but negatively correlated with the total content of clay minerals;the mesopore volume is positively correlated with TOC,the total content of clay minerals and the content of carbonate minerals;the macropore volume is positively correlated with TOC and the content of carbonate minerals,weakly positively correlated with the content of detrital minerals but negatively correlated with the total content of clay minerals.The porosity and TOC of the Niutitang shale are computed using the conventional well-logging method for the Yuke-1 and Youke-1 wells,and the porosities are quite consistent with the core analysis resultsr,but in the shallow reservoir that contains no oil and gas,the TOC exhibits no correlation with the core analysis results. | Xiaomeng Cao Bingsong Yu Xintong Li Mengdi Sun Ling Zhang | 2016 | Petroleum Research2016，1，2： | 3 |
| 4 | Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation显示文摘Background:Largely due to incidental detection,asymptomatic pancreatic cystic le-sions(PCLs)have become prevalent in recent years.Among them,intraductal papillary mucinous neoplasm(IPMN)infrequently advances to pancreatic ductal adenocarcinoma(PDAC).Conservative surveillance versus surgical intervention is a difficult clinical decision for both caregivers and PCL patients.Because RNF43 loss-of-function mutations and KRAS gain-of-function mutations concur in a subset of IPMN and PDAC,their biological significance and therapeutic potential should be elucidated.Methods:Pancreatic Rnf43 knockout and Kras activated mice(Rnf43^(−/−);Kras^(G12D))were generated to evaluate their clinical significance in pancreatic pre-neoplastic initiation and malignant transformation.Results:Loss of Rnf43 potentiated the occurrence and severity of IPMN and PDAC in oncogenic Kras mice.The Wnt/β-catenin signaling pathway was activated in pan-creatic Kras^(G12D)and Rnf43 knockout mice and the PORCN inhibitor LGK974 blocked pancreatic IPMN initiation and progression to PDAC accordingly.Conclusions:Rnf43 is a tumor suppressor in the prevention of pancreatic malignant transformation.This genetically reconstituted autochthonous pancreatic Rnf43^(−/−);Kras^(G12D)preclinical cancer model recapitulates the pathological process from pancreatic cyst to cancer in humans and can be treated with inhibitors of Wnt/β-catenin signaling.Since the presence of RNF43 and KRAS mutations in IPMNs predicts future development of advanced neoplasia from PCLs,patients with these genetic anomalies warrant surveillance,surgery,and/or targeted therapeutics such as Wnt/β-catenin inhibitors. | Xian Zhou Zhichao Sun Mengdi Zhang Xiaoyu Qu Shuhui Yang Lianmei Wang Yanling Jing Li Li Weiwei Deng Fangming Liu Jin Di Jie Chen Jian Wu Hongbing Zhang | 2022 | Animal Models and Experimental Medicine2022，5，1： | 3 |
| 5 | Lamin-like Proteins Negatively Regulate Plant Immunity through NAC WITH TRANSMEMBRANE MOTIF1-LIKE9 and NONEXPRESSOR OF PR 3ENES1 in Arabidopsis thaliana显示文摘 | Tongtong Guo Xuegao Mao Hui Zhang Yu Zhang Mengdi Fu Zhenfei Sun Peng Kuai Yonggen Lou Yuda Fang | 2017 | Molecular Plant2017，10，10： | 3 |
| 6 | QTL mapping of quality traits in peanut using whole-genome resequencing显示文摘Oil and protein content and fatty acid composition are quality traits in peanut.Elucidating the genetic mechanisms underlying these traits may help researchers to obtain improved cultivars by molecular breeding.Whole-genome resequencing of a recombinant inbred population of 318 lines was performed to construct a high-density linkage map and identify QTL for peanut quality.The map,containing 4561 bin markers,covered 2032 c M with a mean marker density of 0.45 c M.A total of 110 QTL for oil and protein content,and fatty acid composition were mapped on the 18 peanut chromosomes.The QTL q A05.1 was detected in four environments and showed a major phenotypic effect on the contents of oil,protein,and six fatty acids.The genomic region spanned by q A05.1,corresponding to a physical interval of approximately 1.5 Mb,contains two SNPs polymorphic between the parents that could cause missense mutations.The two SNP sites were employed as KASP markers and validated using lines with extremely high and low oil contents.These sites may be useful in the marker-assisted breeding of peanut cultivars with high oil contents. | Ziqi Sun Feiyan Qi Hua Liu Li Qin Jing Xu Lei Shi Zhongxin Zhang Lijuan Miao Bingyan Huang Wenzhao Dong Xiao Wang Mengdi Tian Jingjing Feng Ruifang Zhao Xinyou Zhang Zheng Zheng | 2022 | The Crop Journal2022，10，1： | 2 |
| 7 | Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures显示文摘An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic seizures.Irisin reportedly attenuates the apoptosis and injury induced by oxidative stress.Therefore,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat model.The results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and seizures.Irisin treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA administration.Furthermore,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of irisin.The reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin administration.Our findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and UCP2.Moreover,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous irisin.The protective effects of irisin may be mediated through the BDNF-mediated UCP2 level.Our results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures. | Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang Hongliu Sun | 2022 | Neuroscience Bulletin2022，38，11： | 1 |
| 8 | Protein N-myristoylation:functions and mechanisms in control of innate immunity显示文摘Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases(NMTs),which are ubiquitous enzymes in eukaryotes.Specifically,attachment of a myristoyl group is vital for proteins participating in various biological functions,including signal transduction,cellular localization,and oncogenesis.Recent studies have revealed unexpected mechanisms indicating that protein N-myristoylation is involved in host defense against microbial and viral infections.In this review,we describe the current understanding of protein N-myristoylation(mainly focusing on myristoyl switches)and summarize its crucial roles in regulating innate immune responses,including TLR4-dependent inflammatory responses and demyristoylation-induced innate immunosuppression during Shigella flexneri infection.Furthermore,we examine the role of myristoylation in viral assembly,intracellular host interactions,and viral spread during human immunodeficiency virus-1(HIV-1)infection.Deeper insight into the relationship between protein N-myristoylation and innate immunity might enable us to clarify the pathogenesis of certain infectious diseases and better harness protein N-myristoylation for new therapeutics. | Bin Wang Tong Dai Wenhuan Sun Yujun Wei Jiang Ren Long Zhang Mengdi Zhang Fangfang Zhou | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 9 | Reservoir controlling differences between consequent faults and antithetic faults in slope area outside of source: A case study of the south-central Wenan slope of Jizhong Depression, Bohai Bay Basin, East China显示文摘The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of'hard-linkage'faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of'hard-linkage',while the antithetic fault traps are formed at the beginning of the fault active period. | LIU Junqiao WANG Haixue LYU Yanfang SUN Tongwen ZHANG Mengdi HE Wei SUN Yonghe ZHANG Tong WANG Chao CAO Lanzhu | 2018 | Petroleum Exploration and Development2018，45，1： | 1 |
| 10 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
| 11 | Depositional Settings and Enrichment Mechanism of Organic Matter of the Black Shales at the Bottom of Niutitang Formation,Lower Cambrian in Southeast Chongqing:A Case Study from Well Yuke 1显示文摘As one of the most significant research targets of the Southern Marine Shale Gas Exploration and Research in China,Niutitang Formation of Lower Cambrian in Southeast Chongqing developed black shale series which enriched in organic matter at its bottom.Its average total organic carbon(TOC)was 3.75%.Shale gas was | XIA Wei YU Bingsong SUN Mengdi | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 12 | 4-Mercaptopyridine Modified Fiber Optic Plasmonic Sensor for Sub-nM Mercury(II)Detection显示文摘In this paper,we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit,high selectivity,and strong practicability based on the small molecule of the 4-mercaptopyridine(4-MPY)modified tilted fiber Bragg grating surface plasmon resonance(TFBG-SPR)sensing platform.The TFBG-SPR sensor has a rich mode field distribution and a narrow bandw idth,which can detect the microscopic physical and chemical reactions on the sensor surface with high sensitivity without being disturbed by the external temperature.For the environmental compatibility and highly efficient capture of the toxic mercury ion,4-MPY is modified on the sensor surface forming a stable(4-MPY)-Hg-(4-MPY)structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg+via multidentate N-bonding.Moreover,gold nanoparticles(AuNPs)are connected to the sensor surface through the(4-MPY)-Hg-(4-MPY)structure,which could play an important role for signal amplification.Under the optimized conditions,the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10^(-10)M(0.1643 nM),and the detection range is 1×10^(-9)M-1×10^(-5)M.At the same time,the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples.We develop a valuable sensing technology for on-time environmental Hg t detection and in-vivo point of care testing in clinic applications. | Yifan DUAN Yang ZHANG Fang WANG Yuting SUN Ming CHEN Zhenguo JING Qiao WANG Mengdi LU Wei PENG | 2022 | Photonic Sensors2022，12，1： | 1 |
| 13 | Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus显示文摘Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. However, the role of the TSP-1-regulated TGFb1/p Smad2/3 pathway in seizures remains unclear. In this study, changes in this pathway were assessed following kainic acid(KA)-induced status epilepticus(SE) in rats.The results showed that increases in the TSP-1/TGF-b1/p Smad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein(GFAP)/chondroitin sulfate(CS56) levels following KA administration.Inhibition of TSP-1 expression by small interfering RNA or inhibition of TGF-b1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. These anti-seizure effects were accompanied by decreased GFAP/CS56 expression and Smad2/3 phosphorylation. Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity. These results suggest that the TSP-1-regulated TGF-b1/p Smad2/3 pathway plays a key role in KA-induced SE and astrogliosis, and that inhibiting this pathway may be a potential anti-seizure strategy. | Yurong Zhang Mengdi Zhang Wei Zhu Xiaohong Pan Qiaoyun Wang Xue Gao Chaoyun Wang Xiuli Zhang Yuxia Liu Shucui Li Hongliu Sun | 2020 | Neuroscience Bulletin2020，36，3： | 1 |
| 14 | Toward photocatalytic hydrogen generation over BiVO_(4) by controlling particle size显示文摘Owing to excellent light absorption and high activity fo r oxygen evolution,monoclinic bismuth vanadate(BiVO_(4)) is regarded as an ideal candidate for photocatalytic water splitting.However,its application is limited by the large particle size in micrometer scale,as well as the slightly positive conduction band.In this work,we successfully synthesized nano-BiVO_(4) with particle size ranged from 27 nm to 57 nm by wet chemical method based on electrostatic spinning method.Unlike bulk BiVO_(4),the nano-sized BiVO_(4) possesses the ability to generate hydrogen by water splitting,and the activity could reach up to1.66 μmol h^(-1) g^(-1) with the assistance of Pt.The enhanced activity is mainly attributed to the improvements resulted from reduced particle size,which includes elevated conduction band,enlarged specific surface area and promoted charge separation.This work provides a simple method for synthesizing photocatalyst with small particle size and high yield. | Mengdi Sun Zemin Zhang Qiujin Shi Jianlong Yang Mingzheng Xie Weihua Han | 2021 | Chinese Chemical Letters2021，32，8： | 1 |
| 15 | Research on the Construction of Industrial Catalysis Course Under the Background of Specialty-Innovation Integration显示文摘“Specialty-innovation integration”is a positive response of higher education to economic and social development needs,and it is also an inherent requirement for the reform and development of higher education.This paper discusses the construction of an“industrial catalysis”curriculum system under the background of specialty-innovation integration.Overall,it raises students’comprehensive quality from three aspects,including teaching content,teaching method,and the concept of specialty-innovation integration,aiming to cultivate students as the innovative talents required by the development of the era for national and regional development. | Yuxue Wei Sixue Chen Fengye Zhou Jie Liu Lisheng Guo Fang Chen Mengdie Cai Jingshuai Chen Jiaqi Bai Qin Cheng Song Sun | 2023 | Journal of Contemporary Educational Research2023，7，9： | 0 |
| 16 | Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1显示文摘Vision formation is classically based on projections from retinal ganglion cells(RGC)to the lateral geniculate nucleus(LGN)and the primary visual cortex(V1).Neurons in the mouse V1 are tuned to light stimuli.Although the cellular information of the retina and the LGN has been widely studied,the transcriptome profiles of single light-stimulated neuron in V1 remain unknown.In our study,in vivo calcium imaging and whole-cell electrophysiological patch-clamp recording were utilized to identify 53 individual cells from layer 2/3 of V1 as lightsensitive(LS)or non-light-sensitive(NS)by single-cell light-evoked calcium evaluation and action potential spiking.The contents of each cell after functional tests were aspirated in vivo through a patch-clamp pipette for mRNA sequencing.Moreover,the three-dimensional(3-D)morphological characterizations of the neurons were reconstructed in a live mouse after the whole-cell recordings.Our sequencing results indicated that V1 neurons with a high expression of genes related to transmission regulation,such as Rtn4r and Rgs7,and genes involved in membrane transport,such as Na+/K+ATPase and NMDA-type glutamatergic receptors,preferentially responded to light stimulation.Furthermore,an antagonist that blocks Rtn4r signals could inactivate the neuronal responses to light stimulation in live mice.In conclusion,our findings of the vivo-seq analysis indicate the key role of the strength of synaptic transmission possesses neurons in V1 of light sensory. | Jianwei Liu Mengdi Wang Le Sun Na Clara Pan Changjiang Zhang Junjing Zhang Zhentao Zuo Sheng He Qian Wu Xiaoqun Wang | 2020 | Protein & Cell2020，11，6： | 0 |
| 17 | Kinetically accelerated and high-mass loaded lithium storage enabled by atomic iron embedded carbon nanofibers显示文摘Carbonaceous materials represent the dominant choice of materials for anodic lithium storage in many energy storage devices.Nevertheless,the nonpolar carbonaceous materials offer weak adsorption toward Li+that largely denies the high-rate Li+storage.Herein,the atomic Fe sites decorated carbon nanofibers(AICNFs)facilely produced by electrospinning are reported for kinetically accelerated Li+storage.Theoretical calculation reveals that the atomic Fe sites possess coordination unsaturated electronic configuration,enabling suitable bonding energy and facilitated diffusion path of Li+.As a result,the optimal structure displays a high capacitive contribution up to 95.9%at a scan rate of 2.0 mV·s^(−1).In addition,ultrahigh capacity retention of 97%is afforded after 5,000 cycles at a current density of 3 A·g^(−1).Moreover,the interlaced fiber structure enabled by electrospinning benefits structural stability and improved conductivity even at thick electrodes,thus allowing a high areal capacity of 1.76 mAh·cm−2 at a loading of 8 mg·cm−2.Because of these structure and performance merits,the lithium-ion capacitor containing the AICNF-based anode delivers a high energy density and large power density. | Qian Xu Yanan Li Chenghao Wu Xitong Sun Qiang Li Huabin Zhang Le Yu Yuanyuan Pan Yujuan Wang Shiwei Guo Mengdi Zhang Han Hu Mingbo Wu | 2022 | Nano Research2022，15，7： | 0 |
| 18 | Identification of a stable major QTL for fresh-seed germination on chromosome Arahy.04 in cultivated peanut(Arachis hypogaea L.)显示文摘Fresh-seed germination(FSG)impairs peanut production,especially in areas where the peanut harvest season coincides with rainy weather.Developing FSG-resistant cultivars by molecular breeding is expected to mitigate yield loss and quality impairment caused by FSG.However,the genetic control of FSG awaits elucidation.In this study,FSG at 1,3,5,7,and 9 days post-imbibition in three environments were tested,and quantitative-trait loci(QTL)associated with FSG were mapped in a peanut recombinant inbred line population by leveraging existing high-density peanut genetic maps.Of 24 QTL identified in 13 linkage groups,qFSGA04 was a stable major QTL on linkage group 04(LG04).It was consistently detected in five germination stages and three environments.By designing and validating DNA markers in the confidence interval of qFSGA04,we identified one single-nucleotide polymorphism and one In Del closely associated with FSG that could be used as linked markers for FSG resistance in peanut breeding. | Maoning Zhang Qing Zeng Hua Liu Feiyan Qi Ziqi Sun Lijuan Miao Xiaona Li Chenyu Li Debing Liu Junjia Guo Mengyuan Zhang Jing Xu Lei Shi Mengdi Tian Wenzhao Dong Bingyan Huang Xinyou Zhang | 2022 | The Crop Journal2022，10，6： | 0 |
| 19 | Multifunctional electroactive bio-adhesive for robustly-integrated wound therapy and postoperative wound-status warning and assessment显示文摘Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures.The continuous treatment,healing induction,and real-time visualization of wound status and complications,including wound re-tearing,inflammation,and morphology,are key focal points for comprehensive healthcare.Herein,an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic double-layer gelatin-based bio-adhesive(DLGel)by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains.The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue,providing a basis for reliable wound closure.DLGel achieves comprehensive wound-healing induction through electrical stimulation and possesses reversible underwater light/thermal adhesion,excellent hemostatic performance,outstanding antimicrobial properties,and self-repair capability.Furthermore,a novel deep-learning strategy is creatively established to respond to mechanical deformation due to wound anomalies.This strategy translates biological information into visual graphics,providing real-time early warning and assessment of postoperative wound-abnormality/-morphology,such as laceration,inflammation,and necrosis.Therefore,DLGel and its associated signal collection and processing protocol enable the integration of reliable wound closure,wound healing,and real-time postoperative wound-status warning and assessment within the unobservable and undetectable“black box”regions in a context of non-clinical comprehensive therapy. | Ouyang Yue Xuechuan Wang Mengdi Hou Siwei Sun Manhui Zheng Xiaoliang Zou Zhongxue Bai Chunlin Liu Xinhua Liu | 2024 | Nano Research2024，17，5： | 0 |
| 20 | Decoding the spatiotemporal regulation of transcription factors during human spinal cord development显示文摘The spinal cord is a crucial component of the central nervous system that facilitates sensory processing and motor performance.Despite its importance,the spatiotemporal codes underlying human spinal cord development have remained elusive.In this study,we have introduced an image-based single-cell transcription factor(TF)expression decoding spatial transcriptome method(TF-seqFISH)to investigate the spatial expression and regulation of TFs during human spinal cord development.By combining spatial transcriptomic data from TF-seqFISH and single-cell RNA-sequencing data,we uncovered the spatial distribution of neural progenitor cells characterized by combinatorial TFs along the dorsoventral axis,as well as the molecular and spatial features governing neuronal generation,migration,and differentiation along the mediolateral axis.Notably,we observed a sandwich-like organization of excitatory and inhibitory interneurons transiently appearing in the dorsal horns of the developing human spinal cord.In addition,we integrated data from 10×Visium to identify early and late waves of neurogenesis in the dorsal horn,revealing the formation of laminas in the dorsal horns.Our study also illuminated the spatial differences and molecular cues underlying motor neuron(MN)diversification,and the enrichment of Amyotrophic Lateral Sclerosis(ALS)risk genes in MNs and microglia.Interestingly,we detected disease-associated microglia(DAM)-like microglia groups in the developing human spinal cord,which are predicted to be vulnerable to ALS and engaged in the TYROBP causal network and response to unfolded proteins.These findings provide spatiotemporal transcriptomic resources on the developing human spinal cord and potential strategies for spinal cord injury repair and ALS treatment. | Yingchao Shi Luwei Huang Hao Dong Meng Yang Wenyu Ding Xiang Zhou Tian Lu Zeyuan Liu Xin Zhou Mengdi Wang Bo Zeng Yinuo Sun Suijuan Zhong Bosong Wang Wei Wang Chonghai Yin Xiaoqun Wang Qian Wu | 2024 | Cell Research2024，34，3： | 0 |
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